[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Hunter College of City University of New York\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":174},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,41,65,87,113,134,156],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":4},"100635418","cognitive-musical-screening-and-therapeutic-innovation-in-multiple-sclerosis-100635418",false,"NCT07552428","Cognitive Musical Screening and Therapeutic Innovation in Multiple Sclerosis","Neurocognitive Musical Screening and Therapeutic Innovation: A Crossover Randomized Controlled Pilot Study","MS","Inclusion Criteria:\n\n* diagnosed with multip\\[le sclerosis (MS)\n* aged 18 and older\n* speak fluent English\n\nExclusion Criteria:\n\n* Mental incapacity\u002Fmajor depression or psychiatric illness as determined by the neurology team and a score ≥11 on the Patient Health Questionnaire-9 (PHQ9)\n* Neurological conditions (other than MS) or medical illnesses that affect cognitive function (i.e., Alzheimer's disease, stroke)\n* On psychoactive medications or medications that may influence cognition (e.g. Aricept, Adderall) or active substance abuse\n* Professional musician (≥2 years formal training in last 5 years or ≥ 2 hours\u002Fweek of currently playing a musical instrument)\n* Severe vision\u002Fhearing impairments precluding assessments: color blindness, considering the diverse colors featured on the Ipsilon tool.","ALL","18 Years",{"count":20,"type":21},32,"ESTIMATED","OBSERVATIONAL","This pilot study evaluates the effectiveness of screening and improving cognitive function in patients with multiple sclerosis (MS) using a musical tool, the Ipsilon. The Ipsilon performance will be compared with established neuropsychological assessments, including the Minimal Assessment of Cognitive Function in MS (MACFIMS) and the Processing Speed Test (PST). Thirty-two participants will be enrolled in a crossover design: half will complete the Ipsilon musical test for 15 minutes daily for seven consecutive days, while the other half will begin with no intervention before switching sequences. Participants will undergo screening for depression, colorblindness, musical background, and upper extremity function. Primary outcomes include evaluating whether the Ipsilon more reliably predicts cognitive domains measured by MACFIMS than the PST and assessing its potential to improve cognitive function. Secondary outcomes will examine associations with work functioning and quality of life.",[25],"Multiple Sclerosis",[15,27,28],"Cognitive Function","Musical Tool","NOT_YET_RECRUITING","2026-04-20",{"date":32,"type":33},"2026-04-27","ACTUAL",{"date":35,"type":21},"2026-10-01",{"date":37,"type":21},"2028-12-31",{"name":39,"class":40},"Hunter College of City University of New York","OTHER",{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":47,"enrollmentInfo":48,"targetDuration":4,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":64},"100582255","a-palliative-care-model-impact-on-knowledge-and-attitudes-100582255","NCT06860932","A Palliative Care Model Impact on Knowledge and Attitudes","Inclusion Criteria:\n\n* Diagnosed with MS, NMOSD, or anti-MOG, at least 2 years after their diagnosis.\n* Aged 18-65\n* Speak English since all instruments are available in English.\n\nExclusion Criteria:\n\n* Visually impaired (note, hearing impaired is not an exclusion criterion as the video is closed captioned).\n* Psychological state not appropriate for PC discussions as determined by the Patient Health Questionnaire 9 (PHQ9).\n* A score of 11 or higher, indicative of major depressive disorder, will be referred to immediate management and excluded from the study.\n* Unable to participate in PC discussions due to cognitive impairment as determined by the Processing Speed Test (PST) score below -1.5 Z score.","65 Years",{"count":49,"type":21},50,"INTERVENTIONAL",[52],"NA","This study is using a central, computer-generated simple randomization technique. Participants will be randomly assigned to groups within the constraints of ensuring balanced representation of gender, ethnicity, and race.