[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"He Eye Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":185},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,44,68,96,118,139,165],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100537526","comparing-myopia-treatments-in-youth-defocus-spectacles-glasses-and-ortho-k-100537526",false,"NCT06278974","Comparing Myopia Treatments in Youth: Defocus Spectacles, Glasses, and Ortho-K","A Comparative Study on the Clinical Efficacy, Quality of Life, and Cost of Use of Peripheral Defocus Spectacles, Frame Glasses, and Orthokeratology Lenses in Myopic Children and Adolescents","Inclusion Criteria:\n\n* Children aged 7-17 years.\n* Myopia between -1.00D and -6.00D; astigmatism \\\u003C±1.5D; best corrected visual acuity ≥1.0.\n* First-time spectacle wearers who use a single correction method and meet the indications for it (any one of orthokeratology lenses, single-vision frame glasses, or myopia control frame glasses)\n* Willing to participate in the entire research process and complete all the examinations, questionnaires and cost records as required.\n* Be able to maintain contact throughout the research period, such as having a fixed address and contact information.\n\nExclusion Criteria:\n\n* History of strabismus, amblyopia, refractive disparity or retinal diseases\n* Previous history of eye surgery\n* Severe psychological disorders or behavioral problems\n* History of allergy to contact lenses or contact lens care solutions","ALL","7 Years","17 Years",{"count":20,"type":21},90,"ESTIMATED","OBSERVATIONAL","The research project titled \"A Comparative Study on the Clinical Efficacy, Quality of Life, and Cost of Use of Peripheral Defocus Spectacles, Frame Glasses, and Orthokeratology Lenses in Myopic Children and Adolescents\" aims to evaluate different non-surgical myopia correction methods in children. It focuses on assessing the impact of peripheral defocus spectacles, frame glasses, and orthokeratology lenses on the quality of life, clinical effectiveness, and costs associated with each method. The study is a prospective cohort study involving 90 children aged 8-17 years with myopia ranging from -1.00D to -6.00D. It aims to compare the psychological, social, and educational aspects of these correction methods, alongside their costs and clinical outcomes over a period of one year.",[25,26,27],"Myopia","Cost-effectiveness Analysis","Quality of Life",[25,29,30],"youth","glasses","RECRUITING","2026-03-19",{"date":34,"type":35},"2026-03-23","ACTUAL",{"date":37,"type":35},"2023-11-10",{"date":39,"type":21},"2027-07-01",{"name":41,"class":42},"He Eye Hospital","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":65,"leadSponsor":67,"locationsCount":4},"100600471","compare-the-clinical-efficacy-of-3-diquafosol-and-01-hyaluronic-acid-in-patients-with-dry-eye-after-lasik-100600471","NCT07097922","Compare the Clinical Efficacy of 3% Diquafosol and 0.1% Hyaluronic Acid in Patients With Dry Eye After LASIK","Inclusion Criteria:\n\n* History of LASIK surgery for more than six months\n* Confirmed dry eye: patients complained of one of the subjective symptoms of ocular dryness, foreign body sensation, burning sensation, fatigue, discomfort, redness of the eyes, and fluctuating visual acuity; as well as (a) OSDI questionnaire score of ≥13 and (b) non-invasive tear break-up time (NITBUT) of \\\u003C10 s or (c) ocular surface staining assessed in \\>5 corneal patches\u002Fgreater than 9 conjunctival patches\n* Participants were able to co-operate with the use of eye drops as required, complete the examination, and return to the hospital within the specified time for follow-up examinations to complete the follow-up visit.\n\nExclusion Criteria:\n\n* Suspected of having keratoconus, a definite diagnosis of keratoconus or another type of corneal dilatation disease.\n* There is active inflammation or symptoms of infection in the eye\n* There are serious lesions in the accessory structures of the eye, such as defects or deformations of the eyelids\n* Patients with Connective tissue diseases and Autoimmune disorders (e.g., SLE, RA)","18 Years","40 Years",{"count":53,"type":21},140,"INTERVENTIONAL",[56],"NA","The prevalence of refractive ametropia is rising year by year. Refractive surgery has become the main approach for adults to correct refractive ametropia, and postoperative complications have aroused extensive attention from clinicians. Dry eye after refractive surgery is one of the postoperative complications, which is an important cause of affecting the postoperative visual quality and satisfaction of patients. It was reported that 3% diquafosol (DQS) and 0.1% hyaluronic acid (HA) can relieve dry eye symptoms. This study aims to compare the efficacy of 3% DQS and 0.1% HA in treating dry eye after LASIK",[59],"Dry