[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Hongying Jiang, MD\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":117},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,40,65,91],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":25,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100643039","multidimensional-dysfunction-in-patients-with-post-intensive-care-syndrome-in-china-100643039",false,"NCT07585578","Multidimensional Dysfunction in Patients With Post-Intensive Care Syndrome in China","Multidimensional Dysfunction in Patients With Post-Intensive Care Syndrome in China: A Multi-center Real-world Study","Inclusion Criteria:\n\n* Age ≥18 years\n* First admission to ICU, with ICU length of stay ≥ 48 hours before transfer to HDU\n* Complete the PICS assessment within 7 days after HDU admission\n* Complete clinical data available (demographics, ICU-related information)\n* Signed informed consent obtained from participants or legal guardians\n\nExclusion Criteria:\n\n* Prior ICU admission\n* Terminal illness or estimated life expectancy \\\u003C6 months\n* Participants or family members refuse to complete questionnaires","ALL","18 Years",{"count":19,"type":20},800,"ESTIMATED","OBSERVATIONAL","Over the past two decades, the rapid advancement of critical care medicine has significantly reduced short-term mortality among critically ill patients. However, a growing number of intensive care unit (ICU) survivors experience persistent physical, cognitive, and psychological impairments after hospital discharge, a syndrome termed post-intensive care syndrome (PICS). Although PICS has gained increasing attention in recent years, existing studies still have multiple limitations. Given the continuously increasing number of ICU survivors in China and the marked heterogeneity in critical care delivery models across different regions and healthcare institutions, there is an urgent need for large-scale multicenter observational studies to systematically characterize the epidemiological features, multidimensional functional impairment profiles, and clinical impact of PICS in Chinese patients, thereby providing an evidence-based foundation for the development of a scientific post-ICU continuum of care.",[24],"Post-Intensive Care Syndrome (PICS)",[24,26,27],"High-dependency unit","functional outcome","RECRUITING","2026-06-09",{"date":31,"type":32},"2026-06-11","ACTUAL",{"date":34,"type":32},"2026-05-12",{"date":36,"type":20},"2027-05-31",{"name":38,"class":39},"Hongying Jiang, MD","OTHER",{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":47,"enrollmentInfo":48,"targetDuration":4,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":64},"100626445","comparison-of-speaking-valve-trial-and-capping-trial-for-tracheostomy-decannulation-in-stroke-patients-100626445","NCT07435727","Comparison of Speaking Valve Trial and Capping Trial for Tracheostomy Decannulation in Stroke Patients","Comparison of Speaking Valve Trial and Capping Trial in the Decannulation Process for Stroke Patients: A Randomized, Controlled, Multicenter Study","Inclusion Criteria:\n\nStroke (ischemic or hemorrhagic) with subsequent tracheostomy. Stable stage of stroke: clinically in the post-acute or sequelae stage, with stable vital signs, resolved cerebral edema, normalized intracranial pressure, no new neurological deficits.\n\nClinically stable, defined as: ventilator-free for ≥48 hours prior to enrollment; stable vital signs (temperature \\\u003C38°C, heart rate 60-100 bpm, respiratory rate \\\u003C20\u002Fmin, systolic blood pressure 90-160 mmHg); no active severe infection requiring IV antibiotics; no organ failure; partial pressure of Carbon Dioxide(PaCO₂) \\\u003C60 mmHg.\n\nPeak Cough Flow (PCF) ≥100 L\u002Fmin. 24-hour subglottic secretion volume \\\u003C20 ml. Signed informed consent by patient or legal representative.\n\nExclusion Criteria:\n\nIntolerance to cuff deflation: severe cough, dyspnea, SpO₂ \\\u003C93% (on supplemental oxygen), or respiratory rate \\>20\u002Fmin for \\>5 minutes.\n\nSevere airway structural abnormalities: tracheal stenosis (\\>50% lumen occlusion confirmed by Computed Tomography or bronchoscopy), tracheoesophageal fistula.\n\nLife expectancy \\\u003C2 weeks or planned transfer to a non-participating institution within 2 weeks.\n\nSevere uncontrolled neurological or systemic diseases (e.g., advanced cancer, severe heart failure).","80 Years",{"count":49,"type":20},120,"INTERVENTIONAL",[52],"NA","This study aims to compare the efficacy and safety of the Speaking Valve trial versus the traditional Capping trial as indicators for tracheostomy decannulation in stroke patients. The trial is a prospective, multicenter, randomized, parallel-group, outcomes-assessor-blinded study with an exploratory crossover design.",[55],"Stroke","2026-05-19",{"date":58,"type":32},"2026-05-22",{"date":60,"type":20},"2026-05-15",{"date":62,"type":20},"2027-08-15",{"name":38,"class":39},1,{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":4,"eligibilityCriteria":71,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":72,"targetDuration":4,"studyType":50,"phases":74,"briefSummary":75,"conditions":76,"keywords":79,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":64},"100633042","integrated-rehabilitation-in-hdu-for-post-intensive-care-syndromeliberation-in-patients-with-pics-100633042","NCT07521540","Integrated Rehabilitation in HDU for Post-Intensive Care SyndromeLiberation in Patients With PICS","Effect of Integrated Multidisciplinary Rehabilitation in a High-Dependency Unit on Outcomes of Patients With Post-Intensive Care Syndrome: A Prospective Interventional Study","Inclusion Criteria:\n\n* Age ≥18 years\n* Diagnosed with post-intensive care syndrome\n* Transferred from ICU to HDU\n* Available paired admission and discharge data\n\nExclusion Criteria:\n\n* Death within 24 hours after HDU admission\n* Missing primary outcome data",{"count":73,"type":20},250,[52],"Post-intensive care syndrome (PICS) is characterized by persistent physical, cognitive, and psychological impairments among survivors of critical illness. Although advances in intensive care medicine have reduced mortality, a large proportion of ICU survivors experience long-term functional impairments after discharge.