[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Inonu University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":687},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,48,0,25,[9,45,79,103,132,159,180,215,244,273,305,334,363,385,413,436,460,487,511,534,560,591,621,642,663],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100054107","the-effect-of-mandala-art-therapy-on-surgical-fear-and-the-stress-hormone-cortisol-in-high-risk-pregnant-women-before-cesarean-section-100054107",false,"NCT07691320","The Effect of Mandala Art Therapy on Surgical Fear and the Stress Hormone (Cortisol) in High-risk Pregnant Women Before Cesarean Section.","The Effect of Mandala Art Therapy Applied Before Cesarean Section on Surgical Fear and Cortisol Levels in High-Risk Nulliparous Women: A Randomized Controlled Trial","Inclusion Criteria:\n\n* The study sample will consist of high-risk nulliparous women scheduled for elective cesarean section on the same day. Participants will be included if they are 18 years of age or older, diagnosed with high-risk pregnancy conditions (e.g., preeclampsia, gestational diabetes, placenta previa, oligohydramnios, etc.), at term pregnancy (37-42 weeks gestation), with a singleton pregnancy, and able to understand and complete the data collection forms.\n\nExclusion Criteria:\n\n* Women with a diagnosed psychiatric disorder, any condition that impairs communication (such as hearing, visual, or language impairments), those receiving systemic corticosteroid therapy, those with endocrine disorders that may affect cortisol levels, and those with active oral lesions such as aphthous ulcers or other oral mucosal lesions will be excluded from the study.","FEMALE","18 Years","40 Years",{"count":21,"type":22},142,"ESTIMATED","INTERVENTIONAL",[25],"NA","This randomized controlled study aims to evaluate the effect of mandala art therapy applied before cesarean section on surgical fear and cortisol levels in high-risk pregnant women. Participants will be randomly assigned to intervention and control groups. The intervention group will receive mandala art therapy prior to surgery, while the control group will receive standard care. Surgical fear levels and salivary cortisol levels will be measured to assess the outcomes.",[28],"High-risk Nulliparous Pregnancy, Patients Scheduled for Cesarean Section, Surgical Fear, Preoperative Anxiety, and Cortisol Level",[30,31,32],"Cortisol","Surgical Fear","Cesarean","NOT_YET_RECRUITING","2026-07-09",{"date":36,"type":37},"2026-07-13","ACTUAL",{"date":39,"type":22},"2026-08-01",{"date":41,"type":22},"2027-08-01",{"name":43,"class":44},"Inonu University","OTHER",{"id":46,"slug":47,"hasResults":12,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":56,"conditions":57,"keywords":63,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},"100641063","the-effect-of-pre-breastfeeding-breathing-exercises-on-maternal-anxiety-well-being-and-infant-stress-in-mothers-whose-infants-are-in-the-neonatal-intensive-care-unit-100641063","NCT07634445","The Effect of Pre-Breastfeeding Breathing Exercises on Maternal Anxiety, Well-being, and Infant Stress in Mothers Whose Infants Are in the Neonatal Intensive Care Unit","The Effect of Pre-Breastfeeding Breathing Exercises on Maternal Anxiety, Well-being, and Infant Stress in Mothers Whose Infants Are in the Neonatal Intensive Care Unit: A Radicalized Controlled Study","Inclusion Criteria:\n\n* Ability to communicate verbally,\n* Being 18 years of age or older,\n* Having a baby in the neonatal intensive care unit,\n* Breastfeeding.\n\nExclusion Criteria:\n\n* Having a psychiatric diagnosis according to medical records,\n* The mother having a definite health problem in the postpartum period that prevents breastfeeding (heart disease, etc.),\n* The study being terminated due to the newborn being discharged from the hospital,\n* Incomplete data collection.",true,{"count":54,"type":22},70,[25],"Aim: This study was conducted to examine the effects of breathing exercises on maternal anxiety, well-being, and infant stress.\n\nMaterials and Methods: The research was initiated in a hospital in eastern Turkey between November 2024 and November 2026, after obtaining ethical committee and institutional approvals. The study population consisted of mothers whose babies were hospitalized in the neonatal intensive care unit (NICU) of that hospital.The generally available G\\*Power 3.1.9.7 for Windows software was used to calculate the sample size. Similar literature studies were referenced when determining the sample size of the research (Shamsdanesh et al., 2023). Furthermore, after the research is completed, a post-hoc power analysis will be performed on the main dependent variable, maternal anxiety level (MAL), to determine the power of the study (approximately 35 experimental, 35 control). The aim of the research is to ensure that the resulting sample size has sufficient statistical power to reveal the effect being examined. The research data is collected using a Demographic Information Form, prepared by the researcher through a literature review, the State and Trait Anxiety Inventory, the Psychological Well-being Scale, and the Neonatal Stress Scale. Mothers perform this exercise three times a day for two days (days 1 and 2), under the supervision of a researcher. The four-square breathing exercise is a non-pharmacological pain reliever that has been shown to be beneficial in conditions other than pain. Each breathing exercise lasts 5-10 minutes. Mothers in the experimental group are given a questionnaire before the start of the study and after the exercise on days 1 and 2. Mothers in the control group are given only a questionnaire before the start of the study, at the end of day 1, and at the end of day 2. Mothers in the control group do not perform the four-square breathing exercise and receive routine hospital care. At the end of both days, mothers in the control group who wish to practice the breathing exercise are given the opportunity to do so.",[58,59,60,61,62],"Anxiety","Psychological Well-being","Stress","Breath Exercise","Newborn",[64,65,66,67,68],"newborn","anxiety","stress","breathing exercise","psychological well-being","RECRUITING","2026-06-16",{"date":72,"type":37},"2026-06-18",{"date":74,"type":37},"2024-12-10",{"date":76,"type":22},"2026-11",{"name":43,"class":44},1,{"id":80,"slug":81,"hasResults":12,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":52,"sex":86,"minAge":18,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":78},"100642205","anxiety-levels-in-living-liver-donors-100642205","NCT07576920","Anxiety Levels in Living Liver Donors","Evaluation of Preoperative and Postoperative Anxiety in Living Liver Donors","Inclusion Criteria:\n\n* ASA 1-2 group patients aged 18-65 years who are liver transplant donors\n\nExclusion Criteria:\n\n* Patients with communication problems, those who are illiterate,\n* Patients do not have sufficient time for the tests,\n* Patients using sedatives, antidepressants, or antiepileptic drugs,\n* Patients with cerebrovascular or psychiatric diseases,\n* Patients with alcohol or substance addiction,\n* Patients who do not want or cannot undergo the second test","ALL","65 Years",{"count":89,"type":22},100,"OBSERVATIONAL","Anxiety is a state of worry and apprehension caused by internal and external threats. High preoperative anxiety levels have been associated with increased anesthetic requirements, higher morbidity, and mortality rates. In adult patients undergoing various surgical procedures, preoperative anxiety rates have been reported to range from 11% to 80%. Most studies show that postoperative anxiety levels are related to preoperative anxiety levels. In patients undergoing general anesthesia, anxiety levels increase a few days after surgery as issues related to recovery and pain become apparent. Patients with high postoperative anxiety levels have also been reported to have a higher rate of medical complications.",[93],"Anxiety Postoperative",[58,95],"Liver Transplantation","2026-06-15",{"date":70,"type":37},{"date":99,"type":37},"2026-05-04",{"date":101,"type":22},"2026-07-30",{"name":43,"class":44},{"id":104,"slug":105,"hasResults":12,"nctId":106,"briefTitle":107,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":12,"sex":86,"minAge":109,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":23,"phases":113,"briefSummary":114,"conditions":115,"keywords":118,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":78},"100643718","comparison-of-the-efficacy-of-inferior-alveolar-nerve-block-and-digital-anesthesia-in-pulpectomy-of-mandibular-permanent-molars-in-children-100643718","NCT07634900","Comparison