\n\nOne-half of the patients are randomized to the decision aid video model, and one-half will serve as controls and receive a palliative care (PC) informational sheet. Sessions are designed to be consistent with PC principles of care using constructs from the Murray's transition theory including knowledge development coupled with advanced care planning (ACP)-to drive palliative care alongside curative treatment, and to support people with chronic progressive illnesses. The 2 groups will complete the demographic forms, and pre- and post-tests, at baseline and after three months. The intervention group will view the video decision aid, which takes 10 minutes, during their follow up appointment. The controls will read written information of the same content shown on the video and will complete similar questionnaires. The video opens with empathic statements regarding the situation in which patients may find themselves, including an introduction about medical decisions, and statements regarding values and spiritual beliefs and their impact on decision-making. The video translates the information into actionable medical orders using a three-goal framework: life-prolonging care, limited\u002Fblended care, and comfort care. The video describes the features of each of the goals of care and the risks and benefits of each option using visual images that illustrate the interventions. Patients will review the video using iPads and will be able to review the video again as needed. The Flesch-Kincaid ease score for the video narration is 71.6; for the \"Conversation\" piece, it is 65.9. These indicate that the passages require approximately a 7th or 8th grade reading level, which Flesch suggests makes them \"easy to read\" and \"plain English,\" respectively.\n\nThe goal of the video intervention is to help patients express their values and health goals, while achieving their life and core values. The intervention group will view the video which includes modules to teach patients strategies for expressing their concerns and enhance their self-efficacy, helping them overcome any barriers. To enhance intervention fidelity, an ACP facilitator guide will be developed as reference for the intervention implementation. It will detail the key topics and purposes of each session of the intervention, the guiding questions, and the facilitation skills.\n\nAim 1: To explore the preferences of patients with neuroinflammatory diseases, PC knowledge, decisional conflict, and preparation for decision making among 50 adult (18-65 years old) patients randomly assigned to one of two PC modalities: 1. a video depicting PC goals of care (intervention group, n=25), or 2. standard usual care using PC written information (control group, n=25).\n\nH1a: Patients randomized to the video will have higher documented preferences and fewer preferences for life-prolonging interventions (primary outcome) than the control group. The intervention group will have greater knowledge, lower decisional conflict, and greater preparation for decision making than those randomized to the control group.\n\nAim 2: To compare PC conversations and documentation at 3 months among patients with neuroinflammatory diseases.\n\nH2: Patients randomized to the video will have more PC conversations and higher rates of PC documentation after 3 months.",[55],"Multiple Sclerosis, MS","RECRUITING",{"date":58,"type":33},"2026-04-22",{"date":60,"type":33},"2025-02-01",{"date":62,"type":21},"2026-06-30",{"name":39,"class":40},2,{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":4,"eligibilityCriteria":71,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":47,"enrollmentInfo":72,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":74,"conditions":75,"keywords":76,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},"100626808","effect-of-acetominophen-an-gait-fatigue-in-multiple-sclerosis-100626808","NCT07440446","Effect of Acetominophen an Gait Fatigue in Multiple Sclerosis","Effect of Antipyretics in Gait Fatigue in Multiple Sclerosis","Inclusion Criteria:\n\n* A definitive MS diagnosis confirmed by self-report,\n* The ability to walk for 2 minutes continuously with or without assistive device ---Age 18-65\n* Provide a blood test within the last 6 months to 1 year reflecting normal liver and renal profile (normal liver enzymes and normal creatinine level).\n\nExclusion Criteria:\n\n* Any current or recent exacerbations\n* Any adverse reaction to antipyretics\n* Recent use of steroids\n* Any non-MS conditions that interfere with walking performance.",{"count":73,"type":21},20,"The goal of this observational study is to compare the impact of an antipyretic, acetaminophen to a placebo on gait fatigue in persons with multiple sclerosis (MS). The primary question this study is asking is the following: will the antipyretic effects of acetaminophen result in less gait fatigue in persons with MS? Participants will be asked to come for two sessions over a 1 week period. In the first week, subjects will be blind-randomized into either the acetaminophen or placebo group. They will then undergo a test to determine their gait speed by performing two 25 foot walks at their best comfortable pace. The walks will be 1 minute apart. The average speed from those 2 walks will be obtained. Subjects will then take either the acetaminophen or the placebo. Following a 45 minute rest period they will then get on