[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"IRCCS Eugenio Medea\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":680},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,33,0,25,[9,49,79,109,134,159,182,215,243,267,290,323,347,380,410,443,473,498,515,535,568,594,617,637,659],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100563937","clinical-improvement-due-to-the-home-use-of-agilik-in-children-with-cerebral-palsy-100563937",false,"NCT06622655","Clinical Improvement Due to the Home Use of Agilik in Children With Cerebral Palsy","Agilik@Home: Demonstrate the Clinical Improvement Due to the Home Use of Agilik in Children With Cerebral Palsy","Agilik@home","Inclusion Criteria:\n\n* Diagnosis of CP and a crouch gait\n* Provision of signed and dated informed consent form.\n* Stated willingness to comply with all study procedures and availability for the duration of the study, or alternatively, ability to do so based on parent report and physician observation during history and physical examination.\n* Body weight between 20 and 125 Kg\n* Knee flexion retraction assessed in supine position by less than 10°. Hamstring contracture as assessed by straight leg raising test does not limit ability to participate in the study.\n* Subjects must not have had a tibio-tarsal arthrodesis. In addition, they must have at least 5° of passive dorsi-flexion of the ankle.\n* Able to walk at least 3 m without stopping, with or without a walking aid.\n* Able to understand and follow simple directions based on parent report and physician observation during historical and physical examination.\n* GMFCS level I, II and III\n* MAS score ≤ 2\n\nExclusion Criteria:\n\n* Any severe neurological, musculoskeletal and\u002For cardiorespiratory involvement preventing the ability to walk;\n* A history of uncontrolled seizure in the past year\n* Severe spasticity\n* Hip and\u002For knee flexion contracture of more than 20°","ALL","5 Years","17 Years",{"count":22,"type":23},40,"ESTIMATED","INTERVENTIONAL",[26],"NA","The goal of this clinical trial is to learn if a two month training with the Agilik powered orthosis improves the knee extension or the endurance in pediatric patients with Cerebral palsy and a crouch gait. It will also learn about the safety of Agilik. The main questions it aims to answer are:\n\nDoes the Agilik powered orthosis increase the value of the knee extension during walking? What medical problems do participants have when using the Agilik powered orthosis? Researchers will compare a group of patients using the Agilik powered exoskeleton with a group of patients treated with standard therapy.\n\nParticipants will:\n\nUse Agilik at home or perform standard therapy for 2 months Visit the clinic at the beginning of the study, after 3 months and after 1 additional month.",[29],"Cerebral Palsy (CP)",[31,32,33,34,35],"exoskeleton device","powered orthosis","cerebral palsy","crouch gait","home use","RECRUITING","2026-06-24",{"date":39,"type":40},"2026-06-26","ACTUAL",{"date":42,"type":40},"2024-10-29",{"date":44,"type":23},"2026-11",{"name":46,"class":47},"IRCCS Eugenio Medea","OTHER",6,{"id":50,"slug":51,"hasResults":12,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":57,"targetDuration":4,"studyType":24,"phases":59,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},"100644424","ai-based-model-for-rehabilitation-engagement-and-motor-performance-evaluation-in-pediatric-patients-a-pilot-study-100644424","NCT07664033","AI-based Model for Rehabilitation Engagement and Motor Performance Evaluation in Pediatric Patients: A Pilot Study","AI-based Model for Rehabilitation Engagement and Motor Performance Evaluation in Pediatric Patients","AI-REMAP","Inclusion Criteria:\n\n* Subjects aged between 5 and 17 years with neuromotor impairments who are undergoing rehabilitation therapy using the Lokomat and GRAIL devices, according to the existing clinical plan.\n\nExclusion Criteria:\n\n* Uncooperative subjects.",{"count":58,"type":23},15,[26],"What is the purpose of this study? This study aims to evaluate the usability and feasibility of an artificial intelligence-based model designed to monitor in real-time the engagement and motor performance of pediatric patients during technology-assisted rehabilitation.\n\nWho can take part? 15 participants between 5 and 17 years old with neuromotor impairments will take part, along with at least 5 of their referring physiotherapists.\n\nWhat will happen in the study? Each pediatric patient will take part in a single, 1-hour rehabilitation session using either the Lokomat or GRAIL system, according to their standard clinical prescription. During the session, the physiotherapist will have access to a display showing real-time data from the AI model, including the patient's heart rate, engagement level, pleasantness, activation, and motor performance. At the end of the session, the physiotherapist will complete a System Usability Scale (SUS) questionnaire and provide direct feedback on how to improve the model.\n\nWhy is this study important? Assessing the usability of this real-time monitoring tool is a necessary step to understand if it is practical for clinical use. Providing therapists with objective, real-time insights into a child's psychological and physical state can ultimately help tailor therapy to the specific needs of each patient, improving the overall rehabilitation experience.",[62],"Neuromotor Impairments",[64,65,62,66,67,68],"Engagement","Pediatric Rehabilitation","Gait","Heart Rate Variability","Electrodermal Activity","NOT_YET_RECRUITING","2026-06-17",{"date":72,"type":40},"2026-06-23",{"date":74,"type":23},"2026-06-15",{"date":76,"type":23},"2026-09-30",{"name":46,"class":47},1,{"id":80,"slug":81,"hasResults":12,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":12,"sex":18,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":24,"phases":91,"briefSummary":92,"conditions":93,"keywords":95,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":78},"100636248","i-tops-with-patients-with-genetic-syndrome-syn-tops-100636248","NCT07563218","I-TOPS With Patients With Genetic Syndrome SYN-TOPS","SYN-TOPS: A Multicenter Randomized Clinical Trial on the Use of the I-TOPS Intervention to Improve Adaptive Skills in Adolescents and Young Adults With Genetic Syndromes","SYN-TOPS","Inclusion Criteria:\n\n* Diagnosis of genetic syndrome\n* Age: 11 to 39 years and 11 months\n* Ownership of a personal computer and access to the Internet at home;\n* Basic computer literacy of the patient and\u002For family, sufficient to manage email, browse the Internet, use websites and conduct video-calls;\n* Presence of at least one parent, caregiver or guardian living with the patient who is available to participate in the intervention.\n\nExclusion Criteria:\n\n* Presence of severe or profound intellectual disability;\n* Autism Spectrum Disorder, Level 3 (requiring very substantial support) based on DSM-5;\n* Presence of an acute psychiatric disorder.","11 Years","39 Years",{"count":90,"type":23},42,[26],"Genetic syndromes involving the central nervous system are often associated with cognitive, behavioral and communication difficulties that negatively impact adaptive functioning and quality of life. Despite advances in digital health, there remains a lack of evidence-based interventions targeting executive functions and psychosocial outcomes in this population.\n\nThis multicenter study aims to evaluate the feasibility and efficacy of an adapted version of the Teen Online Problem-Solving (TOPS) program, a web-based intervention designed to enhance problem-solving, self-regulation and communication skills in everyday contexts. The adapted intervention (I-TOPS) will be tailored for adolescents and young adults with genetic syndromes involving the central nervous system. The I-TOPS intervention requires the participation of both the adolescent\u002Fyoung adult and at least one parent, caregiver or legal guardian, as it is a family-centered program.\n\nParticipants will complete online modules at home, supported by bimonthly videoconference sessions with a cognitive-behavioral psychologist. Outcomes will be assessed through pre- and post-intervention measures of executive functioning, adaptive behavior and psychological well-being, reported by both participants and caregivers. Psychological well-being of participating parents\u002Fcaregivers\u002Fguardians will also be evaluated.