[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Hospital Universiti Sains Malaysia\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":113},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,45,68,90],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100616938","a-study-to-see-whether-taking-a-mix-of-vitamins-can-help-adults-recover-better-after-surgery-for-carpal-tunnel-syndrome-100616938",false,"NCT07312123","A Study to See Whether Taking a Mix of Vitamins Can Help Adults Recover Better After Surgery for Carpal Tunnel Syndrome","Effect of Oral Alpha-Lipoic Acid, Vitamin E, and Vitamin B Combination on Symptoms and Function in Carpal Tunnel Syndrome Following Carpal Tunnel Surgery","Inclusion Criteria:\n\n* Age more than 18 years old\n* Subjects with symptoms and physical examination of CTS\n* Patients with CTS going for CT release\n\nExclusion Criteria:\n\n* Pregnant or breast-feeding women\n* Patients with history of trauma in the dominant hand","ALL","18 Years",{"count":19,"type":20},84,"ESTIMATED","INTERVENTIONAL",[23],"NA","Carpal Tunnel Syndrome (CTS) is a common condition that causes numbness, tingling, pain, and weakness in the hand due to compression of the median nerve at the wrist. It can affect daily activities, work performance, and quality of life. While surgery is effective in severe cases, many patients with mild to moderate CTS are initially treated with non-surgical options such as splinting and medications. However, the effectiveness of oral supplements for CTS remains uncertain.\n\nThis clinical study aims to evaluate whether an oral combination of alpha-lipoic acid, Vitamin E, and Vitamin B complex can safely reduce symptoms and improve hand function in patients with Carpal Tunnel Syndrome. These supplements are believed to have antioxidant, anti-inflammatory, and nerve-protective properties, which may help reduce nerve irritation and improve nerve recovery.\n\nParticipants in this study will be randomly assigned to receive either the oral supplement combination or a comparator treatment. The study is single-blinded, meaning participants will not know which treatment they are receiving. Symptoms such as pain, numbness, and hand function will be assessed over a defined follow-up period using clinical evaluation and standardized questionnaires.\n\nThe main hypothesis of this study is that patients receiving the oral combination of alpha-lipoic acid, Vitamin E, and Vitamin B will experience greater improvement in symptoms and functional outcomes compared to those who do not receive the combination, without significant side effects.\n\nThe results of this study may help determine whether this oral supplement combination can be used as an effective and safe conservative treatment option for patients with Carpal Tunnel Syndrome, potentially reducing the need for invasive procedures.",[26],"Carpal Tunnel Syndrome",[28,29,30,31],"carpal tunnel syndrome","median nerve compression","vitamin e","peripheral nerve entrapment","RECRUITING","2026-04-20",{"date":35,"type":36},"2026-04-23","ACTUAL",{"date":38,"type":36},"2025-12-08",{"date":40,"type":20},"2027-01-31",{"name":42,"class":43},"Hospital Universiti Sains Malaysia","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":55,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":44},"100615972","effects-of-vitamin-d-in-patients-undergoing-fixed-orthodontic-mechanotherapy-100615972","NCT07299552","Effects of Vitamin D in Patients Undergoing Fixed Orthodontic Mechanotherapy","Effects of Vitamin D on Salivary Opiorphin Level, Pain Perception and Tooth Movement in Patients Undergoing Fixed Orthodontic Mechanotherapy","Inclusion Criteria:\n\n1. Age Range: 18 to 35 years old. This age group is common and suitable for orthodontic treatment. During this period, skeletal remodeling is active, which is conducive to observing tooth movement and related physiological changes. It is also a stage where the regulatory effects of vitamin D on growth, development, and physiological functions are more pronounced.\n2. Orthodontic Requirement: Patients diagnosed with Class I malocclusion with extraction of all first premolars in both upper and lower arches, using MBT orthodontic brackets，and recruited from multiple operators.\n3. Health Status: Patients should be in good general health, without endocrine system diseases that affect calcium and phosphorus metabolism and bone metabolism (such as hyperthyroidism or hypothyroidism, parathyroid diseases, etc.). They should also have no severe liver or kidney diseases (since abnormal liver and kidney functions can interfere with the activation and metabolism of vitamin D), and no autoimmune diseases (as autoimmune abnormalities may affect the inflammatory response and tissue repair mechanisms, thus interfering with the experimental results).