[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Hopital La Musse\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":293},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,47,75,110,139,169,202,233,262],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100641659","a-comparative-study-of-driving-performance-among-adolescents-with-autism-spectrum-disorder-and-neurotypical-adolescents-100641659",false,"NCT07630298","A Comparative Study of Driving Performance Among Adolescents With Autism Spectrum Disorder and Neurotypical Adolescents","Perf-TSA","Inclusion Criteria:\n\nASD Group\n\n* Adolescents aged 15 to 17,\n* With a confirmed diagnosis of ASD by a physician,\n* Without an intellectual disability, with a Fluid Reasoning Index (IRF) greater than 80,\n* Who have passed the written driver's license exam,\n* With no or very limited driving experience (\\\u003C5 hours),\n* Enrolled in the social security system.\n\nNeurotypical group:\n\n* Adolescents aged 15 to 17,\n* Without a diagnosis of neurodevelopmental disorders or learning disabilities,\n* With a standard educational background,\n* Who have passed the written driver's license exam,\n* With no or very limited driving experience (\\\u003C5 hours),\n* Enrolled in the social security system.\n\nExclusion Criteria:\n\n* Adolescents with ADHD (attention-deficit\u002Fhyperactivity disorder) and\u002For ODD (oppositional defiant disorder) and\u002For IDD (intellectual disability) and\u002For SLI (specific language impairment) with associated comprehension difficulties,\n* Adolescents who already have a driver's license,\n* Adolescents currently taking driving lessons and\u002For with more than 5 hours of driving experience,\n* Adolescents who have suffered a head injury during childhood,\n* Other serious medical conditions that may interfere with participation in the sessions,\n* Participation in another research protocol.",true,"ALL","15 Years","17 Years",{"count":21,"type":22},22,"ESTIMATED","INTERVENTIONAL",[25],"NA","The primary objective of this study is to compare the number of driving errors made by novice adolescents (0-5 hours of driving instruction) with ASD to those made by neurotypical adolescents during a standardized driving simulator assessment. The secondary objectives of the study are to:\n\n* Compare the visual strategies used by adolescents with ASD to those of neurotypical adolescents during a driving assessment on a simulator.\n* Compare the types of errors and driving performance (i.e., speed, reaction time, following distance, and braking distance) of adolescents with ASD to those of neurotypical adolescents during the driving simulator assessment.\n* Compare the driving performance of these two groups during a real-world road assessment using the TRIP scale.\n* Examine the consistency between driving performance measured in the simulator and that observed in real-world conditions for both groups.\n* Compare the anxiety levels of these two groups during driving tests on the simulator and on the road.",[28],"Autism Spectrum Disorders",[30,31,32,33],"Drive","learning","Driving simulator","ASD","NOT_YET_RECRUITING","2026-06-15",{"date":37,"type":38},"2026-06-17","ACTUAL",{"date":40,"type":22},"2026-07-01",{"date":42,"type":22},"2027-08-31",{"name":44,"class":45},"Hopital La Musse","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":57,"conditions":58,"keywords":64,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":72,"leadSponsor":74,"locationsCount":4},"100631066","the-impact-of-equine-assisted-therapy-on-mental-health-and-addictive-behaviors-in-patients-receiving-addiction-treatment-100631066","NCT07495839","The Impact of Equine-Assisted Therapy on Mental Health and Addictive Behaviors in Patients Receiving Addiction Treatment","EQUI-ADDICT","Inclusion Criteria:\n\n* Adult patients over the age of 18,\n* Patients who have completed detoxification and have been hospitalized at least once in the nutrition and alcoholism unit at La Musse Hospital or at another facility,\n* Patients with an addiction to a psychoactive substance (e.g., alcohol, tobacco, cannabis),\n* Able to participate in animal-assisted therapy sessions,\n* Ability to understand instructions during sessions,\n* Enrolled in the social security system.\n\nExclusion Criteria:\n\n* Patients with a behavioral addiction not involving substances (e.g., gambling, sexual addiction),\n* Patients who have not yet completed detoxification,\n* Patients under legal guardianship,\n* Patients currently undergoing other animal-assisted therapy,\n* Allergies to horses,\n* Other serious medical conditions that may interfere with participation in the sessions.","18 Years",{"count":21,"type":22},[25],"Addiction is a major public health issue. According to the World Health Organization (2024), approximately 400 million people worldwide suffer from alcohol- or drug-related disorders, resulting in nearly 3.2 million deaths per year. In France, the situation is also cause for concern: approximately three million people engage in risky alcohol consumption, thirteen million smoke daily, and nearly one and a half million use illicit drugs, primarily cannabis.