\n\nThe study aims to provide evidence for an accessible, scalable telehealth intervention to improve cognitive and behavioral outcomes in this underserved population.",[94],"Genetic Syndrome",[96,97,98,99,100],"executive functions","social skills","adaptive skills","telerehabilitation","rehabilitation","2026-04-24",{"date":103,"type":40},"2026-05-01",{"date":105,"type":40},"2026-02-18",{"date":107,"type":23},"2028-02-17",{"name":46,"class":47},{"id":110,"slug":111,"hasResults":12,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":12,"sex":18,"minAge":117,"maxAge":87,"enrollmentInfo":118,"targetDuration":120,"studyType":121,"phases":4,"briefSummary":122,"conditions":123,"keywords":125,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":131,"leadSponsor":133,"locationsCount":4},"100634785","transdiagnostic-dimensional-profiling-of-neurodevelopmental-disorders-100634785","NCT07544199","Transdiagnostic Dimensional Profiling of Neurodevelopmental Disorders","Transdiagnostic Dimensional Profiling of Neurodevelopmental Disorders: Using a Digital Platform to Assess Domain-General and Domain Specific Cognitive Functions","RDoC-CRAB","Inclusion Criteria:\n\n* Age between 3 and 11 years;\n* First access to the NPIA service at IRCCS Eugenio Medea (Bosisio Parini);\n* Suspected neurodevelopmental or psychopathological disorder;\n* Completion of the standard clinical diagnostic pathway;\n* Availability of a compatible device (tablet or computer) for remote administration, if applicable.\n\nExclusion Criteria:\n\n* Age outside the specified range;\n* Failure to complete the diagnostic pathway;\n* Lack of access to a compatible device (for remote administration);\n* Severe sensory impairments (uncorrected blindness or deafness);\n* Motor impairments preventing use of digital devices;\n* Significant lack of understanding of the Italian language affecting task comprehension.","3 Years",{"count":119,"type":23},300,"6 Months","OBSERVATIONAL","In recent years, the growing awareness of the multifactorial nature of neurodevelopmental disorders has stimulated interest in transdiagnostic approaches aimed at investigating underlying etiological mechanisms beyond traditional diagnostic categories. In this context, the present study seeks to provide a transdiagnostic profiling of both domain-general cognitive functions (attention, working memory, executive control) and domain-specific functions (phonological awareness, rapid naming, vocabulary, reading) underlying the main neurodevelopmental disorders in a large sample of preschool and school-age children (3-11 years), through the use of CRAB (Computerized Reading-related Assessment Battery). CRAB is a digital platform specifically developed by SUPSI and the Université de Genève to integrate, within a single testing environment, the assessment of the main domain-general and domain-specific cognitive functions underlying neurodevelopmental disorders. In particular, participating families will receive an email containing a link to access the CRAB platform, which will not include their personal data but rather a code provided by the staff of IRCCS Medea. A screen will open displaying several game-like tasks designed to measure both domain-general and domain-specific cognitive functions, which must be completed by the participating subject. The main objective is to obtain a fine-grained and multidimensional mapping of cognitive profiles prior to the standard diagnostic process, in order to identify early patterns of (a)typical or at-risk functioning.",[124],"Neurodevelopmental Disorder (Diagnosis)",[126],"NDD, CRAB, transdiagnostical profiles, prospective study","2026-04-15",{"date":129,"type":40},"2026-04-22",{"date":103,"type":23},{"date":132,"type":23},"2030-01-30",{"name":46,"class":47},{"id":135,"slug":136,"hasResults":12,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":141,"sex":18,"minAge":142,"maxAge":143,"enrollmentInfo":144,"targetDuration":4,"studyType":121,"phases":4,"briefSummary":146,"conditions":147,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":78},"100633824","cortical-tracking-of-speech-in-the-first-year-of-life-100633824","NCT07531706","Cortical Tracking of Speech in the First Year of Life","Cortical Tracking of Speech in the First Year of Life: a Window Into (a)Typical Language Acquisition","Inclusion Criteria:\n\n* Healthy infants aged between 7 and 8 months\n* Infants with and without familial risk for language disorders (Infants are assigned to the group with familial risk for language disorders if at least one first-degree relative had a certified (clinical) diagnosis of language and\u002For learning disorders).\n* Both parents are native-Italian speakers\n\nExclusion Criteria:\n\n* Gestational age \\\u003C 37 weeks and\u002For birth-weight \\\u003C 2500 grams\n* APGAR scores at birth at 1' and 5' \\\u003C 7\n* Bayley Cognitive Score \\\u003C 7\n* Presence of certified diagnosis of intellectual deficiency, attention-deficit disorder, sensorial and neurological disorders or autism within first-degree relatives.",true,"30 Weeks","34 Weeks",{"count":145,"type":23},50,"The goal of this observational study is to investigate early neural mechanisms underlying the processing of spoken language, specifically the phenomenon of cortical tracking, and to determine whether these mechanisms can serve as early predictors of later language development outcomes in infants, including both typical and atypical trajectories.\n\nThe main questions it aims to answer are:\n\n* How do infants with and without a familial history of language and learning impairments differ in their neural ability to track speech and non-speech auditory stimuli at an early stage of development (around 8 months of age)?\n* To what extent do early cortical tracking mechanisms predict later language abilities, including both receptive and expressive skills, measured at approximately 18 months of age? Researchers will compare infants with a familial risk for language and learning impairments (FH+) to infants without such risk (FH-) to determine whether differences in early neural processing of auditory stimuli are associated with later language outcomes.\n\nParticipants will:\n\n* undergo a neurophysiological assessment involving non-invasive electroencephalographic (EEG) recording while being exposed to auditory stimuli, including: speech stimuli (pre-recorded simple stories in Italian, presented in infant-directed speech); non-speech stimuli (musical sounds matched for rhythmic and acoustic properties)\n* take part in a developmental assessment at approximately 8 months of age, including standardized measures of cognitive and early linguistic abilities\n* be involved in a follow-up assessment approximately 10 months later (around 18 months of age), during which standardized tests will evaluate language comprehension and production abilities\n* have additional background information collected, including family history of language and learning disorders and socio-demographic characteristics, to better understand potential risk and protective factors The study follows a longitudinal design and uses non-invasive procedures that do not require active responses from the infant.",[148,149,150,151],"Language Development","Language Development Disorders","Infant Development","Infant Developmental Assessment","2026-04-09",{"date":127,"type":40},{"date":155,"type":40},"2025-10-14",{"date":157,"type":23},"2028-02",{"name":46,"class":47},{"id":160,"slug":161,"hasResults":12,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":4,"eligibilityCriteria":165,"healthyVolunteers":12,"sex":18,"minAge":166,"maxAge":167,"enrollmentInfo":168,"targetDuration":4,"studyType":121,"phases":4,"briefSummary":170,"conditions":171,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":181},"100629091","sleep-disturbance-in-subjects-with-autism-spectrum-disorders-asd-in-preschool-age-18-60-months-100629091","NCT07470138","Sleep Disturbance in Subjects With Autism Spectrum Disorders (ASD) in Preschool Age (18-60 Months)","Disturbo Del Sonno in Soggetti Con Disturbi Dello Spettro Dell'Autismo (ASD) in età Prescolare (18-60 Mesi)","Inclusion Criteria:\n\n* Subjects with ASD\n* aged between 18 months and 60 months\n\nExclusion Criteria:\n\n\\- Subjects with neurologica theraphy","18 Months","60 Months",{"count":169,"type":23},200,"An observational study is one that aims to collect data from routine clinical practice, without altering a patient's standard diagnostic and therapeutic pathway (no additional instrumental or laboratory tests beyond those performed in clinical practice are envisaged).\n\nThe overall objective of this study is to investigate sleep disorders in preschool-aged children with Autism Spectrum Disorder. Sleep plays a key role in early brain development. The prevalence of sleep disorders in childhood is reported to be between 10 and 50%, with a prevalence of up to 86% in children with neurodevelopmental disorders. Over the past few decades, numerous studies have demonstrated a significant bidirectional connection between sleep problems and various areas of child development. Therefore, early identification of sleep disorders in childhood is essential for adequate treatment and prevention of negative cognitive and socioemotional impacts.\n\nRecent studies have demonstrated a hypothetical role for vitamin D and iron in regulating sleep. The objectives of the study are to describe sleep disturbances in a group of preschool-aged subjects with ASD (18-60 months), to measure blood ferritin and vitamin D levels, and to assess a possible correlation with specific subtypes of sleep disturbances.