[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Hitit University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":457},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,17,0,[8,50,87,112,137,161,187,213,233,259,280,304,331,358,383,409,430],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100644381","preoperative-anxiety-and-surgical-fear-in-holmium-laser-enucleation-of-the-prostate-and-transurethral-resection-of-the-prostate-patients-with-benign-prostatic-hyperplasia-100644381",false,"NCT07663097","Preoperative Anxiety and Surgical Fear in Holmium Laser Enucleation of the Prostate and Transurethral Resection of the Prostate Patients With Benign Prostatic Hyperplasia","Evaluation of the Effects of Preoperative Anxiety and Surgical Fear on Postoperative Functional Outcomes and Patient Satisfaction in Patients Scheduled for HoLEP and TURP Due to Benign Prostatic Hyperplasia: A Prospective Observational Study","HoLEP and TURP","Inclusion Criteria:\n\n* Male patients aged 50 years or older\n* Diagnosis of benign prostatic hyperplasia (BPH)\n* Scheduled to undergo HoLEP or TURP\n* Ability to understand and complete study questionnaires\n* Provided written informed consent\n\nExclusion Criteria:\n\n* History of severe psychiatric disorder\n* Active psychiatric treatment\n* Neurogenic bladder or neurologic voiding dysfunction\n* Diagnosis of prostate cancer\n* Previous prostate surgery\n* Inability to comply with study procedures or follow-up visits","MALE","50 Years",{"count":20,"type":21},80,"ESTIMATED","OBSERVATIONAL","Benign prostatic hyperplasia (BPH) is a common condition in older men and may cause bothersome lower urinary tract symptoms that can negatively affect quality of life. Surgical treatment with Holmium Laser Enucleation of the Prostate (HoLEP) or Transurethral Resection of the Prostate (TURP) is often recommended when medical therapy is insufficient.\n\nThis prospective observational study aims to evaluate whether preoperative anxiety, depression, and surgical fear influence postoperative functional outcomes, urinary continence, erectile function, and patient satisfaction in patients undergoing HoLEP or TURP for BPH. Participants will complete validated psychological and functional questionnaires before surgery and during postoperative follow-up visits at 1 and 3 months. The study will also assess changes in psychological status after surgery and compare outcomes between HoLEP and TURP patients.\n\nThe findings may help improve preoperative patient counseling and identify patients who could benefit from additional psychological support before surgery.",[25],"Benign Prostatic Hyperplasia",[27,28,29,30,31,32,33,34,35,36],"BPH","HOLEP","TURP","Preoperative anxiety","surgical fear","depression","Patient satisfaction","lower urinary tract symptoms","urinary incontinence","erectile function","NOT_YET_RECRUITING","2026-06-23",{"date":40,"type":41},"2026-06-26","ACTUAL",{"date":43,"type":21},"2026-06-14",{"date":45,"type":21},"2027-06-08",{"name":47,"class":48},"Hitit University","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":57,"minAge":58,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":69,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},"100641920","antibiotic-irrigation-and-suction-ureteral-access-sheath-in-rirs-100641920","NCT07655050","Antibiotic Irrigation and Suction Ureteral Access Sheath in RIRS","The Combined Effect of Antibiotic Irrigation and Aspiration Ureteral Access Sheath on Infectious Complications in Retrograde Intrarenal Surgery: A Prospective Randomized Factorial Study","Inclusion Criteria:\n\n* Patients scheduled for retrograde intrarenal surgery (RIRS) due to kidney stones\n* Male and female patients aged 18 years or older\n* Patients who voluntarily sign the informed consent form\n* Patients with sterile urine culture or whose preoperative infection has been treated and urine culture has become sterile\n\nExclusion Criteria:\n\n* Patients with active urinary tract infection before surgery\n* Patients with chronic kidney disease\n* Pregnant patients\n* Patients with allergy to aminoglycoside-group drugs used in the study protocol, specifically gentamicin\n* Cases in which the ureter cannot be accessed and the procedure is postponed by placing a double-J stent instead of performing dilation","ALL","18 Years",{"count":60,"type":21},180,"INTERVENTIONAL",[63],"NA","Retrograde intrarenal surgery (RIRS) is a widely used treatment for kidney stones; however, postoperative infectious complications remain a significant concern. This prospective randomized factorial trial aims to evaluate whether gentamicin-containing irrigation fluid and the use of a suction ureteral access sheath can reduce postoperative fever, systemic inflammatory response syndrome (SIRS), and sepsis after RIRS. The study will also investigate the independent and combined effects of these two interventions on infectious outcomes.",[66,67,68],"Kidney Calculi","Urolithiasis","Urinary Tract Infections",[70,71,72,73,74,75,76],"Retrograde intrarenal surgery","Kidney stone","Gentamicin","Irrigation fluid","Infectious complications","Urinary tract infection","SEPSİS","RECRUITING","2026-06-21",{"date":80,"type":41},"2026-06-24",{"date":82,"type":41},"2026-06-15",{"date":84,"type":21},"2027-05-08",{"name":47,"class":48},2,{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":4,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":57,"minAge":58,"maxAge":4,"enrollmentInfo":94,"targetDuration":4,"studyType":61,"phases":96,"briefSummary":97,"conditions":98,"keywords":100,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":49},"100642011","normal-vs-low-tidal-volume-ventilation-in-retrograde-intrarenal-surgery-100642011","NCT07643324","Normal vs Low Tidal Volume Ventilation in Retrograde Intrarenal Surgery","Comparison of Normal Ventilation and Low Tidal Volume