\n\nAddiction, defined by the National Institute on Drug Abuse (NIDA) as a chronic, relapsing brain disorder, is characterized by the compulsive pursuit and use of a substance despite knowledge of its harmful effects. Its development depends on multiple factors: personal (trauma, psychiatric disorders, genetic predispositions), environmental (stress, isolation, family context), and those related to the substance itself (addictive potential). The diagnosis of substance use disorders is based on 11 criteria defined in the \\*Diagnostic and Statistical Manual of Mental Disorders\\* (DSM-5), the main ones being: loss of self-control, interference of substance use with academic or occupational activities, continued use despite awareness of the problems it causes, and a new central criterion, craving, defined as an irresistible urge to use, which serves as both a symptom and a diagnostic and prognostic marker because it is a predictor of relapse. The cumulative total of criteria allows the disorder to be classified as mild (2-3), moderate (4-5), or severe (≤ 6). Since the 2020 health crisis, researchers have observed an increase in the use of psychoactive substances, particularly among vulnerable populations. Despite public policy efforts and treatment programs, relapses remain common after treatment, affecting 60 to 70% of patients within six months of their hospitalization. This phenomenon is also observed at La Musse Hospital, where many patients admitted to the nutrition and alcoholism unit express a sense of emptiness upon returning home: a void in relationships, therapy, and daily activities. This feeling often contributes to a return to substance use.\n\nTo address these relapses, this study aims to evaluate the impact of a post-hospitalization equine-assisted therapy program on the mental health and addictive behaviors of patients receiving addiction treatment. Already used at La Musse Hospital as part of the care pathway, equine-assisted therapy is based on the interaction between the patient and the horse in a therapeutic setting. Several studies have demonstrated the benefits of this approach on emotional regulation, self-confidence, stress management, and overall well-being.\n\nThis prospective, single-center, interventional study will include twenty-two patients who have been hospitalized at least once in the nutrition and alcoholism unit at La Musse Hospital or another facility. Participants will be randomly assigned to either a group receiving post-hospitalization equine-assisted therapy or a control group.",[59,60,61,62,63],"Equine-assisted Therapy","Addiction","Recidivism","Addictive Behaviors","Mental Health",[65,60,61,66,67],"Equine mediation","Addictive behavior","Mental health","2026-03-26",{"date":70,"type":38},"2026-04-01",{"date":70,"type":22},{"date":73,"type":22},"2028-08-31",{"name":44,"class":45},{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":23,"phases":85,"briefSummary":86,"conditions":87,"keywords":93,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":4},"100631070","sustainability-of-the-effects-of-an-adapted-physical-activity-program-on-physical-fitness-and-psycho-behavioral-factors-in-patients-with-chronic-diseases-100631070","NCT07495891","Sustainability of the Effects of an Adapted Physical Activity Program on Physical Fitness and Psycho-behavioral Factors in Patients With Chronic Diseases","Sustainability of the Effects of an Adapted Physical Activity Program on Physical Fitness and Psycho-behavioral Factors in Patients With Chronic Diseases: the Influence of Program Duration and the Use of a Smartwatch","DURATECH-APA","Inclusion Criteria:\n\n* Patients over the age of 18\n* French-speaking patients\n* Patients with a chronic condition diagnosed by a doctor\n* Patients with a doctor's prescription for APA\n* Patients capable of understanding instructions\n* Patients enrolled in the Social Security system\n* Patients referred to Maison Sport Santé La Musse by a doctor for the first time\n\nNon inclusion Criteria :\n\n* Medical contraindications to physical exertion\n* Pregnant women\n* Individuals under legal guardianship, conservatorship, or judicial protection.\n* Severe cognitive or motor impairment\n* Lack of proficiency in French\n* Patients in the acute phase requiring specialized care\n* Patients simultaneously participating in another interventional research study\n* Inability to attend sessions regularly or adhere to the schedule of evaluations.\n* Patients who have already completed a program at the Maison Sport Santé\n\nExclusion Criteria:\n\n* Completion of fewer than 16 APA sessions (less than 70% of sessions)\n* Acute exacerbation of a chronic condition during follow-up\n* For groups without smartwatches, the use of a digital tool such as a physical activity tracker by participants would constitute an exclusion criterion\n* Completion of a patient therapeutic education program",{"count":84,"type":22},280,[25],"This study aims to determine the extent to which different approaches to adapted physical activity coaching influence physical fitness, psycho-behavioral, and anthropometric parameters in patients with stabilized chronic conditions who have been referred to a Sport-Health Center by their physician. The trial includes four parallel groups, distinguishing between two program durations (3 months or 6 months) and the use or non-use of a smartwatch as a tool for monitoring activity. All participants complete 24 sessions of adapted physical activity (APA), in accordance with the standard practices of the La Musse Sport-Health Center, where the study is entirely conducted. However, the distribution of sessions differs by group: two sessions per week over three months or one session per week over six