\n\nGiven the impact that sleep disturbances have on various areas of children's development, secondary objectives include assessing a possible positive correlation between the severity of sleep disturbances and symptoms related to Autism Spectrum Disorder and\u002For other psychiatric comorbidities.",[172],"Autism Spectrum Disorder","2026-03-20",{"date":175,"type":40},"2026-03-24",{"date":177,"type":40},"2025-01-08",{"date":179,"type":23},"2026-12-15",{"name":46,"class":47},2,{"id":183,"slug":184,"hasResults":12,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":188,"eligibilityCriteria":189,"healthyVolunteers":141,"sex":18,"minAge":190,"maxAge":191,"enrollmentInfo":192,"targetDuration":4,"studyType":24,"phases":194,"briefSummary":195,"conditions":196,"keywords":200,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":213,"locationsCount":214},"100592931","implementation-and-validation-of-instrumented-stair-climb-test-100592931","NCT06999850","Implementation and Validation of Instrumented Stair Climb Test","Implementazione e Validazione di un Test Per l'Analisi Del Movimento Della Salita e Discesa Delle Scale Con Sensori Indossabili","SCTS","Common inclusion criteria for all groups:\n\n\\- Ability to climb and descend 10 steps with supervision, even with handrail support.\n\nCommon exclusion criteria for all groups:\n\n* Need for help from an operator or use of orthoses to make the stairs;\n* Inability to dress the instrumentation (accelerometer\u002Felectromyograph);\n* clinical condition that does not recommend the execution of scales (e.g. NYHA Class IV cardiovascular decompensation, epilepsy not controlled by drugs, serious visual disturbances...);\n* inability to follow verbal instructions.\n\nInclusion criteria for the healthy group :\n\n* age 4-80 years (8 subjects 4-18 years; 8 subjects 19-65 years; 8 subjects 65-80 years);\n* absence of diagnosis of neurological or orthopaedic pathologies, which impair the patient's mobility.\n\nInclusion criteria for the PCI group :\n\n* age range 4-18 years;\n* Diagnosis of Infantile Cerebral Palsy;\n* right or left hemiparesis;\n* ability motor skills in levels I - III according to the GMFCS (Gross Motor Function Classification System).\n\nInclusion criteria for the Orthopaedic group:\n\n* Age 65-80 years;\n* postoperative postoperative hip or knee arthroplasty (in election and post-fracture, any revisions will be excluded).\n\nInclusion criteria for the Amputee group:\n\n* age range from 19 to 80 years;\n* Leg amputation (trans-tibial), fitted with limb prosthesis.\n\nInclusion criteria for the Parkinson's group:\n\n* age range from 65 years;\n* diagnosis of Parkinson's disease or Parkinsonism also on a vascular basis.\n\nInclusion criteria for the group Ictus Cerebri:\n\n* Age 65-80 years;\n* Aftereffects of Ictus Cerebri;\n* left or right hemiparesis.","4 Years","80 Years",{"count":193,"type":23},64,[26],"The aim of this study is to design an instrumented test for the evaluation of the climb of stairs. In particular, the main purpose is to characterize and compare the performance of subjects, both pediatrics and adults, with different pathologies (cerebral palsy, amputee, Parkinson's disease, stroke and arthroplasty) in carrying out the instrumented test of climbing and descending stairs. This would provide potentially useful information to complement the clinical assessment, including investigating the existence of correlations between the instrumental data obtained and the clinical scales collected. The secondary objective is to evaluate, in a first phase of the study, the feasibility and reliability of the test, analyzing the validity of the indices obtained in terms of intra- and inter-operator reliability on healthy subjects.",[197,198,199],"Stair Climbing","Instrumentation","Test",[201,202,203,204,205],"Stair Climb Test","Cerebral Palsy","Stroke","amputee","Parkinson","2026-02-25",{"date":208,"type":40},"2026-02-27",{"date":210,"type":40},"2025-04-04",{"date":212,"type":23},"2026-04-04",{"name":46,"class":47},3,{"id":216,"slug":217,"hasResults":12,"nctId":218,"briefTitle":219,"officialTitle":220,"acronym":221,"eligibilityCriteria":222,"healthyVolunteers":141,"sex":18,"minAge":223,"maxAge":4,"enrollmentInfo":224,"targetDuration":4,"studyType":121,"phases":4,"briefSummary":226,"conditions":227,"keywords":229,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":235,"lastUpdatePostDateStruct":236,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":78},"100624347","antenatal-stress-and-infants-in-mar-100624347","NCT07408453","Antenatal Stress and Infants In MAR","The Effects of Antenatal Stress on the Newborn in Medically Assisted Reproduction: the SARA Study","SARA","Inclusion Criteria:\n\n* Pregnant women in the first trimester and their respective partners.\n* Pregnancy achieved through homologous assisted reproduction techniques.\n* Pregnancy achieved through heterologous assisted reproduction via oocyte donation.\n* Singleton pregnancy.\n* Pregnancy achieved through FIVET techniques.\n\nExclusion Criteria:\n\n* Parents under 18 years of age.\n* Pregnancy achieved through heterologous assisted reproduction via donor sperm.\n* Pregnancy achieved without FIVET techniques.\n* Maternal hypertension during pregnancy.\n* Endocrine or immune system disorders during pregnancy.\n* Chronic use of medications during pregnancy (including anti-inflammatory drugs, antidepressants, or steroids).\n* Alcohol or substance abuse.\n* Smoking during pregnancy.\n* Psychiatric disorders other than anxiety or depression.\n* Pregnancy or perinatal complications.\n* Multiple pregnancy (twins or higher-order multiples).\n* Preterm birth (before 35 weeks of gestation).\n* Health problems in the newborn at birth.","18 Years",{"count":225,"type":23},100,"The goal of this observational longitudinal study is to examine the association between prenatal psychological and biological stress and neonatal health outcomes in couples who conceived through medically assisted reproduction. The study includes expectant mothers and fathers during pregnancy and at birth and focuses on pregnancies achieved through homologous fertilization and heterologous fertilization via oocyte donation.\n\nThe main questions this study aims to answer are:\n\n1. How do psychological and biological indicators of stress manifest during pregnancy in women who have undergone medically assisted reproduction?\n2. Is prenatal maternal stress associated with neonatal health outcomes independently of genetic factors?\n3. How does perceived stress present in expectant fathers during pregnancy? Researchers will compare couples who conceived through homologous fertilization with couples who conceived through heterologous fertilization via oocyte donation to understand whether associations between prenatal maternal stress and neonatal outcomes are independent of shared genetic background.\n\nParticipants will:\n\n* Complete a remote eligibility assessment collecting information on pregnancy characteristics, parental health, and maternal psychological well-being\n* Complete online questionnaires at multiple time points during pregnancy and at birth assessing anxiety and depressive symptoms, perceived social support, and self-efficacy (both parents), as well as pregnancy-specific measures and prenatal bonding (mothers only)\n* In late pregnancy, mothers will collect saliva samples at home over two consecutive days to assess biological markers of stress (cortisol and alpha-amylase)",[228],"Pregnancy and Medically Assisted Reproduction",[230,231,232,233,234],"antenatal anxiety","antenatal depression","salivary cortisol","salivary alpha amylase","medically assisted reproduction","2026-02-05",{"date":237,"type":40},"2026-02-13",{"date":239,"type":23},"2026-04",{"date":241,"type":23},"2027-09",{"name":46,"class":47},{"id":244,"slug":245,"hasResults":12,"nctId":246,"briefTitle":247,"officialTitle":247,"acronym":248,"eligibilityCriteria":249,"healthyVolunteers":141,"sex":18,"minAge":250,"maxAge":4,"enrollmentInfo":251,"targetDuration":4,"studyType":24,"phases":252,"briefSummary":253,"conditions":254,"keywords":255,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":260,"lastUpdatePostDateStruct":261,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":266,"locationsCount":78},"100622907","characterization-of-atypical-sensorimotor-pathways-in-individuals-with-autism-100622907","NCT07389720","Characterization of (A)Typical Sensorimotor Pathways in Individuals With Autism","MovAUT","Inclusion Criteria:\n\n* children aged 2 to 12 years (both autistic and typically developing)\n* Clinical diagnosis of Autism Spectrum Disorder based on clinical judgment according to DSM-5 criteria (for the autism group).\n* being parents of the enrolled children (both autistic and typically developing)\n* infants younger than 24 months of age with a first-degree family member with a clinical diagnosis of Autism Spectrum Disorder.