[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Helios Health Institute GmbH\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":121},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,49,71,93],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100449543","complete-functional-assessment-of-intermediate-coronary-artery-stenosis-before-and-after-transcatheter-aortic-valve-implantation-tavi-in-patients-with-severe-symptomatic-aortic-valve-stenosis-100449543",false,"NCT05133843","Complete Functional Assessment of Intermediate Coronary Artery Stenosis Before and After Transcatheter Aortic Valve Implantation (TAVI) in Patients With Severe Symptomatic Aortic Valve Stenosis","CHOICE-FR","Inclusion Criteria:\n\n* Age \\>18 years\n* Willing to participate and able to understand, read and sign the informed consent document before the planned procedure\n* Severe symptomatic aortic stenosis with indication for TAVI according to current guidelines deemed by the Heart Team\n* Patients who have undergone coronary CT angiography before TAVI in which CAD could not be ruled out\n* CAD in one or more native major epicardial vessels or their branches by coronary angiogram with visually assessed coronary stenosis, in which the physiological severity of the lesion is in question (typically 40-90% diameter stenosis).\n* Eligible for invasive coronary angiography and functional assessment (FFR, RFR, CFR and IMR)\n* Eligible for coronary CT-angiography and functional assessment (CT-FFR)\n\nExclusion Criteria:\n\n* Patients whose CT-angiography was determined to be non-diagnostic\u002Funreadable during its evaluation\n* Previous coronary artery bypass grafting with patent grafts to the interrogated vessel\n* Patients with severe lesions with a diameter stenosis ≥ 90%, flow-limiting lesions, or a significant left main coronary artery stenosis\n* Critical coronary artery disease deemed by the Heart Team to require immediate revascularization\n* Contraindication to adenosine (e.g. bronchial asthma)\n* Chronic renal impairment with severe reduction of glomerular filtration rate (eGFR \\\u003C30 ml\u002Fmin)\n* Presence of cardiogenic shock\n* Participation in another interventional study involving the left heart or coronary arteries","ALL","18 Years",{"count":19,"type":20},50,"ESTIMATED","INTERVENTIONAL",[23],"NA","The purpose of the current study is to assess complete coronary physiology (FFR, RFR, CFR, IMR, and CT-FFR) in TAVI candidates with intermediate coronary artery stenosis before and 6 months after TAVI. This aims to determine how TAVI affects coronary blood flow and coronary microcirculatory function after longer-term follow-up, and how these effects influence FFR and RFR values. In addition, it is aimed to correlate invasive functional testing (FFR and RFR) with non-invasive CT-FFR before and 6 months after TAVI.",[26,27],"Coronary Artery Stenosis","Transcatheter Aortic Valve Implantation",[26,29,30,31,32,33,34,35],"transcatheter aortic valve implantation","coronary physiology","coronary blood flow","coronary microcirculatory function","non-invasive CT-FFR","fractional flow reserve","resting full cycle ratio","RECRUITING","2024-11-22",{"date":39,"type":40},"2024-11-25","ACTUAL",{"date":42,"type":40},"2021-09-29",{"date":44,"type":20},"2025-09-30",{"name":46,"class":47},"Helios Health Institute GmbH","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":21,"phases":59,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":64,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":70},"100323951","comparison-of-vessel-ffr-versus-ffr-in-intermediate-coronary-stenoses-100323951","NCT03497637","Comparison of Vessel-FFR Versus FFR in Intermediate Coronary Stenoses","Comparison of Non-Invasive Vessel Fractional Flow Reserve Calculated From Angiographic Images Versus Fractional Flow Reserve in Patients With Intermediate Coronary Artery Stenoses","LIPSIASTRATEGY","Inclusion Criteria:\n\n* Age \\>18 years\n* Willing to participate and able to understand, read and sign the informed consent document before the planned procedure\n* Eligible for coronary angiography and\u002For PCI\n* Coronary artery disease in one or more native major epicardial vessels or their branches by coronary angiogram with visually assessed de novo coronary stenosis in which the physiological severity of the lesion is in question (typically 40-80% diameter stenosis).