months. Randomization is stratified by age, sex, and baseline fitness level. Assessments are conducted at the following five time points: enrollment (T0), end of the 3-month program (T1), end of the 6-month program (T2), followed by follow-up at 12 months (T3) and 18 months (T4), to observe the durability of the effects after the supervised phase. The primary outcome measure is improvement in physical fitness and anthropometric parameters, objectively measured using tests recognized for their reliability (TDM6, Sit-to-Stand 30s, Timed Up and Go, Sit and Reach, grip strength, BMI, waist circumference). The secondary outcomes focus on changes in motivation toward health-related physical activity (EMAPS), perceived self-efficacy to engage in physical activity (ECS), and self-reported physical activity (IPAQ-SF), which will be collected regularly throughout the program, more frequently than in standard care. A total of 280 patients will be enrolled to ensure sufficient statistical power, taking into account an anticipated loss-to-follow-up rate over 18 months. Data collection and processing will be pseudonymized and conducted on the secure network of La Musse Hospital.",[88,89,90,91,92],"Adapted Physical Activity","Smartwatches","Chronic Disease","Motivation for Physical Activity","Physical Fitness",[94,95,96,97,98,99,100,101],"Adapted physical activity","Chronic diseases","Smartwatch","Sustainability of effects","Motivation for physical activity","Self-efficacy in physical activity","Physical fitness","Longitudinal follow-up","2026-03-23",{"date":104,"type":38},"2026-03-27",{"date":106,"type":22},"2026-03-30",{"date":108,"type":22},"2028-12-31",{"name":44,"class":45},{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":117,"targetDuration":4,"studyType":23,"phases":119,"briefSummary":120,"conditions":121,"keywords":127,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":46},"100621487","effects-of-virtual-reality-with-multisensory-stimulation-on-emotional-and-behavioral-disorders-in-individuals-with-acquired-brain-injury-and-disability-requiring-institutional-care-a-single-case-experimental-design-sced-study-100621487","NCT07371260","Effects of Virtual Reality With Multisensory Stimulation on Emotional and Behavioral Disorders in Individuals With Acquired Brain Injury and Disability Requiring Institutional Care: a Single Case Experimental Design (SCED) Study.","Rév In MAS","Inclusion Criteria:\n\n* Resident aged over 18\n* Diagnosis of stroke, traumatic brain injury, tumor, or cerebral anoxia for more than 3 years.\n* Living in a nursing home for at least 6 months\n* Presence of one or more emotional and behavioral disorders during initial assessments (NPI-ES) for at least 3 months.\n* Sufficient cognitive abilities to understand instructions and answer questions using a Likert scale.\n* Normal or corrected visual acuity\n* Resident affiliated with the social security system\n\nExclusion Criteria:\n\n* Motor or sensory disorders incompatible with the use of VR\n* Unstabilized photosensitive epilepsy or presence of a seizure in the past year\n* Change in the prescription of neuroleptic treatments, antidepressants, benzodiazepines, sedatives, anxiolytics, mood stabilizers, antiepileptics, or betablockers within the last 3 months.\n* Unstabilized major psychiatric disorders.\n* Craniectomy\n* Limited range of cervical movement due to orthopedic disorders\n* Moderate or severe hearing loss not compensated by a hearing aid\n* Anosmia\n* Asthma\n* Pregnant women or women suspected of being pregnant\n* Breastfeeding women\n* Neurocognitive disorders preventing understanding of instructions during assessments\n* The resident is included in another research protocol",{"count":118,"type":22},3,[25],"Acquired brain injuries (ABIs) frequently cause emotional and behavioral disorders that impair independence and quality of life, particularly in institutions. Virtual reality (VR), already used in various mental and neurological disorders, offers therapeutic potential that remains largely unexplored in this context.\n\nMultisensory devices offer enhanced immersion that can potentially increase the relaxation and calming effect. Their use in specialized care home (SCH) could provide additional support for care.\n\nThe main objective of the study is to measure the effect of an 8-week multisensory VR relaxation program on the most significant emotional and behavioral disorders in adults with acquired brain injury living in SCH. The SCED method with multiple baselines across subjects (ABA) is used with three adult residents with ABCI and behavioral disorders living in SCH. The study consists of three phases (baseline, intervention, follow-up), during which the three main emotional and behavioral disorders of each resident are assessed weekly based on observations made throughout the week. Additional measures include the assessment of the socio-emotional profile by the care team (ECCSEG) and the emotional distress experienced by residents (QOLIBRI), collected twice per phase. The intervention consists of eight weeks of VR relaxation (VirtySens®), with two 15-minute sessions per week.