[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Hospital del Mar\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":238},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,51,85,108,132,157,184,211],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":30,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":4},"100643721","evolution-of-physical-frailty-and-patient-reported-outcome-measures-in-kidney-transplant-candidates-a-mixed-methods-longitudinal-study-protocol-100643721",false,"NCT07607041","Evolution of Physical Frailty and Patient-Reported Outcome Measures in Kidney Transplant Candidates: A Mixed-Methods Longitudinal Study Protocol","Longitudinal Tracking of Physical Frailty and Health-Related Quality of Life Through Patient-Reported Outcome Measures in Adult Candidates on the Kidney Transplant Waiting List","Inclusion Criteria:\n\n* Patients aged 18 years or older.\n* Diagnosed with Stage 5 chronic kidney disease (CKD).\n* Currently undergoing clinical evaluation for or actively listed on the deceased-donor kidney transplant waiting list at Hospital del Mar (Barcelona).\n* Cognitive and physical ability to understand and provide written informed consent.\n* Ability to use or have regular access to a digital device (smartphone or tablet) for electronic Patient-Reported Outcome Measures (ePROMs) completion.\n\nExclusion Criteria:\n\n* Severe cognitive impairment or active psychiatric disorders that prevent the reliable completion of questionnaires or physical tests.\n* Major physical disability that precludes the objective assessment of gait speed or handgrip strength (e.g., bilateral lower limb amputation or severe dominant hand deformity).\n* Acute medical illness requiring hospitalization at the time of enrolment.\n* Total language barrier that prevents understanding the study components or the qualitative interview.","ALL","18 Years",{"count":19,"type":20},150,"ESTIMATED","24 Months","OBSERVATIONAL","This study looks at how the physical and emotional health of people changes while they wait for a kidney transplant. Waiting for an organ can take a long time. During this period, some patients become \"frail.\" This means they lose strength and are at a higher risk for health problems.\n\nThe main goal is to follow these patients over time to better understand their needs. Researchers will use a mobile application to collect Patient-Reported Outcome Measures (PROMs) directly from patients about how they feel and their quality of life. The study will also include personal interviews to learn about the patients' experiences and any difficulties they face when using technology.\n\nThe results of this study will help to: • Identify early which patients are losing strength or health. • Improve the support that nurses provide during the transplant waiting period. • Make sure that digital health tools are easy for everyone to use.\n\nIn short, this work aims to help patients reach the day of their surgery in the best possible condition.",[25,26,27,28,29],"Kidney Failure, Chronic","Frailty","Quality of Life","Kidney Transplantation","Patient Reported Outcome Measures",[28,31,32,33,34,35,36,37,38],"Waiting Lists","Health-Related Quality of Life","Digital Health","Longitudinal Studies","Mixed Methods Research","Hermeneutics","Patient-Centered Care","Technology Assessment, Biomedical","NOT_YET_RECRUITING","2026-06-05",{"date":42,"type":43},"2026-06-08","ACTUAL",{"date":45,"type":20},"2026-07",{"date":47,"type":20},"2028-07",{"name":49,"class":50},"Hospital del Mar","OTHER",{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":68,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},"100629983","acute-cholecystitis-biliary-complications---icg-100629983","NCT07481760","Acute Cholecystitis Biliary Complications - ICG","Multicenter Randomized Controlled Trial Evaluating Indocyanine Green Fluorescence to Reduce Biliary Complications in Emergency Cholecystectomy for Acute Cholecystitis","ICG-ACBC","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Diagnosis of acute cholecystitis according to Tokyo Guidelines (TG18) criteria.