Ventilation During Retrograde Intrarenal Surgery (RIRS) Using Video-Based Motion Index: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adult patients aged 18 years or older\n* Patients scheduled for elective retrograde intrarenal surgery under general anesthesia\n* ASA physical status I-III\n* Patients who are able to read and understand the informed consent form\n* Patients who provide written informed consent\n\nExclusion Criteria:\n\n* Patients younger than 18 years\n* Pregnancy\n* Emergency surgery\n* Severe chronic obstructive pulmonary disease, severe restrictive pulmonary disease, or preoperative hypercapnia\n* Severe uncontrolled cardiovascular disease\n* Active urinary tract infection, sepsis, or untreated infectious focus\n* Cases in whom the standardized ventilation protocol is difficult to apply because of morbid obesity\n* Patients scheduled for an additional major urological procedure in the same session\n* Cases in which an intraoperative video recording of sufficient quality cannot be obtained\n* Patients in whom the study protocol cannot be safely continued according to the investigator's clinical judgment",{"count":95,"type":21},60,[63],"Retrograde intrarenal surgery is commonly performed under general anesthesia for the treatment of renal stones. During the procedure, respiratory-related renal movement caused by positive-pressure ventilation may impair endoscopic image stability and reduce the efficiency of laser lithotripsy. This randomized controlled trial aims to compare the effects of normal ventilation and low tidal volume ventilation on intraoperative endoscopic image stability during RIRS using a video-based Motion Index.\n\nEligible adult patients scheduled for elective RIRS under general anesthesia will be randomized in a 1:1 ratio to either normal tidal volume ventilation or low tidal volume ventilation. A standardized 60-second intraoperative video segment in which the stone and\u002For active laser lithotripsy is visible will be analyzed by blinded assessors. The primary outcome is the mean Motion Index value calculated from sequential video frames. Secondary outcomes include additional Motion Index parameters, laser activation time, anesthesia and surgical duration, intraoperative respiratory and hemodynamic safety parameters, vasopressor requirement, complications, and stone-free status at routine follow-up.",[99],"Renal Calculi",[101,70,102,103,104],"General anesthesia","Low tidal volume ventilation","Video-based image analysis","Endoscopic visualization quality","2026-06-19",{"date":38,"type":41},{"date":108,"type":41},"2026-04-29",{"date":110,"type":21},"2026-09-01",{"name":47,"class":48},{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":57,"minAge":58,"maxAge":4,"enrollmentInfo":119,"targetDuration":4,"studyType":61,"phases":121,"briefSummary":122,"conditions":123,"keywords":125,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":131,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":49},"100634317","advanced-vs-standard-hemodynamic-monitoring-during-propofol-sedation-for-ercp-a-prospective-study-100634317","NCT07538115","Advanced vs Standard Hemodynamic Monitoring During Propofol Sedation for ERCP: A Prospective Study","Comparison of Advanced Hemodynamic Monitoring With Standard Monitoring During Propofol Sedation for Endoscopic Retrograde Cholangiopancreatography Procedures: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18 years and older\n* Patients with an ASA physical status score of III or higher scheduled for ERCP\n* Patients maintaining spontaneous respiration\n* Patients who have provided written informed consent\n\nExclusion Criteria:\n\n* Patients requiring general anesthesia\n* Patients requiring mechanical ventilation\n* Patients unsuitable for arterial catheterization due to coagulopathy or local infection\n* Pregnant women\n* Patients who do not sign the informed consent form",{"count":120,"type":21},32,[63],"The aim of this study is to evaluate whether there is a difference in hemodynamic events requiring intervention between patients monitored with advanced hemodynamic monitoring using the MostCare system and those monitored with standard monitoring alone during propofol sedation for ERCP procedures.",[124],"Hemodynamic Instability",[126,127,128,129,130],"Advenced hemodynamic Monitorization","ERCP","Sedation","Propofol","Non-operating room anesthesia",{"date":80,"type":41},{"date":133,"type":41},"2026-03-27",{"date":135,"type":21},"2026-07-15",{"name":47,"class":48},{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":17,"minAge":58,"maxAge":4,"enrollmentInfo":144,"targetDuration":4,"studyType":61,"phases":145,"briefSummary":146,"conditions":147,"keywords":150,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":158,"leadSponsor":160,"locationsCount":86},"100642494","spinal-versus-general-anesthesia-in-open-simple-prostatectomy-100642494","NCT07643415","Spinal Versus General Anesthesia in Open Simple Prostatectomy","Effect of Spinal Versus General Anesthesia on Postoperative Bleeding in Patients Undergoing Open Simple Prostatectomy: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Male patients aged 18 years or older.\n* Diagnosis of benign prostatic hyperplasia (BPH).\n* Scheduled to undergo open simple prostatectomy.\n* American Society of Anesthesiologists (ASA) physical status I-III.\n* Ability to provide written informed consent.\n\nExclusion Criteria:\n\n* Refusal or inability to provide informed consent.\n* Patients scheduled for radical prostatectomy due to prostate cancer.\n* Emergency surgery.\n* Known coagulation disorders or clinically significant thrombocytopenia.\n* Ongoing anticoagulant or antiplatelet therapy that cannot be discontinued according to institutional protocols.\n* Contraindication to spinal anesthesia.\n* Participation in another interventional clinical trial that may affect study outcomes.