Eye","NOT_YET_RECRUITING","2025-07-30",{"date":63,"type":35},"2025-08-01",{"date":63,"type":21},{"date":66,"type":21},"2026-05-01",{"name":41,"class":42},{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":75,"enrollmentInfo":76,"targetDuration":4,"studyType":54,"phases":78,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":4},"100589907","precision-lifestyle-interventions-guided-by-continuous-glucose-monitoring-impact-on-glycemic-outcomes-in-type-2-diabetes-mellitus-100589907","NCT06960512","Precision Lifestyle Interventions Guided by Continuous Glucose Monitoring: Impact on Glycemic Outcomes in Type 2 Diabetes Mellitus","The Impact of Precision Lifestyle Intervention on Blood Glucose Control in Type 2 Diabetes Mellitus","Inclusion Criteria:\n\n* Comply with the diagnostic criteria for T2DM in the 'Clinical guidelines for prevention and treatment of type 2 diabetes mellitus in the elderly in China (2020 edition)', and be diagnosed with type 2 diabetes mellitus, i.e., mainly due to insulin resistance and insufficient relative insulin secretion, and have the typical symptoms of diabetes mellitus (irritable thirst and excessive drinking, excessive urination, excessive food intake, and unexplained weight loss) plus a random glucose level ≥11.1 mmol\u002FL (200 mg\u002Fdl), or plus a fasting Blood glucose level ≥ 7.0 mmol\u002FL (126 mg\u002Fdl), or plus random blood glucose or OGTT (Oral Glucose Tolerance Test) 2-hour blood glucose level ≥ 11.1 mmol\u002FL (200 mg\u002Fdl), or plus glycated hemoglobin (HbA1c) level ≥ 6.5%;\n* Age 18～65 years old (including the threshold), gender is not limited;\n* Can skillfully operate a smartphone by themselves, or their family members can help to use the phone to give feedback on their daily life situation;\n* Willing to participate in this study with good compliance;\n* Agree to authorize He Eye Specialist Hospital to make cases of health management content.\n\nExclusion Criteria:\n\n* Pregnant women, lactating women, and women of childbearing age who do not wish to use contraception during the research period;\n* Severe skin disease, adhesive tape or adhesive allergy at the sensor placement site;\n* People with a history of specific allergies, or allergies (e.g., allergic to two or more drugs, food, or pollen);\n* Patients who meet the criteria for Grade 3 hypertension according to the ratings in the' Chinese Guidelines for the Prevention and Treatment of Hypertension (2024 Revision)', i.e., blood pressure over 180\u002F110 mmHg, or low blood pressure of 110 mmHg or more;\n* Suffering from severe cardiovascular and cerebrovascular diseases (including ST-segment elevation myocardial infarction, unstable angina up to Braunwald classification III (one or more episodes of resting angina within 48 hours), transient ischemic attack, stroke treatment accompanied by various degrees of sequelae (e.g.,hemiplegia,aphasia,impaired consciousness, epilepsy, and even dementia), coronary artery stenosis of moderate stenosis (50%) and above, hemodialysis reconstruction surgery less than 6 months, cerebral embolism and cerebral hemorrhage less than 6 months or with varying degrees of movement disorders after the treatment, cognitive disorders, speech and swallowing disorders, and other sequelae, etc.), or daily accompanied by frequent episodes of angina pectoris, chest tightness, chest pain and other symptoms;\n* Renal insufficiency up to stage III and above (blood creatinine level more than 450μmol\u002FL);\n* History of psychoSsis or psychotropic substance abuse;\n* Any condition judged by the investigator to be unsuitable for participation.","65 Years",{"count":77,"type":21},200,[56],"This study is an interventional research. Through scientific evaluation, it explores the effect of precise lifestyle intervention based on CGM data on the control of chronic type 2 diabetes mellitus. By formulating a safe and effective precise lifestyle intervention plan, lifestyle medicine is integrated into the management of chronic diseases. Through multidimensional evaluations, it is expected to improve patients' self-management ability and provide a reference for the development of chronic diabetes management.",[81],"Type 2 Diabetes Mellitus (T2DM)",[83,84,85,86,87],"lifestyle medicine","Type 2 Diabetes Mellitus","continuous glucose monitoring","HBA1c","Glycosylated hemoglobin","2025-05-05",{"date":90,"type":35},"2025-05-07",{"date":92,"type":21},"2025-05",{"date":94,"type":21},"2026-12",{"name":41,"class":42},{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":51,"enrollmentInfo":102,"targetDuration":4,"studyType":54,"phases":104,"briefSummary":105,"conditions":106,"keywords":108,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":115,"leadSponsor":117,"locationsCount":4},"100581576","compare-the-clinical-efficacy-of-3-diquafosol-and-01-hyaluronic-acid-in-patients-with-dry-eye-after-trans-prk-100581576","NCT06852105","Compare the Clinical Efficacy of 3% Diquafosol and 0.1% Hyaluronic Acid in Patients with Dry Eye After Trans-PRK","Inclusion Criteria:\n\n* Age 18-40 years.