\n* Planned urgent\u002Femergency laparoscopic cholecystectomy during the index admission, as determined by the treating surgical team.\n* Ability to provide written informed consent prior to surgery.\n\nExclusion Criteria:\n\n* Known hypersensitivity or contraindication to indocyanine green (ICG) or its excipients.\n* Pregnancy or breastfeeding.\n* Clinical situation preventing protocol implementation or informed consent (e.g., life-threatening emergency requiring immediate surgery without time for study procedures).\n* Primary open cholecystectomy planned (i.e., not intended laparoscopic approach).\n* Any condition that, in the investigator's opinion, makes participation unsafe or not feasible.",{"count":60,"type":20},296,"INTERVENTIONAL",[63],"NA","Acute cholecystitis is a common indication for emergency laparoscopic cholecystectomy. Inflammatory changes and distorted anatomy may increase the risk of biliary complications, including bile duct injury and bile leak, which are associated with significant morbidity, reinterventions, and prolonged hospitalization. Indocyanine green (ICG) fluorescence cholangiography allows real-time visualization of the extrahepatic biliary anatomy using near-infrared imaging and has shown to improve anatomical identification during elective cholecystectomy. However, its clinical impact in the emergency setting of acute cholecystitis has not been adequately evaluated in randomized multicenter trials.\n\nThe objective of this study is to determine whether the use of ICG fluorescence cholangiography during emergency laparoscopic cholecystectomy reduces the incidence of clinically relevant biliary complications compared with standard surgery without ICG.\n\nThis is a pragmatic, multicenter, open-label randomized controlled trial including 296 adult patients with acute cholecystitis undergoing urgent laparoscopic cholecystectomy. Participants will be randomized 1:1 to surgery with or without ICG fluorescence guidance. The primary outcome is the incidence of clinically relevant biliary complications, including bile duct injury or bile leak, within 90 days after surgery.",[66,67],"Acute Cholecystitis","Biliary Complications",[69,70,71,72,73,67,74,75],"acute cholecystitis","Laparoscopic Cholecystectomy","Indocyanine Green","Fluorescence Cholangiography","Bile Duct Injury","Emergency Surgery","Near-Infrared Fluorescence Imaging","2026-03-14",{"date":78,"type":43},"2026-03-19",{"date":80,"type":20},"2027-01-01",{"date":82,"type":20},"2029-03-31",{"name":49,"class":50},1,{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":93,"targetDuration":95,"studyType":22,"phases":4,"briefSummary":96,"conditions":97,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":84},"100609010","pathways-to-equitable-access-to-kidney-transplantation-in-spain-a-transformative-mixed-methods-study-protocol-100609010","NCT07208994","Pathways to Equitable Access to Kidney Transplantation in Spain: A Transformative Mixed-methods Study Protocol","Pathways to Equitable Access to Kidney Transplantation in Spain (PATH2KT): A Transformative Mixed-methods Study Protocol","PATH2KT","Inclusion Criteria:\n\n* People with CKD\n\nExclusion Criteria:\n\n* Pediatrics",{"count":94,"type":20},3000,"1 Day","Introduction. Chronic kidney disease (CKD) affects 10%-15% of the global population and is projected to become the fifth leading cause of years of life lost by 2040. Despite the benefits of kidney transplantation (KT), access remains inequitable. In Spain, which leads the world in KT rates per million population, disparities may persist due to structural, territorial, and professional barriers. This study aims to explore the mechanisms underlying treatment deprivation and inequity in KT access using a mixed-methods approach.\n\nMethods and analysis. A transformative mixed-methods design will be implemented in four phases: (1) systematic reviews on instruments assessing treatment deprivation and inequalities in CKD and KT; (2) a multicenter quantitative study and qualitative interviews with professionals and patients; (3) a pre-experimental evaluation of a training program on KT; and (4) triangulation and translation of findings to inform national policy. The protocol adheres to GRAMMS and PRISMA guidelines.