[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"IRCCS San Camillo, Venezia, Italy\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":230},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,40,68,98,133,157,181,205],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100635210","clinical-and-instrumental-assessment-tools-for-neurogenic-dysphagia-translation-and-validation-100635210",false,"NCT07549724","Clinical and Instrumental Assessment Tools for Neurogenic Dysphagia: Translation and Validation","Val_Dysphagia","IInclusion Criteria:\n\nAdult patients (≥18 years) diagnosed with neurogenic dysphagia due to any neurological condition (e.g., stroke, Parkinson's disease, multiple sclerosis, traumatic brain injury) Able to understand and comply with study procedures Provide written informed consent (or legal representative consent if necessary) Stable medical and neurological condition at the time of assessment\n\nExclusion Criteria:\n\nActive respiratory infection or acute illness affecting swallowing at the time of assessment History of head and neck surgery or anatomical abnormalities preventing standardized assessment of swallowing or reflex cough Severe uncontrolled comorbidities (cardiac, pulmonary, or systemic) that make study participation unsafe","ALL","18 Years","85 Years",{"count":20,"type":21},100,"ESTIMATED","1 Week","OBSERVATIONAL","This study aims to translate and validate Italian versions of several clinical assessment tools for patients with neurogenic dysphagia. The instruments include:\n\nThe New Zealand Secretion Severity Scale, which evaluates secretion management; The Reflex Cough Test from the I\\&I cranial nerves assessment; The VASES scale used during fiberoptic endoscopic evaluation of swallowing; The Drooling Severity Scale, which measures saliva control.\n\nThe study will include approximately 100 patients with neurogenic dysphagia. The goal is to provide reliable, standardized tools in Italian to support clinicians in assessing swallowing and oral-motor function in patients with neurological disorders.",[26],"Dysphagia","RECRUITING","2026-04-17",{"date":30,"type":31},"2026-04-24","ACTUAL",{"date":33,"type":31},"2025-03-09",{"date":35,"type":21},"2028-12-30",{"name":37,"class":38},"IRCCS San Camillo, Venezia, Italy","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":47,"enrollmentInfo":48,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":50,"conditions":51,"keywords":54,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":39},"100632814","development-and-validation-of-language-and-communication-assessment-scales-100632814","NCT07518576","Development and Validation of Language and Communication Assessment Scales","SCALE_COM","Inclusion Criteria:\n\nPatient admitted to the hospital for an intensive neurorehabilitation cycle or attending as an outpatient Diagnosis of language and communication disorders following a stroke in the right or left hemisphere Age \\> 18 years Ability to provide informed consent Native speaker of Italian (L1 Italian)\n\nExclusion Criteria:\n\n* Unstable clinical conditions that may interfere with participation in the study (e.g., active symptomatic infections, stupor, need for oxygen therapy)","90 Years",{"count":49,"type":21},50,"The aim of speech therapy for people with aphasia is to improve their ability to communicate in daily life. Traditional evaluations focus on linguistic tasks, but they do not fully address everyday communication skills, which are crucial for creating personalized treatment goals. The study suggests a multimodal approach to language assessment, stressing the importance of gestures in communication. It calls for the development of tools that evaluate communication in a wider context, including factors like motivation, attention, awareness, and alternative communication strategies. Additionally, there is a need for tools specifically designed to assess communicative gestures.",[52,53],"Language Disorders","Aphasia",[55,56,57,58,59],"language disorders","aphasia","conversation","gestures","assessment","2026-04-02",{"date":62,"type":31},"2026-04-08",{"date":64,"type":31},"2022-05-09",{"date":66,"type":21},"2026-12-31",{"name":37,"class":38},{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":75,"enrollmentInfo":76,"targetDuration":4,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":84,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":39},"100484668","biofeedback-as-an-adjunctive-treatment-for-post-stroke-dysphagia-100484668","NCT05591040","Biofeedback as an Adjunctive Treatment for Post-stroke Dysphagia","Biofeedback as an Adjunctive Treatment for Post-stroke Dysphagia: A Multicentric Randomized Controlled Trial","Inclusion Criteria:\n\n* first stroke injury\n* onset from more than six weeks\n* presence of dysphagia\n* good comprehension ( not below PT 53 in Token Test)\n* good eyesight and hearing, or