\n\nAll measurements taken during the experiment will be anonymized and used only by the investigators, who are fully aware of the European GDPR (General Data Protection Regulation) concerning the protection of personal data.",[122,123,124,125,126],"Brain Injury","Virtual Reality","Behavior","Emotion","Well-being",[128,124,125,126,123,129,130],"Acquired Brain Injury","Multisensory","Specialized Care Home","2026-01-19",{"date":133,"type":38},"2026-01-27",{"date":135,"type":22},"2026-02-15",{"date":137,"type":22},"2027-02-01",{"name":44,"class":45},{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":146,"targetDuration":4,"studyType":148,"phases":4,"briefSummary":149,"conditions":150,"keywords":155,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":46},"100602931","organizational-strategies-and-psychosocial-skills-for-maintaining-physical-activity-after-a-depressive-episode-a-3-month-post-rehabilitation-study-100602931","NCT07129928","Organizational Strategies and Psychosocial Skills for Maintaining Physical Activity After a Depressive Episode: a 3-month Post-rehabilitation Study.","AP&Depression","Inclusion Criteria:\n\n* Patient over 18 years old\n* French-speaking patient\n* Patient with a depressive episode diagnosed by a physician\n* Patient who completed a stay at the Rehabilitation Center (CDR) at the Clinique des Portes de l'Eure\n* Patient at 3 months post-rehabilitation stay\n* Patient who completed an initial assessment (T0) at the Maison Sport Santé during the clinic stay\n\nExclusion Criteria:\n\n* Exacerbation of the condition\n* Patient who has already completed a 3-month follow-up assessment at the Maison Sport Santé (MSS)",{"count":147,"type":22},15,"OBSERVATIONAL","With nearly 280 million people affected worldwide (2022), the management of depression represents a major public health issue. The study titled \"Organizational Strategies and Psychosocial Skills to Maintain Physical Activity after a Depressive Episode: A 3-Month Post-Rehabilitation Study\" (AP\\&Depression) fits within this context. Physical activity (PA) is now recognized as an effective complementary therapy to pharmacological and psychotherapeutic treatments, helping to regulate mood and reduce depressive symptoms. However, despite these proven benefits, individuals who have experienced a depressive episode often struggle to maintain regular physical activity once they leave the hospital setting. This study aims to identify the mechanisms that influence the continuation of PA after hospitalization by exploring organizational strategies, psychosocial skills, and individual determinants involved in this process.\n\nDepression is a debilitating illness characterized by persistent sadness, loss of interest, chronic fatigue, and impaired cognitive and physical abilities (DSM-5, 2013). Among the aggravating factors, sedentary behavior plays a key role, whereas PA is associated with a significant reduction in the risk of relapse. Yet, 67.8% of individuals with depression do not meet the recommended 150 minutes of weekly PA, and this figure rises to 85.7% when activity is measured objectively. This situation is explained by several barriers: lack of motivation, low self-efficacy, fluctuating mood disorders, social isolation, and limited access to exercise facilities. Conversely, certain factors facilitate the resumption of PA after a depressive episode, including structured support, the establishment of routines, social support, and therapeutic education.\n\nThe study relies on a qualitative methodology using semi-structured interviews conducted with 15 patients who stayed at the Rehabilitation Center of the Clinique des Portes de l'Eure. Participants are selected according to the following criteria: aged over 18, medically diagnosed with a depressive episode, underwent rehabilitation, and completed an initial assessment at the Maison Sport Santé. They will be interviewed three months after discharge to explore their PA practices. Data will be analyzed using NVivo software, following the COREQ (Consolidated Criteria for Reporting Qualitative Research) guidelines. The analysis of transcripts will help identify the organizational strategies implemented, the psychosocial skills involved, and the individual determinants influencing the maintenance of regular PA.\n\nThe expected results should highlight that patients adopt various strategies to maintain PA after hospitalization. Session planning, the gradual integration of PA into daily life, and the anticipation of obstacles are major levers for establishing a sustainable routine. In addition, psychosocial skills, such as stress management and interaction with a support network, emerge as essential elements for maintaining regular physical activity. However, several obstacles may be identified, including persistent fatigue, mood fluctuations, lack of organization, and social isolation. These findings underscore the importance of personalized support after rehabilitation, particularly through mechanisms such as Patient Therapeutic Education (PTE) or individualized follow-up in Maisons Sport Santé.