\n\nExclusion Criteria:\n\n* Presence of medical and\u002For neurological conditions of clinical significance, including epilepsy.\n* Presence of dysmorphic syndromes or known genetic syndromes.\n* Current use of medications and\u002For psychotropic drugs.","1 Year",{"count":119,"type":23},[26],"The goal of this interventional study is to understand whether sensorimotor skills could represent an endophenotype for autism, i.e. a specific class of biomarkers that bridges the gap between biological components of a condition and the behavioral\u002Fclinical dimensions. Motor and sensory differences are often observed in people with autism and may appear early in development or be shared among family members.\n\nThe study will address three main questions:\n\n* What are the developmental effects of early differences in motor and sensory skills?\n* Are motor and sensory abilities influenced by family relationships?\n* Can studying motor and sensory differences in autism help researchers better understand the biological mechanisms underlying the condition? This study is structured in three topic-oriented work packages (WPs): WP1, a longitudinal assessment of sensorimotor skills as early predictors of later social characteristics in a mixed sample of infant siblings of autistic children (at elevated likelihood of autism) or with typical familial likelihood (no first-degree relatives with autism) (Q1); WP2, a cross-sectional investigation of sensorimotor abilities in autistic children and their parents as compared with typically developing children and their parents (Q2); and WP3, a dense-phenotyping approach to establish, within individuals, associations between traits across behavioral, neural, and molecular levels.",[172],[256,257,258,259],"autism","motor skills","social communication","kinematics","2026-02-03",{"date":235,"type":40},{"date":263,"type":40},"2024-05-21",{"date":265,"type":23},"2026-12",{"name":46,"class":47},{"id":268,"slug":269,"hasResults":12,"nctId":270,"briefTitle":271,"officialTitle":272,"acronym":4,"eligibilityCriteria":273,"healthyVolunteers":141,"sex":18,"minAge":223,"maxAge":274,"enrollmentInfo":275,"targetDuration":4,"studyType":121,"phases":4,"briefSummary":277,"conditions":278,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":283,"lastUpdatePostDateStruct":284,"startDateStruct":286,"completionDateStruct":288,"leadSponsor":289,"locationsCount":181},"100567332","observational-study-to-observe-variations-of-gait-parameters-in-patients-with-neuromuscular-diseases-100567332","NCT06666816","Observational Study to Observe Variations of Gait Parameters in Patients With Neuromuscular Diseases","Observational Study for the Identification of Fatigue and Gait Biomarkers in Populations With Neuromuscular Pathologies in the Clinical Context and Daily Life","Inclusion Criteria:\n\n* Ambulant adult patients with genetic diagnosis of muscular dystrophy\u002Fmyopathy (dystrophinopathies, muscular dystrophies and congenital and non-congenital myopathies), of spinal muscular atrophy (SMA) and with molecular diagnosis of Charcot-Marie Tooth 1 or 2.\n* independent walking, even with assistance;\n\nExclusion Criteria:\n\n* Dilated or ischemic heart disease with moderate impairment;\n* Chronic respiratory failure: forced vital capacity (FVC) \\\u003C 40%; more than 5% of nocturnal time spent with peripheral oxygen saturation levels \\\u003C 90.","75 Years",{"count":276,"type":23},120,"This study has the general objective of observing walking parameters during a clinical test to objectively estimate fatigue in patients with neuromuscular diseases. Furthermore, the investigators want to evaluate the feasibility of collecting physical activity in daily life conditions during a one-week monitoring period using a wearable sensor.",[279,280,281,282],"Muscular Dystrophies","Myopathies","Spinal Muscular Atrophy (SMA)","Charcot Marie Tooth Disease","2026-01-15",{"date":285,"type":40},"2026-01-20",{"date":287,"type":40},"2017-10-27",{"date":265,"type":23},{"name":46,"class":47},{"id":291,"slug":292,"hasResults":12,"nctId":293,"briefTitle":294,"officialTitle":294,"acronym":295,"eligibilityCriteria":296,"healthyVolunteers":12,"sex":18,"minAge":297,"maxAge":298,"enrollmentInfo":299,"targetDuration":301,"studyType":121,"phases":4,"briefSummary":302,"conditions":303,"keywords":310,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":316,"lastUpdatePostDateStruct":317,"startDateStruct":319,"completionDateStruct":321,"leadSponsor":322,"locationsCount":78},"100613984","assessing-real-life-effectiveness-of-treatment-in-neurodevelopmental-disorders-100613984","NCT07273695","Assessing Real Life Effectiveness of Treatment in Neurodevelopmental Disorders","ALERT","Inclusion Criteria\n\n* Children and adolescents aged 8-15 years;\n* Diagnosis of externalizing disorder, ADHD, and\u002For emotional dysregulation (assessed with questionnaires, interviews, and\u002For clinical observation);\n* Intelligence quotient ≥ 75.\n\nExclusion Criteria\n\n* IQ \\\u003C 75;\n* Substance abuse and addictions;\n* Psychosis;\n* Acute disorders;\n* Organic brain disorders;\n* Presence of neurological diseases, epilepsy;\n* Genetic syndromes;\n* Co-diagnosis with other psychiatric or neurodevelopmental disorders (e.g., autism, anxiety, depression, etc.) and prior psychopharmacological therapy will not be considered exclusion criteria but will be recorded and declared.","8 Years","15 Years",{"count":300,"type":23},80,"9 Months","The goal of this observational study is to learn if and how pharmacological and psychotherapeutic group treatments can treat clinical symptoms of children and adolescent patients with ADHD.\n\nThe main questions it aims to answer are:\n\n* Are pharmacological and psychotherapeutic treatments effective on the clinical symptoms of patients with ADHD?\n* Are pharmacological and psychotherapeutic treatments effective on symptoms of emotion-behavioral dysregulation?\n* Is it possible to find associations between individual characteristics and treatment responses evaluating behavioral and neural correlates in children and adolescents with traits of emotion-behavioral dysregulation, externalizing disorders, and\u002For ADHD, using a panel of multimodal measures. May the data collected contribute to the definition of profiles useful for generating predictive hypotheses aimed at developing more personalized interventions?\n\nResearchers will compare the data collected from patients treated with pharmacological and psychotherapeutic group treatments with the data of subjects of comparable sex\u002Fgender, age, diagnoses, on the waiting list for treatment to see if pharmacological and psychotherapeutic treatments effects ADHD and emotional dysregulation symprtoms.\n\nParticipants, patients who are offered treatment by clinicians according to standard clinical practice, will be asked to participate in the study by undergoing experimental assessments before and after the treatment.\n\nThe multimodal panel of proposed assessments includes:\n\n* behavioral assessments, conducted through the completion of clinical and socio-demographic questionnaires;\n* neuropsychological assessments, conducted through standardized computerized neuropsychological tests;\n* neurophysiological assessments, conducted through the recording of NIRS (near infrared spectroscopy) and EEG (electroencephalogram) signals during an attentional task (Go-NoGo) and via a smartwatch.",[304,305,306,307,308,309],"Emotional Dysregulation","Externalizing Problems","Oppositional Defiant","Conduct Disorder","Disruptive Behaviours","Attention Deficit Hyerpactivity Disorder",[311,312,313,314,315],"attention deficit hyperactivity disorder","child training","methylphenidate","emotional dysregulation","externalizing disorders\u002Fbehaviors","2025-11-28",{"date":318,"type":40},"2025-12-09",{"date":320,"type":40},"2025-09-19",{"date":265,"type":23},{"name":46,"class":47},{"id":324,"slug":325,"hasResults":12,"nctId":326,"briefTitle":327,"officialTitle":328,"acronym":4,"eligibilityCriteria":329,"healthyVolunteers":141,"sex":18,"minAge":297,"maxAge":20,"enrollmentInfo":330,"targetDuration":4,"studyType":24,"phases":332,"briefSummary":333,"conditions":334,"keywords":335,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":339,"lastUpdatePostDateStruct":340,"startDateStruct":342,"completionDateStruct":344,"leadSponsor":346,"locationsCount":181},"100570673","cortical-correlates-of-spatial-navigation-skills-in-an-immersive-virtual-reality-environment-100570673","NCT06710301","Cortical Correlates of Spatial Navigation Skills in an Immersive Virtual Reality Environment","Study of the Cortical Correlates of Spatial Navigation Skills in an Immersive Virtual Reality Environment","Inclusion Criteria:\n\n* typically developing subjects aged between 8 and 17 years;\n* subjects with CP aged between 8 and 17 years;\n\nExclusion Criteria:\n\n* subjects aged under 8 or over 17 years;\n* subjects with epileptic problems;\n* subjects