adequately corrected\n\nExclusion Criteria:\n\n* All the elements that hinder a good recording of the electromyographic signal (for instance a cutaneous infection, a wound or a dermatitis in the submandibular area);\n* Severe concomitant illnesses (fever, infections, metabolic problems, serious cardiac insufficiency) that can influence patient's collaboration;\n* Serious dystonia or unintentional movements\n* presence of disorders of consciousness;\n* encephalopathy due to multiple infarcts;\n* inability to sustain the experimental treatment;\n* other neurological diseases (for example Parkinson disease)","89 Years",{"count":20,"type":21},"INTERVENTIONAL",[79],"NA","The aim of the study is to evaluate whether the effect of biofeedback treatment is more effective than a control treatment in the recovery of dysphagia.\n\nThis study will be a multicentric randomized, single-blind controlled study. The investigators intend to recruit 100 patients who have suffered a stroke and have dysphagia. Fifty patients will undergo training with bio-feedback (experimental group) and the other fifty patients will undergo standard training, using only verbal feedback rather than visual feedback (control group). Our hypothesis, based on the results obtained in some previous studies, is that in the control group the efficacy of the treatment will be lower in the absence of immediate visual feedback of strength, timing, coordination and efficacy of the swallowing act.",[26,82,83],"Rehabilitation","Stroke",[85,86,87,88,89],"dysphagia","stroke","biofeedback","rehabilitation","randomized controlled study","2026-03-25",{"date":92,"type":31},"2026-03-27",{"date":94,"type":31},"2022-10-30",{"date":96,"type":21},"2027-12-03",{"name":37,"class":38},{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":106,"sex":16,"minAge":107,"maxAge":47,"enrollmentInfo":108,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":110,"conditions":111,"keywords":116,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":132},"100511034","exploring-the-gut-brain-axis-in-ageing-and-neurodegeneration-100511034","NCT05934188","Exploring the Gut-Brain Axis in Ageing and Neurodegeneration","Role of the Gut-microbiota on Ageing and Neurodegeneration: a Clinical and Brain Imaging Study","GutBrain","INCLUSION CRITERIA:\n\nHealthy Young and Old Subjects:\n\n* 20-50 or 60-90 years old\n* Cognitively healthy (Mini-Mental State examination ≥ 26)\n* Absence of significant neurological disorders\n\nPatients with prodromal Alzheimer's Disease:\n\n* Subjective cognitive complaint (corroborated by the informant)\n* Episodic memory deficit on neuropsychological testing\n* Clinical Dementia Rating = 0.5\n* Mini-Mental State Examination (MMSE) \\> 23\n* Independently functioning in activities of daily living\n\nPatients with Parkinson's Disease:\n\n* Recent diagnosis of Parkinson's Disease\n* Mild-moderate score at the Unified Parkinson's Disease Rating Scale (UPDRS)\n* Cognitively healthy (Mini-Mental State examination ≥ 26)\n* In case of taking medications for Parkinson's Disease: stable dosage for at least 6 months\n\nPatients with Multiple Sclerosis:\n\n* Recent diagnosis of relapsing-remitting Multiple Sclerosis\n* Expanded Disability Status Scale score ≤ 4.0\n* Cognitively healthy (Mini-Mental State examination ≥ 26)\n* In case of taking medications for Multiple Sclerosis: stable dosage for at least 6 months.\n\nEXCLUSION CRITERIA:\n\nFor both healthy participants and patients:\n\n* Contraindications to magnetic resonance imaging (metal implant in body, known claustrophobia, pacemakers)\n* Severe comorbidities\n* Antibiotics treatments over the last 3 months",true,"20 Years",{"count":109,"type":21},200,"Neurodegenerative diseases are a major health concern due to their growing societal implications and economic costs. The identification of early markers of pathogenic mechanisms is one of the current main challenges. The gut-brain axis has become a primary target because of its transversal role across the neurodegenerative spectrum and its effect on cognition. However, despite recent progress, how changes in the gut-microbiota composition can affect the human brain is still unclear.\n\nThe goal of this observational study is to characterise the gut-microbiota composition associated with alterations in brain structure and function during the ageing process and across neurodegenerative disorders. This is based on recent studies showing that changes in the human brain and in the microbiota composition, can indicate very sensitively and in a predictive way pathological development and, consequently, be used as markers of neurodegenerative diseases.\n\nThe main questions it aims to answer are:\n\n* How variation in the gut-microbiota composition correlates with the normal brain ageing trajectory?\n* How dysregulation in the gut-microbiota correlates with pathological changes in brain regions in specific neurodegenerative disorders?