of the Efficacy of Inferior Alveolar Nerve Block and Digital Anesthesia in Pulpectomy of Mandibular Permanent Molars in Children","Inclusion Criteria:\n\n* Children aged 6-14 years\n* Patients presenting with acute dental pain\n* Patients requiring emergency endodontic treatment in mandibular permanent molars\n* Cooperative patients who allowed clinical procedures\n* Patients whose parents\u002Flegal guardians provided informed consent\n\nExclusion Criteria:\n\n* Patients with systemic diseases affecting pain perception\n* Patients with known allergy to local anesthetic agents\n* Patients who used analgesics within 12 hours before treatment\n* Patients with non-restorable teeth\n* Patients with a history of behavioral management problems preventing treatment","6 Years","14 Years",{"count":112,"type":22},128,[25],"This study aims to compare the effectiveness of inferior alveolar nerve block (IANB) and computer-controlled digital anesthesia in achieving adequate anesthesia in pediatric patients presenting with acute dental pain and requiring emergency endodontic treatment of mandibular permanent molars. Achieving profound anesthesia in such cases can be challenging due to acute inflammation.\n\nParticipants will be randomly assigned to receive either conventional IANB or digital anesthesia. Pain perception during the procedure will be assessed using validated pain scales. In addition, physiological parameters including heart rate and blood pressure will be recorded to evaluate the stress response associated with each anesthesia technique. Anesthesia success will be determined based on the absence of pain during treatment and the need for supplemental anesthesia.\n\nThe findings of this study are expected to provide evidence-based guidance for selecting the most effective and comfortable anesthesia technique in pediatric dental patients.",[116,117],"Pulpitis - Irreversible","Pulpitis - Reversible",[119,120,121,122,123],"Inferior alveolar nerve block","Digital anesthesia","Pediatric dentistry","Mandibular molar","Pain assessment","2026-06-08",{"date":126,"type":37},"2026-06-09",{"date":128,"type":37},"2026-04-01",{"date":130,"type":22},"2027-03-20",{"name":43,"class":44},{"id":133,"slug":134,"hasResults":12,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":12,"sex":86,"minAge":139,"maxAge":140,"enrollmentInfo":141,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":143,"conditions":144,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":4},"100629857","motor-imaging-neglect-and-upper-extremity-function-in-stroke-100629857","NCT07480122","Motor Imaging, Neglect, and Upper Extremity Function in Stroke","Investigation of the Relationship Between Motor Imagery Skill and Neglect Level, Upper Extremity Motor Function, Activities of Daily Living, and Quality of Life in Individuals After Stroke","Inclusion Criteria:\n\n* Individuals who have experienced hemiplegia after an ischemic stroke,\n* who actively use their right extremity according to the Edinburgh Hand Preference Questionnaire,\n* who have right hemisphere involvement,\n* who are 18 years of age or older,\n* who have been diagnosed with a stroke at least 1 and at most 6 months ago,\n* who have middle cerebral artery involvement,\n* who have a Standardized Mini Mental Test score of 24 or higher,\n* who are Stage 2b or higher according to Eggers staging,\n* who can actively control their hand, wrist, and fingers and perform the release reflex,\n* who wish to participate in the study voluntarily, and\n* who have given their informed consent will be included in the research.\n\nExclusion Criteria:\n\n* Individuals with major neurological, orthopedic, or rheumatological disorders affecting upper extremity function other than stroke (Polyneuropathy, Parkinson's Disease, Multiple Sclerosis, Rheumatoid Arthritis, etc.),\n* Individuals with upper extremity amputation,\n* Individuals with uncontrolled arrhythmia, uncontrolled hypertension, or unstable cardiac conditions,\n* Individuals with active malignancy and receiving related chemo\u002Fradiotherapy,\n* Individuals unable to cooperate due to aphasia or cognitive impairment,\n* Individuals with visual and hearing problems,\n* Individuals with communication problems that would hinder the evaluation and\u002For implementation of the treatment program,\n* Individuals who are unable to undergo mental assessment, complete the scales, or are illiterate will be excluded from the study.","30 Years","80 Years",{"count":142,"type":22},50,"This study aims to investigate the relationship between motor imagery skills and neglect level, upper extremity motor function, activities of daily living, quality of life, lateralization performance, and mental timer performance in individuals with stroke. Individuals with stroke who meet the inclusion criteria and voluntarily agree to participate will be evaluated. Demographic and clinical information of the participants will be recorded on an assessment form prepared by the researcher. Upper extremity motor functions will be assessed using the Fugl-Meyer Upper Extremity Motor Assessment Scale and the Wolf Motor Function Test; activities of daily living will be assessed using the Modified Barthel Index; and quality of life will be assessed using the Stroke-Specific Quality of Life Scale. Motor imagery skills will be measured using the Kinesthetic and Visual Imagery Questionnaire and a mental timer task; upper extremity lateralization performance will be assessed using the Recognise™ application. Neglect level will be assessed using the Catherine Bergego Scale, the Line Splitting Test, and the Star Erase Test. The data obtained will be statistically analyzed to examine the relationships between motor imagery skills and other clinical variables.",[145,146,147,148,149,150],"Stroke","Neglect, Hemispatial","Motor ımargery","Upper Extremity Function","Daily Life Activity","Quality of Life","2026-05-21",{"date":153,"type":37},"2026-05-22",{"date":155,"type":22},"2026-05-25",{"date":157,"type":22},"2026-08-15",{"name":43,"class":44},{"id":160,"slug":161,"hasResults":12,"nctId":162,"briefTitle":163,"officialTitle":163,"acronym":4,"eligibilityCriteria":164,"healthyVolunteers":52,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":165,"targetDuration":4,"studyType":23,"phases":167,"briefSummary":168,"conditions":169,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":4},"100639773","the-effect-of-motivational-interviewing-on-menopause-myths-and-posttraumatic-growth-in-postmenopausal-womenrandomized-controlled-study-100639773","NCT07596368","THE EFFECT OF MOTIVATIONAL INTERVIEWING ON MENOPAUSE MYTHS AND POSTTRAUMATIC GROWTH IN POSTMENOPAUSAL WOMEN:RANDOMIZED CONTROLLED STUDY","Inclusion Criteria:\n\n* Women who have had their last menstrual period between 12 and 36 months ago,\n* are literate,\n* can read and write in Turkish,\n* do not have any problems that may hinder communication, and\n* do not have any diagnosed psychiatric illness will be included in the study.\n\nExclusion Criteria:\n\n* Those receiving HRT treatment,\n* Those whose last menstrual period was 36 months or more ago,\n* Women receiving oncology treatment.",{"count":166,"type":22},96,[25],"This randomized controlled study aims to evaluate the effect of motivational interviewing on menopause myths and posttraumatic growth in postmenopausal women. Participants will be randomly assigned to an intervention group receiving four weekly motivational interviewing sessions or a control group receiving usual care. Outcomes will be assessed before and after the intervention using validated scales.",[170,171],"Menopause","Postmenopausal State","2026-05-12",{"date":174,"type":37},"2026-05-19",{"date":176,"type":22},"2026-05",{"date":178,"type":22},"2026-10",{"name":43,"class":44},{"id":181,"slug":182,"hasResults":12,"nctId":183,"briefTitle":184,"officialTitle":185,"acronym":186,"eligibilityCriteria":187,"healthyVolunteers":52,"sex":86,"minAge":188,"maxAge":189,"enrollmentInfo":190,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":192,"conditions":193,"keywords":198,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":211,"completionDateStruct":212,"leadSponsor":214,"locationsCount":78},"100640692","circadian-clock-proteins-in-gingival-crevicular-fluid-of-individuals-with-and-without-circadian-rhythm-disruption-100640692","NCT07592052","Circadian Clock Proteins in Gingival Crevicular Fluid of Individuals With and Without Circadian Rhythm