[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"IRCCS Burlo Garofolo\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":401},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,44,70,97,124,148,170,192,215,235,260,283,307,330,352,377],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100501478","oral-lesions-in-patients-with-eating-disorders-100501478",false,"NCT05809778","Oral Lesions in Patients With Eating Disorders","Oral Lesions in Patients Dealing With Eating Disorders: an Epidemiological Study","Inclusion Criteria:\n\n1. Diagnosis of ED\n2. Age between 10 and 18 years\n\nExclusion Criteria:\n\n1. Parents or caregivers not understanding the Italian language\n2. Patients affected by other systemic diseases","ALL","10 Years","18 Years",{"count":20,"type":21},81,"ESTIMATED","OBSERVATIONAL","Eating disorders (ED) are common among young. Anorexia (AN) and bulimia (BN) are the most prevalent ED. The American Psychiatric Association's guidelines state a 0.3% AN prevalence among young girls and a 0.1 to 4.2% BN prevalence. Men are not excluded: even if ED are more frequent in females (14-18 years), 1 man off to 10 can be diagnosed with ED. Unfortunately, the onset age is decreasing. In the last few years, always more preteens patients are diagnosed with ED: they generally refer a garbled self perception of body image. ED can have oral manifestations, such as: mucosal lesions, dental erosion, glandular hypertrophy, xerostomia and salivary disorders, dental caries These are the most common manifestations observed in patients with eating disorders, after a routine dental visit. There is not strong evidence that dental caries may be directly related to disordered eating habits; as a matter of fact results are controversial. Despite that, all the studies examined agree on the association between signs listed above and food disorders. Univocal percentages have not been reported in the scientific literature. For instance, a systematic review, dated 2016, showed that dental erosion is diagnosed in 45% of ED people, while other studies documented 70% patients affected by erosion. Another example reported is teeth hypersensitivity. According to some studies, 56% of ED patients reported such complaints, instead of other researches documenting 22% hypersensitivity impairment. As for dental caries, results are dissimilar. Authors showed 78% ED subjects diagnosed with dental caries. Other studies reported almost 50% patients with tooth decay, without statistically significant difference in the values between ED people and controls. All these differences are probably due to the different stages of eating disorders and diagnosis, and oral signs found. Different ages are also considered. The primary aim of the study is to evaluate the prevalence of oral cavity lesions among people affected by eating disorders.",[25],"Eating Disorders",[27,28,29,30],"Eating disorders","Pral lesions","Prevention","Prevalence","RECRUITING","2025-05-13",{"date":34,"type":35},"2025-05-16","ACTUAL",{"date":37,"type":35},"2021-07-21",{"date":39,"type":21},"2025-12-31",{"name":41,"class":42},"IRCCS Burlo Garofolo","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":64,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":43},"100365642","ozone-application-before-fissure-sealants-100365642","NCT04040920","Ozone Application Before Fissure Sealants","The Effect of Ozone Application Before Fissure Sealants: a Split Mouth Randomized Controlled Trial","Inclusion Criteria:\n\n* first or second secondary molars to be sealed\n* possibility to isolate with rubber dam both the teeth involved\n* no clear signs of pigmentations\n* good general health\n\nExclusion Criteria:\n\n* latex allergy\n* epilepsy or other severe neurological pathologies\n* psychiatric disease\n* excessive sensibility to electrical current\n* severe asthma\n* enamel disorders, such as amelogenesis imperfect, white spots, fluorosis or Molar Incisors Hypomineralization","6 Years","16 Years",{"count":54,"type":21},67,"INTERVENTIONAL",[57],"NA","Decay is a multifactorial infective degenerative disease of hard dental tissues, caused by Streptococcus mutans and Lactobacillus forming the bacterial biofilm of teeth surfaces. Decays generally evolve in fissures and pits of secondary molars. Pits and fissure sealants prevent decays if performed in two years from eruption. Ozone has bactericidal effect and remineralizing capacity on enamel.\n\nThe aim of this study is to assess the effectiveness of ozone application before sealants in increasing their duration in time.",[60],"Caries,Dental",[62,63,29],"Ozone","Pits and fissures sealants",{"date":34,"type":35},{"date":66,"type":35},"2019-06-17",{"date":68,"type":21},"2026-12-31",{"name":41,"class":42},{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":16,"minAge":77,"maxAge":18,"enrollmentInfo":78,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":80,"conditions":81,"keywords":84,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":43},"100585127","cardiac-injury-due-to-anthracycline-in-paediatric-oncological-patients-100585127","NCT06898320","Cardiac Injury Due to Anthracycline in Paediatric Oncological Patients","Prediction of Cardiac Injury Due to Anthracycline Chemotherapy in Paediatric Oncological Patients Using Advanced Echocardiography and Circulating Biomarkers.","Inclusion Criteria:\n\n* Paediatric oncological patients 0-18 years\n* Planned start of anthracycline therapy\n* Normal left ventricular systolic function according to International Guidelines before the treatment with AC\n\nExclusion Criteria:\n\n* Previous anthracycline treatment, bone marrow transplantation or chest radiation\n* Pre-anthracycline treatment echocardiographic evidence of:\n* More than mild pericardial effusion\n* More than mild mitral regurgitation\n* Poor echocardiographic acoustic window","0 Years",{"count":79,"type":21},22,"The study investigates the role of echocardiography and of serum biomarkers (NT-proBNP, cardiac Troponin-I) in predicting cardiac injury in a cohort of paediatric oncological patients treated with Anthracycline chemotherapy.",[82,83],"Heart Injuries","Anthracycline",[85,86,87,88],"Cardiac injury","Anthracycline chemotherapy","echocardiography","Circulating biomarkers","2025-05-06",{"date":91,"type":35},"2025-05-09",{"date":93,"type":35},"2023-07-21",{"date":95,"type":21},"2033-07-21",{"name":41,"class":42},{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":104,"enrollmentInfo":105,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":107,"conditions":108,"keywords":110,"overallStatus":115,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":122,"locationsCount":123},"100584893","articular-damage-in-patients-with-juvenile-idiopathic-arthritis-after-transition-to-adult-care-100584893","NCT06895278","Articular Damage in Patients With Juvenile Idiopathic Arthritis After Transition to Adult Care","Evaluation of Articular Damage in Patients With Juvenile Idiopathic Arthritis (JIA) After Transition to Adult Care and Correlation With Disease Characteristics and Treatments.","Inclusion Criteria:\n\n1. Patients aged between 16 to 25 years who received a diagnosis of JIA in pediatric age according to International League of Associations for Rheumatology criteria (2001) and who have begun the process of transition to adult care.