\n* Can the impact of the gut-microbiota on the brain be modulated by blood biomarkers?\n\nThe investigators will recruit 40 young healthy participants, 40 old healthy participants, 40 participants with prodromal Alzheimer's Disease, 40 participants with Parkinson's Disease and 40 participants with Multiple Sclerosis.\n\nParticipants will undergo the following examinations:\n\n* Magnetic Resonance Imaging\n* Analysis of a stool sample\n* Analysis of a blood sample\n* Neuropsychological assessment\n* Questionnaires on eating habits",[112,113,114,115],"Healthy","Prodromal Alzheimer's Disease","Parkinson Disease","Multiple Sclerosis",[117,118,119,120,121,122,123],"MRI","Microbiota","Stool sample","Blood sample","Neuropsychological assessment","Neuroimaging","Biomarkers for brain disorders","2026-01-07",{"date":126,"type":31},"2026-01-09",{"date":128,"type":31},"2023-05-01",{"date":130,"type":21},"2027-04-30",{"name":37,"class":38},3,{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":139,"eligibilityCriteria":140,"healthyVolunteers":106,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":141,"targetDuration":4,"studyType":77,"phases":143,"briefSummary":144,"conditions":145,"keywords":146,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":156},"100590304","assessment-of-eye-movements-in-stroke-patients-and-closed-loop-intervention-100590304","NCT06965673","Assessment of Eye Movements in Stroke Patients and Closed-loop Intervention","Eye-movement Dynamics During Free Viewing as a Biomarker for Assessment of Visuospatial Functions and for Closed-loop Rehabilitation in Stroke","EMS","Inclusion Criteria:\n\n* Vigilant\n* First unifocal ischemic or hemorragic stroke\n* Presence of maximum two lacunae, clinically silent, smaller than 15 mm. in the structural MRI\n* Evident symptoms in the visual, attentive, memory, motor or language domain supported by the radiological exam\n\nExclusion Criteria:\n\n* Previous stroke history, visible at the radiological exam\n* Multifocal deficit\n* Incapacity to remain vigilant during the required assessments\n* Claustrophobia and\u002For metallic objects which could prevent MRI acquisition\n* Presence of other neurological, psychiatric or medical conditions which may undermine interpretation of behavioral and neuroimaging results",{"count":142,"type":21},30,[79],"The current study evaluates first the assumption that eye-movements during free viewing behavior are potential biomarkers of visuospatial deficits in stroke population. Second, it assesses the feasibility of a novel visual exploration training to ameliorate visuospatial deficits, by exploiting an auditory biofeedback system coupled with online parsed fixations.",[83],[147],"Visuospatial","2025-05-01",{"date":150,"type":31},"2025-05-11",{"date":152,"type":31},"2023-04-01",{"date":154,"type":21},"2025-06",{"name":37,"class":38},2,{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":161,"acronym":162,"eligibilityCriteria":163,"healthyVolunteers":11,"sex":16,"minAge":107,"maxAge":18,"enrollmentInfo":164,"targetDuration":4,"studyType":77,"phases":165,"briefSummary":166,"conditions":167,"keywords":169,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":39},"100565321","investigating-visuo-spatial-abilities-and-psychological-effects-in-west-nile-and-multiple-sclerosis-patients-with-a-focus-on-a-possible-rehabilitation-protocol-100565321","NCT06640660","Investigating Visuo-spatial Abilities and Psychological Effects in West Nile and Multiple Sclerosis Patients with a Focus on a Possible Rehabilitation Protocol","Visuomind","Inclusion Criteria:\n\n* Diagnosis of: Multiple Scleroris OR vWN infection ascertained by laboratory analysis and received no later than twelve months prior to the date of hospitalization\n* preserved use of at least one hand\n* normal or corrected to normal vision\n\nExclusion Criteria:\n\n* history of psychiatric and\u002For concurrent neurological diseases\n* inability to provide informed consent,\n* impaired comprehension of oral instructions,",{"count":49,"type":21},[79],"The study aims to investigate visuospatial abilities and psychological outcomes in patients with multiple scleroris (MS) and patients with West Nile virus infection (vWN). Patients will undergo a specific neuropsychological and psychological evaluation. Afterwards, patients will receive 10 sessions of cognitive training integrating digital exercises and prismatic lenses. At the end of the treatment, patients will be re-evaluated to explore for potential changes in the cognitive and psychological profile.",[115,168],"West Nile Virus",[170,171,172],"neurological patients","cognitive