Disruption","Investigation of Circadian Clock Gene\u002FProteins in Individuals With and Without Disrupted Circadian Rhythm: A Prospective Cross-Sectional Clinical Study","Nursma-CIRC-HG","Inclusion Criteria:\n\n* Aged between 20 and 50 years\n* Systemically healthy\n* Diagnosed as periodontally healthy or with gingivitis based on clinical periodontal examination\n* Having at least 20 natural teeth in the oral cavity\n* Willing to provide written informed consent\n* Agreeing to participate in circadian rhythm assessment and completing the Morningness-Eveningness Questionnaire (MEQ) and Munich Chronotype Questionnaire (MCTQ)\n* Sleep duration of 6-9 hours per day\n* For periodontally healthy: PD \\\u003C=3 mm, BOP \\\u003C10%, CAL=0, no radiographic bone loss\n* For gingivitis: PD \\\u003C=3 mm, 10%\\\u003C=BOP\\\u003C=30%, CAL=0, no radiographic bone loss\n* For circadian rhythm disruption group: being a night-shift worker\n\nExclusion Criteria:\n\n* Use of antioxidant or melatonin supplements\n* Presence of any systemic disease\n* Use of antibiotics, anti-inflammatory drugs, or immunosuppressants within the past 3 months\n* Having received periodontal treatment within the past 6 months\n* Pregnancy or lactation\n* Use of tobacco or tobacco products\n* Presence of acute oral infection, abscess, or advanced periodontal disease\n* Currently undergoing orthodontic treatment or having fixed orthodontic appliances\n* Inability to comply with study procedures or refusal to provide informed consent\n* Self-reported sleep duration less than 6 hours or greater than 9 hours per day","20 Years","50 Years",{"count":191,"type":22},116,"This prospective cross-sectional clinical study aims to investigate the relationship between circadian rhythm disruption and periodontal inflammation by evaluating circadian clock protein levels, inflammatory (IL-1beta) and anti-inflammatory (IL-10) cytokine levels in gingival crevicular fluid (GCF) of individuals with and without circadian rhythm disruption.\n\nParticipants aged 20-50 years will be classified into four groups based on their circadian rhythm status (disrupted\u002Fnormal) and gingival health status (gingivitis\u002Fhealthy). Clinical periodontal parameters including plaque index, gingival index, bleeding on probing, and probing depth will be assessed. Circadian rhythm status will be determined using validated questionnaires (Morningness-Eveningness Questionnaire and Munich Chronotype Questionnaire). Night-shift workers will represent the circadian rhythm disruption group.\n\nGCF samples will be analyzed for circadian clock proteins (BMAL-1, CLOCK, PER-1, PER-2, PER-3, CRY-1, CRY-2, REV-ERB-beta, MTNR1B) and cytokines (IL-1beta, IL-10) using ELISA. Serum cortisol and melatonin levels will be measured for biochemical verification of circadian rhythm status.\n\nGingivitis groups will receive standard periodontal treatment and be re-evaluated at 2 weeks post-treatment. A total of 116 participants (29 per group) are planned for enrollment.",[194,195,196,197],"Gingivitis","Circadian Rhythm Disruption","Periodontal Inflammation","Circadian Rhythm Sleep Disorder, Shift Work Type",[199,200,194,201,202,203,204,205,206,207],"Circadian rhythm","Periodontal health","Gingival crevicular fluid","Clock genes","BMAL1","Night shift work","IL-1beta","IL-10","Chronotype","2026-05-11",{"date":210,"type":37},"2026-05-18",{"date":39,"type":22},{"date":213,"type":22},"2027-03-01",{"name":43,"class":44},{"id":216,"slug":217,"hasResults":12,"nctId":218,"briefTitle":219,"officialTitle":219,"acronym":4,"eligibilityCriteria":220,"healthyVolunteers":12,"sex":86,"minAge":18,"maxAge":4,"enrollmentInfo":221,"targetDuration":4,"studyType":23,"phases":223,"briefSummary":224,"conditions":225,"keywords":230,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":238,"startDateStruct":240,"completionDateStruct":242,"leadSponsor":243,"locationsCount":4},"100636216","the-effects-of-virtual-art-therapy-on-physiological-parameters-delirium-risk-anger-anxiety-and-mental-and-spiritual-recovery-in-intensive-care-patients-100636216","NCT07562802","THE EFFECTS OF VIRTUAL ART THERAPY ON PHYSIOLOGICAL PARAMETERS, DELIRIUM RISK, ANGER, ANXIETY, AND MENTAL AND SPIRITUAL RECOVERY IN INTENSIVE CARE PATIENTS.","Inclusion Criteria:\n\n* Being 18 years of age or older Voluntarily agreeing to participate in the study Having no medical diagnosis that may trigger dizziness Having a score of 14 or higher on the Glasgow Coma Scale\n\nExclusion Criteria:\n\n* Refusing to participate in the study Having any psychiatric diagnosis Having a medical diagnosis that may trigger dizziness Having a score of 13 or lower on the Glasgow Coma Scale",{"count":222,"type":22},62,[25],"Patients in intensive care units experience significant physiological and psychological stress due to life-threatening conditions and invasive treatments. This randomized controlled study aims to examine the effects of virtual art therapy on physiological parameters, delirium risk, anger, anxiety, and mental-spiritual recovery in 62 patients in the coronary ICU of Malatya Training and Research Hospital. Data will be collected using validated scales and analyzed with appropriate parametric or non-parametric tests. The study seeks to evaluate the effectiveness and applicability of virtual art therapy as a technology-based complementary intervention in intensive care settings.",[226,227,228,229],"Delirium Risk","Critical Illness in Coronary ICU Patients","Mental and Spiritual Recovery","Effects of Virtual Art Therapy",[58,231,232,233,234,235,236],"Delirium","Nursing","Anger","Spiritual and Mental Healing","Virtual Art Therapy","Intensive Care","2026-04-25",{"date":239,"type":37},"2026-05-01",{"date":241,"type":22},"2026-04-28",{"date":101,"type":22},{"name":43,"class":44},{"id":245,"slug":246,"hasResults":12,"nctId":247,"briefTitle":248,"officialTitle":248,"acronym":249,"eligibilityCriteria":250,"healthyVolunteers":52,"sex":17,"minAge":18,"maxAge":251,"enrollmentInfo":252,"targetDuration":4,"studyType":23,"phases":254,"briefSummary":255,"conditions":256,"keywords":258,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":265,"lastUpdatePostDateStruct":266,"startDateStruct":268,"completionDateStruct":270,"leadSponsor":272,"locationsCount":78},"100635118","the-effect-of-mindfulness-based-self-compassion-training-on-childbirth-fear-pregnancy-stress-and-comfort-in-primiparous-women-100635118","NCT07548528","The Effect of Mindfulness-Based Self-Compassion Training on Childbirth Fear, Pregnancy Stress, and Comfort in Primiparous Women","SelfCompassion","Inclusion Criteria:\n\n* Women aged between 18 and 45, Women who are pregnant for the first time, Women who live with their partner, Women who are 28 weeks or older in pregna\n\nExclusion Criteria:\n\n* Women with multiple pregnancies, Women with any communication disorder, Women with a diagnosed psychiatric disorder, Women who have any health problems during pregnancy (such as hypertension, gestational diabetes, etc.) will be excluded from the study.","45 Years",{"count":253,"type":22},80,[25],"The purpose of this study was to determine the effects of mindfulness-based self-compassion training provided to primiparous women on fear of childbirth, pregnancy stress, and comfort.\n\nResearch Hypotheses H1a: Mindfulness-based self-compassion training provided to primiparous women reduces fear of childbirth.\n\nH1b: Mindfulness-based self-compassion training provided to primiparous women reduces pregnancy stress.