\n* Administration of tranexamic acid or any additional hemostatic agent during the perioperative period.",{"count":20,"type":21},[63],"Open simple prostatectomy is still performed for selected patients with benign prostatic hyperplasia, particularly in cases with large prostate volume. Postoperative bleeding, hematuria, clot retention, and transfusion requirement are clinically important complications after this procedure.\n\nThis prospective randomized controlled trial will compare the effects of spinal anesthesia and general anesthesia on postoperative bleeding in patients undergoing open simple prostatectomy. Participants will be randomized into two groups: spinal anesthesia or general anesthesia. Tranexamic acid or any additional hemostatic agent will not be used. Postoperative bleeding will be assessed using hemoglobin and hematocrit changes, transfusion requirement, hematuria, clot retention, need for bladder irrigation, and bleeding-related reintervention.\n\nThe study aims to determine whether spinal anesthesia is associated with reduced postoperative bleeding compared with general anesthesia in open simple prostatectomy.",[148,25,149],"Urologic Neoplasms","Anesthesia",[151,152,153,154],"Open simple prostatectomy","Spinal anesthesia","general anesthesia","postoperative bleeding",{"date":156,"type":41},"2026-06-16",{"date":108,"type":41},{"date":159,"type":21},"2026-09-15",{"name":47,"class":48},{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":4,"eligibilityCriteria":167,"healthyVolunteers":11,"sex":57,"minAge":58,"maxAge":168,"enrollmentInfo":169,"targetDuration":4,"studyType":61,"phases":171,"briefSummary":172,"conditions":173,"keywords":175,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":181,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":49},"100636363","comparison-of-extracorporeal-shock-wave-therapy-and-low-level-laser-therapy-in-patients-with-lateral-epicondylitis-100636363","NCT07564713","Comparison of Extracorporeal Shock Wave Therapy and Low-Level Laser Therapy in Patients With Lateral Epicondylitis","Effects of Extracorporeal Shock Wave Therapy Versus Low-Level Laser Therapy on Ultrasonographic Tendon Thickness and Clinical Outcomes in Patients With Lateral Epicondylitis","Inclusion Criteria:\n\n* Clinical diagnosis of lateral epicondylitis based on physical examination findings\n* Symptom duration of at least 6 weeks\n* Presence of lateral elbow pain aggravated by wrist extension and\u002For gripping activities\n* Ability to understand and comply with study procedures\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Previous surgery involving the affected elbow\n* History of corticosteroid or other injection therapy to the affected elbow within the last 6 months\n* Presence of inflammatory rheumatic diseases (e.g., rheumatoid arthritis)\n* Neurological disorders affecting the upper extremity\n* Systemic inflammatory or metabolic diseases that may affect tendon structure or healing\n* Cervical radiculopathy or other causes of referred upper extremity pain\n* Pregnancy or breastfeeding\n* Use of anticoagulant therapy or bleeding disorders\n* Severe comorbid conditions that may interfere with participation","65 Years",{"count":170,"type":21},50,[63],"Background:\n\nLateral epicondylitis is a common musculoskeletal condition characterized by pain and functional impairment of the elbow, often associated with degenerative changes in the common extensor tendon. Extracorporeal shock wave therapy (ESWT) and low-level laser therapy (LLLT) are widely used noninvasive treatment modalities; however, comparative evidence regarding their clinical and structural effects remains limited.\n\nObjective:\n\nThis study aims to compare the effects of ESWT and LLLT on pain intensity, elbow function, quality of life, grip strength, and ultrasonographic characteristics of the extensor tendon (thickness and echogenicity) in patients with lateral epicondylitis.\n\nMethods:\n\nThis prospective, randomized, single-blind, comparative clinical trial will be conducted at the Physical Medicine and Rehabilitation outpatient clinic. Patients aged 18-65 years with clinically diagnosed lateral epicondylitis and symptom duration of at least six weeks will be included. All participants will receive a tennis elbow brace and a standardized exercise program. Participants will be randomly assigned to receive either ESWT or LLLT. ESWT will be applied to the lateral epicondyle region using a standardized protocol once weekly for 3 weeks. LLLT will be administered to the same region using standard clinical protocol three times per week for 3 weeks.\n\nAssessments will be performed before and after treatment. Pain will be evaluated using the Visual Analog Scale (VAS), elbow function using the Patient-Rated Tennis Elbow Evaluation (PRTEE), quality of life using the Short Form-36 (SF-36), and grip strength using a hand dynamometer. Ultrasonographic evaluation of the common extensor tendon will be performed by a blinded specialist using a high-frequency linear probe to assess tendon thickness.",[174],"Lateral Epicondylitis (Tennis Elbow)",[176,177,178,179,180],"Lateral epicondylitis","extracorporeal shock wave therapy","ultrasonography","tennis elbow","low level laser therapy",{"date":156,"type":41},{"date":183,"type":41},"2026-05-04",{"date":185,"type":21},"2026-09-29",{"name":47,"class":48},{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":4,"eligibilityCriteria":193,"healthyVolunteers":11,"sex":57,"minAge":58,"maxAge":194,"enrollmentInfo":195,"targetDuration":4,"studyType":61,"phases":197,"briefSummary":198,"conditions":199,"keywords":201,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":206,"startDateStruct":208,"completionDateStruct":210,"leadSponsor":212,"locationsCount":49},"100636692","ureteral-access-sheaths-in-endoscopic-kidney-stone-surgery-100636692","NCT07568990","Ureteral