\n* Stable angina or acute coronary syndrome (non-culprit vessels only and outside of primary intervention during acute STEMI or NSTE-ACS)\n* Participation in another interventional study\n\nExclusion Criteria:\n\n* Previous CABG with patent grafts to the interrogated vessel\n* Tandem stenoses separated by more than 10 mm that require separate pressure guide wire interrogation or PCI (not to be interrogated or treated as a single stenosis)\n* Total coronary occlusions\n* Hemodynamic instability (Killip class III-IV)\n* Heavily calcified or tortuous vessels\n* Terminal disease with life expectancy of less than 12 months\n* STEMI within 48 hours of procedure\n* Severe valvular heart disease\n* ACS patients with difficulty in assessing which the culprit lesion is\n* Significant contraindication to adenosine administration (e.g. Asthma bronchiale)\n* Pregnancy",{"count":58,"type":20},1054,[23],"This is a prospective, randomized, controlled, multicenter, open-label study designed to assess whether vFFR is non-inferior to FFR in assessment of intermediate coronary stenosis in terms of the occurrence of MACE during 12 months after randomization.",[62,63],"Coronary Artery Disease","Coronary Artery Stenoses",{"date":39,"type":40},{"date":66,"type":40},"2020-10-23",{"date":68,"type":20},"2026-11-01",{"name":46,"class":47},8,{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":78,"targetDuration":80,"studyType":81,"phases":4,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":48},"100440450","the-leipzig-tavi-registry-100440450","NCT05015452","The Leipzig TAVI Registry","An Observational Follow-up Assessment of Transcatheter Aortic Valve Implantation in Leipzig","Inclusion Criteria:\n\n* All patients treated with TAVI\n\nExclusion Criteria:\n\n* None",{"count":79,"type":20},20000,"10 Years","OBSERVATIONAL","A single-center registry including all patients treated with TAVI at the Heart Center, Leipzig, Germany",[84],"Aortic Valve Stenosis","2024-10-07",{"date":87,"type":40},"2024-10-09",{"date":89,"type":40},"2020-03-01",{"date":91,"type":20},"2030-12-31",{"name":46,"class":47},{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":99,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":101,"targetDuration":103,"studyType":81,"phases":4,"briefSummary":104,"conditions":105,"keywords":108,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":114,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":120},"100427356","the-helios-heart-registry-a-standardized-registry-for-patients-with-specific-cardiac-diseases-100427356","NCT04844944","The Helios Heart Registry: A Standardized Registry for Patients With Specific Cardiac Diseases","The Helios Heart Registry: A Standardized Registry for Capturing Clinical and Patient-reported Outcomes in Patients With Specific Cardiac Diseases: Application of the ICHOM Standard in Clinical Practice","H²-Registry","Inclusion Criteria:\n\n* Age of 18 years or older\n* Inpatient Treatment\n* Present diagnosis of at least one of the three cardiovascular disease entities of interest according to the current guidelines of the European Society of Cardiology (ESC): HF, CAD, AF\n\nExclusion Criteria:\n\n* Inability to provide informed consent\n* Initial presentation (index hospitalization) in cardiogenic shock or other kinds of shock\n* Patient after heart transplantation or patient with present ventricular assist device (VAD)",{"count":102,"type":20},24000,"5 Years","Investigator-initiated, prospective, non-randomized, open label, non-interventional multicenter registry to evaluate current treatment of three major cardiovascular disease entities in clinical practice using a standardized variable-set of relevant covariates and outcome measures.",[106,62,107],"Heart Failure","Atrial Fibrillation",[109,110,111,112,113],"cardiovascular disease","HF","CAD","AF","ICHOM",{"date":87,"type":40},{"date":116,"type":40},"2021-03-30",{"date":118,"type":20},"2026-03-01",{"name":46,"class":47},10,""]