training","neuropsychology","2024-10-11",{"date":175,"type":31},"2024-10-15",{"date":177,"type":31},"2022-09-21",{"date":179,"type":21},"2024-12-30",{"name":37,"class":38},{"id":182,"slug":183,"hasResults":11,"nctId":184,"briefTitle":185,"officialTitle":185,"acronym":186,"eligibilityCriteria":187,"healthyVolunteers":106,"sex":16,"minAge":188,"maxAge":47,"enrollmentInfo":189,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":191,"conditions":192,"keywords":194,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":199,"startDateStruct":200,"completionDateStruct":202,"leadSponsor":204,"locationsCount":39},"100565322","electrophysiological-signature-of-mild-cognitive-impairment-and-its-relationship-with-parkinsons-disease-a-high-density-eeg-investigation-100565322","NCT06640673","Electrophysiological Signature of Mild Cognitive Impairment and Its Relationship with Parkinson's Disease: a High-density EEG Investigation","MMCI","Inclusion Criteria:\n\n* Upper score \\>24 MMSE or \\>15.5 Moca\n* If taking medications, taking stable doses for at least 4 weeks prior to the inclusion visit - of anticholinesterase drugs (donepezil, memantine, rivastigmine, ...) or antidepressants (SSRIs, tricyclics, SNARI, ...) or Levodopa.\n* Having signed the informed consent\n\nExclusion Criteria:\n\n* Subjects with severe dementia ( MMSE \\\u003C 24 )\n* Lower score \\\u003C15.5 Moca\n* Subjects on antipsychotic treatment for less than 3 months\n* Subjects with uncontrolled comorbidities\n* Subjects with metal prostheses or dentures and in general conditions for which MRI examinations are prevented.\n* Subjects with an inability to walk independently.","50 Years",{"count":190,"type":21},42,"The study aims to investigate neural correlate of Mild Cognitive Impairment (MCI) in Parkinson's disease (PD) and to identify a link between functional impairment (in both cognitive and motor domains) and electrophysiological cortical sing of MCI in PD. A sample of 42 subjects will be divide into three subgroup: healthy control, PD with MCI (PD-MCI) and PD without MCI (PD-ctrl). Those subjects will undergo a specific neuropsychological evaluation and, to measure the electro-cortical activity, high-density electroencephalography (hdEEG) will be record during both resting state and cognitive tasks. Furthermore, hdEEG data will be combine with structural magnetic resonance to obtain information about network connectivity.",[114,193,112],"Parkinson Disease, Mild Cognitive Impairment",[195,196,197,198],"MCI in PD","Mild Cognitive Impairment","Parkinson's disease","Hd-EEG",{"date":175,"type":31},{"date":201,"type":31},"2023-06-18",{"date":203,"type":21},"2025-05",{"name":37,"class":38},{"id":206,"slug":207,"hasResults":11,"nctId":208,"briefTitle":209,"officialTitle":209,"acronym":210,"eligibilityCriteria":211,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":212,"targetDuration":4,"studyType":77,"phases":214,"briefSummary":215,"conditions":216,"keywords":217,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":222,"lastUpdatePostDateStruct":223,"startDateStruct":225,"completionDateStruct":227,"leadSponsor":229,"locationsCount":39},"100502768","financial-abilities-in-neurological-diseases-development-of-a-telerehabilitation-program-finage-100502768","NCT05826548","Financial Abilities in Neurological Diseases. Development of a Telerehabilitation Program: FINAGE","FINAGE","Inclusion Criteria:\n\n* diagnosis of: Mild Cognitive Impairment, Parkinson's disease and stroke\n* preserved use of at least one hand,\n* normal or corrected to normal vision\n\nExclusion Criteria:\n\n* history of psychiatric and\u002For concurrent neurological diseases\n* inability to provide informed consent,\n* impaired comprehension of oral instructions,",{"count":213,"type":21},140,[79],"Financial Abilities (FA) are a set of capacities that allow a person to independently manage her\u002Fhis financial affairs in a manner consistent with personal self-interests and values. This project will: a) assess Financial Abilities in different neurological conditions: Mild Cognitive Impairment, Parkinson's disease and Stroke patients; b) investigate both cognitive correlations, specifically the role of executive functions, thought to be critically involved in the FA multi-dimensional concept, and neuro-anatomical correlates of Financial Abilities; c) build a rehabilitation tool in order to improve FA. Secondary aims are to apply this rehabilitation tool at long distance and evaluate its behavioral, functional and neuroanatomical effects. The starting point for this project is the recently published NADL-F - Numerical Activities of Daily Living - Financial, a multi-domain ecological battery aimed at assessing FA in healthy people as well as in neurological patient populations",[114,196,83],[218,219,220,221],"Financial Abilities","Telerehabilitation","Cognitive rehabilitation","Changes in neurocognitive and functional domains","2024-10-04",{"date":224,"type":31},"2024-10-08",{"date":226,"type":31},"2021-03-11",{"date":228,"type":21},"2025-02-17",{"name":37,"class":38},""]