\n\nEthics and dissemination. Approved by the Hospital del Mar Research Institute Ethics Committee (ID: XX), the study complies with EU data protection laws. Informed consent will be obtained. Findings will be disseminated via peer-reviewed publications, conferences, social media, and patient forums to support equity-focused strategies in KT.",[98,99],"Chronic Kidney Disease","Kidney Transplant","2025-09-29",{"date":102,"type":43},"2025-10-06",{"date":104,"type":20},"2026-01-01",{"date":106,"type":20},"2027-12-31",{"name":49,"class":50},{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":116,"targetDuration":4,"studyType":61,"phases":118,"briefSummary":119,"conditions":120,"keywords":4,"overallStatus":123,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":84},"100477067","unravelling-the-impact-of-radiofrecuency-in-liver-surgery-the-key-to-decrease-local-recurrence-100477067","NCT05492136","Unravelling the Impact of Radiofrecuency in Liver Surgery: the Key to Decrease Local Recurrence?","Unravelling the Impact of Radiofrecuency in Liver Surgery: the Key to Decrease Local Recurrence? (Study LIVERaTION)","LIVERaTION","Inclusion criteria:\n\n1. Written informed consent granted prior to the initiation of the surgical procedure, given with the understanding that the patient has the right to withdraw from the study at any time, without prejudice.\n2. 18 year of age or older.\n3. WHO performance scale 0-2\n4. Consecutive patients (both sexes equally distributed) suffering from CRLM confirmed either by abdominal CT, abdominal MRI or\u002Fand by histologic-cytological evaluation or patients suffering from HCC.\n5. Any previous chemotherapy regime is permitted.\n6. ASA score 1 to 3.\n\nExclusion criteria:\n\n1. Previous or concurrent cancer that is distinct from one primary tumor of which the Liver metastasis comes from EXCEPT cervical carcinoma in situ, treated basal cell carcinoma, superficial bladder tumors (Ta, Tis \\& T1).\n2. Any cancer curatively treated \\> 3 years prior to enrollment is permitted.\n3. ASA 4.\n4. Non-resectable extrahepatic metastases.\n5. Liver metastasis from other origin apart from colorectal.\n6. Bening primary tumor of the liver.\n7. Pregnant woman.\n8. Participation in another clinical trial.",{"count":117,"type":20},720,[63],"Radiofrequency devices have been increasingly employed in liver surgery in order to achieve proper hemostasis and this use has become more evident with the implementation of minimal invasive surgery. Due to its well-known efficacy for tumor ablation (i.e. hepatocarcinoma) it use has been extended in some cases to ablate the liver surface after resection in questionable resection. Till date, despite the majority of surgeons apply an additional coagulation in doubtful margins, there is not an evidence that this maneuver really decreases the local recurrence or increases the overall survival. On the contrary, some studies have suggested that non-anatomical resections in order to spare liver parenchyma could lead to major zones of liver ischemia in the remnant liver and thus favoring recurrence. However, major liver ischemia (defined as grade 2 o more) is unlikely to be provoked by 1 cm-depth additional coagulation of the margin.\n\nThe investigators previously published in a retrospective study the concept of additional margin coagulation within liver resections and narrow margins and demonstrated that the study group had significantly less local recurrence compared to the controls. Therefore, in the present study the aim is to continue this evaluation through a multicenter randomized clinical trial.",[121,122],"Liver Cancer","Cancer, Treatment-Related","RECRUITING","2025-09-01",{"date":126,"type":43},"2025-09-03",{"date":128,"type":43},"2023-11-01",{"date":130,"type":20},"2028-06-30",{"name":49,"class":50},{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":138,"eligibilityCriteria":139,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":140,"targetDuration":4,"studyType":61,"phases":142,"briefSummary":143,"conditions":144,"keywords":146,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":154,"leadSponsor":156,"locationsCount":84},"100591503","robotic-vs-open-pancreatoduodenectomy-100591503","NCT06981273","Robotic vs Open Pancreatoduodenectomy","SPAIN Trial Comparing Open vs Robotic Pancreatoduodenectomy","SPAIN PD","Inclusion Criteria:\n\n* Age 18 years or older.