\n4. Medication History: Patients who have not taken any medications affecting calcium and phosphorus metabolism (such as bisphosphonates), bone metabolism (such as recombinant human growth hormone or other drugs that promote or inhibit bone growth), and pain perception (such as long-term use of opioid analgesics, antidepressants that affect neurotransmitters) within the past three months are eligible. This ensures that the experiment is not interfered with by external drug factors.\n\nExclusion Criteria:\n\n1. Oral Local Problems: Patients with uncontrolled acute or chronic oral inflammations are excluded, such as the acute stage of pericoronitis of wisdom teeth, severe gingivitis, or periodontitis in the progressive and destructive stage. Such inflammations can interfere with the reaction of orthodontic teeth to force and pain assessment. Those with oral mucosal lesions that affect the comfort of wearing orthodontic appliances and the stability of the oral microenvironment are also excluded.\n2. Systemic Diseases: Besides the aforementioned endocrine, liver and kidney, and autoimmune diseases, patients with severe cardiovascular diseases (who may have difficulty tolerating the stimulation of orthodontic force application and the regular follow-up process), hematological diseases (which affect blood coagulation and tissue repair and increase the risks of orthodontic treatment), malignant tumors (undergoing radiotherapy or chemotherapy that affects systemic metabolism and immunity) are also excluded. These systemic diseases will introduce too many complex variables and affect the observation of the single factor effect of vitamin D.\n3. Special Physiological Periods or Conditions: Pregnant or lactating women are excluded because of the significant fluctuations in hormones and the special nutritional requirements of the fetus or infant, which change the pattern of calcium and phosphorus metabolism. Patients with a recent history of major traumas such as fractures, whose bodies are in a critical period of trauma repair and bone metabolism is in a special stress state, are also not suitable for this experiment as it may interfere with the study of normal orthodontic bone remodeling.\n4. Poor Compliance: Patients who cannot be guaranteed regular follow-ups, take medications as prescribed, and cooperate with various examinations are excluded. For example, those with mental or psychological disorders that make it difficult to follow the medical plan, or those who are highly mobile and unable to maintain stable and continuous treatment and observation. Excluding such patients ensures the integrity and reliability of experimental data and the smooth progress of the experimental process.","35 Years",{"count":54,"type":20},48,[23],"The goal of this interventional research is to determine the impact of vitamin D intake on substances in saliva, pain, tooth movement, and the density of the bone around teeth in patients during orthodontic treatment. It will compare the effects of vitamin D supplementation with a placebo to clarify its role in the aforementioned aspects of orthodontic care. The main questions it aims to answer are:\n\nHow does vitamin D supplementation affect salivary opiorphin levels in patients undergoing fixed orthodontic mechanotherapy at Specialist Hospital Universiti Sains Malaysia? What is the impact of vitamin D supplementation on pain perception during fixed orthodontic mechanotherapy? How does vitamin D supplementation influence the rate and quality of tooth movement in patients undergoing fixed orthodontic mechanotherapy? What is the relationship between salivary opiorphin levels and pain perception in patients supplemented with vitamin D during fixed orthodontic mechanotherapy? How does vitamin D supplementation affect changes in alveolar bone density during fixed orthodontic mechanotherapy? Researchers will provide vitamin D to the experimental group while the control group receives a placebo to see if vitamin D intake has an impact on substances in saliva, pain, tooth movement, and the density of the bone around teeth during orthodontic treatment.\n\nParticipants will:\n\nTake vitamin D or a placebo every day for 4 months Visit the clinic once every 4 weeks for checkups and tests Participate in the study for a duration of up to 4 months",[58],"Malocclusions","NOT_YET_RECRUITING","2025-12-09",{"date":62,"type":36},"2025-12-23",{"date":64,"type":20},"2025-12-30",{"date":66,"type":20},"2027-01-01",{"name":42,"class":43},{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":75,"minAge":17,"maxAge":4,"enrollmentInfo":76,"targetDuration":4,"studyType":21,"phases":78,"briefSummary":80,"conditions":81,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":89,"locationsCount":44},"100584434","phase-4-comparison-of-safety-and-efficacy-between-pieb-and-cei-for-labour-epidural-analgesia-100584434","NCT06889285","Comparison of Safety and Efficacy Between PIEB and CEI for Labour Epidural Analgesia","Comparison of Safety and Efficacy Between Programmed Intermittent Epidural Bolus (PIEB) and Continuous Epidural Infusion (CEI) for Labour Epidural Analgesia: a Randomized Controlled Trial","Inclusion Criteria:\n\n* age \\> 18 years old\n* ASA 2 \\& 3w\n\nExclusion Criteria:\n\n* patient refusal\n* significant comorbiddities, eg patient with heart disease, kidney diseae, neurological disoder\n* contraindicated to neuraxial blockade\n* allergic to local anesthetic agent or opioid\n* obstetric complications, eg pre-eclampsia, leaking liqour, suspicious CTG\n* morbid obesity, BMI \\> 40\n* grandmultiparous ( \\> 5biths at \\> 20 weeks gestation)\n* combined spinal epidural technique for labour epidural analgesia\n* height \\\u003C 145cm","FEMALE",{"count":77,"type":20},76,[79],"PHASE4","The goal of this clinical trial is to compare safety and efficacy of programmed intermittent epidural bolus (PEIB) and continuous epidural infusion (CEI) in parturients during active phase of labour.