\n2. Young adults undergoing healthcare transition process from the the pediatric to adult rheumatology since 2016.\n3. Patients with radiological evidence of joint plates closure.\n4. X-ray images of hands, hips, and knees available\n\nExclusion Criteria:\n\n1. Patients cared at the adult rheumatology clinic who received a diagnosis of arthritis in the adult age.\n2. Patients with other orthopedic conditions or affected by other diseases leading to osteoporosis or skeletal deformities.\n3. Patients affected by other rheumatological conditions who underwent healthcare transition process from the the pediatric to adult rheumatology center.","25 Years",{"count":106,"type":21},100,"Juvenile idiopathic arthritis (JIA) is the most common childhood chronic rheumatic disease, encompassing all forms of arthritis that persist for more than 6 weeks, with onset before age 16, after exclusion of other causes of arthritis. It is a heterogeneous disease, whose complexity is only partially encompassed by the actual classification criteria and it is characterized by prolonged synovial inflammation that can lead to joint destruction.\n\nWhilst the assessment of structural joint damage is part of the routinary evaluation of disease severity and progression in patients with rheumatoid arthritis (RA), to the extent that it is considered a key end-point outcome in treatment efficacy studies, this is not the same for JIA. Some recommendations have been elaborated based on expert opinion, but only recently they have been translated into clinical practice. Such a discrepancy in approaching chronic arthritis has been for many years due to the lack of articular damage radiographic scoring system validated for pediatric age. Actually, joint space narrowing, bone erosions and demineralization, which is typical of adult articular damage, are not the same changes observed in pediatric population where early growth plate closure, epiphyseal deformity and growth asymmetries can be the major signs.\n\nThe transition process from the pediatric to the adult health care team is a critical moment in the clinical history of patients with JIA, often hampered by the absence of specific criteria for the assessment of disease activity, the lack of specific treatment recommendations for JIA adult patients, the poor adolescent-specific training for adult rheumatologists, and the lack of communication between pediatric and adult centers. Adult patients with JIA have their own specific identity and should not be inappropriately re-categorized as having RA, ankylosing spondylitis or another condition once transitioned to the adult rheumatologist.\n\nThe aim of this study is to quantify the articular damage of adult patient with JIA after closure of growth plates. This represent a sort of starting burden carried by the patients who receive transition to the adult rheumatologist care and which should be minimized in order to reduce long-term complications. Furthermore, the study aims to analyze possible correlations between the presence of articular damage, therapies taken in pediatric age, and characteristics of JIA at the onset and during the clinical course of the disease",[109],"Juvenile Chronic Arthritis",[111,112,113,114],"Juvenile idiopathic arthritis","JIA","transition to adult","articular damage","NOT_YET_RECRUITING","2025-03-19",{"date":118,"type":35},"2025-03-26",{"date":120,"type":21},"2025-04-01",{"date":39,"type":21},{"name":41,"class":42},3,{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":131,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":132,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":134,"conditions":135,"keywords":137,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":147},"100541030","defects-of-keratinocytes-function-in-dermatologic-patients-100541030","NCT06324552","Defects of Keratinocytes Function in Dermatologic Patients","Defects of Keratinocytes Function in Dermatologic Patients Carrying Genetic Variants Involved in NOTCH Signaling","Inclusion Criteria:\n\n* diagnosis of HS\n\nExclusion Criteria:\n\n* no informed consent",true,{"count":133,"type":21},50,"NOTCH signaling in the skin exerts a pivotal role in the regulation of normal keratinocytes turnover by mediating the balance between proliferation, differentiation, apoptosis and autophagic flux progression. Two skin diseases are characterized by the presence of gene variants that cause an impairment in NOTCH signaling: hidradenitis suppurativa(HS) and Dowling-Degos disease(DDD). To date, both HS and DDD are orphan diseases still lacking of specific treatments. This project aims at improving the current knowledge on the pathogenesis of HS and DDD, by deepening the understandings on the role played by keratinocytes in these pathologies and also by determining why mutations found in the same pathway cause different diseases. This study aimed to obtain in vitro models, derived directly from patients (from hair follicles) and from keratinocytes (HaCaT) cell cultures, for the study of these skin pathologies and also for the testing of novel innovative therapies such as photobiomodulation therapy.",[136],"Hidradenitis Suppurativa",[136,138],"NOTCH signaling","2024-06-13",{"date":141,"type":35},"2024-06-14",{"date":143,"type":35},"2020-10-12",{"date":145,"type":21},"2024-08-31",{"name":41,"class":42},15,{"id":149,"slug":150,"hasResults":11,"nctId":151,"briefTitle":152,"officialTitle":153,"acronym":4,"eligibilityCriteria":154,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":18,"enrollmentInfo":155,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":157,"conditions":158,"keywords":160,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":163,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":169},"100516663","clinical-laboratory-and-ultrasound-stratification-of-patients-with-juvenile-idiopathic-arthritis-100516663","NCT06007456","Clinical, Laboratory