\n\nThe aim of this study is to shed light on the mechanisms that enable individuals who have experienced a depressive episode to autonomously maintain physical activity after hospitalization. This research seeks to provide concrete recommendations for improving support during and after hospitalization to enhance adherence to PA. The study's conclusions could contribute to the development of new therapeutic approaches aimed at improving patients' quality of life.",[151,152,153,154],"Physical Activity","Depression Disorder","Rehabilitation","Organizational Behavior",[156,157,153,158,159,160],"Physical activity","depression","Organizational strategies","Psychosocial skills","Determinants of physical activity","2025-08-11",{"date":163,"type":38},"2025-08-19",{"date":165,"type":22},"2025-09-01",{"date":167,"type":22},"2026-12-31",{"name":44,"class":45},{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":174,"acronym":175,"eligibilityCriteria":176,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":177,"targetDuration":4,"studyType":23,"phases":178,"briefSummary":179,"conditions":180,"keywords":185,"overallStatus":193,"whyStopped":4,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":195,"startDateStruct":197,"completionDateStruct":199,"leadSponsor":201,"locationsCount":46},"100571346","effect-of-immersive-virtual-reality-with-multisensory-stimulation-on-the-functional-impact-of-hemineglect-secondary-to-a-right-sided-stroke-100571346","NCT06719063","Effect of Immersive Virtual Reality With Multisensory Stimulation on the Functional Impact of Hemineglect Secondary to a Right-Sided Stroke","Effect of Immersive Virtual Reality With Multisensory Stimulation on the Functional Impact of Hemineglect Secondary to a Right-Sided Stroke: A Single Case Experimental Design (SCED) Study","NEGLISENS","Inclusion Criteria:\n\n* Patient aged over 18 years\n* Diagnosis of first ischemic right stroke established by a neurologist using clinical examination and brain imaging (CT scan or MRI)\n* Stroke occurring less than 3 months ago\n* Presence of left hemineglect, diagnosed using the Neglect Assessment Battery (NAB)\n* Normal vision or corrected to normal\n* Patient affiliated with the social security system\n\nExclusion Criteria:\n\n* History of neurological or psychiatric illness\n* Epilepsy\n* Craniotomy\n* Limited range of cervical motion due to orthopedic disorders\n* Moderate or severe deafness (hearing loss of 40 dB in one ear, as measured by tonal audiometry)\n* Anosmia (loss of smell)\n* Asthmatic disease\n* Pregnant women or women suspected of being pregnant\n* Breastfeeding women\n* Severe neurocognitive disorders with an MMSE score \\\u003C 21\n* Patient under legal protection measures\n* Minor patient\n* Patient enrolled in another research protocol",{"count":118,"type":22},[25],"A stroke is a common and potentially serious condition that affects 130,000 people each year in France. It is the second leading cause of major cognitive disorders after Alzheimer's disease.\n\nHemineglect is a frequently observed cognitive impairment following a stroke. The individual becomes unable to orient themselves or respond to stimuli appearing in the contralesional hemispace. Hemineglect occurs in approximately 25-30% of stroke patients, with the right hemisphere being affected in 90% of cases.\n\nDespite potential spontaneous recovery within the first 2 to 3 months post-stroke, neglect tends to persist chronically. One-third of patients suffer from long-term neglect. The condition is more severe after a right-sided lesion. The functional impact is significant, particularly when considering the anosognosia and anosodiaphoria often associated with it. Rehabilitation stays are longer for patients with neglect, and autonomy in daily activities is reduced. Neglect leads to poorer functional outcomes after a stroke, making it a critical factor to address in a patient's rehabilitation program.\n\nThe goal of rehabilitation is to reduce impairments, improve activity limitations and participation restrictions secondary to hemineglect, and achieve functional progress beyond what is possible through spontaneous recovery. Since no single rehabilitation method for neglect is superior to another, it is currently recommended to combine multiple approaches.\n\nThe top-down approach is based on intention and conscious effort. This technique is among the first used for neglect rehabilitation and remains widely used today. The goal is to help the patient become aware of their neglectful behavior.\n\nThe bottom-up approach relies on more automatic mechanisms of action and aims to modulate the spatial reference system through passive sensory manipulations or visuomotor adaptation.\n\nThe use of virtual reality in stroke rehabilitation promotes plasticity and neural reorganization. In the field of hemineglect, several studies have examined the effects of virtual reality using top-down and\u002For bottom-up approaches and have shown significant functional improvements. In the case of multisensory stimulation, delivering different stimuli to the same side of space and at the same time increases neuronal activity, leading to a stronger clinical response than unisensory stimulation.\n\nThe VirtySens® multisensory travel capsule is an immersive virtual reality technique. This total immersion is achieved through the simultaneous stimulation of four out of the five senses. Firstly, vision and hearing are stimulated by a virtual reality headset that projects high-definition films. Smell is activated through the release of micro-droplets of fragrances synchronized with the imagery. Finally, touch is stimulated by warm and cold airflows that enhance the various scenes presented.\n\nThe investigators emit the hypothesis that the VirtySens® capsule, immersive virtual reality combining multisensory stimulation via four of the five senses and training in visual scanning, introduced in rehabilitation, allows to significantly reduce the functional impact of hemineglect in the adult victim of a right cerebral infarction dating less than 3 months.