\n\nThe main questions aimed to answer are:\n\n* Will parturient using PIEB+PCEA has lower incidence of motor block as compared to CEI during labour?\n* Will parturient using PIEB + PCEA has lower local anaesthetic consumption (in mg\u002Fhr) as compared to CEI during labour?\n* Will parturient using PIEB + PCEA has shorter duration of second stage labour as compared to CEI?\n* Will parturient using PIEB + PCEA has better satisfaction score when compared to CEI during labour?\n\nParticipants will be randomised into PIEB group and CEI group after informed consent taken\n\n* All participants will be taken baseline demographic data, vital signs, Bromage score, cardiotocograph prior intervention\n* Labour epidural will be inserted and started on PIEB protocol or CEI protocol based on randomisation\n* Participants vital signs and Bromage score will be recorded hourly till baby delivery\n* In the end of delivery, total LA consumption and duration of second stage will be recorded\n* Within 24 hours, participants will be interviewed on their satisfaction score on labour epidural analgesia.\n\nResearchers will compare PIEB and CEI to see if PIEB has better safety and efficacy as compared to CEI in labour epidural analgesia.",[82],"Analgesia, Epidural","2025-03-15",{"date":85,"type":36},"2025-03-21",{"date":87,"type":20},"2025-04-01",{"date":64,"type":20},{"name":42,"class":43},{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":4,"eligibilityCriteria":96,"healthyVolunteers":11,"sex":16,"minAge":97,"maxAge":98,"enrollmentInfo":99,"targetDuration":4,"studyType":21,"phases":101,"briefSummary":102,"conditions":103,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":44},"100582351","effect-of-meal-replacement-therapy-on-glucose-control-and-metabolic-parameters-in-patients-with-uncontrolled-diabetes-100582351","NCT06862180","Effect of Meal Replacement Therapy on Glucose Control and Metabolic Parameters in Patients With Uncontrolled Diabetes","The Effect of Meal Replacement Therapy on Glucose Control and Other Metabolic Parameters in Patients With Uncontrolled Type 2 Diabetes on Oral Hypoglycemic Agents: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Patients between ≥ 30 to ≤ 65 years old\n2. Diagnosed as having type 2 diabetes mellitus base on CPG Malaysia Clinical Practice Guidelines (CPG) for Type 2 Diabetes Mellitus (T2DM) 6th edition 2020.\n3. On oral hypoglycaemic agent(s)\n4. HbA1c 7- 10 % (result 3 months from the date of recruitment)\n5. Agree not to take other beverages, herbal or nutritional supplements for the duration of the study.\n\nExclusion Criteria:\n\n1. Severe diabetic complication(s) including end-stage renal disease and proliferative retinopathy.\n2. Pregnancy or plan to get pregnant during the study period\n3. Newly diagnosed diabetic less than 3 months from the date of recruitment\n4. Currently involve in any weight loss program\n5. Currently consuming any meal replacement product\n6. Patients with chronic kidney disease with eGFR ≤ 25 ml\u002Fmin.\n7. Patients with advanced liver disease, such as non-alcoholic steatohepatitis (NASH) with significant fibrosis (e.g., liver stiffness measurement \\> 9.5 kPa by FibroScan) or cirrhosis.\n8. Patients with significantly elevated liver enzymes (e.g., ALT or AST ≥ 3 times the upper limit of normal), which may indicate more severe liver damage.","30 Years","65 Years",{"count":100,"type":20},108,[23],"To evaluate the effect of meal replacement therapy on glucose control and other metabolic parameters in patients with uncontrolled type 2 diabetes.\n\nMethodology:\n\nThis is an open-label, prospective, randomized control trial study. Study duration. August 2023 - March 2026. Study location. This study will be conducted at the Klinik Rawatan Keluarga and diabetes clinic Hospital Universiti Sains Malaysia.\n\nSource Reference :\n\nPeople with type 2 diabetes mellitus attending the Hospital Universiti Sains Malaysia.\n\nStudy source population :\n\nPeople with type 2 diabetes mellitus attended Klinik Rawatan Keluarga and diabetes clinic Hospital Universiti Sains Malaysia during the study period.",[104],"Diabetes Mellitus, Type 2","2025-03-02",{"date":107,"type":36},"2025-03-06",{"date":109,"type":36},"2024-11-01",{"date":111,"type":20},"2026-03",{"name":42,"class":43},""]