and Ultrasound Stratification of Patients With Juvenile Idiopathic Arthritis","Clinical, Laboratory and Ultrasound Stratification of Patients With Juvenile Idiopathic Arthritis and Outcomes Evaluation During Transition to Adult Care","Inclusion Criteria:\n\n* Subjects under the age of 18 years\n* Arthritis persisting for at least 6 weeks with no known cause\n\nExclusion Criteria:\n\n* No consent from the patients' guardians\n* Patients with Systemic onset Juvenile Idiopathic Arthritis\n* Patients who developed arthritis on a pre-existing inflammatory disorder such as Inflammatory Bowel Disease, and had received previous treatments",{"count":156,"type":21},80,"Juvenile Idiopathic Arthritis (JIA), the most common rheumatologic chronic disease in children, is defined as arthritis persisting for at least 6 weeks with no known cause in a patient under the age of 16. The term JIA is an umbrella that includes very different diseases. The current International League of Associations for Rheumatology (ILAR) classification divides JIA patients into 7 categories based on number of involved joints and time of involvement, presence of systemic symptoms, psoriatic findings and spondyloarthritis. This classification groups together patients with different disease and divides patients with the same disease. In the first case, unifying distinct diseases could lead to undifferentiated therapeutic choices, moving away from the modern concept of therapeutic personalization. In the second case, similarities between paediatric and adult arthritis could not be found. This involves both a loss of collaboration with the adult rheumatologist and the difficulty in accessing possibly effective therapies approved only for adult arthritis.\n\nIn clinical practice, it is increasingly evident that the number of affected joints and the speed of joint involvement are not useful criteria for defining the type and severity of disease. Joint counts lead to underestimate the importance of joint distribution in the identification of distinct forms of arthritis. A recent study found that patterns of joint involvement represent prognostic features, so grouping patients by joint pattern and degree of localization may help clinicians tailor treatments based on predicted disease trajectories. Another important point to differentiate some forms of arthritis is the presence of enthesitis and tenosynovitis. Sometimes tendon inflammation can be not clinically evident, so ultrasound evaluation is useful to detect it. Musculoskeletal ultrasound (MSUS) has been used worldwide by adult rheumatologist, but it is beginning a useful tool also in patients with JIA. Recent studies underline the important role of MSUS findings to assess disease activity and assist disease classification. In recent years, the need has emerged to replace the ILAR criteria with a new nomenclature based on the disease biology. This approach could help clinicians to choose a personalized therapeutic strategy for patients with arthritis.",[159],"Juvenile Idiopathic Arthritis",[112,161,162],"classification","transition of care",{"date":141,"type":35},{"date":165,"type":35},"2022-01-10",{"date":167,"type":21},"2026-03-15",{"name":41,"class":42},2,{"id":171,"slug":172,"hasResults":11,"nctId":173,"briefTitle":174,"officialTitle":175,"acronym":4,"eligibilityCriteria":176,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":18,"enrollmentInfo":177,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":179,"conditions":180,"keywords":182,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":186,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":190,"locationsCount":191},"100501637","mercaptopurine-therapeutic-drug-monitoring-to-optimize-the-maintenance-phase-of-childhood-all-100501637","NCT05811845","Mercaptopurine Therapeutic Drug Monitoring to Optimize the Maintenance Phase of Childhood ALL","Optimizing the Maintenance Phase of Childhood Acute Lymphoblastic Leukemia AIEOP Protocol Through Mercaptopurine Therapeutic Drug Monitoring and Proactive Strategies for Adherence","Inclusion Criteria:\n\n* Newly diagnosed ALL\n* Age \\\u003C18 years at diagnosis\n* Written informed consent given\n\nExclusion Criteria:\n\n\\-",{"count":178,"type":21},250,"Acute lymphoblastic leukemia (ALL) is the most common hematological malignancy in children (\\\u003C18 years). The success of pediatric ALL therapy is remarkable but important challenges still need to be faced, including cure rates in specific patients' subsets (e.g.: adolescents and relapsed patients), and short- and long-term chemotherapy-related toxicities. The therapeutic scheme of the Associazione Italiana Emato-oncologia pediatrica (AIEOP) ALL protocols consists in a more intensive and toxic earlier phase (to induce and consolidate remission, about 6 months), followed by a prolonged period of immunosuppression (achieved by self- or parent-administered daily mercaptopurine (MP) and weekly methotrexate (MTX) per os). It is now well established that the length of the maintenance phase (up to 24 months after diagnosis) is as necessary as the early remission induction for sustained event-free survival (EFS). Both MP and MTX can lead to potentially serious complications, including potentially life-threatening myelosuppression and infections. To exert its therapeutic effect, MP requires an intracellular enzymatic conversion into active thionucleotides (TGN) and is thus susceptible to intra- and inter-individual variations in efficacy and toxicity. Patients carrying variants in TPMT and NUTD15 genes are at risk of adverse effects when treated with standard MP doses: these patients are identifiable by pre-emptive genotyping. Recent studies demonstrated that an adequate and constant MP exposure during maintenance is associated with higher therapeutic success. Prescribed MP doses are often changed by physicians to target a white blood cell count (WBC) range of 2.0-3.0 × 109\u002FL during maintenance. In the AIEOP ALL 2009 protocol, patients with lower mean TGN exposure during maintenance showed a trend towards a higher risk of relapse compared to others. Similarly, patients with higher