\n\nHigh-dependency units (HDUs) serve as transitional care settings between intensive care units and general wards. Many critically ill survivors who cannot directly return home are transferred to HDU for continued treatment and rehabilitation. However, evidence regarding systematic multidisciplinary rehabilitation interventions in HDU settings remains limited.\n\nThis prospective single-center interventional study aims to evaluate the effects of an integrated multidisciplinary rehabilitation model implemented in the HDU on physical, cognitive, and psychological outcomes among patients with post-intensive care syndrome. All enrolled patients will receive standardized integrated medical, nursing, and rehabilitation interventions. Multidimensional functional assessments will be conducted at baseline, during hospitalization, and before discharge from the HDU.",[24,77,78],"Critical Illness Recovery","Mechanical Ventilation",[80,26,81],"Ventilator liberation","Post-ICU rehabilitation","NOT_YET_RECRUITING","2026-04-08",{"date":85,"type":32},"2026-04-13",{"date":87,"type":20},"2026-04-01",{"date":89,"type":20},"2027-12-31",{"name":38,"class":39},{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":4,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":98,"enrollmentInfo":99,"targetDuration":4,"studyType":50,"phases":101,"briefSummary":102,"conditions":103,"keywords":105,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},"100617374","cough-flow-as-a-criterion-decannulation-threshold-in-prolonged-tracheostomy-patients-100617374","NCT07317791","Cough Flow as a Criterion Decannulation Threshold in Prolonged Tracheostomy Patients","Multicenter Prospective Validation of Cough Flow With Tracheostomy Tube and Speaking Valve (CFsv) >100 L\u002FMin as a Criterion Decannulation Threshold in Prolonged Tracheostomy Patients","Inclusion Criteria:\n\n* Age ≥18 years\n* Tracheostomy tube in place for ≥14 days\n* Weaned from ventilator for more than 48 hours, or in a state of spontaneous breathing\n* Patient and family members have provided informed consent\n\nExclusion Criteria:\n\n* Severe craniofacial deformity preventing CFsv measurement\n* Known obstructive upper airway pathology precluding tracheostomy tube removal\n* Laryngopharyngeal trauma\n* Inability to tolerate cuff deflation","90 Years",{"count":100,"type":20},500,[52],"Background: International studies have proposed a cough peak flow (CPF) of ≥160 L\u002Fmin as a reference threshold for safe decannulation. However, this measurement requires prior removal of the tracheostomy tube, which is often difficult for Chinese patients and their families to accept due to cultural and safety concerns. Additionally, there is a lack of rapid, user-friendly, and widely applicable quantitative tools in clinical practice within ICUs or rehabilitation specialties in China. Moreover, the heterogeneity among domestic patient populations with different underlying conditions (such as neuromuscular diseases, spinal cord injuries, stroke, and respiratory failure) makes it challenging to apply a single foreign-derived indicator. In our center's prospective study from 2019 to 2022(Respiratory Research 2024;25:128), the investigators proposed and preliminarily validated that a cough flow measured with tracheostomy tube and speaking valve (CFSV) \\>100 L\u002Fmin could serve as a threshold for safe decannulation. Among 193 patients with long-term tracheostomy tubes, 105 were decannulated based on this threshold, with a success rate of 98.1%. Only two cases required reintubation within 48 hours (1.9%), and the six-month reintubation rate was 2.9%, which is significantly better than previously reported domestic and international data (reintubation rates of 5-15%). For patients with insufficient CFSV, after an average of 26 days of individualized cough enhancement rehabilitation, 91% achieved the threshold and ultimately succeeded in decannulation. This suggests that 100 L\u002Fmin may be a more physiologically appropriate threshold for Chinese (and even East Asian) populations with indwelling tracheostomy tubes, and that CFSV combined with systematic rehabilitation interventions can significantly improve decannulation rates. However, these conclusions are derived from single-center data with a limited sample size, and the diversity of diseases and regional variations in medical standards may affect generalizability. Therefore, there is an urgent need for multicenter, large-sample prospective studies to validate the effectiveness, accuracy, and feasibility of CFSV \\>100 L\u002Fmin as a quantitative standard for safe decannulation.",[104],"Tracheostomy",[106,107],"Decannulation","Cough peak flow","2026-01-17",{"date":110,"type":32},"2026-01-21",{"date":112,"type":20},"2026-01-01",{"date":114,"type":20},"2027-09-30",{"name":38,"class":39},5,""]