\n* Patients requiring planned pancreatoduodenectomy (robotic or open).\n* Signed informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Patients who refuse the procedure.\n* Uncertainty about vascular involvement that could affect resectability.\n* Poor general health status (American Society of Anesthesiologists \\[ASA\\] classification IV).\n* Pancreatitis",{"count":141,"type":20},93,[63],"Pancreatic surgery, specifically pancreatoduodenectomy (PD), is a complex procedure often required for patients with pancreatic or other periampullary cancers. In recent years, minimally invasive techniques have become more popular, especially robotic-assisted surgery. However, there are limited studies comparing robotic surgery to traditional open surgery.\n\nThis is a national, multicenter study in Spain comparing the outcomes of robotic versus open pancreatoduodenectomy (PD). The main goal is to assess complications within 90 days after surgery. This study is important because it will provide evidence on which approach is safer and more effective for patients.\n\nThe study follows a \\*\\*prospective, randomized, and multicenter design\\*\\*, meaning patients are assigned to either robotic or open surgery randomly, and multiple hospitals are involved. The study will include all eligible patients undergoing planned PD surgery, either by robotic or open technique.\n\nTo be included in the study, patients must meet these conditions:\n\n* Be \\*\\*18 years or older\\*\\*.\n* Require \\*\\*planned PD surgery\\*\\*.\n* Sign an \\*\\*informed consent form\\*\\*.\n\nWho Cannot Participate?\n\nPatients will \\*\\*not\\*\\* be included if they:\n\n* \\*\\*Refuse the procedure\\*\\*.\n* Have \\*\\*uncertainty about vascular involvement\\*\\*.\n* Have a severe health condition classified as \\*\\*ASA IV\\*\\* (high-risk for surgery).\n\nThe main outcome measured will be the \\*\\*Comprehensive Complication Index (CCI), a standardized way to assess post-surgical complications. Additional factors being studied include:\n\n* \\*\\*Clinical outcomes\\*\\* during and after surgery.\n* \\*\\*Quality of life\\*\\* assessments.\n* \\*\\*Surgical costs\\*\\*.\n* \\*\\*Hospital stay duration\\*\\*.\n* \\*\\*Need to switch from robotic to open surgery\\*\\*.\n* \\*\\*Need for additional surgery (reoperations)\\*\\*.\n* \\*\\*Hospital readmissions\\*\\*.\n\nWhere Is the Study Being Conducted?\n\nThe study is being conducted in \\*\\*ten major hospitals across Spain\\*\\*:\n\n1. Hospital del Mar, Barcelona\n2. Hospital Balmis, Alicante\n3. Hospital Vall d'Hebron, Barcelona\n4. Arnau de Vilanova, Lleida\n5. Joan XXIII, Tarragona\n6. Hospital Sant Pau, Barcelona\n7. Germans Trias i Pujol, Barcelona\n8. Hospital Clínic, Barcelona\n9. HM Sanchinarro, Madrid\n10. Hospital Rio Hortega, Valladolid\n\nHow Long Will the Study Last? The study will take \\*\\*two years\\*\\* to complete, and patients will be followed for \\*\\*three years\\*\\* after surgery to track long-term outcomes.\n\nWhy Is This Study Important for Patients? For patients undergoing PD, this study will provide essential information about the risks and benefits of robotic versus open surgery. The findings will help doctors determine the best surgical approach, leading to improved safety, faster recovery, and better long-term health outcomes.