\n\nTo respond to these research objectives, the investigators will carry out a pilot study in Single Case Experimental Design (SCED). The experimentation will take place in mainland France within La Musse hospital. The recruitment of 3 subjects will be necessary for the realization of this study.\n\nThe study will consist of repeated evaluation and rehabilitation sessions. Evaluations will be conducted at La Musse Hospital by an occupational therapist. The purpose of the evaluation sessions is to measure the impact of hemineglect on autonomy. This measurement will be performed using the Catherine Bergego Scale, which will be completed by both the patient and the occupational therapist. Evaluation sessions will last approximately 45 minutes and will take place once a week for 10 to 12 weeks.\n\nAfter 3 to 5 weeks of evaluations, the patient will participate in three weekly rehabilitation sessions, each lasting 45 minutes, over a 5-week period. These sessions will be individual and conducted by an occupational therapist. Each session will follow a similar structure: review of the previous session, explanation of the current session, a 15-minute multisensory experience using virtual reality, followed by a review of the session, particularly focusing on tolerance.",[181,182,183,123,153,184],"Stroke","Hemineglect","Neuropsychology","Immersion",[186,187,188,189,190,191,192],"stroke","hemineglect","neuropsychology","virtual reality","rehabilitation","multisensory","immersion","RECRUITING","2025-05-09",{"date":196,"type":38},"2025-05-11",{"date":198,"type":38},"2025-04-04",{"date":200,"type":22},"2025-08-31",{"name":44,"class":45},{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":206,"acronym":207,"eligibilityCriteria":208,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":209,"targetDuration":4,"studyType":148,"phases":4,"briefSummary":211,"conditions":212,"keywords":219,"overallStatus":193,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":228,"completionDateStruct":230,"leadSponsor":232,"locationsCount":46},"100570901","study-of-the-link-between-freezing-of-gait-and-oropharyngeal-freezing-in-parkinsons-patients-100570901","NCT06713265","Study of the Link Between Freezing of Gait and Oropharyngeal Freezing in Parkinson's Patients","Freez in park","Inclusion Criteria:\n\n* Diagnosis of idiopathic Parkinson's disease established by a neurologist;\n* Patient affiliated with the social security system;\n* Patient aged over 18 years.\n\nExclusion Criteria:\n\n* Patients under legal protection measures;\n* Neurological history that could be the cause of a swallowing disorder (e.g., stroke) or a history of ENT cancer;\n* Patient with a gastrostomy without oral intake;\n* Pregnant women or those suspected of being pregnant;\n* Minor patients",{"count":210,"type":22},66,"Parkinson's Disease: Study of the Link Between Gait Freezing and Oropharyngeal Freezing Parkinson's disease is the second most common neurodegenerative disorder worldwide. Parkinsonian dysphagia is a frequently encountered disorder in this condition, affecting all phases of swallowing: oral, pharyngeal, and esophageal. This dysphagia can occur at any stage of the disease. While most swallowing difficulties develop in the advanced stages of Parkinson's disease, they can also appear early on and are often underdiagnosed. The prevalence of swallowing disorders in Parkinson's disease is estimated to range from 40% to 80%, with this variability explained by the significant differences in the precision of swallowing evaluations conducted and the fact that dysphagia is still too frequently underdiagnosed. Yet, dysphagia is the leading cause of mortality in Parkinson's patients.\n\nDysphagia can negatively affect patients' quality of life. It leads to difficulties during oral intake (food, liquids, and medications), weight loss, dehydration, malnutrition, and limitations in social activities. Depression is frequently associated with reduced quality of life in Parkinson's patients with swallowing disorders. Moreover, aspiration pneumonia due to mis-swallowing is one of the primary reasons for hospitalization in Parkinson's patients, potentially leading to severe complications and, at times, death.\n\nOropharyngeal freezing, also called oral festination, is an involuntary, repetitive anteroposterior movement of the tongue against the soft palate performed before transferring the food bolus to the pharynx. This movement is also observed during multiple swallows. This phenomenon is more frequent in dysphagic Parkinson's patients, yet its impact on swallowing dynamics remains poorly understood. Oropharyngeal freezing has been observed in approximately 40% to 75% of Parkinson's patients during videofluoroscopic swallow studies, also known as swallowing pharyngography. Oropharyngeal freezing inhibits the initiation of swallowing, keeping the airway open and leading to tracheal aspiration of residues. Some fragments then slide into the valleculae and pyriform sinuses. Thus, oropharyngeal freezing exacerbates pharyngeal phase incoordination, increasing the risk of aspiration pneumonia. Therefore, addressing this swallowing disorder is essential.\n\nOropharyngeal freezing is intrinsically rhythmic. While limited studies have been conducted on the topic, they agree that gait freezing (difficulty initiating walking, stopping in response to obstacles, or circumventing them) and oropharyngeal freezing share common pathophysiological mechanisms. Gait freezing is not limited to deficits in the locomotor network but is part of a broader deficit affecting spatiotemporal coordination in various tasks, similar to oropharyngeal freezing.