Access Sheaths in Endoscopic Kidney Stone Surgery","The Impact of Two Different Ureteral Access Sheaths on Success and Complications in Endoscopic Kidney Stone Surgery","Inclusion Criteria:\n\n* Patients aged between 18 and 75 years\n* Patients diagnosed with kidney stones smaller than 2 cm\n* Patients scheduled for retrograde intrarenal surgery (RIRS)\n* Patients who provide written informed consent\n\nExclusion Criteria:\n\n* Patients with active urinary tract infection\n* Patients with coagulopathy\n* Pregnant patients\n* Patients unable to tolerate the lithotomy position\n* Patients with incomplete clinical or laboratory data","75 Years",{"count":196,"type":21},70,[63],"This prospective, randomized, comparative study aims to evaluate the impact of aspirating and non-aspirating ureteral access sheaths on success rates and complications in patients undergoing retrograde intrarenal surgery (RIRS) for kidney stones. A total of 70 patients with renal stones smaller than 2 cm will be enrolled and randomly assigned to two groups. One group will undergo RIRS using a non-aspirating ureteral access sheath, while the other group will be treated using an aspirating ureteral access sheath.\n\nThe primary outcome of the study is the stone-free rate, which will be assessed at postoperative follow-up. Secondary outcomes include operative time, fluoroscopy time, length of hospital stay, postoperative complications according to the Clavien-Dindo classification, infection-related parameters, and the need for ureteral stenting.\n\nThe study aims to determine whether the use of an aspirating access sheath improves surgical outcomes by reducing intrarenal pressure, enhancing visualization, and decreasing complication rates. The findings are expected to contribute to optimizing device selection and improving clinical outcomes in endoscopic kidney stone surgery.",[200],"Kidney Stones",[202,203,204],"retrograd intrarenal surgery","kidney stone","kidney","2026-06-07",{"date":207,"type":41},"2026-06-10",{"date":209,"type":41},"2026-04-20",{"date":211,"type":21},"2027-05-11",{"name":47,"class":48},{"id":214,"slug":215,"hasResults":11,"nctId":216,"briefTitle":217,"officialTitle":218,"acronym":4,"eligibilityCriteria":219,"healthyVolunteers":11,"sex":57,"minAge":58,"maxAge":4,"enrollmentInfo":220,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":222,"conditions":223,"keywords":4,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":228,"completionDateStruct":230,"leadSponsor":232,"locationsCount":49},"100634316","respiratory-physiotherapy-and-diaphragm-thickness-in-ventilated-icu-patients-100634316","NCT07538102","Respiratory Physiotherapy and Diaphragm Thickness in Ventilated ICU Patients","Effect of Respiratory Physiotherapy on Diaphragmatic Thickness in Mechanically Ventilated Patients in Intensive Care Unit: A Prospective Observational Controlled Trial","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Mechanically ventilated for at least 5 days\n* Hemodynamically stable\n* Unconscious (Glasgow Coma Scale indicating impaired consciousness)\n* Informed consent obtained from legal representatives\n\nExclusion Criteria:\n\n* Neuromuscular disease\n* Traumatic diaphragm injury\n* Thoracic deformity causing mechanical impairment of respiration\n* Terminal-stage patients\n* Patients in whom respiratory physiotherapy is contraindicated\n* Presence of a cardiac pacemaker or implantable cardioverter-defibrillator (ICD)",{"count":221,"type":21},66,"This study aims to evaluate the effect of respiratory physiotherapy on diaphragm thickness in patients receiving mechanical ventilation support in the intensive care unit. Thinning and dysfunction of the diaphragm muscle observed during mechanical ventilation complicate the extubation process and increase the risk of respiratory failure in patients. Diaphragm dysfunction prolongs ventilator use and increases ICU mortality. The main objective of this research is to determine whether respiratory physiotherapy has protective or ameliorative effects on diaphragm muscle structure and function, to optimize the ventilator weaning process, and to provide scientific contributions to the field of respiratory rehabilitation. Changes in diaphragm thickness will be objectively evaluated using ultrasonography, and the aim is to obtain evidence-based data on the effectiveness of respiratory physiotherapy.",[224],"Diaphragm Dysfunction","2026-05-07",{"date":227,"type":41},"2026-05-08",{"date":229,"type":41},"2025-08-01",{"date":231,"type":21},"2026-10-01",{"name":47,"class":48},{"id":234,"slug":235,"hasResults":11,"nctId":236,"briefTitle":237,"officialTitle":238,"acronym":4,"eligibilityCriteria":239,"healthyVolunteers":11,"sex":57,"minAge":58,"maxAge":240,"enrollmentInfo":241,"targetDuration":4,"studyType":61,"phases":243,"briefSummary":244,"conditions":245,"keywords":248,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":252,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":49},"100636103","comparing-acbipack-and-acbbifes-block-combinations-for-analgesia-in-total-knee-arthroplasty-100636103","NCT07561333","Comparing ACB+IPACK and ACB+BiFeS Block Combinations for Analgesia in Total Knee Arthroplasty","Comparison of Analgesic Efficacy of Infiltration Between the Popliteal Artery and Capsule of the Knee (IPACK) Versus Biceps Femoris Short Head Block Combined With Adductor Canal Block in Total Knee Arthroplasty","Inclusion Criteria:\n\n* Scheduled for primary total knee arthroplasty surgery\n* ASA physical status classification I-III\n* Hemodynamically stable\n* Age ≥ 18 years and ≤ 80 years\n* BMI ≤ 35 kg\u002Fm²\n* Signed written informed consent form\n\nExclusion Criteria:\n\n* Revision total knee arthroplasty surgery\n* Simultaneous bilateral total knee arthroplasty\n* BMI \\> 40 kg\u002Fm²\n* ASA physical status classification 4-5\n* Inability