[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Hospital Municipal Pedro T. Orellana\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":44},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100573389","carotid-sinus-massage-in-trendelenburg-position-for-headache-relief-100573389",false,"NCT06745648","Carotid Sinus Massage in Trendelenburg Position for Headache Relief","Effectiveness of Carotid Sinus Massage in Modified Trendelenburg Position for Acute Headache Episodes: A Pilot Study","INCLUSION CRITERIA:\n\n* Participants must be at least 16 years of age.\n* Must have a diagnosis of one of the following, according to the International Classification of Headache Disorders (ICHD-3):\n\n  * Migraine\n  * Tension-type headache\n  * Mixed headache\n* The headache episode must have started within the past 24 hours.\n\nEXCLUSION CRITERIA:\n\n* Any contraindication to carotid sinus massage, including:\n\n  * Carotid bruits\n  * Recent myocardial infarction\n  * History of stroke\n  * Known or suspected carotid artery stenosis\n* Any contraindication to the Trendelenburg position, including:\n\n  * Increased intracranial pressure\n  * Respiratory distress\n  * Congestive heart failure\n  * History of syncope\n  * History of cardiac arrhythmias","ALL","16 Years",{"count":19,"type":20},18,"ESTIMATED","INTERVENTIONAL",[23],"NA","Headaches significantly impact patients' quality of life, with tension-type headaches and migraines being among the most prevalent types. There is growing evidence suggesting that blood pressure regulation and baroreceptor activity play a role in headache pathophysiology. Carotid sinus massage (CSM), particularly when combined with the modified Trendelenburg position, may modulate autonomic nervous system activity to relieve headache symptoms.\n\nAn initial open-label pilot study (n = 17) was completed, and the results were published in a preprint server for health sciences, the Medical Research Archive (medRxiv), demonstrating the feasibility, safety, and promising preliminary efficacy of CSM+T. Based on these findings, a follow-up randomized, sham-controlled, parallel-arm trial will further evaluate the efficacy of the treatment.",[26,27],"Migraine","Tension-Type Headache",[29,30,31],"Carotid Sinus Massage","Trendelenburg","Autonomic Nervous System","RECRUITING","2025-06-11",{"date":35,"type":36},"2025-06-15","ACTUAL",{"date":38,"type":36},"2024-12-21",{"date":40,"type":20},"2025-12-30",{"name":42,"class":43},"Hospital Municipal Pedro T. Orellana","OTHER",""]