intra-individual variability in TGN over time showed a trend towards a worse outcome. Daily compliance to prescribed MP over time is a challenging issue for patients and may result in less effective therapy. The high intra-individual variability in exposure due to the frequent dose adjustments and the potential lack of patients' adherence to oral MP therapy over time might contribute to the risk of relapse. The aim of this study is to assess through therapeutic drug monitoring of MP if patients' exposure during maintenance is adequate and constant.",[181],"Acute Lymphoblastic Leukemia",[183,184,185],"Acute lymphoblastic leukemia","Compliance","Mercaptopurine",{"date":141,"type":35},{"date":188,"type":35},"2022-07-30",{"date":68,"type":21},{"name":41,"class":42},4,{"id":193,"slug":194,"hasResults":11,"nctId":195,"briefTitle":196,"officialTitle":197,"acronym":4,"eligibilityCriteria":198,"healthyVolunteers":11,"sex":16,"minAge":199,"maxAge":200,"enrollmentInfo":201,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":203,"conditions":204,"keywords":207,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":209,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":214,"locationsCount":43},"100503079","gut-oral-axis-microbiome-in-autism-spectrum-disorders-100503079","NCT05830591","Gut-oral Axis Microbiome in Autism Spectrum Disorders","The Role of Gut-oral Axis Microbiome in Autism Spectrum Disorders","INCLUSION CRITERIA\n\nCase group\n\n1. Caucasian\n2. Diagnosed with ASD or with a newly formulated diagnosis of ASD\n3. Aged between 1 and 17 years\n\nControl group\n\n1. Caucasian\n2. Healthy at the time of sampling\n3. No ASD or other neurological disorders\n4. Aged between 1 and 17 years\n\nEXCLUSION CRITERIA\n\n1. Antibiotic use in the month before sample collection\n2. Probiotic use in the month before sample collection\n3. Other neurological diseases\n4. Chronic inflammatory diseases\n5. The use of constipation drugs during the three days before sample collection","1 Year","17 Years",{"count":202,"type":21},86,"Autism Spectrum Disorder (ASD) is a neurodevelopment disorder characterized by impairment in social interaction, communication, and behavior, as well as sensory challenges. In addition, secondary symptoms can appear, such as gastrointestinal disorders. Gut microbiota has an important role in the harvest of nutrients and energy from our diet. It influences a wide range of metabolic, developmental, and physiological processes such as the maintenance of the gut epithelial layer, immune system development, protection against pathogens, detoxification and xenobiotics degradation. The ecosystem of a healthy human gastrointestinal (GI) tract is mainly populated by Firmicutes and Bacteroidetes phyla, to a lesser extent by Actinobacteria and Proteobacteria, in this case the microbiota is in an eubiosis condition. Whether a disturbance of the microbial ecosystem occurs, gut microbiota is in a dysbiosis condition and it could lead different metabolic disorders. The two-way communication between gut microbiota and central nervous system (CNS) affects stress response, pain perception, neurochemistry and several disorders. The gut microbiota in ASD patients revealed some peculiarities such as the high percentage of Propionibacter and Clostridium, well known for their production of pro inflammatory metabolites, or an increment of Sutterella spp. and Ruminococcus torques, which are negatively associated with the health of the gut. Recent studies suggest that also the oral microbiota may be involved in ASD symptoms assuming the existence of a \"microbiota-oral-brain axis\". ASD patients are often suffering of several oral cavity disorders like caries, gingivitis and periodontitis, probably due to the poor oral hygiene. These disorders are linked to a dysbiosis of the oral microbiota: the characterization of the ASD subjects oral microbiota showed a lower biodiversity of bacteria species and different levels of specific bacteria, comparing to the controls. Several studies suggest that some bacteria species invade the blood-brain barriers as well as their metabolites, triggering inflammatory response and an alteration of the metabolic activity in the CNS. It has been demonstrated that ASD patients have a high level of pro-inflammatory cytokines and chemokines in the cerebrospinal fluid and an upregulation of the microglia. The oral microbiota could also affect the lower GI tract and have a significant role within the ASD-associated GI disorders and CNS inflammation",[205,206],"Autism Spectrum Disorder","Microbiota",[205,206,208],"Inflammatory cytokines",{"date":141,"type":35},{"date":211,"type":35},"2021-05-20",{"date":213,"type":21},"2024-12-31",{"name":41,"class":42},{"id":216,"slug":217,"hasResults":11,"nctId":218,"briefTitle":219,"officialTitle":220,"acronym":4,"eligibilityCriteria":221,"healthyVolunteers":11,"sex":16,"minAge":51,"maxAge":17,"enrollmentInfo":222,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":223,"conditions":224,"keywords":226,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":229,"startDateStruct":230,"completionDateStruct":232,"leadSponsor":234,"locationsCount":43},"100501218","use-of-a-glass-ionomer-sealant-in-molar-incisor-hypomineralization-100501218","NCT05806398","Use of a Glass Ionomer Sealant in Molar Incisor Hypomineralization","Use of a Glass Ionomer Sealant in First Permanent Molars Affected by Molar Incisor Hypomineralization","Inclusion Criteria:\n\n1. FPMs of children aged between 6 and 10 years;\n2. Erupted MIH affected FPMs presenting lesions on the occlusal surface;\n3. Good general health conditions;\n4. Sufficient cooperative behaviour;\n5. Signature of the informed consent to the study by patients' parents or by their legal guardians\n\nExclusion Criteria:\n\n1. FPMs presenting fluorosis, amelogenesis imperfecta, white spots, or other enamel defects that are in differential diagnosis with MIH;\n2. FPMs presenting the occlusal surface already sealed or restored;\n3. FPMs presenting occlusal cavitated caries (ICDAS Pit and Fissures ≥ 3)\n4. FPMs presenting severe PEB involving the dentin;\n5. Children with orthodontic devices hiding FPMs.",{"count":147,"type":21},"Molar Incisor Hypomineralization (MIH) is a worldwide widespread qualitative developmental defect of the dental enamel with a multifactorial aetiology defined in 2001 as an \"hypomineralization of systemic origin affecting one or more permanent molars, usually