to perform NRS pain scoring\n* Known allergy to local anesthetics\n* Pregnancy or breastfeeding\n* Age \\\u003C 18 or \\> 80 years\n* Uncontrolled anxiety disorder\n* Alcohol or drug dependency\n* Neuromuscular disease or peripheral nerve disease\n* High-dose opioid use within 3 days prior to surgery\n* Widespread chronic pain syndrome\n* Diabetes mellitus\n* Hepatic or renal insufficiency\n* Coagulation disorders\n* Current use of anticoagulant medications\n* Infection at the peripheral nerve block needle insertion site\n* Refusal to participate in the study","80 Years",{"count":242,"type":21},78,[63],"Total knee arthroplasty (TKA) is associated with severe postoperative pain that delays mobilization, prolongs hospital stay, and reduces patient satisfaction. Regional analgesia techniques have gained prominence due to their opioid-sparing effects and favorable complication profiles compared to general anesthesia. While adductor canal block (ACB) effectively manages anterior knee pain with preserved motor function, posterior knee pain remains a challenge. IPACK (Infiltration between the Popliteal Artery and Capsule of the Knee) and the Biceps Femoris Short Head (BiFeS) block are techniques targeting posterior capsule innervation without causing motor block.This prospective study aims to compare the postoperative analgesic efficacy of ultrasound-guided ACB+IPACK versus ACB+BiFeS block combinations in patients undergoing TKA under spinal anesthesia. Patients (ASA I-III, age 18-80, BMI ≤35) will be randomized into two groups (n=39 each). Primary outcomes include NRS pain scores at rest and on movement, and opioid consumption at 0, 1, 3, 6, 12, 18, and 24 hours postoperatively. Secondary outcomes include time to first mobilization, motor block incidence, quadriceps muscle strength assessment, PONV, and quality of recovery (QoR-15).",[246,247],"Postoperative Pain","Total Knee Arthroplasty",[249,250],"Total knee arthroplasty","Regional anesthesia","2026-04-27",{"date":253,"type":41},"2026-05-01",{"date":255,"type":41},"2025-10-01",{"date":257,"type":21},"2026-11-01",{"name":47,"class":48},{"id":260,"slug":261,"hasResults":11,"nctId":262,"briefTitle":263,"officialTitle":264,"acronym":4,"eligibilityCriteria":265,"healthyVolunteers":11,"sex":57,"minAge":58,"maxAge":4,"enrollmentInfo":266,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":267,"conditions":268,"keywords":270,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":209,"lastUpdatePostDateStruct":274,"startDateStruct":276,"completionDateStruct":278,"leadSponsor":279,"locationsCount":49},"100634993","comparison-of-analgesic-efficacy-of-suprainguinal-fascia-iliaca-and-quadro-iliac-blocks-in-hip-fracture-surgery-100634993","NCT07546903","Comparison of Analgesic Efficacy of Suprainguinal Fascia Iliaca and Quadro-iliac Blocks in Hip Fracture Surgery","Comparison of the Postoperative Analgesic Efficacy of Ultrasound-Guided Suprainguinal Fascia Iliaca Block and Quadro-Iliac Plane Block in Patients Undergoing Hip Fracture Surgery","Inclusion Criteria:\n\n* Patients aged 18 years and older\n* ASA physical status I-III\n* Hemodynamically stable patients\n* Scheduled for surgical treatment of hip fracture\n* Body mass index (BMI) ≤ 35 kg\u002Fm²\n* Provided written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate\n* ASA physical status IV-V\n* Hemodynamically unstable patients\n* Surgery not completed as planned\n* Infection at the block site\n* History of allergy to local anesthetics or tramadol\n* Presence of neuromuscular or peripheral nerve diseases\n* Chronic pain conditions\n* Coagulopathy or ongoing anticoagulant therapy\n* High-dose opioid use within the last 3 days\n* Severe hepatic or renal insufficiency\n* Diabetes mellitus\n* Pregnancy or breastfeeding\n* NRS score \\>7 for four consecutive hours despite multimodal analgesia\n* Inability to understand or use assessment tools (e.g., NRS, QoR-15)\n* Inability to communicate in Turkish\n* Inability to use PCA device due to technical reasons",{"count":196,"type":21},"Hip fractures are common in the elderly and are associated with significant morbidity and mortality. Effective early analgesia is crucial for facilitating mobilization, reducing pulmonary complications, and improving overall outcomes. Although opioids are traditionally used for postoperative pain management, their adverse effects have led to increased interest in multimodal analgesia, particularly peripheral nerve blocks.\n\nThe suprainguinal fascia iliaca block (SIFI) is a modified technique that allows wider spread of local anesthetic, providing more effective blockade of the femoral, obturator, and lateral femoral cutaneous nerves. The quadro-iliac plane block (QIPB), a recently described interfascial block, is performed at the level of the anterior superior iliac spine and may also affect branches of the lumbar and sacral plexus.\n\nWhile both techniques have been shown to provide effective analgesia and reduce opioid consumption, there is no study directly comparing them. Therefore, this study aims to compare the postoperative analgesic efficacy of SIFI and QIPB in patients undergoing hip fracture surgery.",[269],"Post Operative Pain",[271,272,273],"Hip Fracture","Suprainguinal Fascia Iliaca Block","Quadro-Iliac Plane Block",{"date":275,"type":41},"2026-04-23",{"date":277,"type":41},"2025-10-20",{"date":82,"type":21},{"name":47,"class":48},{"id":281,"slug":282,"hasResults":11,"nctId":283,"briefTitle":284,"officialTitle":285,"acronym":4,"eligibilityCriteria":286,"healthyVolunteers":11,"sex":57,"minAge":58,"maxAge":168,"enrollmentInfo":287,"targetDuration":4,"studyType":61,"phases":288,"briefSummary":289,"conditions":290,"keywords":294,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":209,"lastUpdatePostDateStruct":298,"startDateStruct":299,"completionDateStruct":301,"leadSponsor":303,"locationsCount":49},"100635439","usg-guided-tapa-vs-rifb-block-for-postoperative-analgesia-in-laparoscopic-cholecystectomy-100635439","NCT07552701","USG-Guided