[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Horizon Health Network\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":70},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100623838","standardized-sleep-bundle-for-cardiac-surgery-patients-100623838",false,"NCT07401836","Standardized Sleep Bundle for Cardiac Surgery Patients","Can a Standardized Sleep Bundle Reduce Sleep Disruption After Cardiac Surgery: A Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Adult patients over 19 years old, undergoing non-emergent cardiac surgery with cardiopulmonary bypass at the Saint John Regional Hospital (SJRH).\n\nExclusion Criteria:\n\n* Emergent surgery.\n* Severe renal or hepatic impairment (creatinine clearance (CrCl) \\\u003C30 mL\u002Fmin, Chronic Kidney Disease (CKD) stage ≥4, cirrhosis, Alanine Transaminase (ALT) ≥ 3 × upper limit of normal (ULN)).\n* Sleep apnea.\n* Restless leg syndrome (RLS).\n* Insomnia with chronic use of pharmacological sleep aids prior to admission (trazodone, benzodiazepines, zopiclone, mirtazapine, quetiapine, tricyclic antidepressants \\[nortriptyline, amitriptyline, doxepin\\]).\n* Prior use of a monoamine oxidase inhibitor in the past 14 days.\n* Corrected QT Interval (QTc) \\> 500ms \u002F history of prolonged QTc, Torsade de points or ventricular tachycardia.\n* History of dementia, alcohol, or opioid use disorder.\n* Documented or previous intolerance to melatonin, trazodone, or quetiapine. Unable to provide informed consent.\n\nRun-in Period Exclusions:\n\nAfter enrolment and before randomization, participants will be monitored for specific postoperative criteria. Those meeting any of the following criteria will be withdrawn prior to randomization.\n\n* Radial artery harvest required (unable to place Fitbit device on the wrist contralateral to the arterial monitoring line).\n* Prolonged intubation or sedation (\\> 48 hours) post-surgery.\n* Major intra- or early postoperative complications (stroke, transient ischemic attach (TIA), major bleeding, need for mechanical\u002Fcirculatory support, reoperation, open chest, pulmonary embolism, acute renal failure requiring dialysis or other major surgical complications that would inhibit ability to participate).","ALL","19 Years",{"count":19,"type":20},20,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to evaluate the feasibility of using a standardized sleep bundle in adults undergoing cardiac surgery. The main questions it aims to answer are:\n\n1. Can eligible participants be recruited and retained in the study?\n2. Can participants follow the study procedures, including using sleep aids and completing daily assessments?\n3. Can sleep and other clinical data be reliably collected during the hospital stay? Researchers will compare participants who receive the sleep bundle to participants who receive usual postoperative care.\n\nParticipants will:\n\n* Use non-drug sleep aids, including a sleep mask, ear plugs, and a noise machine (sleep bundle group only).\n* Take sleep medications if needed, following a stepwise protocol (sleep bundle group only).\n* Complete daily sleep assessments using the Richards-Campbell Sleep Questionnaire (RCSQ).\n* Wear a Fitbit device at night to track sleep.\n* Follow usual postoperative care routines (control group)\n\nThe study will also collect and describe data on sleep duration, nighttime awakenings, subjective sleep quality, incidence of postoperative delirium, and hospital length of stay to inform the design of a future larger trial.",[26],"Sleep",[28,29],"cardiovascular surgery","sleep","RECRUITING","2026-03-27",{"date":33,"type":34},"2026-03-30","ACTUAL",{"date":36,"type":34},"2026-03-02",{"date":38,"type":20},"2026-06",{"name":40,"class":41},"Horizon Health Network","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":21,"phases":53,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":4},"100629368","virtual-reality-for-anxiety-management-in-persons-with-amyotrophic-lateral-sclerosis-100629368","NCT07473765","Virtual Reality for Anxiety Management in Persons With Amyotrophic Lateral Sclerosis","Just... Breathe: Virtual Reality Guided Breathing Exercise for Anxiety Management in Amyotrophic Lateral Sclerosis","VR ALS","Inclusion Criteria:\n\n* Diagnosed with ALS (gold coast or El-Escorial), or ALS variants of flail limb, progressive muscle atrophy, UMN or LMN predominant\n* Able to use VR device with no negative effects (i.e. headaches, vision changes, dizziness, nausea, disorientation)\n\nExclusion Criteria:\n\n\\- Cognitive impairment that impacts ability to participate fully in assessments",{"count":52,"type":20},60,[23],"Virtual Reality (VR) is gaining traction as a new and innovative leisure to augment healthcare services. Several benefits of the leisure experience, such as distraction and full sensory immersion, have demonstrated a potential to significantly impact the field of healthcare through pain reduction, anxiety reduction, and is seen as an innovative approach to motor learning. Persons with ALS (pwALS) have a high prevalence of anxiety over the course of their illness, which has a negative impact on their quality of life, and the quality of life of those closest to them. The use of VR for anxiety management and subsequent quality of life improvement has yet to be explored in the ALS population.\n\nFor individuals with ALS, VR can be both (1) an escape from the reality of living day to day with a progressive fatal diagnosis; and (2) the opportunity to potentially improve anxiety, both of which are linked to the quality of life of individuals living with ALS. Our hypothesis is that a simple and accessible home VR-guided relaxation exercise program can improve subjective anxiety symptoms in a person living with ALS and subsequently improve quality of life.",[56],"ALS (Amyotrophic Lateral Sclerosis)",[58,59,60],"Amyotrophic Lateral Sclerosis (ALS)","Virtual Reality","Anxiety Management","NOT_YET_RECRUITING","2026-03-11",{"date":64,"type":34},"2026-03-16",{"date":66,"type":20},"2026-04-01",{"date":68,"type":20},"2027-06-30",{"name":40,"class":41},""]