\n\nH1c: Mindfulness-based self-compassion training provided to primiparous women increases comfort.",[257],"Pregnancy Related",[259,260,261,262,263,264,66],"fear of birth","midwife","pregnant","comfort","self-compassion","primiparous","2026-04-21",{"date":267,"type":37},"2026-04-23",{"date":269,"type":22},"2026-04",{"date":271,"type":22},"2026-08",{"name":43,"class":44},{"id":274,"slug":275,"hasResults":12,"nctId":276,"briefTitle":277,"officialTitle":278,"acronym":4,"eligibilityCriteria":279,"healthyVolunteers":52,"sex":86,"minAge":280,"maxAge":281,"enrollmentInfo":282,"targetDuration":4,"studyType":23,"phases":284,"briefSummary":285,"conditions":286,"keywords":292,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":299,"startDateStruct":300,"completionDateStruct":302,"leadSponsor":304,"locationsCount":78},"100634533","effect-of-mbsr-training-on-childbirth-fear-bonding-and-breastfeeding-in-adolescent-pregnant-women-100634533","NCT07540923","Effect of MBSR Training on Childbirth Fear, Bonding and Breastfeeding in Adolescent Pregnant Women","Effect of Mindfulness-Based Stress Reduction Training on Fear of Childbirth, Maternal and Paternal Bonding and Breastfeeding Success in Adolescent Pregnant Women and Their Partners","Inclusion Criteria:\n\n1. Being between 15-19 years of age\n2. Being in the third trimester of pregnancy (30-33 weeks of gestation)\n3. Being primiparous\n4. Having no history of miscarriage, abortion or similar obstetric problems during pregnancy\n5. Not having a high-risk pregnancy diagnosis\n6. Being literate\n7. Partner accepting to actively participate in the parenting process\n\nExclusion Criteria:\n\n1. Having a chronic disease\n2. Having physical or psychological health problems\n3. Having a psychiatric diagnosis in the participant or their partner\n4. Having a detected health problem or congenital anomaly in the fetus\n5. Having previously received Mindfulness-Based Stress Reduction (MBSR) training\n6. Not completing the planned training program\n7. Voluntarily withdrawing from the study","15 Years","19 Years",{"count":283,"type":22},54,[25],"This randomized controlled study aims to evaluate the effect of Mindfulness-Based Stress Reduction (MBSR) training given to adolescent pregnant women and their partners on fear of childbirth, maternal and paternal bonding, and breastfeeding success. Adolescent pregnancy is associated with increased stress, fear of childbirth and parenting anxiety, which negatively affect mother-infant and father-infant bonding and breastfeeding outcomes. MBSR training is expected to reduce fear of childbirth, strengthen maternal and paternal bonding, and improve breastfeeding success in adolescent pregnant women and their partners compared to the control group receiving routine care.",[287,288,289,290,291],"Pregnancy in Adolescence","Fear","Mother-Child Relations","Mindfulness","Breastfeeding",[293,294,295,296,297,291],"Adolescent Pregnancy","Fear of Childbirth","Maternal Bonding","Paternal Bonding","Mindfulness-Based Stress Reduction","2026-04-17",{"date":265,"type":37},{"date":301,"type":37},"2025-12-01",{"date":303,"type":22},"2026-05-30",{"name":43,"class":44},{"id":306,"slug":307,"hasResults":12,"nctId":308,"briefTitle":309,"officialTitle":310,"acronym":311,"eligibilityCriteria":312,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":251,"enrollmentInfo":313,"targetDuration":4,"studyType":23,"phases":315,"briefSummary":316,"conditions":317,"keywords":320,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":327,"lastUpdatePostDateStruct":328,"startDateStruct":330,"completionDateStruct":332,"leadSponsor":333,"locationsCount":78},"100633226","midwife-led-digital-follow-up-after-cesarean-section-100633226","NCT07523932","Midwife-Led Digital Follow-Up After Cesarean Section","The Effect of a Midwife-Led Digital Follow-Up Program on Postpartum Depression, Perceived Social Support, and Breastfeeding Self-Efficacy in Women After Cesarean Section: A Randomized Controlled Trial","MID-CS","Inclusion Criteria:\n\n* Women aged between 18 and 45 years\n* Women who have undergone cesarean section\n* Within the first 24 hours postpartum\n* Able to communicate in Turkish\n* Having a healthy singleton newborn\n* Willing to participate and provide informed consent\n\nExclusion Criteria:\n\n* History of psychiatric disorders\n* Presence of severe maternal complications\n* Newborn requiring intensive care unit admission\n* Women with communication difficulties\n* Participation in another intervention study",{"count":314,"type":22},104,[25],"This randomized controlled trial aims to evaluate the effect of a midwife-led digital follow-up program on postpartum depression, perceived social support, and breastfeeding self-efficacy in women who will undergo cesarean section.\n\nParticipants will be randomly assigned to either an intervention group that will receive structured face-to-face education followed by a 4-week digital follow-up program, or a control group that will receive routine postpartum care.\n\nData will be collected at baseline (postpartum day 1), at 1 week, and at 4 weeks postpartum using validated measurement tools.\n\nThe study will provide evidence on the effectiveness of continuous, midwife-led digital support in improving maternal psychological well-being and breastfeeding outcomes in the early postpartum period.",[318,291,319],"Postpartum Depression","Postpartum Period",[321,322,323,324,325,326],"Cesarean Section","Midwife-Led Intervention","Digital Follow-Up","Breastfeeding Self-Efficacy","Social Support","Postpartum Care","2026-04-13",{"date":329,"type":37},"2026-04-16",{"date":331,"type":22},"2026-06",{"date":178,"type":22},{"name":43,"class":44},{"id":335,"slug":336,"hasResults":12,"nctId":337,"briefTitle":338,"officialTitle":339,"acronym":340,"eligibilityCriteria":341,"healthyVolunteers":52,"sex":342,"minAge":18,"maxAge":4,"enrollmentInfo":343,"targetDuration":4,"studyType":23,"phases":345,"briefSummary":346,"conditions":347,"keywords":349,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":356,"lastUpdatePostDateStruct":357,"startDateStruct":359,"completionDateStruct":360,"leadSponsor":362,"locationsCount":78},"100633707","effects-of-l-tyrosine-and-caffeine-on-performance-in-elite-boxers-100633707","NCT07530185","Effects of L-Tyrosine and Caffeine on Performance in Elite Boxers","Effects of L-Tyrosine and Caffeine Supplementation on Cognitive, Physical, and Physiological Parameters in Elite Boxers: A Randomized Double-Blind Placebo-Controlled Crossover Study","TYCAF-BOX","Inclusion Criteria:\n\nMale elite boxers aged ≥18 years At least 8 years of boxing training experience Active participation in national or international competitions Regular training schedule No injury or illness affecting performance\n\nExclusion Criteria:\n\nUse of nutritional supplements or stimulants within the last 4 weeks Any cardiovascular, metabolic, or neurological disorder Current injury or musculoskeletal limitation Smoking or excessive caffeine intake Failure to comply with study procedures","MALE",{"count":344,"type":22},18,[25],"Participants will complete five sessions, including one familiarization and baseline session and four experimental conditions (placebo, L-tyrosine, caffeine, and combined supplementation). The baseline session will include resting measurements. The experimental conditions will be performed in a randomized, counterbalanced crossover design with a washout period of at least 72 hours between sessions.",[348],"Sports Performance",[350,351,352,353,354,355],"L-tyrosine","Caffeine","Boxing","BDNF","Cognitive performance","Anaerobic performance","2026-04-08",{"date":358,"type":37},"2026-04-15",{"date":269,"type":22},{"date":361,"type":22},"2027-03",{"name":43,"class":44},{"id":364,"slug":365,"hasResults":12,"nctId":366,"briefTitle":367,"officialTitle":368,"acronym":4,"eligibilityCriteria":369,"healthyVolunteers":12,"sex":86,"minAge":18,"maxAge":87,"enrollmentInfo":370,"targetDuration":4,"studyType":23,"phases":372,"briefSummary":373,"conditions":374,"keywords":375,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":356,"lastUpdatePostDateStruct":379,"startDateStruct":380,"completionDateStruct":382,"leadSponsor":384,"locationsCount":78},"100631355","effect-of-morus-nigra-mouthwash-on-gingivitis-treatment-100631355","NCT07499596","Effect of Morus Nigra Mouthwash on Gingivitis Treatment","Evaluation of the Efficacy of Morus Nigra Mouthwash as an Adjunct to Scaling and Root Planing in the Treatment of Gingivitis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Diagnosis of generalized gingivitis (Gingival Index \\> 1).\n* Presence of at least 20 natural teeth.\n* Systemically healthy individuals.\n* Ability to provide informed consent.\n\nExclusion Criteria:\n\n* Smoking or use of tobacco products.\n* Presence of periodontitis (no clinical attachment loss).\n* Use of antibiotics or anti-inflammatory drugs in the last 6 months.\n* Pregnancy or lactation.\n* History of allergy to Morus nigra or mouthwash components.