TAPA vs RIFB Block for Postoperative Analgesia in Laparoscopic Cholecystectomy","Comparison of Ultrasonography-Guided the Postoperative Analgesic Efficacy of Perichondrial Approach Modified Thoracoabdominal Nerve Block and Recto-Intercostal Fascial Plan Block in Patients Who Underwent Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* Age 18-65 years\n* ASA physical classification I-II\n* BMI \\\u003C 35 kg\u002Fm²\n* Scheduled for elective laparoscopic cholecystectomy due to cholelithiasis\n* Able to use and understand the NRS pain scoring system\n* Able to use and understand the QoR-15 scale\n* Able to communicate in Turkish\n* Provided written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* BMI \\> 35 kg\u002Fm²\n* ASA physical classification III-V\n* Age \\\u003C 18 or \\> 65 years\n* Allergy to local anesthetics or study analgesics\n* Pregnancy or breastfeeding\n* Inability to use or understand the NRS pain scoring system or QoR-15 scale\n* Inability to communicate in Turkish\n* Uncontrolled anxiety disorder\n* Alcohol or drug dependency\n* Neuromuscular or peripheral nerve disease\n* High-dose opioid use within 3 days prior to surgery\n* Widespread chronic pain\n* Diabetes mellitus\n* Hepatic or renal insufficiency\n* Coagulation disorders or anticoagulant use\n* Infection at the block needle insertion site\n* Concurrent second surgical procedure alongside laparoscopic cholecystectomy\n* Previous abdominal surgery or trauma history\n* Conversion from laparoscopic to open surgery\n* Technical problems with the PCA device\n* NRS score \\> 7 for four consecutive hours despite multimodal analgesia\n* Planned postoperative non-extubation\n* Termination of surgery before completion for any reason",{"count":196,"type":21},[63],"Laparoscopic cholecystectomy (LC) can cause moderate-to-severe postoperative pain from visceral, referred shoulder, and incisional sources. Multimodal analgesia is recommended, but opioids carry significant side effects. Ultrasound-guided interfascial plane blocks offer a safe alternative. The Modified Thoracoabdominal Nerve Block through Perichondrial Approach (M-TAPA) blocks T5-T12 dermatomes, while the Recto-Intercostal Fascial Plane Block (RIFPB) provides sensory blockade across the upper anterolateral abdomen. This study compares the postoperative analgesic efficacy of bilateral M-TAPA versus bilateral RIFPB in patients undergoing LC.",[246,291,292,293],"Acute Cholecystitis","Cholelithiasis","Postoperative Nausea and Vomiting",[295,296,297],"Laparoscopic Cholecystectomy","Transversus abdominis Plane Block","Rectus-intercostalis facial plane block",{"date":251,"type":41},{"date":300,"type":41},"2025-03-16",{"date":302,"type":21},"2026-05-30",{"name":47,"class":48},{"id":305,"slug":306,"hasResults":11,"nctId":307,"briefTitle":308,"officialTitle":309,"acronym":310,"eligibilityCriteria":311,"healthyVolunteers":312,"sex":57,"minAge":58,"maxAge":313,"enrollmentInfo":314,"targetDuration":316,"studyType":22,"phases":4,"briefSummary":317,"conditions":318,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":323,"lastUpdatePostDateStruct":324,"startDateStruct":326,"completionDateStruct":328,"leadSponsor":330,"locationsCount":49},"100591522","caspase-1-activity-il-1beta-and-il-18-in-patients-with-fmf-100591522","NCT06981520","Caspase-1 Activity, IL-1beta, and IL-18 in Patients With FMF","Effect of Caspase-1 Activity, IL-1beta, and IL-18 on Inflammation in the Mucosa of the Small Intestine of Patients With FMF","FMF","Inclusion Criteria:Age 18 years or older\n\nConfirmed diagnosis of Familial Mediterranean Fever (FMF) according to Tel-Hashomer clinical criteria and\u002For MEFV gene mutation analysis (for FMF group)\n\nUndergoing routine endoscopy with mucosal biopsy sampling\n\nAvailability of sufficient formalin-fixed paraffin-embedded (FFPE) tissue for immunohistochemical analysis\n\nFor controls: absence of systemic inflammatory or autoimmune disease -\n\nExclusion Criteria:History of inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis)\n\nCurrent use of immunosuppressive therapy (excluding colchicine)\n\nSevere infection, active malignancy, or other systemic disease affecting intestinal mucosa\n\nInadequate biopsy specimen quality for histopathological evaluation\n\n\\-",true,"55 Years",{"count":315,"type":21},30,"8 Months","This study aims to investigate the intestinal mucosal expression of key inflammatory markers, namely Interleukin-1 (IL-1), Interleukin-18 (IL-18), and Caspase-1, in patients with Familial Mediterranean Fever (FMF). FMF is an autoinflammatory disorder characterized by recurrent episodes of fever and serosal inflammation. Recent studies suggest a possible role of intestinal immune activation in the disease pathogenesis, particularly through inflammasome-related cytokines. To better understand mucosal involvement in FMF, immunohistochemical staining for IL-1, IL-18, and Caspase-1 will be performed on intestinal biopsy samples obtained during routine endoscopic procedures. The staining intensity and distribution patterns will be evaluated and compared with age- and sex-matched healthy controls. The findings may help clarify mucosal inflammatory pathways involved in FMF and provide insight into novel therapeutic targets.",[319,320,321,322],"Familial Mediterranean Fever","Intestinal Disease","Genetic Disease","Fever","2025-05-13",{"date":325,"type":41},"2025-05-20",{"date":327,"type":21},"2025-07-10",{"date":329,"type":21},"2026-01-19",{"name":47,"class":48},{"id":332,"slug":333,"hasResults":11,"nctId":334,"briefTitle":335,"officialTitle":336,"acronym":4,"eligibilityCriteria":337,"healthyVolunteers":11,"sex":57,"minAge":4,"maxAge":4,"enrollmentInfo":338,"targetDuration":4,"studyType":61,"phases":340,"briefSummary":342,"conditions":343,"keywords":345,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":350,"lastUpdatePostDateStruct":351,"startDateStruct":353,"completionDateStruct":355,"leadSponsor":357,"locationsCount":4},"100580359","phase-2-cleaning-the-biopsy-needle-in-trus-bx-100580359","NCT06836271","Cleaning