first permanent molars (FPMs), with or without the involvement of one or more affected permanent incisors\". Clinically MIH lesions appear as demarcated opacities with a creamy-white to yellow-brown colour depending on the severity of the defect that is classified as mild or severe (levels of severity) according to the European Academy of Pediatric Dentistry (EAPD) severity criteria. The distribution of the lesions is asymmetrical and their severity varies from a patient to another and also within the mouth of the same patient. Due to its porous structure with an altered prism organization and an increased content of proteins, the hypomineralized enamel has reduced mechanical properties and a lower refractive index if compared to the sound enamel. MIH is associated to a large number of objective and subjective problems as an altered aesthetics, an increased risk of plaque accumulation, caries, post-eruptive breakdown (PEB), reduced retention rates of adhesive materials, hypersensitivity and difficulty in anesthetizing the affected teeth making its management a challenging condition. Among preventive measures, pit-and-fissure sealants are a valuable and effective treatment to prevent occlusal caries in FPMs when they are still intact. However, since their efficacy is closely related to the sealant retention, they have to be monitored over time. When the molar to be sealed is fully erupted and isolation is adequate, resin-based sealants are indicated while if the moisture control is inadequate and\u002For the tooth is hypersensitive and patient is not sufficiently cooperative, low-viscous glass ionomer cements (GICs) are suggested as a temporary measure until the eruption is completed and both symptoms and cooperation are improved. To date, the scientific knowledge regarding the use of different type of sealants in MIH affected molars is insufficient to draw exhaustive conclusions and further studies are needed to deepen the knowledge on this topic. The aim of this study is to assess, by clinical examination, the survival rate of a glass ionomer sealant in MIH affected FPMs at 12 months of follow-up.",[225],"Molar Incisor Hypomineralization",[227,228,29],"Molar Incisor Hypomineralization (MIH) Molars","Glass ionomer sealant",{"date":141,"type":35},{"date":231,"type":35},"2022-06-01",{"date":233,"type":21},"2026-01-15",{"name":41,"class":42},{"id":236,"slug":237,"hasResults":11,"nctId":238,"briefTitle":239,"officialTitle":240,"acronym":4,"eligibilityCriteria":241,"healthyVolunteers":11,"sex":242,"minAge":4,"maxAge":200,"enrollmentInfo":243,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":245,"conditions":246,"keywords":248,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":253,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":259},"100541031","role-of-preoperative-d-dimer-levels-in-the-diagnosis-of-adnexal-torsion-100541031","NCT06324565","Role of Preoperative D-dimer Levels in the Diagnosis of Adnexal Torsion","The Role of Preoperative D-dimer Levels in the Diagnosis of Adnexal Torsion in Children and Adolescents","Inclusion Criteria:\n\n* Female patients\n* Age \\\u003C 18 years\n* presenting with lower quadrants abdominal pain\n* Imaging suspicious for adnexal torsion\n\nExclusion Criteria:\n\n* Female patients aged \\> 18 years\n* Previous surgery for adnexal pathologies\n* Clinical symptoms and imaging suggesting a different surgical pathology (i.e., appendicitis, gastroenteritis)","FEMALE",{"count":244,"type":21},130,"Adnexal torsion is the fifth most common gynecologic emergency. Thirty percent of all cases of adnexal torsion occur in females younger than 20 years. Approximately 5 of 100,000 females aged 1-20 years are affected, with girls older than 10 years at increased risk because of hormonal influences and gonadal growth that result in an increased frequency of physiologic and pathologic masses. The most common clinical symptom of torsion is sudden-onset abdominal pain that is intermittent, non-radiating, and associated with nausea and vomiting in 62% and 67% of cases respectively. Moreover, abdominal tenderness is a clinical sign which is reported in up to 88% of patients with adnexal torsion. None of the following tests are useful in the diagnosis of adnexal torsion: leukocytosis, pyuria, C-reactive protein, and erythrocyte sedimentation rate. Actually, transabdominal ultrasonography is the imaging modality of choice with a sensitivity of 92% and specificity of 96% in detecting adnexal torsion. A second-line imaging tool in the diagnosis of adnexal torsion is magnetic resonance, which may require a sedation in selected cases. Consequently, there are no clinical or imaging criteria sufficient to confirm the preoperative diagnosis of adnexal torsion to date. Therefore, patients with a clinical suspicion for adnexal torsion should undergo emergent diagnostic laparoscopy.",[247],"Adnexal Torsion",[249,250,251],"D-dimer","Diagnosis","Adnexal torsion","2024-06-12",{"date":139,"type":35},{"date":255,"type":35},"2022-01-13",{"date":257,"type":21},"2024-12-13",{"name":41,"class":42},9,{"id":261,"slug":262,"hasResults":11,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":4,"eligibilityCriteria":266,"healthyVolunteers":11,"sex":16,"minAge":267,"maxAge":200,"enrollmentInfo":268,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":270,"conditions":271,"keywords":273,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":277,"startDateStruct":278,"completionDateStruct":280,"leadSponsor":282,"locationsCount":191},"100541029","validation-of-a-new-innovative-method-for-specific-marker-detection-in-celiac-disease-100541029","NCT06324539","Validation of a New Innovative Method for Specific Marker Detection in Celiac Disease","Validation of a New Innovative Method for the Easy Detection of a Disease Specific Marker to Make Prompt Diagnosis of Celiac Disease in All the Clinical Manifestations: a Paediatric Multicenter Study.","Inclusion Criteria:\n\n\\- Patients undergoing an elective esophagogastroduodenoscopy (EGD) for suspected Celiac Disease (CD), eosinophilic esophagitis, autoimmune enteropathy, inflammatory bowel disease, gastritis, gastric or duodenal ulcer, gastroesophageal reflux disease.