\n* Systemic diseases (Diabetes, cardiovascular diseases, etc.).",{"count":371,"type":22},30,[25],"The aim of this study is to evaluate the clinical, microbiological, and biochemical effects of Morus nigra (black mulberry) mouthwash when used as an adjunct to non-surgical periodontal treatment (scaling and root planing - SRP) in patients with generalized gingivitis. Participants will be randomly assigned to two groups: one receiving SRP only, and the other receiving SRP plus Morus nigra mouthwash twice daily for 14 days. Clinical parameters, cytokine levels in gingival crevicular fluid (TNF-alpha, IL-1beta, IL-10), and subgingival bacterial load will be assessed at baseline, 1 month, and 3 months.",[194],[376,377,378],"Morus nigra","Mouthwash","Cytokines",{"date":327,"type":37},{"date":381,"type":37},"2026-01-15",{"date":383,"type":22},"2026-07-15",{"name":43,"class":44},{"id":386,"slug":387,"hasResults":12,"nctId":388,"briefTitle":389,"officialTitle":390,"acronym":4,"eligibilityCriteria":391,"healthyVolunteers":12,"sex":86,"minAge":18,"maxAge":392,"enrollmentInfo":393,"targetDuration":4,"studyType":23,"phases":395,"briefSummary":396,"conditions":397,"keywords":399,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":405,"lastUpdatePostDateStruct":406,"startDateStruct":408,"completionDateStruct":410,"leadSponsor":412,"locationsCount":78},"100633585","virtual-reality-based-motor-imagery-in-patients-with-fibromyalgia-100633585","NCT07528599","Virtual Reality-based Motor Imagery in Patients With Fibromyalgia","The Effect of Virtual Reality-Based Motor Imagery on Pain, Psychological Status and Quality of Life in Fibromyalgia Patients","Inclusion Criteria:\n\n* To be a volunteer,\n* To have been diagnosed with fibromyalgia according to the 2016 ACR diagnostic criteria,\n* To be aged between 18 and 60,\n* To have had pain symptoms for at least 3 months,\n* To be receiving standard medical treatment,\n\nExclusion Criteria:\n\n* The presence of neurological or orthopaedic conditions that would prevent participation in the rehabilitation programme\n* Pregnancy,\n* The presence of cognitive impairments that could affect cooperation,\n* The presence of serious, uncontrolled health problems,\n* A history of lower limb or spinal surgery\n* Visual or hearing impairments;\n* Serious psychiatric disorders\n* A diagnosis of migraine\n* Regular physical exercise in the last three months (≥2 days per week)\n* Participation in any concurrent physiotherapy or rehabilitation intervention","60 Years",{"count":394,"type":22},28,[25],"This study investigated the effects of a virtual reality-based motor imagery intervention integrated into a conventional exercise programme on pain outcomes (pain intensity, central sensitisation, pressure pain threshold, galvanic skin response, pain catastrophising), quality of life, sleep quality, fatigue, psychological outcomes (Hospital Anxiety and Depression Scale), imagery ability and patient satisfaction.",[398],"Fibromyalgia Patients",[400,401,402,403,404],"Fibromyalgia","motor imagery","exercise","rehabilitation","virtual reality","2026-04-07",{"date":407,"type":37},"2026-04-14",{"date":409,"type":22},"2026-03-25",{"date":411,"type":22},"2026-12",{"name":43,"class":44},{"id":414,"slug":415,"hasResults":12,"nctId":416,"briefTitle":417,"officialTitle":418,"acronym":4,"eligibilityCriteria":419,"healthyVolunteers":12,"sex":86,"minAge":18,"maxAge":140,"enrollmentInfo":420,"targetDuration":422,"studyType":90,"phases":4,"briefSummary":423,"conditions":424,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":429,"lastUpdatePostDateStruct":430,"startDateStruct":431,"completionDateStruct":433,"leadSponsor":435,"locationsCount":78},"100633225","functional-and-respiratory-determinants-of-long-term-colorectal-cancer-outcomes-100633225","NCT07523919","Functional and Respiratory Determinants of Long-Term Colorectal Cancer Outcomes","The Impact of Functional Status and Respiratory Parameters on Long-Term Outcomes in Colorectal Cancer","Inclusion Criteria:\n\n* Age between 18 and 80 years\n* Voluntary participation in the study\n\nExclusion Criteria:\n\n* Presence of musculoskeletal disorders that may prevent completion of the required tests\n* Presence of cognitive impairment\n* History of psychiatric disease\n* History of major surgery",{"count":421,"type":22},52,"2 Years","Colorectal cancer is one of the most commonly diagnosed malignancies worldwide and a leading cause of cancer-related morbidity and mortality. Its global incidence continues to increase, with a substantial proportion of cases diagnosed at advanced stages, which adversely affects prognosis. Patients diagnosed at an early stage and treated with surgery have significantly better long-term survival outcomes. Five-year survival rates are approximately 90% for stage I disease, decreasing to around 70% in stage II and 60% in stage III, and dropping to as low as 8% in stage IV disease.\n\nAdvanced age, family history, and environmental exposures are well-established risk factors for colorectal cancer. In addition, modifiable lifestyle factors-including smoking, physical inactivity, unhealthy dietary patterns, and obesity-have been shown to significantly increase the risk of disease.\n\nAlthough surgical resection remains the cornerstone of curative treatment in colorectal cancer, long-term outcomes are influenced not only by tumor stage but also by various patient-related factors, including comorbidities, functional capacity, and respiratory reserve. Functional status, which reflects a patient's ability to perform activities of daily living, is a key determinant of postoperative recovery and long-term outcomes. Reduced functional capacity has been associated with poorer long-term survival, diminished quality of life, and increased late morbidity. Therefore, objective preoperative assessment of functional status is considered essential for predicting long-term prognosis.\n\nRespiratory function also plays a critical role, particularly in patients undergoing abdominal surgery. Impaired pulmonary capacity increases the risk of postoperative pulmonary complications, prolongs hospital stay, and may indirectly affect long-term survival. However, studies evaluating the impact of preoperative respiratory parameters on long-term outcomes in patients with colorectal cancer remain limited. Furthermore, comprehensive analyses integrating both functional capacity and respiratory function are scarce in the current literature. Therefore, further investigation in this area is warranted.\n\nThe aim of this study is to evaluate the impact of functional status and respiratory parameters on long-term clinical outcomes in patients with colorectal cancer.\n\nH0: There is no statistically significant association between functional status, respiratory parameters, and long-term clinical outcomes in patients with colorectal cancer.\n\nH1: There is a statistically significant association between functional status, respiratory parameters, and long-term clinical outcomes in patients with colorectal cancer.",[425,426,427,428],"Colorectal Cancer","Respiratory Function","Functional Status","Long Term","2026-04-05",{"date":327,"type":37},{"date":432,"type":37},"2026-03-10",{"date":434,"type":22},"2028-03-10",{"name":43,"class":44},{"id":437,"slug":438,"hasResults":12,"nctId":439,"briefTitle":440,"officialTitle":440,"acronym":4,"eligibilityCriteria":441,"healthyVolunteers":12,"sex":86,"minAge":18,"maxAge":87,"enrollmentInfo":442,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":444,"conditions":445,"keywords":447,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":452,"lastUpdatePostDateStruct":453,"startDateStruct":455,"completionDateStruct":457,"leadSponsor":459,"locationsCount":4},"100632211","the-effect-of-cross-training-on-clinical-and-functional-outcomes-in-frozen-shoulder-rehabilitation-100632211","NCT07510737","The Effect of Cross Training on Clinical and Functional Outcomes in Frozen Shoulder Rehabilitation","Inclusion Criteria:\n\n* Having a diagnosis of unilateral primary or secondary frozen shoulder.\n* Range of motion in external rotation, abduction, or flexion reduced by less than 50% in at least one of these directions compared to the unaffected shoulder.\n* Loss of joint range of motion exceeding 30% in at least two movement planes compared to the unaffected shoulder.\n* Aged between 18 and 65 years.\n\nExclusion Criteria:\n\n* Presence of a concomitant shoulder injury (e.g., rotator cuff tear).\n* Osteoarthritis in both shoulders or in the acromioclavicular joint.\n* Previous treatment for frozen shoulder.\n* Psychiatric disorders that may interfere with adherence to medical or physical therapy.\n* Presence of other neurological disorders.\n* A score below 24 on the Mini-Mental State Examination (MMSE).",{"count":443,"type":22},38,"This randomized controlled, single-blind, quasi-experimental study primarily aims to investigate the effects of unilateral resistance exercise applied without directly loading the affected shoulder on muscle strength and upper extremity function in individuals with frozen shoulder. Additionally, the study seeks to examine the effects on joint range of motion, quality of life, and activities of daily living. The study will be conducted among individuals diagnosed with frozen shoulder at the Physiotherapy and Rehabilitation Outpatient Clinic of Malatya Battalgazi State Hospital. The data collection process is planned to be completed between February 2026 and December 2026.