with poor head control;\n* subjects with visual problems that can not be corrected with prescription lens;",{"count":331,"type":23},70,[26],"The goal of this study is to investigate the neural mechanisms that undergoes spatial navigation skills in children\u002Fadolescents aged between 8 and 17 years. These skills play an important role in daily life, as they allow us to orient ourselves in familiar and unfamiliar environments, locate objects, interact with them and memorize their position. Navigation abilities vary widely between individuals, change with age and might be affected by diseases, such as the cerebral palsy (CP). Previous studies have, in fact, demonstrated differences in the learning and adaptation methods of spatial navigation skills in children affected by CP compared to typically developing (TD) peers. Through the use of the electroencephalogram (EEG) we want to shed light on the mechanisms that govern this ability with the aim of:\n\n1. better characterize spatial navigation skills in children\u002Fadolescents, both TD and affected by CP;\n2. investigate the origin of the differences found between the spatial navigation skills of TD children and those affected by CP, improving knowledge of the pathology and thus allowing, in the future, to identify more adequate rehabilitation interventions.",[29],[336,337,338,202],"Navigation skills","EEG","Virtual Reality","2025-11-18",{"date":341,"type":40},"2025-11-19",{"date":343,"type":40},"2024-11-14",{"date":345,"type":23},"2026-12-31",{"name":46,"class":47},{"id":348,"slug":349,"hasResults":12,"nctId":350,"briefTitle":351,"officialTitle":352,"acronym":353,"eligibilityCriteria":354,"healthyVolunteers":12,"sex":18,"minAge":120,"maxAge":355,"enrollmentInfo":356,"targetDuration":4,"studyType":24,"phases":358,"briefSummary":359,"conditions":360,"keywords":364,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":339,"lastUpdatePostDateStruct":372,"startDateStruct":374,"completionDateStruct":376,"leadSponsor":378,"locationsCount":379},"100567329","speech-therapy-and-parenting-for-early-socio-communicative-skills-100567329","NCT06666777","Speech Therapy and Parenting for Early Socio-communicAtive sKills","Speech Therapy and Parenting for Early Socio-communicative Skills in Children With Neurodevelopmental Disabilities","SPEAK","Inclusion criteria:\n\nFor children:\n\n* Age between 6 months (corrected age in cases of prematurity) and 5 years.\n* Documented developmental delay and\u002For socio-communicative difficulties, based on clinical signs or standardized developmental scales (e.g., Griffiths Scales).\n* Mental age of at least 6 months.\n* Diagnosis of neurodevelopmental disability, including cerebral palsy, genetic syndromes, rare diseases with non-progressive neurological impairments, or congenital disorders of undetermined nature.\n\nFor parents:\n\n* Adult age (≥ 18 yo)\n* Good knowledge and fluency in Italian.\n* No manifest psychiatric conditions.\n* No documented intellectual disability.\n\nExclusion criteria:\n\nFor children:\n\n* Age greater than 5 years at the time of recruitment.\n* Mental age below 6 months.\n* Absence of developmental delay (developmental quotient \\> 85) and socio-communicative difficulties.\n* Diagnosis of neurodevelopmental disability resulting from neurodegenerative diseases or brain tumor outcomes.\n* Severe sensory impairments (profound deafness and\u002For blindness).\n\nFor Parents:\n\n* Inability to speak Italian.\n* Documented psychiatric conditions or intellectual disability.","59 Months",{"count":357,"type":23},60,[26],"Every year, millions of children are diagnosed with neurodevelopmental disabilities. This term covers a wide range of conditions, from genetic syndromes to brain injuries such as cerebral palsy. Children with neurodevelopmental disabilities often struggle in multiple areas, including language development. While standard speech therapy mainly focuses on understanding and producing words, these children may also have difficulties with the social and communicative skills needed for language. The parent-child relationship is especially important for helping kids develop in their early years.\n\nThis clinical trial aims to find out if an intervention focused on early social and communication skills, and involving parents, can help children with neurodevelopmental disabilities. The study includes children aged 6 months to 5 years. It seeks to answer two key questions:\n\n* Does this intervention improve social and communication skills better than standard speech therapy?\n* Does this intervention affect how parents interact with their child?\n\nTo find the answers, the study will compare two groups: one group will get the parent-involved intervention that focuses on early communication skills, while the other group will get standard speech therapy.\n\nIn the first intervention, therapists will guide parents in observing and supporting their child's social and communication behaviors during various activities like playtime and snack time. In contrast, the standard speech therapy will focus on traditional goals, such as improving the child's ability to vocalize, understand, and use words, without involving parents.\n\nBoth interventions will follow the same schedule-eight weekly sessions, each lasting 45 minutes, over two months.\n\nBefore and after the interventions, the children and parents will:\n\n* Have an assessment of the child's language, social, and communication development.\n* Participate in a 10-minute video recording of parent-child playtime, which will be used to study parenting behavior.",[361,94,362,363,149],"Neurological Impairments","Neurodevelopmental Disability","Developmental Delays",[365,366,367,368,369,370,371],"Socio-communicative skills","early intervention","Speech therapy","Parenting","Parental support","Intersubjectivity","Neurodevelopmental disabilities",{"date":373,"type":40},"2025-11-24",{"date":375,"type":40},"2025-03-19",{"date":377,"type":23},"2026-09-01",{"name":46,"class":47},9,{"id":381,"slug":382,"hasResults":12,"nctId":383,"briefTitle":384,"officialTitle":385,"acronym":386,"eligibilityCriteria":387,"healthyVolunteers":12,"sex":388,"minAge":389,"maxAge":4,"enrollmentInfo":390,"targetDuration":4,"studyType":24,"phases":392,"briefSummary":393,"conditions":394,"keywords":396,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":402,"lastUpdatePostDateStruct":403,"startDateStruct":405,"completionDateStruct":407,"leadSponsor":409,"locationsCount":78},"100600722","transition-to-adulthood-in-people-with-muscular-dystrophy-100600722","NCT07101185","Transition to Adulthood in People With Muscular Dystrophy","Transition to Adulthood in People With Dystrophy: Social Cognition Mechanisms, Psychosocial Adjustment, and Mental Health and Coping Strategies.","TAMDY","Inclusion Criteria:\n\n* Defined diagnosis of DMD\n* Age \\> 14 years\n* Willingness and ability to comply to study procedures\n* Comprehension of the study and Signature of the informed consent\n\nExclusion Criteria:\n\n* Clinical history of cerebral palsy, severe intellectual deficit, severe behavioral disturbances\n* absence of compliance to the studyof the patient and the caregivers.","MALE","14 Years",{"count":391,"type":23},250,[26],"The study will involve boys with Duchenne Muscular Dystrophy (DMD), from adolescence to adulthood living in Italy, and their families\u002F caregivers.\n\nThe Investigators want to explore patients' mental health, social cognition and perception of body image as well as patients'and caregivers' ability to adapt to changes related to both the disease and various personal and social needs, through the use of short and simple questionnaires, neuropsychological tests and neurocognitive evaluation in ecological scenarios using Virtual Reality. The desire for autonomy and the awareness of both personal and social difficulties in achieving them put a strain on both patients and their families.Some studies conducted in the USA and in various European countries underline that the transition to adulthood of patients with muscular dystrophy is featured by a good ability to adapt to the more advanced stages of the disease in general; nevertheless, facing the worsening of health entails experiences of anxiety and depression.In this historical phase, clinical trials of gene therapy and gene modulating therapies are involving an increasing number of patients, mainly represented by children in the early phase of the disease. Hence, adolescents and young adults could develop feelings of exclusion from research efforts, losing confidence and hope in any future improvement of their condition, social participation and quality of life.This study could lead to identify strengths and weaknesses in social cognition and psychosocial adaptation; through the evaluation of characteristics of patients\u002Fcaregivers or exogenous factors influencing higher levels of social adaptation, we ultimately aim to define strategies to improve not only physical (already