\n\nIf you are a patient facing this type of surgery, participating in this study could contribute to valuable medical knowledge while ensuring that you receive a carefully monitored treatment plan.",[145],"Pancreas Neoplasms",[147,148,149],"Robotic","pancreaticoduodenectony","Robotic surgery","2025-05-19",{"date":152,"type":43},"2025-05-20",{"date":124,"type":20},{"date":155,"type":20},"2027-09-01",{"name":49,"class":50},{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":163,"eligibilityCriteria":164,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":165,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":167,"conditions":168,"keywords":170,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":4},"100574881","textbook-outcomes-in-urgent-appendectomy-100574881","NCT06765044","Textbook Outcomes in Urgent Appendectomy","Textbook Outcomes of Surgical Treatment of Acute Appendicitis","APPX_TEXTBOOK","Inclusion Criteria:\n\n* Acute Appendicits in older than 18 years old\n* Acute Appendicitis that needs appendectomy\n\nExclusion Criteria:\n\n* Age under 18 years old\n* Other diagnostic than an Acute Appendicitis",{"count":166,"type":20},500,"A \"textbook outcome\" patient is defined as one whose surgical course is uneventful, with no complications, readmissions, or mortality. There is a lack of published research regarding textbook outcomes with an acute appendicitis that are treated with an appendectomy.",[169],"Valid MeSH Conditions",[171,172,173,174,175],"Textbook Outcomes","Laparoscopy","Acute Appendicitis","Open Surgery","Urgent Appendectomy","2025-01-02",{"date":178,"type":43},"2025-01-09",{"date":180,"type":20},"2025-01-15",{"date":182,"type":20},"2025-02-15",{"name":49,"class":50},{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":188,"acronym":189,"eligibilityCriteria":190,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":191,"targetDuration":193,"studyType":22,"phases":4,"briefSummary":194,"conditions":195,"keywords":197,"overallStatus":123,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":206,"completionDateStruct":208,"leadSponsor":210,"locationsCount":84},"100433625","troms-trainee-reported-outcome-measurement-the-new-era-of-surgical-evaluation-100433625","NCT04926558","TROMS (Trainee Reported Outcome Measurement): the New Era of Surgical Evaluation","TROMS","Inclusion criteria:\n\nAll surgical residents in the department of general and digestive surgery\n\nExclusion criteria:\n\nNot applicable",{"count":192,"type":20},120,"10 Years","TROMS (trainee reported outcome assessment): assessment of surgical training of residents in general surgery",[196],"Surgical Procedure, Unspecified",[189,198,199,200,201,202],"PROMS","surgical assessment","learning curve","OSATS","MIR","2024-06-05",{"date":205,"type":43},"2024-06-07",{"date":207,"type":43},"2021-01-01",{"date":209,"type":20},"2025-12-31",{"name":49,"class":50},{"id":212,"slug":213,"hasResults":11,"nctId":214,"briefTitle":215,"officialTitle":216,"acronym":217,"eligibilityCriteria":218,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":219,"targetDuration":221,"studyType":22,"phases":4,"briefSummary":222,"conditions":223,"keywords":224,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":230,"lastUpdatePostDateStruct":231,"startDateStruct":233,"completionDateStruct":235,"leadSponsor":237,"locationsCount":4},"100533608","external-validation-os-the-acme-scoring-system-100533608","NCT06228027","External Validation os the ACME Scoring System","Prediction of the Mortality in Acute Calculous Cholecystitis. The ACME Project.","ACME_2","Inclusion Criteria:\n\n* Acute Calculous Cholecystitis\n\nExclusion Criteria:\n\n* Acute Cholangitis\n* Chronic Cholecystitis\n* Neoplasia\n* Acute Pancreatitis\n* Pregnant",{"count":220,"type":20},10000,"90 Days","Acute calculous cholecystitis (ACC) is the second most frequent surgical condition in emergency departments. The recommended treatment is surgical treatment (ST) and the accepted mortality is \\\u003C1%, but in severe and\u002For fragile patients is higher. Despite the Tokyo Guidelines, there no consensus on who is the unfit patient for ST. A recent study has identified 4 risk factors that predicts the mortality in a 92% of patients (ACME) and could help to develop new guidelines in ACC. The aim of this study is to perfom an external validation of the new simplified scoring system for mortality in ACC.",[66],[66,225,226,227,228,229],"Cholecystectomy","Tokyo Guidelines","Postoperative Complications","Mortality","High-risk patient","2024-03-07",{"date":232,"type":43},"2024-03-12",{"date":234,"type":20},"2025-01-01",{"date":236,"type":20},"2027-04-15",{"name":49,"class":50},""]