\n\nExclusion Criteria:\n\n* Bleeding disorders\n* Patients fulfilling the new European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) guidelines for diagnosing CD (version 2020) for a serology-based CD diagnosis\n* Subjects in whom intestinal biopsies are not indicated as part of the diagnostic process","2 Years",{"count":269,"type":21},332,"Celiac disease (CD) is a common auto-immune disorder induced by gluten ingestion in genetically susceptible individuals (HLA-DQ2\u002FDQ8). Gluten induces small-bowel villous atrophy and a specific immune response characterized by the production of CD-autoantibodies against transglutaminase 2 (anti-TG2) and endomysium (EMA). In symptomatic patients with positive-serum antibodies and villous atrophy, the diagnosis of CD is clearcut.\n\nHowever, 10-30% of patients evaluated for suspected CD show only mild histopathologic changes and fluctuating serologic markers, a condition identified as potential CD. In such cases the diagnosis may remain uncertain.\n\nCD-autoantibodies are produced by intestinal B-cells in the early phases of the disease, before their appearance in the serum and when the duodenal mucosa is still normal. Intestinal CD-antibodies (I-CD-abs) are a marker of CD, have a high sensitivity and specificity for CD and identify those patients with potential CD who are at risk of progression to villous atrophy. I-CD-abs can be detected by double immunofluorescence staining on frozen duodenal sections or by using an endomysial antibody assay in the culture medium of duodenal biopsies (EMAbiopsy).\n\nThe diagnostic accuracy of these techniques is comparable as they both have high sensitivity and specificity. However, their implementation in clinical practice is limited because they require both experienced operators and well-equipped laboratories. There is an unmet need: the development of a new simple and effective diagnostic tool that any gastroenterology unit can use in routine diagnostics to ensure a prompt diagnosis in suspected CD patients, who may benefit from a therapy based on gluten-free diet, and to reduce both unnecessary medical investigations and diagnostic delays.\n\nIn order to simplify and shorten times for the detection of these intestinal antibodies, the study aims to substitute the EMAbiopsy assay with a supernatant obtained quickly after mechanical lysis of fresh intestinal biopsy specimen. The obtained samples will be tested with rapid (about 15 minutes) immune-chromatographic anti-TG2 assay (Rapid Intestinal anti-TG2 Assay).",[272],"Celiac Disease in Children",[274,275,276],"Celiac disease","Intestinal antibodies","Rapid test",{"date":139,"type":35},{"date":279,"type":35},"2023-10-04",{"date":281,"type":21},"2025-05",{"name":41,"class":42},{"id":284,"slug":285,"hasResults":11,"nctId":286,"briefTitle":287,"officialTitle":288,"acronym":4,"eligibilityCriteria":289,"healthyVolunteers":11,"sex":16,"minAge":290,"maxAge":291,"enrollmentInfo":292,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":294,"conditions":295,"keywords":297,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":301,"startDateStruct":302,"completionDateStruct":304,"leadSponsor":305,"locationsCount":306},"100540488","hearing-impairment-in-children-pupillometry-and-hearing-thresholds-assessment-100540488","NCT06317493","Hearing Impairment in Children: Pupillometry and Hearing Thresholds Assessment","Using Pupillometry to Assess Hearing Thresholds in Young Children With Hearing Impairment","Inclusion Criteria:\n\n* Normal or corrected-to-normal vision\n* No history of relevant neurological or psychiatric concomitant disease\n* Age: 4-36 months\n* At least 1 months of more after initial fitting of the CI or hearing aid (only for aided subjects)\n\nExclusion Criteria:\n\n* Developmental disorders\n* Unwillingness of the subject to participate further","4 Months","36 Months",{"count":293,"type":21},180,"The results of the previous study on auditory effort in young children with cochlear implants show that pupils respond to the presence or the absence of the perceived stimuli. The investigators hypothesize that the perceived sounds will elicit increased pupil dilation compared to the non-perceived sounds and that the hearing threshold as measured with pure tone audiometry will correlate to the results in pupillometry test. The investigators hypothesize that the effect will be visible in all testing groups albeit the relative increase of pupil size with age. Hypothesis confirmed, the investigators will develop a standardised procedure for the auditory signal detection using pupillometry. Such a procedure could represent an important bridge between automatic and behavioral hearing tests. With a more precise test of auditory threshold of young children, post-operative monitoring and fitting of cochlear implants or hearing aids, and rehabilitation procedures, could be considerably more targeted and consequentially more efficient.",[296],"Hearing Impaired Children",[298,299,300],"Pupillometry","Hearing threshold","Pediatric cochlear implants",{"date":139,"type":35},{"date":303,"type":35},"2021-01-03",{"date":213,"type":21},{"name":41,"class":42},5,{"id":308,"slug":309,"hasResults":11,"nctId":310,"briefTitle":311,"officialTitle":312,"acronym":4,"eligibilityCriteria":313,"healthyVolunteers":11,"sex":16,"minAge":314,"maxAge":315,"enrollmentInfo":316,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":318,"conditions":319,"keywords":321,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":325,"startDateStruct":326,"completionDateStruct":328,"leadSponsor":329,"locationsCount":169},"100539849","empowerment-and-burnout-of-midwives-at-the-end-of-health-emergency-from-covid-19-100539849","NCT06309186","Empowerment and Burnout of Midwives at the End of Health Emergency From COVID-19","Empowerment and Burnout of Midwives at the End of Health Emergency From SARS-CoV2: a Cross-sectional Observational Study in Friuli-Venezia Giulia Region","Inclusion Criteria:\n\n1. Midwives registered in the orders of Friuli Venezia Giulia (FVG) region\n2. Midwives in practice for at least one year\n3. Midwives practicing in FVG region\n\nExclusion Criteria:\n\n1. Consent not granted\n2. Midwives in retirement for more than a year","21 Years","65 Years",{"count":317,"type":21},64,"As the fifth wave of COVID-19 comes to an end and the pandemic's countermeasures expire, there is a need to assess the impact of the pandemic on health care providers, especially midwives, as the professionals deputed to promote and protect women's holistic health, in all phases, physiological and otherwise, of the life cycle. The midwife considers the person as a whole, in which the mind-body-culture components interact