defined by guidelines) but also psychological care, social cognition and social support in all stages of DMD, particularly in later ones.",[395],"Duchenne \u002F Becker Muscular Dystrophy",[397,398,399,400,401],"Duchenne muscular dystrophy","transition to adulthood,","social cognition","psychosocial adjustment","mental health and coping strategies","2025-08-01",{"date":404,"type":40},"2025-08-03",{"date":406,"type":23},"2025-09",{"date":408,"type":23},"2027-08",{"name":46,"class":47},{"id":411,"slug":412,"hasResults":12,"nctId":413,"briefTitle":414,"officialTitle":415,"acronym":416,"eligibilityCriteria":417,"healthyVolunteers":12,"sex":18,"minAge":297,"maxAge":418,"enrollmentInfo":419,"targetDuration":4,"studyType":24,"phases":421,"briefSummary":422,"conditions":423,"keywords":426,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":436,"lastUpdatePostDateStruct":437,"startDateStruct":439,"completionDateStruct":441,"leadSponsor":442,"locationsCount":78},"100600251","electroencephalogram-in-patients-with-friedreichs-ataxia-for-the-study-of-the-structural-and-functional-connectome-100600251","NCT07095062","Electroencephalogram in Patients With Friedreich's Ataxia for the Study of the Structural and Functional Connectome.","Structural-Functional Connectome and High Density Electroencephalogram: Pilot Study in Patients With Friedreich's Ataxia.","CONNETTOMA","Inclusion criteria:\n\n* age between 8 and 60 years;\n* genetic diagnosis of FRDA: presence of guanine-adenine trinucleotide (GAA) expansion in the two alleles of the fratassin gene, GAA1 and GAA2;\n* score on the Scale for the Assessment and Rating of Ataxia (SARA) \\\u003C 30;\n* ability to take part in a neuropsychological assessment in Italian.\n\nExclusion criteria:\n\n* age different from the range 8-60 years;\n* diagnosis of acquired ataxia or other genetic ataxias;\n* SARA scale score ≥ 30;\n* inability to take part in an Italian-language neuropsychological assessment","60 Years",{"count":420,"type":23},30,[26],"Prospective, exploratory, multicenter pilot study investigating the structural and functional connectome in patients with Friedreich's Ataxia (FRDA) using high-density electroencephalogram (HD-EEG). The aim is to identify neurophysiological biomarkers and analyze the relationship between cortical connectivity, cognitive functioning, and clinical severity, particularly in response to rehabilitation treatment.",[424,425],"Friedreich's Ataxia","Motor Disorders",[427,428,429,430,431,432,433,434,435],"Functional Connectivity","HD-EEG","FRDA","Connectome","Cognitive Functioning","Neurodegenerative Disease","Cerebellar Disorders","Neurophysiological Biomarkers","Friedreich Ataxia","2025-07-23",{"date":438,"type":40},"2025-07-31",{"date":440,"type":40},"2025-07-07",{"date":345,"type":23},{"name":46,"class":47},{"id":444,"slug":445,"hasResults":12,"nctId":446,"briefTitle":447,"officialTitle":448,"acronym":4,"eligibilityCriteria":449,"healthyVolunteers":141,"sex":18,"minAge":450,"maxAge":298,"enrollmentInfo":451,"targetDuration":4,"studyType":24,"phases":453,"briefSummary":454,"conditions":455,"keywords":458,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":465,"lastUpdatePostDateStruct":466,"startDateStruct":468,"completionDateStruct":470,"leadSponsor":472,"locationsCount":214},"100588907","personalization-of-visual-characters-and-text-to-speech-tts-to-support-learning-in-students-with-reading-difficulties-100588907","NCT06947512","Personalization of Visual Characters and Text-to-Speech (TTS) to Support Learning in Students With Reading Difficulties","Efficacy of the Personalization of Visual Parameters and Text-to-Speech to Improve Reading Speed, Accuracy and Comprehension in Students With Learning Disorders","Inclusion Criteria (for TD group):\n\n* age 7-15 years\n* no history of reading difficulties\n* attends school in Italy\n\nExclusion Criteria (for TD group):\n\n* special educational needs or diagnosis of neurodevelopmental disorders\n\nInclusion Criteria (for DD group):\n\n* age 7-15 years\n* diagnosis of Developmental Dyslexia or Specific Reading Disorder\n* Attends school in Italy\n\nExclusion Criteria (for DD group):\n\n* diagnosis of Intellectual Disability\n\nInclusion Criteria (for SEN group):\n\n* age 7-15 years\n* reported by school to have significant difficulties in reading and writing\n* Attends school in Italy (at least 6 months continued schooling and exposure to the Italian language)\n\nExclusion Criteria (for SEN group):\n\n* diagnosis of Intellectual Disability","7 Years",{"count":452,"type":23},90,[26],"Previous research has shown the importance of font type, size and spacing to facilitate text reading in dyslexia. A special automatized procedure was designed to select the most favorable parameters for both text visualization and text-to-speech (TTS) conversion to be used by students with reading difficulties. The validation of its outcomes will be carried out through a systematic comparison of the use of the personalized versus standard fonts and voices in reading and writing tests.",[456,457],"Developmental Dyslexia","Reading Problem",[456,459,460,461,462,463,464],"Reading Difficulties","Personalization","Visual parameters","Auditory parameters","Fonts","Text-to-Speech (TTS)","2025-04-30",{"date":467,"type":40},"2025-05-04",{"date":469,"type":40},"2023-02-16",{"date":471,"type":23},"2025-12-31",{"name":46,"class":47},{"id":474,"slug":475,"hasResults":12,"nctId":476,"briefTitle":477,"officialTitle":478,"acronym":4,"eligibilityCriteria":479,"healthyVolunteers":141,"sex":18,"minAge":190,"maxAge":480,"enrollmentInfo":481,"targetDuration":4,"studyType":24,"phases":483,"briefSummary":484,"conditions":485,"keywords":487,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":465,"lastUpdatePostDateStruct":492,"startDateStruct":493,"completionDateStruct":495,"leadSponsor":497,"locationsCount":78},"100588120","dynamic-assessment-of-the-risk-for-language-and-reading-disorders-in-monolingual-and-multilingual-children-100588120","NCT06937255","Dynamic Assessment of the Risk for Language and Reading Disorders in Monolingual and Multilingual Children","Validation of Computerized Dynamic Assessment Tasks to Identify the Risk of Developmental Language Disorders (DLD) and Specific Reading Disorder (SRD) in Monolingual and Multilingual Children","Inclusion Criteria:\n\n* age 4-6 years (Kindergarten) or 7-9 years (Primary school);\n* Attendance at an Italian-language school in Italy or Switzerland\u002FGermany.\n\nAdditional inclusion criteria for the multilingual group only:\n\n* (i) At least one parent speaks at least one language other than Italian in the family;\n* (ii) Continuous exposure to the Italian language for at least two years.\n\nExclusion Criteria:\n\n* Intellectual disability, major psychopathological disorders, exposure to Italian language for less than two years.","9 Years",{"count":482,"type":23},150,[26],"The project represents the completion of a part of the recently concluded European project MultiMind, in which a computer platform called MuLiMi was developed and validated. The platform hosts screening tests for the identification of the risk of Language and Learning Disorders in preschool and primary school children, respectively. The aim is to validate the Dynamic Assessment (DA) tests (a first test assessing the capacity to learn new words for preschool children and a second one assessing the capacity to learn a new spelling code for school-age children) in a population of monolingual and bilingual children attending preschool and primary school. The main goal of the study is to complete the validation of the two Dynamic Assessment tests implemented in the MuLiMi platform developed for the MultiMind project.",[456,486],"Developmental Language Disorder",[456,486,488,489,490,491],"Dynamic Assessment","computerized assessment","multilingual population","children",{"date":467,"type":40},{"date":494,"type":40},"2023-04-03",{"date":496,"type":23},"2025-12",{"name":46,"class":47},{"id":499,"slug":500,"hasResults":12,"nctId":501,"briefTitle":502,"officialTitle":503,"acronym":4,"eligibilityCriteria":504,"healthyVolunteers":12,"sex":18,"minAge":190,"maxAge":505,"enrollmentInfo":506,"targetDuration":4,"studyType":121,"phases":4,"briefSummary":507,"conditions":508,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":465,"lastUpdatePostDateStruct":510,"startDateStruct":511,"completionDateStruct":513,"leadSponsor":514,"locationsCount":78},"100572093","robot-assisted-walking-treatment-in-hereditary-spastic-paraplegia-hsp-100572093","NCT06728787","Robot-assisted Walking Treatment in Hereditary Spastic Paraplegia (HSP)","Efficacy of Robot-assisted Walking Treatment on Gait Biomechanics, Functional Outcomes, and Quality of Life in Subjects With Hereditary Spastic Paraplegia (HSP)","Inclusion Criteria:\n\n* genetic or clinical diagnosis of HSP.\n* age greater than 4 years and less than 70\n* femur length \\> 23 cm\n* ability to walk independently indoors, with or without walking aids.