the Biopsy Needle in TRUS Bx","The Effect of Cleaning the Biopsy Needle With Isopropyl Alcohol, Povidone Iodine and Formalin Before Transrectal Ultrasonography-guided Prostate Biopsy on Procedure-related Infective Complications","Inclusion Criteria:\n\n* Oriented-coopere patients\n* Patients without active urinary tract infection - Patients without active urinary tract infection\n* Patients without bleeding diathesis\n* Patients who accept the study\n\nExclusion Criteria:\n\n* Patients with active urinary tract infection\n\n  * Patients with bleeding diathesis\n  * Patients with sonal or cystofix\n  * Patients with a history of previous prostate surgery",{"count":339,"type":21},200,[341],"PHASE2","Prostate cancer(PCa) is the second most common cancer diagnosed in men. Clinical suspicion of PCa is mentioned in patients with digital rectal examination findings and elevated serum PSA. Despite all the advances in radiological imaging methods, the gold standard method in the diagnosis of the disease is systematic prostate biopsy performed under the guidance of transrectal ultrasonography, which is an invasive procedure.\n\nIn TRUS-guided transrectal prostate biopsy, bacteriuria may develop as a result of the rectum flora being injected into the urinary system through a biopsy needle. Infective complications may be encountered as a result of this contamination. Infective complications can present with conditions ranging from asymptomatic bacteriuria to sepsis.\n\nA study has shown that disinfection of the biopsy needle with isopropyl alcohol reduces sepsis due to prostate biopsy compared to the standard procedure. In another study, disinfection of the biopsy needle tip with formalin was found to be associated with a decrease in infectious complications after transrectal prostate biopsy.\n\nIn this study, investigators aimed to conduct a prospective study comparing Transrectal Ultrasonography-guided Prostate Biopsy cases, in which the biopsy needle was cleaned with isopropyl alcohol, povidone iodine and formalin, and standard biopsy patients in terms of infectious complications.",[344],"Prostatic Cancer",[346,347,348,349],"Prostatic Neoplasms","Needle washing","Prostate biopsy","Sepsis","2025-02-14",{"date":352,"type":41},"2025-02-20",{"date":354,"type":21},"2025-03-01",{"date":356,"type":21},"2025-06-30",{"name":47,"class":48},{"id":359,"slug":360,"hasResults":11,"nctId":361,"briefTitle":362,"officialTitle":362,"acronym":4,"eligibilityCriteria":363,"healthyVolunteers":312,"sex":364,"minAge":58,"maxAge":365,"enrollmentInfo":366,"targetDuration":4,"studyType":61,"phases":367,"briefSummary":368,"conditions":369,"keywords":371,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":375,"lastUpdatePostDateStruct":376,"startDateStruct":378,"completionDateStruct":380,"leadSponsor":382,"locationsCount":49},"100574494","the-effect-of-su-jok-therapy-applied-in-the-first-stage-of-labor-on-pain-level-in-primiparas-100574494","NCT06760013","The Effect of Su-jok Therapy Applied in the First Stage of Labor on Pain Level in Primiparas","Inclusion Criteria:\n\n* Being primiparous\n* The pregnant woman must be over 18 years of age\n* To participate in the research voluntarily\n* The beginning of labor (water breaking, presence of non-stress testa contractions, engagement)\n\nExclusion Criteria:\n\n* Pregnancies outside 37-41 weeks\n* Multiparas\n* Those who are not pregnant\n* Having visual, mental and auditory disabilities\n* Being pregnant as an adolescent\n* Not accepting participation in the research","FEMALE","60 Years",{"count":95,"type":21},[63],"The aim of this study is to examine the effect of sujok therapy applied in the first stage of labor on the pain level in primiparas.",[370],"Labor Pain",[372,373,374],"su jok therapy","labor pain","primiparous","2024-12-30",{"date":377,"type":41},"2025-01-06",{"date":379,"type":21},"2025-01-15",{"date":381,"type":21},"2025-08-30",{"name":47,"class":48},{"id":384,"slug":385,"hasResults":11,"nctId":386,"briefTitle":387,"officialTitle":388,"acronym":4,"eligibilityCriteria":389,"healthyVolunteers":312,"sex":364,"minAge":58,"maxAge":168,"enrollmentInfo":390,"targetDuration":4,"studyType":61,"phases":392,"briefSummary":393,"conditions":394,"keywords":396,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":401,"lastUpdatePostDateStruct":402,"startDateStruct":404,"completionDateStruct":406,"leadSponsor":408,"locationsCount":4},"100568501","stress-ball-application-on-anxiety-and-pain-during-pap-smear-test-100568501","NCT06682052","Stress Ball Application on Anxiety and Pain During Pap Smear Test","Stress Ball Application on Pap Smear Test","Inclusion Criteria:\n\n* Women aged 18 and over,\n* At least primary school graduates,\n* Not pregnant,\n* Married,\n* No physical obstacles to using the anti-stress ball,\n* Those who agree to participate in the study.