profoundly. Prevention and containment measures have impacted on midwifery clinical and nursing practices with the mandatory continuous use of personal protective equipments (PPE) and social distancing to protect the patient and the practitioner, effectively hindering the intimacy of the woman-midwife relationship. The impact assessment focuses on two dimensions: learning, investigated as perceived empowerment, and perceived malaise, investigated as burnout. Empowerment has a positive connotation, which can offset burnout, a syndrome that affects the physical, psychological and emotional health of midwives and can have significant negative implications on midwife turnover, patient safety and outcomes, and the efficiency of healthcare organisations.",[320],"COVID-19",[322,323,324],"Midwifery","Empowerment","Burnout",{"date":139,"type":35},{"date":327,"type":35},"2023-01-09",{"date":213,"type":21},{"name":41,"class":42},{"id":331,"slug":332,"hasResults":11,"nctId":333,"briefTitle":334,"officialTitle":335,"acronym":336,"eligibilityCriteria":337,"healthyVolunteers":11,"sex":16,"minAge":267,"maxAge":17,"enrollmentInfo":338,"targetDuration":4,"studyType":55,"phases":339,"briefSummary":340,"conditions":341,"keywords":343,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":347,"startDateStruct":348,"completionDateStruct":350,"leadSponsor":351,"locationsCount":43},"100474652","effectiveness-of-a-mhealth-application-as-a-family-supportive-tool-in-pediatric-otolaryngology-perioperative-process-100474652","NCT05460689","Effectiveness of a mHealth Application as a Family Supportive Tool in Pediatric Otolaryngology Perioperative Process","A Randomized Controlled Trial to Evaluate the Effectiveness of a mHealth Application as a Family Educational and Supportive Tool in Children Tonsillectomy and\u002For Adenoidectomy Perioperative Process Compared to Standard Care","TONAPP","Inclusion Criteria:\n\n* Caregivers of children aged 2-10 scheduled for tonsillectomy and\u002For adenoidectomy with or without tympanostomy tubes insertion;\n* Caregivers who are capable of oral and written communication without any impairment;\n* Caregivers who guarantee access to a smartphone and internet connection.\n\nExclusion Criteria:\n\n* Caregivers with cognitive deficits;\n* Caregivers of children with cognitive impairment\n* Caregivers with visual impairment;\n* Caregivers of children affected by chronic pain;\n* Caregivers of children who had another surgery operation in the previous month.\n* Caregivers who never used at least one smart phone application",{"count":293,"type":21},[57],"Tonsillectomy and\u002For adenoidectomy are common surgeries in children. Authors report how distressed children and their families are by perioperative processes. Fear of the unknown can put a strain on the preoperative period, while pain and other possible complications such as fever, vomiting, restricted oral feeding or bleeding can create difficulties in postoperative home management. Parental anxiety has been found to worsen the perception of pain, perioperative discomfort and recovery of operated children. Providing children and families with preparation for hospitalisation, surgery and postoperative home management has been shown to improve perioperative outcomes. However, not all individuals can understand and benefit from the information provided by healthcare professionals: higher levels of anxiety in the perioperative process have been associated with individuals with low health literacy. Furthermore, unmet information needs may lead parents to expose themselves to health-related misinformation through autonomous investigations on the Web and common social media resources. Patient- and family-centred education and support is a complex and time-consuming care practice, while some surgeries such as tonsillectomy are characterised by short hospitalisations that limit the amount of time health professionals can devote to this programme. Health systems have been testing different types of formats, content and ways of delivering health information\u002Feducation in order to meet the requirements of clients, time availability and effectiveness. MHealth apps in particular are an essential element of e-health and consist of medical information that is available via mobile phones or other wireless devices and can be used by patients or health professionals. Their use is growing and evolving into a variety of functionalities and positive outcomes related to improving the wellbeing of individuals, including diagnostics and clinical decision-making; interventions on healthy behaviours and lifestyles; patient disease management and self-care. Findings from literature highlight the need for further randomised controlled trials to confirm positive results.",[342],"TONSILLECTOMY",[344,345,346],"MHealth","Tonsillectomy","Education",{"date":139,"type":35},{"date":349,"type":35},"2022-12-16",{"date":213,"type":21},{"name":41,"class":42},{"id":353,"slug":354,"hasResults":11,"nctId":355,"briefTitle":356,"officialTitle":357,"acronym":4,"eligibilityCriteria":358,"healthyVolunteers":11,"sex":16,"minAge":359,"maxAge":360,"enrollmentInfo":361,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":363,"conditions":364,"keywords":366,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":370,"lastUpdatePostDateStruct":371,"startDateStruct":372,"completionDateStruct":374,"leadSponsor":376,"locationsCount":123},"100501822","ultrasonography-in-children-with-first-febrile-urinary-tract-infection-100501822","NCT05814250","Ultrasonography in Children With First Febrile Urinary Tract Infection","Is Ultrasonography Mandatory in All Children at Their First Febrile Urinary Tract Infection?","Inclusion Criteria:\n\n\\- Patient with first episode of fUTI that subsequently do KUS.