a treadmill and will walk at the previously determined speed for as long as they can. Walking will stop if the subject can no longer maintain the speed or if they wish to no longer continue. The subjects will wear a safety harness at all times during the walk to prevent falls. Heart rate and core body temperature will be measured via skin sensors. One week later the subjects will return and repeat the procedure but this time in the opposite condition. Subjects who took the acetaminophen will take the placebo and subjects who took the placebo will take the acetaminophen. The difference between distance walked in the 2 conditions will be compared.",[25],[77],"Fatigue","2026-03-16",{"date":80,"type":33},"2026-03-17",{"date":82,"type":21},"2026-03",{"date":84,"type":21},"2026-12",{"name":39,"class":40},1,{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":94,"sex":95,"minAge":18,"maxAge":96,"enrollmentInfo":97,"targetDuration":4,"studyType":50,"phases":99,"briefSummary":100,"conditions":101,"keywords":4,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":112},"100539756","couples-motivational-interviewing-to-reduce-drug-use-and-hiv-risk-in-vulnerable-male-couples-100539756","NCT06307977","Couples Motivational Interviewing to Reduce Drug Use and HIV Risk in Vulnerable Male Couples","CHP","Inclusion Criteria:\n\n* Have a main partner who is another cisgender male and have been in a relationship for 3 month or longer\n* Index participant must be between 18 and 55; Main partner can be any age 18 and older\n* One participant must be HIV negative (as confirmed by rapid test)\n* One participant must have used at least 1 drug in the past 30 days (cocaine\u002Fcrack, opiates, misuse of prescription medication, stimulants, psychedelics, ecstasy, ketamine, GHB, amyl nitrite)\n* Index participant must have engaged in TRB in the past 30 days- Defined as CAS with a casual partner, or a serodiscordant or non-monogamous main partner\n* Live in the United States\n* Speak and read English\n\nExclusion Criteria\n\n* Any signs of serious mental illness or cognitive deficit\n* Current suicidal\u002Fhomicidal ideations\n* History of IPV with their main partner and safety concerns in the current relationship.",true,"MALE","55 Years",{"count":98,"type":21},360,[52],"This study utilizes a randomized controlled trial design to evaluate the efficacy of couples motivational interviewing (MI) to reduce the frequency and severity of illicit drug use and frequency of HIV transmission risk behavior (TRB). Participants are randomized to one of two conditions: couples MI or standard couples HIV testing and counseling (CHTC).",[102,103],"Substance Use","HIV Infections","2025-06-10",{"date":106,"type":33},"2025-06-13",{"date":108,"type":33},"2024-05-25",{"date":110,"type":21},"2029-02",{"name":39,"class":40},3,{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":4,"eligibilityCriteria":119,"healthyVolunteers":94,"sex":17,"minAge":18,"maxAge":120,"enrollmentInfo":121,"targetDuration":4,"studyType":50,"phases":123,"briefSummary":124,"conditions":125,"keywords":4,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":86},"100555041","task-specific-training-for-advanced-multiple-sclerosis-100555041","NCT06506929","Task Specific Training for Advanced Multiple Sclerosis","The Effect of Task Specific Physical Therapy for Persons With Advanced Multiple Sclerosis","Inclusion Criteria:\n\n1. definitive diagnosis of Multiple Sclerosis\n2. Expanded Disability Status Scale (EDSS) of 7.0-8.0\n3. Ability to read, understand , and sign an informed consent -\n\nExclusion Criteria:\n\n1. evidence of MS exacerbation in the 4 weeks prior to starting the study\n2. any orthopedic, cardiopulmonary, or non-MS neurologic symptoms that will interfere with their ability to participate in the study","75 Years",{"count":122,"type":21},15,[52],"The purpose of this study is to find effective physical therapy treatments for individuals who have severe multiple sclerosis. Physical therapy treatments for mild-to-moderate multiple sclerosis exists, however, very limited research has been done for physical therapy for severe multiple sclerosis (MS). In this study 10 participants diagnosed with severe MS will engage in 1-hour physical therapy sessions twice a week for 6 weeks to address limitations in standing, balancing, and bed mobility.",[25],"2024-07-18",{"date":128,"type":33},"2024-07-19",{"date":130,"type":33},"2024-07-10",{"date":132,"type":21},"2026-01",{"name":39,"class":40},{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":120,"enrollmentInfo":141,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":143,"conditions":144,"keywords":145,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":86},"100554925","eccentric-exercise-and-fatigue-in-multiple-sclerosis-100554925","NCT06505421","Eccentric Exercise and Fatigue in Multiple Sclerosis","The Effect of Lower Extremity Eccentric Resistance Training on Fatigue in Multiple Sclerosis","Inclusion Criteria:\n\n* Definitive diagnosis of Multiple Sclerosis.