\n\nExclusion Criteria:\n\n* Acute pelvic pain,\n* Any injury or lesion to the perineum that may cause pain during the examination,\n* Analgesic or anxiolytic use within 24 hours before the examination,\n* Vaginismus,\n* History of sexual abuse,\n* History of a traumatic pelvic examination.",{"count":391,"type":21},90,[63],"A negative pelvic examination experience may deter women from returning for follow-up tests, thus reducing the intended benefit of gynecological screening. For all these reasons, women's experiences with pelvic examinations and related conditions should be taken into account by healthcare services. Although the pelvic examination is relatively brief, cognitive-behavioral interventions that focus or distract the patient's attention have been shown to be effective in reducing pain and anxiety during brief medical interventions. Reducing pain and anxiety during medical procedures is an important factor in patient satisfaction. Although there are many methods to reduce stress, it is thought that the inexpensive and easily accessible anti-stress ball can be used as a distraction method. A study has determined that a stress ball reduces anxiety and pain during angiography. No studies were found in the literature examining the effects of an anti-stress ball on anxiety and pain during a pelvic examination.",[395],"Pain Management",[397,398,399,400],"pap smear","anti stress ball","pain","anxiety","2024-11-08",{"date":403,"type":41},"2024-11-12",{"date":405,"type":21},"2024-12-20",{"date":407,"type":21},"2025-03-15",{"name":47,"class":48},{"id":410,"slug":411,"hasResults":11,"nctId":412,"briefTitle":413,"officialTitle":414,"acronym":4,"eligibilityCriteria":415,"healthyVolunteers":312,"sex":364,"minAge":416,"maxAge":417,"enrollmentInfo":418,"targetDuration":4,"studyType":61,"phases":420,"briefSummary":421,"conditions":422,"keywords":424,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":401,"lastUpdatePostDateStruct":426,"startDateStruct":427,"completionDateStruct":428,"leadSponsor":429,"locationsCount":4},"100568499","effect-of-distraction-technique-on-pain-and-anxiety-during-mammography-100568499","NCT06682026","Effect of Distraction Technique on Pain and Anxiety During Mammography","Mammography and Distraction Technique","Inclusion Criteria:\n\n* Women aged 40-69,\n* Those without a benign tumor in their breasts,\n* Those without any hearing-related health problems.\n\nExclusion Criteria:\n\n* Women under 40 and over 69,\n* Women with suspected breast cancer.","40 Years","69 Years",{"count":419,"type":21},62,[63],"One of the non-medical interventions aimed at reducing sensitization is the cognitive-behavioral approach, in which the individual's attention is shifted from a painful stimulus to an external stimulus. This non-pharmacological approach can be adopted to alleviate stress and reduce cortisol concentrations in response to stress. There are a limited number of studies in the literature using distraction techniques during mammography. This study will examine the effects of distraction techniques on pain and anxiety during mammography.",[423],"Mammography Screening",[425,399,400],"mammography",{"date":403,"type":41},{"date":405,"type":21},{"date":407,"type":21},{"name":47,"class":48},{"id":431,"slug":432,"hasResults":11,"nctId":433,"briefTitle":434,"officialTitle":435,"acronym":4,"eligibilityCriteria":436,"healthyVolunteers":11,"sex":57,"minAge":58,"maxAge":240,"enrollmentInfo":437,"targetDuration":4,"studyType":61,"phases":439,"briefSummary":441,"conditions":442,"keywords":444,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":449,"lastUpdatePostDateStruct":450,"startDateStruct":452,"completionDateStruct":454,"leadSponsor":456,"locationsCount":49},"100560685","phase-4-comparing-sennosid-ab-and-sodium-picosulfatemagnesium-oxidecitric-acid-for-bowel-preparation-100560685","NCT06580366","Comparing Sennosid A+B and Sodium Picosulfate\u002FMagnesium Oxide\u002FCitric Acid for Bowel Preparation","Sennosid A+B Versus Sodium Picosulfate\u002FMagnesium Oxide\u002FCitric Acid for Bowel Preparation; A Prospective Randomized Observer-Blinded Study","Inclusion Criteria:\n\n* Adults aged 18-80 years scheduled for elective outpatient colonoscopy.\n* Ability to provide informed consent.\n\nExclusion Criteria:\n\n* History of intra-abdominal surgery.\n* Chronic kidney failure.\n* Congestive heart failure.\n* Chronic liver failure.\n* Inflammatory bowel disease.\n* Electrolyte imbalance.\n* Hospitalized patients.\n* Patients unable to use the bowel preparation treatment\n* Known allergy or hypersensitivity to Sennoside A+B or PM\u002FCa components\n* Known gastrointestinal motility disorders.",{"count":438,"type":21},600,[440],"PHASE4","Colonoscopy Preparation: Comparing Sennoside A+B and PM\u002FCa\n\nColonoscopy is a test used to examine the inside of the bowel. Proper bowel preparation is crucial because it helps doctors get a clear view during the procedure.\n\nWhat is Sennoside A+B? Sennoside A+B is a type of laxative made from the senna plant. It works by stimulating the bowel to move and reducing the absorption of water, making it easier to pass stools. Research has shown that high doses of sennoside A+B can be effective for bowel preparation.\n\nSennoside A+B vs. PEG:\n\nSome studies have found that sennoside A+B is more effective than PEG, another laxative, but can cause more abdominal pain. Other studies have found no significant difference in effectiveness between the two.\n\nWhat is Picosulfate\u002FMagnesium Oxide\u002FCitric Acid (PM\u002FCa)? PM\u002FCa is a combination of sodium picosulfate, magnesium oxide, and citric acid. Sodium picosulfate stimulates bowel movements, while magnesium oxide and citric acid help increase water in the bowel, making it easier to pass stools.\n\nPM\u002FCa vs. PEG:\n\nResearch has shown that PM\u002FCa is as effective as PEG for bowel preparation. Patients using PM\u002FCa generally tolerate the preparation process better than those using PEG.\n\nConclusion:\n\nWhile PEG is the preferred option according to guidelines, its high cost can make it less accessible in some places. In this study, we aim to compare the effectiveness and patient tolerance of Sennoside A+B and PM\u002FCa since no direct comparison between these two preparations has been made before.",[443],"Bowel Preparation",[445,446,447,448],"Bowel preparation","Colonoscopy","sennosid A+B","Sodium Picosulfate","2024-08-28",{"date":451,"type":41},"2024-08-30",{"date":453,"type":21},"2024-08-22",{"date":455,"type":21},"2025-03-22",{"name":47,"class":48},""]