\n\nParticipants will be selected from the relevant population using a non-probability convenience sampling method. Individuals meeting the inclusion criteria will be enrolled after providing written informed consent. The study will be carried out in accordance with the principles of the Declaration of Helsinki. Participants will be randomly assigned to either the control or intervention group.\n\nThe study will include individuals aged 18-65 years with a diagnosis of unilateral primary or secondary frozen shoulder, presenting with more than 50% restriction in at least one of the following shoulder movements compared to the unaffected side: external rotation, abduction, or flexion, and with more than 30% limitation in joint range of motion in at least two movement planes.\n\nIndividuals with concomitant shoulder trauma (e.g., rotator cuff injury), bilateral shoulder involvement, acromioclavicular joint osteoarthritis, prior treatment for frozen shoulder, psychiatric disorders that may affect compliance with medical or physical therapy interventions, concomitant neurological conditions, or a Mini-Mental State Examination (MMSE) score below 24 will be excluded from the study.",[446],"Frozen Shoulder",[448,449,450,451],"Frozen shoulder","Cross training","Muscle strength","Function","2026-03-30",{"date":454,"type":37},"2026-04-03",{"date":456,"type":22},"2026-03-15",{"date":458,"type":22},"2026-12-25",{"name":43,"class":44},{"id":461,"slug":462,"hasResults":12,"nctId":463,"briefTitle":464,"officialTitle":465,"acronym":4,"eligibilityCriteria":466,"healthyVolunteers":12,"sex":86,"minAge":467,"maxAge":87,"enrollmentInfo":468,"targetDuration":4,"studyType":23,"phases":470,"briefSummary":471,"conditions":472,"keywords":475,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":409,"lastUpdatePostDateStruct":480,"startDateStruct":482,"completionDateStruct":484,"leadSponsor":486,"locationsCount":78},"100631641","effectiveness-of-telerehabilitation-in-ankylosing-spondylitis-100631641","NCT07503327","Effectiveness of Telerehabilitation in Ankylosing Spondylitis","Investigation of the Effectiveness of Different Telerehabilitation Applications in Patients With Ankylosing Spondylitis","Inclusion Criteria:\n\n* Being between the ages of 18-65\n* Having been diagnosed with Ankylosing Spondylitis by a specialist at least one year ago,\n* Agreeing to participate in the study voluntarily,\n* Owning and being able to use a smartphone,\n* Being able to read and write.\n\nExclusion Criteria:\n\n* Having a history of pregnancy, malignancy, or recent surgery (within the last six months)\n* Having a history of hypertension and diabetes that cannot be controlled with medication\n* Having a history of exacerbations in the last three weeks and having received treatment for exacerbations\n* Having instable medical treatment within the last three months\n* Having any orthopedic, neurological, or mental illness that would affect exercise\n* Having any assistive device for ambulation\n* Having participated in any exercise-based intervention program within the last month Exclusion Criteria\n* Failure to attend three consecutive treatment sessions,\n* Failure to complete the tests and questionnaires,\n* Voluntarily withdrawing from the study.","16 Years",{"count":469,"type":22},66,[25],"Purpose of the study:\n\nAnkylosing spondylitis (AS) is a chronic disease that affects the spine and joints, causing pain, stiffness, fatigue, and reduced quality of life. Exercise is known to help reduce pain and improve function in individuals with AS. However, the most effective type and method of exercise are not fully known. This study aims to compare the effects of different telerehabilitation methods-synchronous (live video) and asynchronous (pre-recorded video)-on disease activity, physical function, mobility, fatigue, quality of life, kinesiophobia (fear of movement), and pain levels in individuals with AS.\n\nStudy design and methods:\n\nThis is a randomized controlled experimental study. Participants will be randomly assigned to one of three groups:\n\nSynchronous telerehabilitation: Exercise sessions via live video, 3 times per week for 8 weeks.\n\nAsynchronous telerehabilitation: Exercise sessions via pre-recorded videos, 3 times per week for 8 weeks.\n\nControl group: Exercise instructions provided in a brochure.\n\nAll groups will perform exercises for approximately 40-50 minutes per session, focusing on flexibility, strength, posture, balance, coordination, and functional movements. Participants will be evaluated before the intervention (week 0) and after 8 weeks for disease activity, physical function, mobility, fatigue, quality of life, kinesiophobia, and pain during rest, movement, and sleep.\n\nParticipants:\n\nThe study will include adults aged 18-65 years diagnosed with AS at least one year prior, able to use a smartphone, and willing to participate. Individuals who are pregnant, have serious comorbidities, recent surgery, or conditions affecting mobility will be excluded.\n\nExpected benefits:\n\nThe study will identify which telerehabilitation method is more effective for individuals with AS. telerehabilitation may provide easier access to treatment, improve adherence to exercise programs, and contribute to better disease management and quality of life.",[473,474],"Anklyosing Spondylitis","Telerehabilitation",[476,477,478,479],"Spondylitis, Ankylosing","Telemedicine","Rehabilitation","Mobility Limitation",{"date":481,"type":37},"2026-03-31",{"date":483,"type":37},"2025-08-01",{"date":485,"type":22},"2026-12-31",{"name":43,"class":44},{"id":488,"slug":489,"hasResults":12,"nctId":490,"briefTitle":491,"officialTitle":492,"acronym":4,"eligibilityCriteria":493,"healthyVolunteers":52,"sex":17,"minAge":18,"maxAge":494,"enrollmentInfo":495,"targetDuration":4,"studyType":23,"phases":496,"briefSummary":497,"conditions":498,"keywords":500,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":504,"lastUpdatePostDateStruct":505,"startDateStruct":507,"completionDateStruct":508,"leadSponsor":510,"locationsCount":4},"100558644","genital-self-mage-and-satisfaction-with-genital-appearance-100558644","NCT06553807","Genital Self İmage and Satisfaction With Genital Appearance","The Effect of Education Given to Women With Low Genital Self Image on Satisfaction With Genital Appearance and Quality of Sexual Life","Inclusion Criteria:\n\n* 18-49 years old,\n* Sexually active for at least 1 year,\n* Not having language and communication problems,\n* Literate.\n\nExclusion Criteria:\n\n* Pregnancy within the last year,\n* She had a previous gynaecological operation,\n* Experiencing early menopause,\n* Diagnosed with gynaecological cancer or undergoing cancer treatment,","49 Years",{"count":253,"type":22},[25],"The concept of genital self-image first emerged alongside genital identity. Womens perceptions of their genital self encompass their feelings and subjective thoughts about their sexual organs. One of the most significant problems resulting from a negative genital self-image is sexual health. It has been reported that genital self-perception and self-image are related to sexual health. Another study that examined the effects of viewing various vulvar photographs on womens genital attitudes found that women had relatively positive genital self-images before viewing the photographs, but their perceptions became even more positive after viewing them. This study aims to examine the impact of education on genital appearance satisfaction and sexual quality of life in women with low genital self-image. It is hypothesized that women with low genital self-image who receive education will have more knowledge about genital anatomy, which will positively influence their genital appearance, genital self-image, and consequently improve their sexual quality of life.