\n* The refractive status should be maintained at least for more than 2 years, during which the annual increase in myopia should be controlled within 0.50 D.\n* Pherical equivalent (SE) ≤-6.00D, astigmatic power≤-2.00D.\n* Best corrected vision before surgery≥1.0.\n* Patients should stop wearing soft contact lenses for at least 2 weeks and hard contact lenses for at least 4 weeks before surgery.\n\nPostoperative corneal stromal thickness was preserved (280 μm).\n\nExclusion Criteria:\n\n* Suspected of having keratoconus, a definite diagnosis of keratoconus, or another type of corneal dilatation disease.\n* There is active inflammation or symptoms of infection in the eye.\n* The thickness of the cornea does not meet the preset cutting depth requirement: the thickness of the central cornea should be greater than 450 μm, and the thickness of the central corneal stroma remaining under the corneal flap should be maintained above 250 μm after the intended cutting (280 μm recommended).\n* Dry eye.\n* There are serious lesions in the accessory structures of the eye, such as defects or deformations of the eyelids.\n* People with uncontrolled systemic connective tissue diseases and autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis.",{"count":103,"type":21},76,[56],"The prevalence of refractive ametropia is rising year by year. Refractive surgery has become the main approach for adults to correct refractive ametropia, and postoperative complications have aroused extensive attention from clinicians. Dry eye after refractive surgery is one of the postoperative complications, which is an important cause of affecting the postoperative visual quality and satisfaction of patients. It was reported that 3% diquafosol (DQS) and 0.1% hyaluronic acid (HA) can relieve dry eye symptoms. This study aims to compare the efficacy of 3% DQS and 0.1% HA in treating dry eye after Trans-PRK",[59,107],"Tear Break-Up Time",[109,110],"dry eye","Trans-PRK","2025-02-21",{"date":113,"type":35},"2025-02-28",{"date":113,"type":21},{"date":116,"type":21},"2026-05-31",{"name":41,"class":42},{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":122,"acronym":4,"eligibilityCriteria":123,"healthyVolunteers":11,"sex":16,"minAge":124,"maxAge":125,"enrollmentInfo":126,"targetDuration":4,"studyType":54,"phases":128,"briefSummary":129,"conditions":130,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":43},"100571034","effect-of-spectacle-distribution-to-myopic-secondary-school-students-in-rural-communities-of-liaoning-province-on-communities-academic-high-school-enrolment-100571034","NCT06714994","Effect of Spectacle Distribution to Myopic Secondary School Students in Rural Communities of Liaoning Province on Communities Academic High School Enrolment","Inclusion Criteria:\n\n* Year 1 students (about 12-15 years old) from schools in county-level cities and below in Liaoning Province\n* Uncorrected (self-glasses) visual acuity of ≤6\u002F12 in both eyes\n* Refractive error meets cut-offs shown to be associated with significantly greater improvement in visual acuity when corrected7 (myopia ≤-0.75 diopters (D, or astigmatism (non-spherical refractive error) ≥1.00 D\n* Best corrected visual acuity ≥6\u002F7.5 in either eye\n\nExclusion Criteria:\n\n* Hyperopia ≥2.00 D\n* Presence of visually-significant ocular condition besides refractive error","11 Years","16 Years",{"count":127,"type":21},1980,[56],"To determine whether provision of free spectacles to rural-dwelling Chinese secondary school students with visually-significant refractive error, together with a teacher-based incentive to promote their use, increases the proportion of children going on to academic high school, as opposed to dropping out or pursuing a vocational track.",[25],"2024-12-03",{"date":133,"type":35},"2024-12-04",{"date":135,"type":21},"2024-12-01",{"date":137,"type":21},"2027-12-01",{"name":41,"class":42},{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":143,"acronym":4,"eligibilityCriteria":144,"healthyVolunteers":145,"sex":16,"minAge":50,"maxAge":146,"enrollmentInfo":147,"targetDuration":4,"studyType":54,"phases":149,"briefSummary":150,"conditions":151,"keywords":154,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":4},"100566532","effect-of-artificial-tears-on-ocular-biometry-parameters-100566532","NCT06656403","Effect of Artificial Tears on Ocular Biometry Parameters","Inclusion Criteria:\n\n(1) age ≥18 years,(2) able and willing to comply with the treatment schedule.\n\nExclusion Criteria:\n\n1. The eyes cannot fixate on the fixation lamp (such as children, nystagmus diseases, severe low vision, inattention, etc.) and cannot act according to the user's instructions and sit in the front of the equipment (the forehead or lower song is injured so that it cannot be supported on the forehead \u002F lower song bracket)\n2. The eyes are cloudy with optical media (such as corneal opacity, central corneal scar, mature cataract, posterior chamber bag opacity, vitreous hemorrhage, etc.).