\n\nExclusion Criteria:\n\n* patients with previous episodes of UTIs\n* patients on antibiotic prophylaxis\n* previous finding of malformative uropathies or cystic disease\n* prenatal diagnosis of CAKUT with the following parameters: Presence of oligohydramnios, alterations in renal number, location and echo structure, bladder alteration, dilations of the renal pelvis and ureters","2 Months","3 Years",{"count":362,"type":21},20,"In recent decades, different tests have been recommended by guidelines in the management of first febrile urinary tract infection (fUTI) in children, including kidney ultrasound (KUS), cystography (VCUG) and renal scintigraphy in order to exclude underlying kidney anomalies. The majority of guidelines, continue to recommend a routine KUS for all children at the first fUTI. On the other hand, as this approach is not based on robust evidence, other guidelines suggest that KUS should only be performed on selected patients according to specific risks. Despite being a non-invasive and radiation-free method, KUS tests negative in 83% of cases of fUTIs and possesses low specificity for low grade vesico-ureteral reflux (VUR). Since VUR is the most commonly associated renal malformation with UTI, it is evident that all the guidelines focus on the research of VUR, especially in times when antenatal ultrasound allows to screen for major congenital anomalies of kidney and urinary tract (CAKUT). However, VUR-associated nephropathy appears to be related to primary dysplastic damage rather than to be secondary to the reflux itself and not preventable from antibiotic prophylaxis in terms of recurrence and of kidney scar. To reduce the number of normal VCUGs performed, recent evidence regarding VUR suggests that the presence of pathogens different from E. coli and UTI recurrence may help to identify children who necessitate further investigations. A preliminary retrospective monocentric study enrolling all patients aged 2 to 36 months diagnosed with first fUTI who subsequently underwent US evaluation of the kidneys and urinary tract, found that atypical germ and recurrence of UTI exhibits a 85% sensitivity to detect pathological ultrasound. The aim of this multicentric study is to prospectively evaluate the diagnostic accuracy of the presence of atypical germ combined with the recurrence of UTI in predicting the positivity of KUS in children aged 2 months to 3 years old with first episode of fUTI",[365],"Urinary Tract Infections",[367,368,369],"Urinary tract infection","Kidney ultrasound","Congenital anomalies of the kidney and urinary tract","2024-06-11",{"date":252,"type":35},{"date":373,"type":35},"2022-06-13",{"date":375,"type":21},"2028-03-31",{"name":41,"class":42},{"id":378,"slug":379,"hasResults":11,"nctId":380,"briefTitle":381,"officialTitle":382,"acronym":4,"eligibilityCriteria":383,"healthyVolunteers":11,"sex":242,"minAge":18,"maxAge":4,"enrollmentInfo":384,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":386,"conditions":387,"keywords":389,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":393,"lastUpdatePostDateStruct":394,"startDateStruct":396,"completionDateStruct":398,"leadSponsor":400,"locationsCount":43},"100540486","role-of-anti-c1q-autoantibodies-in-pregnancy-100540486","NCT06317467","Role of Anti-C1q Autoantibodies in Pregnancy","Characterization of the Physiological and the Pathological Role of Anti-C1q Autoantibodies in Pregnancy: a Potential Treatment for Pre-eclampsia to Prevent Fetal Intrauterine Growth Restriction?","Inclusion Criteria Group 1. Women occurring physiological pregnancies that sign the consent to participate in the study and agree to spontaneously return to the maternal hospital 40 days after delivery.\n\nGroup 2. Patients diagnosed for PE (hypertension arisen suddenly after the 20th week of pregnancy with associated proteinuria, greater than or equal to 300 mg\u002F24 hours often corresponding to 30 mg\u002FdL (1+) on a single sample).\n\nGroup 3. Women affected by SLE, APS, or autoimmune thyroiditis attending the medically assisted procreation department or the Department of Rheumatology, Division of Internal Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia\n\nExclusion criteria\n\n1. Women aged under 18 years\n2. Viral or bacterial blood transmitted infections.\n3. Patients whose informed consent cannot be obtained.",{"count":385,"type":21},54,"Preeclampsia (PE) is a very frequent obstetric complication. C1q, the first recognition molecule of the classical pathway of complement system (C), represents a double-edged molecule in determining pregnancy outcomes. In animal models, C1q deficiency caused the development of a dysfunctional placenta and PE-like symptoms. Conversely, lower levels of C components were detected in the sera of patients with PE due to C consumption and increased deposition of activated C components in the placenta, as well as to the binding to placental apoptotic bodies, syncytiotrophoblast microvesicles (STBM) and debris which are increased in the circulation of patients with PE.\n\nC1q is a hexameric glycoprotein of 460kDa composed by six copies of three polypeptide chains A, B and C, each made by a C-terminal globular head (gC1q) and a N-terminal collagen-like region (CLR). This molecule can be the target of an antibody response. Autoantibodies targeting C1q were first recognized in the serum of Systemic Lupus Erythematosus (SLE) patients. The presence of anti-C1q autoantibodies was also detected in patient affected by autoimmune disease (ie, kidney disorders, vasculitis, thyroiditis). Almost all of these autoimmune disorders are associated with an increased risk of developing PE during pregnancy.\n\nAnti-C1q detection mainly concerns the prediction of the onset of lupus nephritis (LN) in SLE patients. Although anti-C1q autoantibodies do not deplete circulating C1q, their presence in maternal circulation and in placenta may trigger improper C activation and impair C1q activity. In pregnancies complicated by autoimmune affection such as SLE, autoimmune thyroid disorders and Antiphospholipid syndrome (APS) the prevalence of anti-C1q appeared to be higher than in control pregnancies and associated with miscarriage. High levels of anti-C1q have been found in a group of Japanese patients suffering recurrent pregnancy loss (RPL). In a group of anti-C1q positive healthy pregnancies and LN patients was assessed whether C1q autoantigenic behaviour could vary among individuals with or without correlated manifestation. Sera from healthy pregnancies and LN patients were screened for the presence of autoantibodies against the CLR fragment and\u002For the gC1q: antibodies against gC1q were found in both groups, whereas anti-CLR were only detected in the LN one, suggesting that only the latter may have a pathogenic role. Despite this, the biological functions of anti-C1q remain far from clear",[388],"Pre-Eclampsia",[390,391,392],"Anti-C1q autoantibodies","Intra Uterine Growth Restriction (IUGR)","Pre-eclampsia","2024-03-12",{"date":395,"type":35},"2024-03-19",{"date":397,"type":35},"2023-09-13",{"date":399,"type":21},"2026-12",{"name":41,"class":42},""]