\n\nThe study is a randomized controlled experimental research. The research will be conducted women aged 18-49 years with low genital self-image who are registered at a Family Health Center (FHC). Data collection tools in the study will include a socio-demographic data form prepared by the researchers, the Genital Self-Image Scale, the Genital Appearance Satisfaction Scale, and the Sexual Quality of Life Scale. The SPSS 24.0 software package is planned to be used for data analysis. Descriptive statistics such as mean, standard deviation, number, and percentage will be used in the analysis of the quantitative data. The normality of the data distribution will be assessed, and parametric or non-parametric tests will be applied based on the distribution. Additionally, regression analyses will be used to evaluate the effect, and a significance level of 0.05 will be accepted for the entire study.",[499],"Women",[501,502,499,503],"Genital self-image","Satisfaction with genital appearance","Quality of sexual life","2026-03-23",{"date":506,"type":37},"2026-03-27",{"date":303,"type":22},{"date":509,"type":22},"2026-10-20",{"name":43,"class":44},{"id":512,"slug":513,"hasResults":12,"nctId":514,"briefTitle":515,"officialTitle":515,"acronym":4,"eligibilityCriteria":516,"healthyVolunteers":12,"sex":86,"minAge":19,"maxAge":140,"enrollmentInfo":517,"targetDuration":4,"studyType":23,"phases":519,"briefSummary":520,"conditions":521,"keywords":524,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":527,"lastUpdatePostDateStruct":528,"startDateStruct":530,"completionDateStruct":532,"leadSponsor":533,"locationsCount":78},"100629012","effects-of-low-load-blood-flow-restriction-training-of-the-upper-extremity-in-patients-with-chronic-obstructive-pulmonary-disease-100629012","NCT07469111","Effects Of Low-Load Blood Flow Restriction Training Of The Upper Extremity In Patients With Chronic Obstructive Pulmonary Disease","Inclusion Criteria:\n\n* Individuals aged 40-80 years with stage 2 and 3 COPD diagnosed according to GOLD criteria\n\n  * Clinically stable COPD (no exacerbation in the last 6 weeks)\n  * Stable medical treatment for at least 4 weeks\n  * No orthopedic or neurological problems that would prevent them from performing upper extremity exercises\n  * Resting SpO2 ≥ 88%\n  * Able to understand and follow verbal instructions in Turkish\n  * Individuals with a Montreal Cognitive Assessment Scale (MoCa) score ≥ 24 will be included.\n\nExclusion Criteria:\n\n* Uncontrolled hypertension\n\n  * Severe arrhythmia\n  * Recent MI\n  * Deep vein thrombosis\n  * Peripheral vascular disease\n  * Presence of infection or open wound\n  * Having undergone upper extremity surgery within the last 6 months\n  * Cognitive impairment or cooperation problems will be among the exclusion criteria",{"count":518,"type":22},36,[25],"Chronic Obstructive Pulmonary Disease (COPD) is characterized by persistent airflow limitation, progressive dyspnea, and peripheral muscle dysfunction, significantly impairing functional capacity and quality of life. Although the combined implementation of aerobic and resistance exercises is recommended in pulmonary rehabilitation programs, early-onset ventilatory limitation in individuals with COPD often hinders tolerance to high exercise intensities. This limitation increases the need for alternative exercise approaches targeting peripheral muscle adaptations. Low-load blood flow restriction training (LL-BFRT), which enables improvements in muscle strength with low mechanical loads, has emerged as a potential option for this patient population. However, evidence regarding the effects of LL-BFRT in individuals with COPD-particularly on upper extremity muscles-remains limited.\n\nThe aim of this study is to comparatively investigate the effects of LL-BFRT and sham-BFRT, both administered in addition to an aerobic exercise program in individuals diagnosed with stage II and III COPD, on upper extremity muscle strength, upper extremity functional capacity, activities of daily living performance, quality of life, functional exercise capacity, muscle oxygenation, and respiratory parameters. The study is designed as a randomized controlled, single-blind, quasi-experimental interventional trial.\n\nThe expected outcomes are that LL-BFRT may enhance upper extremity muscle strength and functional capacity, improve activities of daily living and quality of life, and increase exercise tolerance due to its applicability at low mechanical loads. Furthermore, findings related to muscle oxygenation and respiratory parameters are anticipated to provide clinical evidence regarding the physiological effects of LL-BFRT on peripheral muscle adaptations. These results are expected to guide the integration of LL-BFRT as an alternative and safe approach in upper extremity exercise prescription within pulmonary rehabilitation programs, support clinical decision-making processes, and establish a scientific foundation for future research.",[522,523],"Chronic Obstructive Pulmonary Disease (COPD)","Blood Flow Restriction Training (BFRT)",[522,525,148,526,523],"Los Load Resistance Exercise","Muscle Strength","2026-03-09",{"date":529,"type":37},"2026-03-13",{"date":531,"type":22},"2026-02-15",{"date":458,"type":22},{"name":43,"class":44},{"id":535,"slug":536,"hasResults":12,"nctId":537,"briefTitle":538,"officialTitle":539,"acronym":4,"eligibilityCriteria":540,"healthyVolunteers":12,"sex":86,"minAge":18,"maxAge":4,"enrollmentInfo":541,"targetDuration":4,"studyType":23,"phases":542,"briefSummary":543,"conditions":544,"keywords":547,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":553,"lastUpdatePostDateStruct":554,"startDateStruct":555,"completionDateStruct":557,"leadSponsor":558,"locationsCount":559},"100628523","the-effectiveness-of-education-in-diabetic-hemodialysis-patients-100628523","NCT07462741","The Effectiveness of Education in Diabetic Hemodialysis Patients","The Health Belief Model Approach in Diabetic Foot Management: The Effectiveness of Education for Diabetic Hemodialysis Patients","Inclusion criteria:\n\n* Voluntary participation in the study\n* Literacy\n* Absence of psychiatric distress\n* Being over 18 years of age\n* Open to communication and cooperation, no speech problems\n* Receiving continuous hemodialysis treatment\n* Having been diagnosed with diabetes for at least 6 months\n\nExclusion criteria:\n\n* Unwillingness to participate in the study or desire to withdraw from the study\n* Receiving acute hemodialysis treatment\n* Being under 18 years of age\n* Open to communication and cooperation, no speech problems",{"count":142,"type":22},[25],"Diabetes is a significant health problem affecting approximately half a billion people worldwide, reaching alarming levels. Diabetic foot ulcers are among the most common and serious complications of diabetes. Diabetes is the most common cause of end-stage renal failure, and diabetic nephropathy is identified as a major risk factor for foot ulcers and amputation. The health belief model is a model that explains behavior. Focusing on the necessary motivational resources for the development of positive health behaviors in individuals is crucial for positive patient outcomes in the education of diabetic hemodialysis patients. It is necessary for hemodialysis nurses to educate diabetic patients on foot care knowledge, improve foot care behaviors, and prevent the development of foot ulcers and lower extremity amputations. However, the lack of studies in the literature on nurse-led foot care education interventions based on the health belief model for diabetic patients undergoing hemodialysis constitutes the strength and unique aspect of this study. The research will be conducted using a randomized controlled pretest-posttest design.",[545,546],"Hemodialysis Patient","Diabetes Foot Care",[548,549,550,551,552],"Diabetic foot","patient education","hemodialysis","self-efficacy","health belief model","2026-03-05",{"date":432,"type":37},{"date":556,"type":37},"2026-01-26",{"date":527,"type":22},{"name":43,"class":44},3,{"id":561,"slug":562,"hasResults":12,"nctId":563,"briefTitle":564,"officialTitle":565,"acronym":4,"eligibilityCriteria":566,"healthyVolunteers":12,"sex":86,"minAge":18,"maxAge":4,"enrollmentInfo":567,"targetDuration":4,"studyType":23,"phases":568,"briefSummary":569,"conditions":570,"keywords":577,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":583,"lastUpdatePostDateStruct":584,"startDateStruct":586,"completionDateStruct":588,"leadSponsor":590,"locationsCount":78},"100625910","online-watch-summarize-question-ask-method-in-falls-education-for-nursing-students-100625910","NCT07428772","Online Watch-Summarize-Question-Ask Method in Falls Education for Nursing Students","The Effect of the Online Watch-Summarize-Question-Ask Learning Method on Nursing Students' Knowledge, Skills, Attitudes, and Behaviors Regarding Patient Falls","Inclusion Criteria:\n\n* Volunteers from the 4th year students of the Nursing Faculty at İnönü