\n* Ability to walk for 6 minutes continuously with or without assistive device\n* Ability read, understand and sign and informed consent\n\nExclusion Criteria:\n\n* Evidence of recent exacerbation in the last 2 months prior to starting the study\n* Orthopedic, cardiopulmonary, or non -MS neurologic condition that could interfere with carrying out the study protocol",{"count":142,"type":21},30,"The goal of this observational study is to compare the impact of eccentric resistance training to traditional resistance training on fatigue in persons with multiple sclerosis (MS). The primary question this study is asking is the following: is eccentric resistance training more fatiguing than traditional resistance training in persons with MS?. Participants will be asked to come for two sessions for two weeks. In the first week, subjects will undergo a bout of either traditional or eccentric resistance training. The next day they will return to assess their level of fatigue. The following week the subject will return and undergo whatever type of training they did not experience the first week, and it's effects on fatigue will again be assessed. The difference between the subjects level of fatigue for either condition will be compared.",[25,77],[146,147],"Exercise","resistance training","2024-07-16",{"date":150,"type":33},"2024-07-17",{"date":152,"type":33},"2024-07-01",{"date":154,"type":21},"2026-12-30",{"name":39,"class":40},{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":4,"eligibilityCriteria":162,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":120,"enrollmentInfo":163,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":164,"conditions":165,"keywords":4,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":169,"completionDateStruct":171,"leadSponsor":173,"locationsCount":86},"100523374","effect-of-cooling-on-balance-performance-in-multiple-sclerosis-100523374","NCT06094855","Effect of Cooling on Balance Performance in Multiple Sclerosis","Effect of Cooling on Balance Performance in Persons With Multiple Sclerosis","Inclusion Criteria: 1-Definitive diagnosis of Multiple Sclerosis 2-Capable of standing unassisted for at least 1 minute 3-ability to read and understand an informed consent 4- age 18-75\n\nExclusion Criteria:\n\n1. Any orthopedic, cardiopulmonary, or non-MS neurologic complication that would interfere with balance because it is study on Multiple Sclerosis.\n2. Under age 18 or over 75",{"count":142,"type":21},"The goal of this observational study to examine the effects of cooling on balance in persons with Multiple Sclerosis. Persons with Multiple Sclerosis frequently have problems with balance leading to falls and related injuries, as well as avoidance of activities that may challenge balance. Persons with Multiple Sclerosis are also well known to experience worsening of their symptoms when they become too warm, a condition known as thermosensitivity. This suggests that heat may worsen balance and increase falls risk in persons with Multiple Sclerosis. In this study we are examining the effects of wearing a cooling vest on balance performance in persons with MS. The main questions our study aims to answer are:\n\nQuestion 1- Does wearing a cooling vest result in better balance performance in persons with MS when compared to a condition when they are not wearing the vest.\n\nParticipants will be given a balance test to assess their baseline balance performance. Following the test participants will be randomly assigned to either a cooled or an uncooled condition. In the cooled condition, participants will wear a commercially available cooling vest while pedaling for 20 minutes at their best comfortable pace on a recumbent stationary bicycle. Immediately following the 20 minutes of exercise the vest shall be removed and the balance test repeated. Subjects in the uncooled condition will perform the same task but without wearing the vest. One week later, participants will return and will perform the opposite of what they did the previous week; subjects who were in the cooled group will perform the 20 minute exercise test without the cooling vest and subjects who were uncooled will perform the test with a cooling vest. The same balance test will be performed before and after the exercise bout.The change in the balance scores between the 2 conditions will be compared.",[25],"2023-11-14",{"date":168,"type":33},"2023-11-15",{"date":170,"type":33},"2023-11-02",{"date":172,"type":21},"2026-12-31",{"name":39,"class":40},""]