[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Igenomix\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":111},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,80],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100625935","pilot-study-of-discarded-blastocysts-100625935",false,"NCT07429097","Pilot Study of Discarded Blastocysts","Prospective Observational Pilot Study of Discarded Blastocysts: a Molecular Approach to Uncovering Hidden Reproductive Potential","DECODE","Inclusion Criteria:\n\n* Patients whose written informed consent approved by the Ethic Committee has been obtained, after having been duly informed of the nature of the study and voluntarily accepted to participate after being fully aware of the potential risks, benefits, and any discomfort involved.\n* Patients undergoing regular IVF\u002FICSI cycles with fresh oocytes and embryo culture to the blastocyst stage (day 5-6 after fertilization)\n* Patients' age will be between 20-42 years of age.\n* Patients without PGT-M or PGT-SR indication.\n\nExclusion Criteria:\n\n* Patients who do not have at least one discarded blastocyst on day 5-6 of development.\n* Patients with discarded blastocysts that do not meet these criteria:\n* Presence of ICM\n* Non-degenerated","FEMALE","20 Years","42 Years",{"count":21,"type":22},150,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to determine multiomics patterns related to global embryo quality to help overcome the limitations of conventional embryo quality assessment. The main question it aims to answer is:\n\n• Do discarded blastocysts that reach the blastocyst stage (days 5-6) show characteristic multiomics profiles which correlate with chromosomal abnormalities, providing insights into embryo viability?\n\nFor that, patients undergoing an IVF treatment will be asked to donate their clinically discarded 5\u002F6-day embryos (those that do not meet clinical criteria to be used for reproductive purposes). Participation in the study will not interfere with the planned IVF treatment. Patient participation is limited to signature of the informed consent to donate embryos and no other study-specific procedures will be performed on participants.",[26],"Infertility (IVF Patients)",[28,29,30,31,32],"blastocyst","aneuploidy","inner cell mass","PGT-A","trophectoderm","NOT_YET_RECRUITING","2026-02-23",{"date":36,"type":37},"2026-02-24","ACTUAL",{"date":39,"type":22},"2026-02",{"date":41,"type":22},"2027-05",{"name":43,"class":44},"Igenomix","INDUSTRY",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},"100556403","international-pilot-study-for-dual-non-invasive-assesment-of-embryo-development-100556403","NCT06524648","International Pilot Study for Dual Non-invasive Assesment of Embryo Development","A Prospective, Multicenter, Observational Pilot Study to Evaluate the Combination of niPGT-A and Morphokinetics for the Non-invasive Assessment of Embryo Development","PANDORA","Inclusion Criteria:\n\n* Study ICF signature.\n* Female age between 20 and 42 years (bot included).\n* IVF, ICSI or IVF\u002FICSI performed in fresh own or donated oocytes. Note: donor sperm is allowed.\n* niPGT-A cases with a deferred SET (of a day 6\u002F7 vitrified blastocyst) for any medical indication.\n* Embryos cultured individually in a TL system from day 0\u002F1 to day 6\u002F7.\n\nExclusion Criteria:\n\n* Embryos with abnormal fertilization (different from 2PN). (Note: In case of no 2PN embryos, patients may repeat the COS cycle).\n* Female\u002Fcouple with PGT-M and\u002For PGT-SR indication.\n* Assisted hatching and\u002For artificial collapse before media collection.\n* Known abnormal karyotype.\n* Pathologies or malformations affecting the uterine cavity (polyps, intramural myomas ≥ 4cm or submucosal, septum or hydrosalpinx) during the patient's participation. (Note: patients are allowed to participate if the pathology is previously operated at least 3 months before patient enrollment).\n* Any illness or medical condition that is unstable or which, according to medical criteria, may put at risk the patient's safety and her compliance in the study.",{"count":55,"type":22},200,"Choosing the best embryo is one of the major challenges for achieving success in in vitro fertilization (IVF). Traditionally, embryo evaluation has been based on morphological quality (how the embryo looks like) and chromosomal status as diagnosed by a genetic testing. However, recently new techniques that do not require manipulation of the embryo have been developed and have shown promising results.\n\nThe goal of this observational study is, by combining two non-invasive techniques, to find out some parameters during embryo development which may be related with the embryo's chromosomic status. For that, infertile women planning to undergo an IVF\u002FICSI treatment with a recommended niPGT-A (non-invasive Preimplantation Genetic Testing for Aneuploidies) will be invited to join the study. The main question it aims to answer is:\n\n* Can morphokinetics parameters correlate with embryo chromosomal status?\n\nParticipants will follow their previously programmed IVF\u002FICSI treatment and no additional visits\u002Finterventions will be required by their participation in the study. The obtained embryos will be cultured in a time-lapse system instead of in a conventional incubator, and niPGT-A will be performed. Following the standard practice, a deferred single embryo transfer (SET) will be performed according to the niPGT-A results. After the transfer, patients will be followed-up as usual.",[58],"Infertility",[58,60,61,62,63,64,65,66,67,68,69],"In vitro fertilization","Time lapse","niPGT-A","Embryo Development","Embryonic cell-free DNA","Morphokinetics","Artificial Intelligence","Embryo selection","Blastocyst","Ongoing pregnancy rate","RECRUITING","2025-07-29",{"date":73,"type":37},"2025-08-01",{"date":75,"type":37},"2024-10-29",{"date":77,"type":22},"2027-01",{"name":43,"class":44},8,{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":88,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":93,"conditions":94,"keywords":95,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":45},"100588405","study-of-abnormally-fertilized-embryos-100588405","NCT06940973","Study of Abnormally Fertilized Embryos","Prospective Observational Study of the Morphokinetics and Ploidy of Blastocysts With Abnormal Fertilization (1PN, 2.1PN and 3PN) to Identify the Origin of Fertilization Alterations","SAFE","Inclusion Criteria:\n\n* ART patients who sign the Informed Consent of the study.\n* Age: oocytes from women ≤ 49 years and semen from men ≤ 60 years. Donation of gametes is allowed.\n* ≥1 blastocysts from oocytes with an abnormal pronuclear pattern (1PN, 2.1PN, and\u002For 3PN) and with the presence of 2 polar bodies (PB), cultured in a time-lapse incubator.\n\nExclusion Criteria:\n\n* No exclusion criteria have been considered for this study.","ALL","18 Years","49 Years",{"count":92,"type":22},300,"The goal of this observational study is to determine the diploidy rate of haploid and triploid embryos from in vitro fertilization (IVF) cycles. The main questions it aims to answer are:\n\n* Can a molecular genetic fertilization check of abnormally fertilized embryos be used to expand opportunities for couples undergoing assisted reproduction treatment?\n* Is the chromosomal loss or gain present in abnormally fertilized embryos predominantly maternal in origin?\n\nFor this purpose, we will evaluate the morphokinetics and ploidy of about 300 embryos with different types of abnormal pronuclear patterns (1PN, 2.1PN, and 3PN) that reach the blastocyst stage. Whenever possible, embryos with a non-diploid chromosomal complement will also be assessed to determine the origin (maternal or paternal) of the chromosomal set that has been lost or gained.\n\nStudy subjects will follow their previously scheduIed IVF\u002FICSI treatment and no additional visits\u002Finterventions will be required for participating.",[26],[31,62,68,58,60,96,97,98,99,100,101,102],"Ploidy","Embryo development","Time-lapse culture","Triploid","Haploid","Abnormal fertilization","Pronuclei","2025-04-16",{"date":105,"type":37},"2025-04-23",{"date":107,"type":22},"2025-04",{"date":109,"type":22},"2026-09",{"name":43,"class":44},""]