[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Humanity and Health Research Centre\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":79},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,39,59],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100300397","nonalcoholic-steatohepatitis-in-chinese-children-100300397",false,"NCT03190538","Nonalcoholic Steatohepatitis in Chinese Children","Nonalcoholic Steatohepatitis in Chinese Children: a Long Term Follow-up","Inclusion Criteria:\n\n* age 1-18 with biopsy-proven NAFLD\n* Alcohol consumption less than 20g\u002Fday and 10g\u002Fday for boys and girls respectively\n\nExclusion Criteria:\n\n* with viral hepatitis, e.g. HBV, HCV\n* with a1-anti-trypsin disease\n* with autoimmune hepatitis\n* with Wilson disease\n* with liver impaired by drugs","ALL","1 Year","18 Years",{"count":20,"type":21},400,"ESTIMATED","OBSERVATIONAL","Nonalcoholic steatohepatitis (NASH) is now recognised as an increasing clinical problem in children. Steatosis without significant liver cell injury or fibrosis is the most common form of nonalcoholic fatty liver disease (NAFLD) in both adults and children. Studies in the adult population have variably suggested that steatosis is a benign nonprogressive condition and NASH is recognised as a potentially serious condition with significantly risk of morbidity and mortality.\n\nA growing body of evidence suggests that children with NASH frequently show histopathological features that differ from those of adults. The prevalence of this pattern in a wide range of paediatric cases as well as other histopathological lesions and their relevance and prognostic significance in children with NAFLD remains to be determined. Thus the investigators would like to conduct a study of biopsies and clinical information to document the histological features of paediatric NAFLD, to explore the natural history of paediatric NAFLD, and to determine the frequency and prognostic value of these features.",[25],"Non-Alcoholic Fatty Liver Disease","RECRUITING","2025-03-21",{"date":29,"type":30},"2025-03-24","ACTUAL",{"date":32,"type":30},"2017-05-01",{"date":34,"type":21},"2028-05-31",{"name":36,"class":37},"Humanity and Health Research Centre","OTHER",1,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":46,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":49,"conditions":50,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":53,"startDateStruct":54,"completionDateStruct":56,"leadSponsor":58,"locationsCount":38},"100297397","longitudinal-observational-study-of-chinese-with-nafldnash-100297397","NCT03151473","Longitudinal Observational Study Of Chinese With NAFLD\u002FNASH","Prospective Cohort Assessing The Prevalence And Progress Of Non-Alcoholic Fatty Liver Disease (NAFLD)\u002FNon-Alcoholic Steatohepatitis (NASH) In Chinese Subjects","Inclusion Criteria:\n\n* Males or females aged 18 and older;\n* Adults being managed or treated for NAFL or NASH;\n* Be able to communicate meaningfully with the Investigator and be legally competent to provide written informed consent.\n\nExclusion Criteria:\n\n* Incompetent to understand and\u002For sign the informed consent;\n* Ethanol consumption exceeding more than 14 standard beverages per week for males and more than 7 standard beverages per week for female;\n* Causes for secondary hepatic fat accumulation such as significant alcohol consumption, medications, Wilson's disease, viral infections, starvation or parenteral nutrition, among others, and conditions associated with microvesicular steatosis\n* Diagnosis of liver cirrhosis and\u002For hepatocellular carcinoma;\n* Diagnosis of chronic inflammatory disease (i.e. inflammatory bowel disease, rheumatoid arthritis, inflammatory lung disease, severe infectious diseases), other than NAFL\u002FNASH.",true,{"count":48,"type":21},20000,"This is a 10-year, longitudinal, observational study of patients with NAFLD\u002FNASH designed to specifically address important clinical questions that remain incompletely answered from registration trials. In addition to the study database, the biospecimen repository will also be included so that translational studies of genomics and biomarkers of response may be performed.",[51,52],"Non-Alcoholic Fatty Liver Disease (NAFLD)","Non-Alcoholic Steatohepatitis (NASH)",{"date":29,"type":30},{"date":55,"type":30},"2017-05-08",{"date":57,"type":21},"2027-09-30",{"name":36,"class":37},{"id":60,"slug":61,"hasResults":11,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":4,"eligibilityCriteria":65,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":66,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":68,"conditions":69,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":38},"100275322","follow-up-of-chronic-hepatitis-b-patients-with-comorbid-nonalcoholic-fatty-liver-disease-100275322","NCT02863757","Follow-up of Chronic Hepatitis B Patients With Comorbid Nonalcoholic Fatty Liver Disease","Disease Progression and Clinical Outcomes in Chronic Hepatitis B (CHB) Patients With Comorbid Nonalcoholic Fatty Liver Disease (NAFLD)","Inclusion Criteria:\n\n* Liver biopsy proved CHB and\u002For NAFLD at baseline;\n* Chinese\n* Follow-up duration\\>12 months\n\nExclusion Criteria:\n\n* Other liver diseases;\n* Secondary causes of hepatic steatosis;\n* Alcohol abuse;\n* Liver cirrhosis, cirrhosis related complications or HCC at baseline;\n* Malignancy;\n* History of liver transplantation",{"count":67,"type":21},1500,"The purpose of this study is to determine the disease progression in CHB\u002FNAFLD compared with CHB and NAFLD including liver cirrhosis, cirrhotic complications and hepatocellular carcinoma (HCC).",[70,71],"Chronic Hepatitis B","Nonalcoholic Fatty Liver Disease","2025-03-20",{"date":29,"type":30},{"date":75,"type":30},"2016-08-01",{"date":77,"type":21},"2026-12",{"name":36,"class":37},""]