\n\nIt is, therefore, crucial to detect this oral phase swallowing disorder as early as possible, enabling tailored early intervention that helps patients maintain their swallowing abilities for as long as possible and prevents complications mentioned earlier. Since gait freezing is diagnosed much earlier and more systematically, it would be interesting to investigate whether there is a correlation between the presence of gait freezing and oropharyngeal freezing in these patients. This could guide patients with gait freezing toward early speech-language assessments to evaluate the presence of oropharyngeal freezing.\n\nThe objectives of the study are examine the prevalence of oropharyngeal freezing in Parkinson's patients. Based on the results obtained from the NFOG-Q (New Freezing of Gait Questionnaire), two groups will be formed: The first group will consist of patients exhibiting gait freezing. The second group will consist of patients without gait freezing. The secondary objectives of the study are examine the common characteristics between these two types of freezing (gait and oropharyngeal). To assess the sensitivity and reliability of the NFOG-Q in detecting oropharyngeal freezing.To determine the prevalence of oropharyngeal freezing based on the score obtained on the UPDRS (Unified Parkinson's Disease Rating Scale). To analyze the link between patients' rhythmic abilities and the presence or absence of one or both types of freezing.",[213,214,215,216,217,218],"Parkinson's Disease","Dysphagia","Swallowing Disorder","Freezing of Gait","Oropharyngeal Disease","Gait Disorders",[220,214,221,222,223,224],"Parkinson's Disease","Swallowing disorder","Freezing of gait","oropharyngeal freezing","Gait","2024-12-02",{"date":227,"type":38},"2024-12-04",{"date":229,"type":38},"2024-10-04",{"date":231,"type":22},"2025-11-30",{"name":44,"class":45},{"id":234,"slug":235,"hasResults":11,"nctId":236,"briefTitle":237,"officialTitle":238,"acronym":239,"eligibilityCriteria":240,"healthyVolunteers":11,"sex":17,"minAge":241,"maxAge":242,"enrollmentInfo":243,"targetDuration":4,"studyType":23,"phases":245,"briefSummary":246,"conditions":247,"keywords":251,"overallStatus":193,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":256,"startDateStruct":258,"completionDateStruct":260,"leadSponsor":261,"locationsCount":46},"100569732","impact-of-equine-assisted-therapy-on-the-quality-of-life-of-children-with-autism-spectrum-disorders-asd-100569732","NCT06698068","Impact of Equine-Assisted Therapy on the Quality of Life of Children with Autism Spectrum Disorders (ASD)","Impact of Equine-Assisted Therapy on the Quality of Life of Children with Autism Spectrum Disorders (ASD): a Pilot Study","EQUI-TSA","Inclusion Criteria:\n\n* Children aged between 8 and 12 years.\n* Diagnosed with ASD by a doctor.\n* Able to participate in equine therapy sessions.\n* Capable of understanding instructions during equine therapy sessions.\n* Affiliated with the social security system.\n\nExclusion Criteria:\n\n* Children with ASD associated with ADHD (Attention Deficit Hyperactivity Disorder) and\u002For ODD (Oppositional Defiant Disorder) and\u002For ID (Intellectual Developmental Disorder) and\u002For DLD (Developmental Language Disorder) with comprehension impairments.\n* Ongoing equine-assisted therapy interventions.\n* Other severe medical conditions that may impair participation in sessions.\n* Allergies to horses.","8 Years","12 Years",{"count":244,"type":22},20,[25],"The main objective of this research is to measure the influence of equine-assisted therapy sessions on the quality of life of children with ASD, using the PedsQL™ 4.0 questionnaire as an evaluation tool.\n\nThe secondary objectives of this study are to measure the influence of these equine therapy sessions on the quality of life of parents of children with ASD, using the PAR-DD-QOL questionnaire, and to qualitatively analyze the progress of children in terms of communication, motor skills, social connections, etc., during equine therapy sessions, through tracking sheets.\n\nThis interventional, prospective, and monocentric study aims to evaluate the effect of equine therapy on the quality of life of children with ASD and their families. As a pilot study, it aims to assess the feasibility of a larger-scale study with a rigorous methodology, with the aim of including a control group and conducting a randomized, multicentric, single-blind trial in future studies. It will take place at the La Musse Hospital - La Renaissance Sanitaire, specifically within the equine therapy center of the La Musse facilities. Recruiting 20 children (8-12 years old) with ASD is required for this study. To do this, the inclusion criteria are as follows: participants must be children aged 8 to 12, diagnosed with ASD by a doctor. They must be able to participate in equine-assisted therapy sessions and understand instructions during these sessions. In addition, they must be affiliated with the social security system. The primary and secondary assessment criteria respectively include the average of the two scores obtained from the PedsQL™ 4.0 child and parent report questionnaires; the overall score of the PAR-DD-QOL questionnaire, as well as the qualitative analysis of the equine therapists' tracking sheets. Measures are taken to minimize selection, recruitment, and confusion biases, and specific eligibility criteria are defined. Each participant will benefit from 15 equine therapy sessions, twice a week, over 7 to 8 weeks. Each session will last 60 minutes.