\n3. The eyelid is completely closed or too small (drooping, relaxation) resulting in complete or partial occlusion of the cornea\n4. Just after contact measurement or examination, use a corneal local anesthesia solution. (IOL Master 700 should avoid using local anesthetic before all contact examinations)\n5. Tear film deformation (lack of specular reflection of the cornea during corneal curvature measurement), the severity of grade IV dry eye, and whether eye drops were used 24 hours before the examination.\n6. Any corneal lesions (corneal irregularity, corneal scar or corrosive burning, severe irregular astigmatism of cornea)\n7. Fundus lesions (changes in the anatomical morphology of retinal macular fovea during axial length measurement, such as retinal detachment, edema, ulcer, etc.)\n8. Patients with ocular trauma, surgery, and excessive photosensitivity, such as photodynamic therapy (PDT), were excluded.\n9. using eye drops (0.1% Sodium hyaluronate) allergic patients",true,"60 Years",{"count":148,"type":21},100,[56],"Due to the instability of the tear film, the biometry often needs to be done multiple times in a clinical environment. The high variability of both short-term and long-term repeatability in keratometry of dry eyes is well-known. Consequently, enhancing the condition of the eye surface in individuals with dry eyes will result in improved precision when choosing the power of intraocular lenses (IOLs). This prospective and before-and-after self-control study will recruit 100 patients.",[152,153],"Dry Eye Disease","Tear Film",[109,155,156],"IOL Master 700","tear film","2024-10-22",{"date":159,"type":35},"2024-10-24",{"date":161,"type":21},"2024-10-30",{"date":163,"type":21},"2024-11-21",{"name":41,"class":42},{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":169,"acronym":4,"eligibilityCriteria":170,"healthyVolunteers":11,"sex":16,"minAge":171,"maxAge":50,"enrollmentInfo":172,"targetDuration":4,"studyType":54,"phases":174,"briefSummary":175,"conditions":176,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":4},"100557379","effects-of-3-diquafosol-on-tear-film-and-vision-related-quality-of-life-in-orthokeratology-lens-related-dry-eye-100557379","NCT06537349","Effects of 3% Diquafosol on Tear Film and Vision-related Quality of Life in Orthokeratology Lens Related Dry Eye","Inclusion Criteria:\n\n* Age 8-18 years old\n* Wearing corneal shape mirror more than one year and at least eight hours every night\n* Myopia -5.50 to -1.00 D, astigmatism \\\u003C 1.75 D, or curvature between 41.00 and 46.00D, astigmatism \\\u003C -0.75D, and best corrected visual acuity ≥1.0.\n* Diagnosis of dry eye: patients complained of dry eye, foreign body sensation, burning sensation, fatigue, discomfort, envy, subjective symptom such as vision fluctuation; (a) OSDI questionnaire score \\>13 points, and (b) NITBUT \\\u003C10 s or (c) ocular surface dyeing assessment \\> 5 corneal spots\u002Fmore than nine conjunctival spots.\n* Participants were able to use eye drops as required, complete examinations, and return to the hospital for follow-up examinations within the specified time to complete follow-up.\n\nExclusion Criteria:\n\n* Suffering from allergic or autoimmune disease associated with dry eye of the participants are not suitable for wearing OK lens\n* Pathological changes in the corneal rim\n* Eyelid rim lesions, cornea, uveitis, retina and other systemic diseases may affect the ocular surface. Examples include severe ocular surface diseases (Sjögren's syndrome, allergic conjunctivitis, ocular papules, conjunctival chafing, conjunctival scarring, and chemical damage);\n* Received any dry eye treatment within 14 days prior to the start of this study or continued use of other topical eye drops that would affect the results of the study.\n* Have received any other eye treatment or surgery","8 Years",{"count":173,"type":21},30,[56],"Investigate the effect of 3% Diquafosol on tear film and vision-related quality of life in dry eye patients wearing orthokeratology lenses(OK lens), and to provide reference for clinical treatment.This prospective, open label study will include 60 eyes of 30 OK lens related dry eye patients.Participants will receive 3% Diquafosol ophthalmic solution. The dosage for both drugs will be one drop, six times per day for 4 weeks. Pediatric Refractive Error Profiletear(PREP), tear film lipid layer (TFLL),non-invasive breakup time (NITBUT), corneoconjunctival staining score (CS), tear meniscus height (TMH), objective visual quality,ocular surface disease index (OSDI) will be assessed and compared at baseline, day-14, and day-28",[59],"2024-08-08",{"date":179,"type":35},"2024-08-12",{"date":181,"type":21},"2024-08-15",{"date":183,"type":21},"2024-12-31",{"name":41,"class":42},""]