[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Heartland Health Research Alliance\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":49},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":32,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100477111","the-heartland-study-100477111",false,"NCT05492708","The Heartland Study","Children's Health in the Heartland Study","Inclusion Criteria:\n\n* Pregnant persons ages 18 or older at time of consent who are ≤20+6 weeks pregnant. Best clinical estimate of gestational age will be utilized for recruitment purposes. Enrollment in the first trimester (≤ 13 + 6) is preferred, but anyone ≤ 20 +6 is permitted.\n* Living in one of the 13 Heartland Study region states at the time of enrollment (Arkansas, Illinois, Indiana, Iowa, Kansas, Michigan, Minnesota, Missouri, Nebraska, North Dakota, Ohio, South Dakota, or Wisconsin) Optional inclusion of the putative biological father\n\nExclusion Criteria:\n\n* Participants who are not fluent in and\u002For do not fully understand, read, write, or speak the English language.\n* Other inability to provide informed consent to participate",true,"FEMALE","18 Years",{"count":20,"type":21},2600,"ESTIMATED","OBSERVATIONAL","The Heartland Study is a prospective, observational study that will enroll up to 2,600 pregnant participants across the Heartland States in the U.S..\n\nThe objective of the Heartland Study is to address major knowledge gaps concerning the health effects of herbicides on maternal and infant health. The study is being conducted to evaluate the associations between environmental exposures to herbicides during and after pregnancy and reproductive health outcomes. The study is measuring multiple biomarkers of herbicide exposure among pregnant Midwesterners and their partners to evaluate associations with pregnancy and childbirth outcomes, epigenetic biomarkers of exposure, and child development.",[25,26,27,28,29,30,31],"Pregnancy Related","Pregnancy Complications","Birth Defect","Gestational Age and Weight Conditions","Spontaneous Abortion","Miscarriage","Exposure to Herbicides",[33,34,35],"pesticide exposure","birth outcomes","biomonitoring","RECRUITING","2025-06-25",{"date":39,"type":40},"2025-06-29","ACTUAL",{"date":42,"type":40},"2020-01-11",{"date":44,"type":21},"2029-01",{"name":46,"class":47},"Heartland Health Research Alliance","OTHER",4,""]