\n\nThe intervention of this study begins with the participant selection process, including an initial contact by phone or during a medical consultation, followed by an oral explanation and the provision of written information to parents and the child. After a reflection period, and if they agree, the parents and the child sign a consent form. The children then undergo 15 equine therapy sessions, including various activities such as emotional expression, contact with the horse, grooming, activities on foot or on horseback, and a debriefing time. Quality-of-life evaluations will be conducted five times during the study using the PedsQL™ 4.0 child, PedsQL™ 4.0 parent report, and PAR-DD-QOL questionnaires (before the first session, after the first session, at the 5th session, at the 10th session, and at the 15th session). Additionally, a tracking sheet will be completed by equine therapists during the sessions. The criteria for interrupting or modifying interventions are established, allowing participants to withdraw at any time for various reasons. Strategies are implemented to improve adherence to rehabilitation protocols, such as regular reminders and the distribution of a schedule of appointments. The individuals concerned are fully informed of the study and their rights.\n\nThe expected outcomes include an improvement in the average quality-of-life scores of children with ASD, an improvement in the quality-of-life score of their parents, and behavioral progress in the children. The sample size is set at 20 children with ASD, with a detailed statistical analysis plan using Excel and SPSS.",[59,248,249,250],"Children","Autism Spectrum Disorder","Quality of Lifte",[252,253,254],"Equine-assisted therapy","children with ASD","Quality of life","2024-11-18",{"date":257,"type":38},"2024-11-20",{"date":259,"type":38},"2024-09-12",{"date":231,"type":22},{"name":44,"class":45},{"id":263,"slug":264,"hasResults":11,"nctId":265,"briefTitle":266,"officialTitle":267,"acronym":268,"eligibilityCriteria":269,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":270,"targetDuration":4,"studyType":23,"phases":272,"briefSummary":273,"conditions":274,"keywords":278,"overallStatus":193,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":286,"startDateStruct":288,"completionDateStruct":290,"leadSponsor":292,"locationsCount":46},"100569531","the-effect-of-an-auditory-rhythmic-cue-on-the-frequency-of-rolling-in-patients-with-dysphagia-and-parkinsons-disease-100569531","NCT06695455","The Effect of an Auditory Rhythmic Cue on the Frequency of Rolling in Patients with Dysphagia and Parkinson's Disease","The Effect of an Auditory Rhythmic Cue on the Frequency of Rolling in Patients with Dysphagia and Parkinson's Disease: a Pilot Study","Rhythm'nRoll","Inclusion Criteria:\n\n* Diagnosis of idiopathic Parkinson's disease established by a neurologist using a DAT SCAN and clinical examination;\n* Presence of a swallowing disorder, specifically rolling;\n* Patient affiliated with the social security system;\n* Patient aged 18 years or older\n\nExclusion Criteria:\n\n* Severe pharyngeal dysphagia (leading to aspiration with nectar and pudding textures);\n* Severe cognitive impairment (score \\\u003C24 on the Mini Mental Parkinson test);\n* Known deafness\u002Fprofound hearing loss;\n* Patients under legal protection measures;\n* History of reconstructive ENT surgery at the oropharyngeal level;\n* Neurological history that could cause a swallowing disorder (e.g., stroke);\n* Patient with a gastrostomy and no oral feeding;\n* Ongoing speech therapy for swallowing;\n* The patient is included in another research protocol;\n* Pregnant women or women suspected of being pregnant;",{"count":271,"type":22},18,[25],"The main objective of this clinical study is to measure the effect of rhythmic auditory cueing, introduced in rehabilitation with three weekly sessions over a period of 7 weeks, on the frequency of rolling in idiopathic Parkinson's disease patients using pharyngography (swallowing radiography). The primary question of this study is:\n\nDoes the rhythmic cueing introduced in rehabilitation significantly reduce the frequency of rolling in dysphagic Parkinson's patients?\n\nThe researchers will assess the various stages of swallowing before, after, and 3 months after the rehabilitation protocol, focusing on the oral phase to determine if rhythmic auditory cueing reduces the frequency of rolling.\n\nParticipants will be required to:\n\n* Perform three complete assessments (clinical speech therapy examination + pharyngography) before the protocol, after the protocol, and 3 months post-protocol.\n* Attend three times per week for 7 weeks at the La Musse hospital to participate in the protocol sessions under the supervision of a speech therapist.",[275,276,214,215,277],"Oral Festination","Lingual Pumping","PARKINSON DISEASE (Disorder)",[279,280,281,282,283,284,190,285],"oral festination","lingual pumping","dysphagia","swallowing disorder","parkinson disease","rhythmic auditory cue","behavioral intervention",{"date":287,"type":38},"2024-11-19",{"date":289,"type":38},"2024-04-05",{"date":291,"type":22},"2026-09-05",{"name":44,"class":45},""]