\n\nExclusion Criteria:\n\n* botulinum toxin injection or lower limb surgery in the previous 6 months\n* severe lower limb muscle retractions\n* severe osteoporosis\n* unhealed skin lesions in lower limbs\n* cardiovascular instability\n* acute or progressive neurological disorders\n* behavioral problemS","70 Years",{"count":145,"type":23},"Patients will undergo a combined rehabilitation treatment consisting of 15 sessions on Lokomat and 15 sessions of physical therapy over three weeks for a total of 30 sessions. Two sessions\u002Fday for 5 days a week. The same subjects will conduct clinical-functional assessments before, at the end of treatment, and after a 3-month follow-up:\n\n3D Gait Analysis with defined protocol (BTSBioenginner); Spastic Paraplegia Rating Scale (SPRS); Six-Minute Walk Test (6MWT), Ten Meters Walk Test (10MWT), Gross Motor Function Measure-88 (GMFM-88) and Berg Balance Scale (BBS); Quality of life questionnaires: Medical Outcome Survey Short Form (SF-36) and ad hoc questionnaire for subjective assessment of symptoms during walking (HSP-SNAP).\n\nThis study is part of normal clinical practice and does not involve any changes to the current rehabilitation course for patients.",[509],"Hereditary Spastic Paraplegia",{"date":467,"type":40},{"date":512,"type":40},"2012-01-01",{"date":345,"type":23},{"name":46,"class":47},{"id":516,"slug":517,"hasResults":12,"nctId":518,"briefTitle":519,"officialTitle":520,"acronym":521,"eligibilityCriteria":522,"healthyVolunteers":12,"sex":18,"minAge":523,"maxAge":19,"enrollmentInfo":524,"targetDuration":4,"studyType":121,"phases":4,"briefSummary":526,"conditions":527,"keywords":528,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":465,"lastUpdatePostDateStruct":530,"startDateStruct":532,"completionDateStruct":533,"leadSponsor":534,"locationsCount":48},"100572761","cp-early-rehabilitation-100572761","NCT06737471","Cp eArly REhabilitation","Italian Cp eArly REhabilitation (iCARE)","iCARE","Inclusion Criteria:\n\n* age between 6 months (corrected age in case of prematurity) and 5 years;\n* a diagnosis of cerebral palsy due to perinatal suffering, neurological syndromes, rare diseases with neurological impairment or congenital diseases of unknown nature.\n\nExclusion Criteria:\n\n* profound deafness and\u002For severe hypovisus\u002Fblindness;\n* a diagnosis of neurodegenerative diseases, acquired brain injury or brain tumor.","36 Months",{"count":525,"type":23},96,"The present study aims to investigate the efficacy of play-based rehabilitation delivered as usual care in children with cerebral palsy in a rehabilitation center offering both intensive and extensive care. Up to now, few studies described and examined treatments' efficacy in this population.\n\nSecondary aim of the study will be comparing the efficacy of the two rehabilitation treatment formats (intensive vs. extensive), which will have the same dose (sessions delivered) and ingredients (content). The intervention delivered as extensive care (3 sessions per week per 15 weeks) will be offered in community rehabilitation centers (Centri di Riabilitazione-CDR), while the one delivered as intensive care (3 sessions daily per 5 days a week for 3 weeks) will be offered to children admitted to hospital inpatient care units. This comparison allows verifying if delivery time may affect outcomes.",[202],[529],"cerebral-palsy; children; pediatric; intervention; rehabilitation; motor; cognitive",{"date":531,"type":40},"2025-05-01",{"date":263,"type":40},{"date":345,"type":23},{"name":46,"class":47},{"id":536,"slug":537,"hasResults":12,"nctId":538,"briefTitle":539,"officialTitle":540,"acronym":4,"eligibilityCriteria":541,"healthyVolunteers":12,"sex":18,"minAge":389,"maxAge":4,"enrollmentInfo":542,"targetDuration":4,"studyType":24,"phases":544,"briefSummary":545,"conditions":546,"keywords":547,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":560,"lastUpdatePostDateStruct":561,"startDateStruct":563,"completionDateStruct":565,"leadSponsor":567,"locationsCount":78},"100569288","efficacy-of-stabilometric-platform-to-improve-standing-balance-in-patients-with-friedreichs-ataxia-100569288","NCT06692296","Efficacy of Stabilometric Platform to Improve Standing Balance in Patients With Friedreich's Ataxia","Studio Pilota Sull'Efficacia Della Pedana Stabilometrica Nel Trattamento Del Paziente Con Atassia di Friedreich","Inclusion Criteria:\n\n* Age ≥ 14 years;\n* Weight \\\u003C 150 kg;\n* Genetic diagnosis of Friedreich's Ataxia;\n* Subscores of SARA (Scale for the Assessment and Rating of Ataxia) as follows: (1) from 1 to 6 for the item 'Gait (walking ability)'; (2) from 1 to 3 for the item 'Stance (ability to maintain a stable posture)'; (3) ability to walk ≥10 metres with or without walking aids; (4) ability to stand unsupported; Stadiation of the Friedreich Ataxia Rating Scale between 2 and 4.\n\nExclusion Criteria:\n\n* Age \\\u003C 14 years;\n* Diagnosis of acquired ataxia;\n* Subscores for items on the SARA scale of: (1) 0 or 7 for gait; (2) 0 or 4-6 for stance;\n* Inability to walk;\n* Ability to walk \\\u003C 10 meters;\n* Standing position possible only with support;\n* Other associated neurological conditions;\n* Current major psychiatric disorder (psychosis and major depression).",{"count":543,"type":23},24,[26],"The primary objective is to evaluate the potential effectiveness of an individualized intensive rehabilitation intervention using the \"Prokin 252\" stabilometric platform in the treatment of adolescent and adult patients with Friedreich's Ataxia. The secondary objective is to assess the retention of the rehabilitation treatment effects over time.\n\nEnrolled patients will be randomized and assigned to one of two treatment groups for four weeks. Three assessments will be conducted for each patient: one before treatment (T0), one at the end of treatment (T1), and a follow-up assessment 90 days after T1 via telemedicine (T2).\n\nThis study is:\n\n* Exploratory: The study aims to explore the usefulness of the stabilometric platform in a rehabilitative setting in combination with conventional therapy;\n* Not \"first-in-human\";\n* Longitudinal: The study will investigate changes over time in motor and functional ability scales, as well as stabilometric platform parameters, within the same cohort;\n* Randomized, controlled, open-label;\n* Monocentric: The study will be conducted only at the \"La Nostra Famiglia\" Association in Conegliano and Pieve di Soligo - IRCCS Eugenio Medea in Conegliano - UOC Neuromotor Rehabilitation in Pieve di Soligo, Via Monte Grappa, 96, 31053 Pieve di Soligo TV;\n* Prospective;\n* Post-market.",[435],[548,435,549,100,550,551,552,553,554,555,556,557,558,559],"randomized controlled trial","balance","training","stabilometric platform","ataxia","therapeutic exercise","standing balance","Scale for the assessment and rating of ataxia","six minute walking test","functional reach test","timed up and go","Friedreich ataxia rating scale","2025-04-29",{"date":562,"type":40},"2025-05-02",{"date":564,"type":40},"2025-02-03",{"date":566,"type":23},"2027-12",{"name":46,"class":47},{"id":569,"slug":570,"hasResults":12,"nctId":571,"briefTitle":572,"officialTitle":573,"acronym":4,"eligibilityCriteria":574,"healthyVolunteers":141,"sex":18,"minAge":575,"maxAge":576,"enrollmentInfo":577,"targetDuration":4,"studyType":24,"phases":578,"briefSummary":579,"conditions":580,"keywords":582,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":586,"lastUpdatePostDateStruct":587,"startDateStruct":589,"completionDateStruct":591,"leadSponsor":593,"locationsCount":181},"100585287","sustained-endogenous-attention-deficits-in-attention-deficit-hyperactivity-disorder-100585287","NCT06900400","Sustained Endogenous Attention Deficits in Attention Deficit Hyperactivity Disorder","Evaluation of Sustained Endogenous Attention Deficits in Attention Deficit Hyperactivity Disorder: Validation of a Computerized Neuropsychological Test.\"","Inclusion Criteria:\n\n* ADHD Group (1) Subjects with a diagnosis of ADHD of any severity level and subtype\n* ADHD Group (2) \"Medication-naive\" ADHD subjects, meaning subjects who have not been prescribed and\u002For have not yet started any pharmacological treatment for ADHD\n* ADHD Group (3) IQ ≥ 70\n* Non-ADHD Group, Normal IQ\n\nExclusion Criteria:\n\n* for both groups, symptomatology suggestive of autism spectrum disorders, psychotic disorders, mood disorders, and anxiety disorders\n* for both groups, use of psychotropic drugs\n* for both groups, subjects with cerebral palsy and\u002For neuromotor and neuromuscular disorders\n* for both groups, CNS diseases, e.g., epilepsy and\u002For neurodegenerative diseases, or central nervous system injuries resulting from, for example, head trauma or stroke\n* for the non-ADHD group, presence of ADHD symptoms","6 Years","13 Years",{"count":145,"type":23},[26],"Subjects with ADHD may exhibit deficits in sustained internal attention. The \"Sustained-Paced Finger Tapping\" test was recently developed and experimentally used in international literature to assess sustained internal attention in typically developing children. This clinical study has several objectives: 1) to assess the presence of \"internal\" sustained attention deficits in children with ADHD through the \"Sustained-Paced Finger Tapping\"; 2) to evaluate the discriminant and ecological validity of the \"Sustained-Paced Finger Tapping.