[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Hospital Clínico Universitario de Valladolid\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":110},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,72],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100586568","mylead-spanish-prospective-registry-100586568",false,"NCT06917066","MYLEAD Spanish Prospective Registry","Spanish Prospective Registry: MYval Induced Late and EArly Conduction Disturbances (MYLEAD)","MYLEAD","Inclusion Criteria:\n\n* Adult patients (over 18 years of age)\n* Patients with Severe Aortic stenosis undergoing TAVR using Myval Transcatheter Heart Valve.\n\nExclusion Criteria:\n\n* Patients with pre-existing permanent pacemaker.\n* Patients unable or unwilling to follow up for pre and post procedure clinical assessments and investigations.","ALL","18 Years",{"count":20,"type":21},500,"ESTIMATED","12 Months","OBSERVATIONAL","Investigator-initiated, prospective, multicentre registry, whose objectives are: 1\u002F to evaluate the incidence of conduction defects and the need of pacemaker implantation post-procedure, at discharge, at 30 days and at 1 year post Myval transcatheter heart valve deployment, and 2\u002F To evaluate the factors determining in-hospital and late (at 30 days and 1 year) conduction defects post Myval transcatheter heart valve.\n\nPatients with Severe Aortic stenosis undergoing TAVR using Myval Transcatheter Heart Valve that meet all inclusion criteria and any exclusion criteria will be able to participate in this study if they sign the informed consent. Electrocardiogram, echocardiogram and computed tomography will be performed to patients at different time points (Baseline, post-procedure, discharge, 30 days and 1 year post procedure) and their parameters will be added into a dedicated REDCAP database.",[26],"Severe Aortic Valve Stenosis",[26,28,29],"TAVR","Myval Transcatheter Heart Valve","RECRUITING","2025-04-01",{"date":33,"type":34},"2025-04-08","ACTUAL",{"date":36,"type":34},"2024-10-23",{"date":38,"type":21},"2026-12",{"name":40,"class":41},"Hospital Clínico Universitario de Valladolid","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":42},"100552876","effects-of-resistance-training-in-multiple-sclerosis-a-randomized-trial-100552876","NCT06478784","Effects of Resistance Training in Multiple Sclerosis: a Randomized Trial.","Effects of Resistance Training in Multiple Sclerosis: a Randomized Trial. ACTIVE (Physical Activity and Its Impact on Patients With Multiple Sclerosis.)","ACTIVE","Inclusion Criteria:\n\n1. \\- Diagnosis of multiple sclerosis according to the 2017 Mc Donald criteria (Thompson A et al).\n2. \\- Age \\> 18 years - up to no age limit\n3. \\- Disability assessed by the EDSS (Expanded disability status scale) with a score less than or equal to 4.\n4. \\- Clinical stability. Not having had an outbreak of the disease in the last 6 months.\n5. \\- No changes in the disease-modifying treatment in the last 6 months or no treatment.\n6. \\- Radiological stability. Patients with last MRI (magnetic resonance imaging) performed without inflammatory activity (absence of new lesions on T2 sequences or lesions that enhance with gadolinium).\n7. \\- They must sign the informed consent\n\nExclusion Criteria:\n\n1. \\- Patients with a high level of physical activity according to the International Physical Activity Questionnaire(IPAQ) or latest WHO (World Health Organization) recommendations on physical activity\n2. \\- Pregnant or breastfeeding patients.\n3. \\- Concomitant pathologies that limit the performance of physical exercise",{"count":52,"type":21},50,"INTERVENTIONAL",[55],"NA","This is a longitudinal study to examine the effects of a short-term training program on neurofilamet and GFAP plasma levels. Participants will be divided in two groups: control group (moderate aerobic training) and active group (resistance training). The change in biomarkers will be analyzed pre and post intervention in both groups. Differences between groups will be also evaluated by investigators.",[58],"Multiple Sclerosis",[60,61,62,63],"physical exercise","resistance training","neurofilaments","GFAP","2024-06-24",{"date":66,"type":34},"2024-06-27",{"date":68,"type":34},"2024-01-01",{"date":70,"type":21},"2025-01-30",{"name":40,"class":41},{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":80,"targetDuration":82,"studyType":23,"phases":4,"briefSummary":83,"conditions":84,"keywords":89,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},"100413461","peri-implant-and-peri-prosthetic-fractures-epidemiology-morbidity-mortality-treatment-and-outcome-analysis-100413461","NCT04663893","Peri-Implant and Peri-Prosthetic Fractures: Epidemiology, Morbidity, Mortality, Treatment and Outcome Analysis","Peri-Implant and Peri-Prosthetic Fractures: Epidemiology, Morbility, Mortality, Treatment and Functional Outcome Analysis. A Prospective Multi Center Observational Collaborative Study","PIPPAS","Inclusion Criteria:\n\n* Patient with the diagnose of Periprosthetic fracture of the shoulder, elbow, hip or knee. Or patients with the diagnose of Peri-implant fracture of the scapula, humerus, forearm, pelvis, femur, patella, tibia or fibula. Or patient presenting cut-out or cut-in after DHS or nail after a proximal humeral fracture.\n* 18 years or older\n\nExclusion Criteria:\n\n* Spine PP or PI fracture\n* PP or PI secondary to metastasis or tumoral fracture\n* PP or PI intraoperative fracture\n* PP or PI pathologic fracture\n* PP ankle fracture\n* PP or PI wrist or hand fracture\n* Fixation failure without any new fracture line: except cut-out or cut-in after DHS or nail of a proximal humeral fracture.\n* Pregnancy",{"count":81,"type":21},2500,"5 Years","This study supports Spanish data collection and analysis on Periprosthetic and Peri-implant fractures of the upper and lower limb. Treatment and clinical management of this fractures are complex and goes along with complications. There will be more than 70 hospitals providing information. This study will provide evidence on which is the best treatment for every unique patient. This will help trauma surgeons and geriatricians to provide better treatments, to improve health care in our society, reducing mortality, morbidity, improving functional outcomes, and reducing costs, which in turn will be advances in trauma care.",[85,86,87,88],"Periprosthetic Fracture of the Upper or Lower Limb","Peri-implant Fracture of the Upper or Lower Limb","Periprosthetic Fractures","Peri-implant Fracture",[90,91,92,93,94,95,96,97,98,99,100],"Periprosthetic fracture","peri-implant fracture","mortality","morbidity","loosening","prosthesis revision","fixation","osteosynthesis","complication","ambulate","quality of life","2022-01-16",{"date":103,"type":34},"2022-02-01",{"date":105,"type":34},"2021-01-01",{"date":107,"type":21},"2027-12-31",{"name":40,"class":41},7,""]