\"",[581],"ADHD - Attention Deficit Disorder With Hyperactivity",[583,584,585],"Case control","diagnostic","ADHD","2025-03-27",{"date":588,"type":40},"2025-03-28",{"date":590,"type":40},"2024-11-11",{"date":592,"type":23},"2026-05",{"name":46,"class":47},{"id":595,"slug":596,"hasResults":12,"nctId":597,"briefTitle":598,"officialTitle":599,"acronym":4,"eligibilityCriteria":600,"healthyVolunteers":141,"sex":388,"minAge":190,"maxAge":4,"enrollmentInfo":601,"targetDuration":4,"studyType":121,"phases":4,"briefSummary":603,"conditions":604,"keywords":607,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":611,"lastUpdatePostDateStruct":612,"startDateStruct":614,"completionDateStruct":615,"leadSponsor":616,"locationsCount":4},"100583272","social-cognition-in-dystrophinopathies-and-neurodevelopmental-disorders-100583272","NCT06874166","Social Cognition in Dystrophinopathies and Neurodevelopmental Disorders","Social Cognition in Dystrophinopathies and Neurodevelopmental Disorders. Behavioural and Psychophisiological Measures","Inclusion Criteria:\n\n* Patients diagnosed with Duchenne and Becker muscular dystrophy (genetic and histological diagnosis and clinical diagnosis) (ambulant and non-ambulant).\n* Patients diagnosed with osteogenesis imperfecta.\n* Control group: participants without any neurological or psychiatric disorder\n\nExclusion Criteria:\n\n* presence of comorbid diagnoses,\n* sensory deficit\n* specific condition that could prevent the application of the tests and tasks under study, such as: a) the need for PEG; b) the need for tracheostomy; c) the need for assisted ventilation.\n* cognitive level lower than 60.",{"count":602,"type":23},45,"The primary aim of this observational study is to investigate specific aspects of social cognition in dystrophinopathies. Body awareness, interpersonal distance and emotional processing will be measured in a sample of patients affected by Becker (BMD) and Duchenne (DMD) muscular dystrophy, compared with a sample of patients affected by osteogenesis imperfecta (OI), and both compared with a control sample with typical development.\n\nThe secondary aim is to study cortical activity at rest, by means of electroencephalography (EEG), to explore frequencies and time course of EEG responses. Moreover, the relationship between EEG activity and neuropsychological, dispositional and subjective measures will be explored through correlational analyses.",[395,605,606],"Osteogenesis Imperfecta (OI)","Social Cognition",[606,608,605,337,609,610],"Duchenne \u002F Becker muscular dystrophy","Interpersonal distance","Interoception","2025-03-11",{"date":613,"type":40},"2025-03-13",{"date":406,"type":23},{"date":566,"type":23},{"name":46,"class":47},{"id":618,"slug":619,"hasResults":12,"nctId":620,"briefTitle":621,"officialTitle":622,"acronym":4,"eligibilityCriteria":623,"healthyVolunteers":141,"sex":18,"minAge":576,"maxAge":4,"enrollmentInfo":624,"targetDuration":4,"studyType":24,"phases":626,"briefSummary":627,"conditions":628,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":630,"lastUpdatePostDateStruct":631,"startDateStruct":633,"completionDateStruct":635,"leadSponsor":636,"locationsCount":78},"100540689","assessment-of-navigation-abilities-in-children-with-cerebral-palsy-and-their-peers-100540689","NCT06320106","Assessment of Navigation Abilities in Children With Cerebral Palsy and Their Peers","Evaluation of Spatial Navigation Skills in Typically Developing Children and in Children With Cerebral Palsy Using a Head Mounted Display","Inclusion Criteria:\n\n* IQ higher than 70\n\nExclusion Criteria:\n\n* Subjects with epileptic issues\n* Subjects with poor head control\n* Visual acuity not correctable with eyeglasses",{"count":625,"type":23},26,[26],"Spatial navigation skills are very important in everyday activities and quality of life but spatial navigation abilities are not part of the standard process of assessment and rehabilitation of patients. Furthermore, it is known that children with cerebral palsy have impaired visuo-spatial competences. The main objective of this study is to evaluate and compare the spatial navigation abilities of typically developing children and of children with cerebral palsy using the \"StarMaze\" application delivered by means of a Head Mounted Display (HMD). The second aim is to investigate the user experience during the session. A similar application was already developed and tested in a virtual reality large scale platform whose size and cost limit the accessibility. Therefore, the assessment (and future training) of navigation abilities with affordable and easy-to-use technology such as HMD open new perspectives.",[202,629],"Healthy Volunteers","2025-02-25",{"date":632,"type":40},"2025-02-26",{"date":634,"type":40},"2023-02-07",{"date":345,"type":23},{"name":46,"class":47},{"id":638,"slug":639,"hasResults":12,"nctId":640,"briefTitle":641,"officialTitle":642,"acronym":643,"eligibilityCriteria":644,"healthyVolunteers":12,"sex":18,"minAge":645,"maxAge":4,"enrollmentInfo":646,"targetDuration":4,"studyType":24,"phases":647,"briefSummary":648,"conditions":649,"keywords":650,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":652,"lastUpdatePostDateStruct":653,"startDateStruct":655,"completionDateStruct":657,"leadSponsor":658,"locationsCount":78},"100581520","expanding-ngs-data-with-optical-genome-mapping-ogm-100581520","NCT06851377","Expanding NGS Data with Optical Genome Mapping (OGM)","Expanding NGS Data with Optical Genome Mapping (OGM): More Comprehensive Variant Detection in Children with Unexplained Rare Genetic Disorders","OGM","Inclusion Criteria:\n\n* individuals without a molecular diagnosis (negative to ES\u002FCMA analyses);\n* individuals with genetic diagnoses that explain only one component of their primary phenotype;\n* individuals carrying one or more variants of uncertain clinical significance\n* individuals with a phenotype highly reminiscent of clinically and molecularly well-defined syndromes (i.e., Marfan Syndrome) but negative to routine molecular analysis.\n\nExclusion Criteria:\n\n* individuals who have not undergone initial diagnostic genetic tests (ES\u002FCMA)","2 Years",{"count":357,"type":23},[26],"Over 50% of pediatric neurological and neurodevelopmental disorders lack a molecular diagnosis after standard DNA sequencing and molecular karyotyping. This is due to technical limitations, incomplete variant interpretation, and inadequate genotype-phenotype correlations. New sequencing technologies are crucial for clinical decision-making, offering complete profiles of variants in a patient's DNA to personalize treatment. Optical Genome Mapping (OGM) can detect nearly all structural variants in one experiment. This project aims to use OGM alongside NGS to improve diagnostic yield in 60 children with severe disorders who tested negative for NGS\u002FCMA.",[124],[651],"Optical Genome Mapping, neurodevelopmental disorders, genome sequencing","2025-02-24",{"date":654,"type":40},"2025-02-28",{"date":656,"type":40},"2024-05-23",{"date":265,"type":23},{"name":46,"class":47},{"id":660,"slug":661,"hasResults":12,"nctId":662,"briefTitle":663,"officialTitle":664,"acronym":4,"eligibilityCriteria":665,"healthyVolunteers":12,"sex":18,"minAge":666,"maxAge":667,"enrollmentInfo":668,"targetDuration":4,"studyType":121,"phases":4,"briefSummary":669,"conditions":670,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":672,"lastUpdatePostDateStruct":673,"startDateStruct":675,"completionDateStruct":677,"leadSponsor":679,"locationsCount":214},"100580060","intensive-physiotherapy-in-children-affected-by-posterior-fossa-tumors-100580060","NCT06832384","Intensive Physiotherapy in Children Affected by Posterior Fossa Tumors","Intensive Physiotherapy Intervention in Children Affected by Tumors Located in Posterior Cranial Fossa","Inclusion Criteria:\n\n* subjects who underwent to surgical resection of tumors located in posterior fossa, age between 0 and 25 years\n\nExclusion Criteria:\n\n* Subjects that are currently addressed to rehabilitative protocols availing of technological devices","0 Years","25 Years",{"count":22,"type":23},"The objective of the current study is to describe the effectiveness of conventional and intensive physiotherapeutic intervention in improving gross motor skills (i.e. postural changes, walking and balance skills) in children affected by posterior fossa tumors",[671],"Posterior Fossa Tumor","2025-02-12",{"date":674,"type":40},"2025-02-18",{"date":676,"type":40},"2023-01-19",{"date":678,"type":23},"2026-01-19",{"name":46,"class":47},""]