University\n\nExclusion Criteria:\n\n* Graduates of high school, associate's degree, or bachelor's degree programs in a health-related field\n* Students who have enrolled in the 4th grade for the second time\n* Students who do not have the technical means to access the online education platform\n* Students who wish to withdraw from the research at any stage\n* Students who do not participate in the training sessions\n* Students who do not complete the data collection forms",{"count":469,"type":22},[25],"This randomized controlled study will evaluate the effectiveness of an online Watch-Summarize-Question-Ask (WSQA) learning method on nursing students' knowledge, skills, attitudes, and behaviors related to patient fall prevention and management. Sixty-six nursing students will be randomly assigned to intervention and control groups. Both groups will receive standard patient safety education, while the intervention group will additionally participate in an online, evidence-based fall prevention training program structured according to the WSQA method, including video-based learning, summarization, question generation, and interactive discussions. Outcomes will be assessed using validated instruments measuring fall management knowledge, self-efficacy, attitudes toward fall prevention, care planning performance, and student satisfaction. The study aims to determine the effectiveness of an innovative educational approach to improve fall prevention competencies and enhance the quality and safety of nursing care.",[571,572,573,574,575,576],"Education","Online Learning","Fall Prevention","Fall, Accidental","Nursing Students","Patient Safety",[578,579,580,581,582],"online learning","patient falls","fall prevention","patient safety","nursing students","2026-02-17",{"date":585,"type":37},"2026-02-24",{"date":587,"type":22},"2026-02-27",{"date":589,"type":22},"2026-06-07",{"name":43,"class":44},{"id":592,"slug":593,"hasResults":12,"nctId":594,"briefTitle":595,"officialTitle":596,"acronym":4,"eligibilityCriteria":597,"healthyVolunteers":12,"sex":86,"minAge":18,"maxAge":87,"enrollmentInfo":598,"targetDuration":4,"studyType":23,"phases":600,"briefSummary":601,"conditions":602,"keywords":607,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":613,"lastUpdatePostDateStruct":614,"startDateStruct":616,"completionDateStruct":618,"leadSponsor":620,"locationsCount":78},"100624171","nonpharmacological-management-of-pain-and-fear-during-hormone-injection-in-breast-cancer-patients-100624171","NCT07406165","Nonpharmacological Management of Pain and Fear During Hormone Injection in Breast Cancer Patients","ShotBlocker and Helfer Technique in the Management of Pain and Fear During Hormone Injection in Patients With Breast Cancer: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged between 18 and 65 years.\n* Patients diagnosed with breast cancer.\n* Requirement of intramuscular (IM) injection of premenopausal or postmenopausal hormonal medications as part of their prescribed treatment.\n* Cognitive competence to provide informed consent for the injection procedure. Intact skin integrity and normal sensory perception at the injection site (gluteal region).\n\nExclusion Criteria:\n\n* History of chronic pain disorders, neuropathic pain syndrome, or any disease requiring regular analgesic use.\n* Presence of neurological or cognitive disorders that may alter pain or fear perception.\n* Use of analgesics within the last 24 hours (or a specific timeframe relevant to your study).",{"count":599,"type":22},99,[25],"This randomized controlled study will compare the effects of the ShotBlocker device and the Helfer Skin Tap Technique on pain and fear during intramuscular hormone injections in premenopausal and postmenopausal breast cancer patients. Ninety-nine participants will be randomly assigned to three groups (ShotBlocker, Helfer, control). All injections will be administered by the same nurse using standardized procedures. Pain will be assessed with the Visual Analog Scale, and fear with the Injection Fear Scale. The study aims to identify effective nonpharmacological methods to enhance patient comfort, support treatment adherence, and improve nursing care quality.",[603,604,288,605,606],"Breast Cancer","Pain Management","Injection Fear","Injection Pain Prevention",[608,609,610,611,612],"Breast cancer","Hormone therapy","Intramuscular injection","Pain","Injection fear","2026-02-11",{"date":615,"type":37},"2026-02-13",{"date":617,"type":22},"2026-02-10",{"date":619,"type":22},"2026-07",{"name":43,"class":44},{"id":622,"slug":623,"hasResults":12,"nctId":624,"briefTitle":625,"officialTitle":626,"acronym":4,"eligibilityCriteria":627,"healthyVolunteers":52,"sex":86,"minAge":18,"maxAge":4,"enrollmentInfo":628,"targetDuration":4,"studyType":23,"phases":630,"briefSummary":631,"conditions":632,"keywords":634,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":617,"lastUpdatePostDateStruct":635,"startDateStruct":637,"completionDateStruct":639,"leadSponsor":641,"locationsCount":4},"100625083","effects-of-cold-spray-and-buzzy-device-an-pain-and-fear-during-penicillin-injection-100625083","NCT07418021","Effects of Cold Spray and Buzzy Device an Pain and Fear During Penicillin Injection","The Effect of Innovative Cold Applications (Cold Spray and Buzzy Device) on Pain and Fear Associated With Penicillin Injection: A Randomized Controlled Trial","Eligibility Criteria\n\nInclusion Criteria:\n\nAdults aged 18 years and older\n\nIndividuals scheduled to receive intramuscular penicillin injection\n\nAble to communicate and report pain and fear levels\n\nWilling to participate in the study\n\nProvided written informed consent\n\nExclusion Criteria:\n\nKnown allergy or hypersensitivity to cold applications\n\nSkin lesions, infection, or injury at the injection site\n\nNeurological or psychiatric conditions that may affect pain or fear perception\n\nUse of analgesic or anxiolytic medication prior to injection\n\nPrevious adverse reaction to intramuscular injections",{"count":629,"type":22},90,[25],"This study investigates the effect of cold spray and Buzzy devices on pain and fear experienced during penicillin injections. There are three groups: a cold spray and Buzzy device, and a control group. Penicillin injections are commonly used in clinical practice and can cause discomfort, pain, and fear, particularly in patients receiving intramuscular injections.\n\nCold spray and Buzzy devices are non-pharmacological methods that can help reduce pain and fear by providing a cooling effect and vibration at the injection site. Participants will be randomly assigned to one of the study groups, and their pain and fear levels during injection will be assessed using standardized measurement tools.\n\nThe results of this study are expected to contribute to improving patient comfort and supporting the use of simple, non-invasive methods to reduce pain and fear during injections.",[633,604,288],"Injection",[611,633,612],{"date":636,"type":37},"2026-02-18",{"date":638,"type":22},"2026-02-05",{"date":640,"type":22},"2026-05-05",{"name":43,"class":44},{"id":643,"slug":644,"hasResults":12,"nctId":645,"briefTitle":646,"officialTitle":646,"acronym":647,"eligibilityCriteria":648,"healthyVolunteers":52,"sex":342,"minAge":251,"maxAge":392,"enrollmentInfo":649,"targetDuration":4,"studyType":23,"phases":650,"briefSummary":651,"conditions":652,"keywords":655,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":657,"lastUpdatePostDateStruct":658,"startDateStruct":659,"completionDateStruct":661,"leadSponsor":662,"locationsCount":4},"100623858","effect-of-a-mindfulness-based-stress-reduction-program-on-hot-flashes-and-sleep-quality-in-menopausal-women-a-randomized-controlled-trial-100623858","NCT07402096","Effect of a Mindfulness-Based Stress Reduction Program on Hot Flashes and Sleep Quality in Menopausal Women: A Randomized Controlled Trial","MBSR-MENO","Inclusion Criteria:\n\n* \\- Women aged between 45 and 60 years\n* Postmenopausal status defined as at least 12 months since the last menstrual period\n* Presence of hot flashes\n* Poor sleep quality (Pittsburgh Sleep Quality Index score \\>5)\n* Ability to understand and complete questionnaires\n* Access to the internet and ability to use a smartphone or computer for online sessions\n* Willingness to participate and provide written informed consent\n\nExclusion Criteria:\n\n* Current use of hormone replacement therapy\n\n  * Use of psychiatric medications\n  * Diagnosis of a psychiatric disorder\n  * Severe hearing or visual impairment\n  * Previous participation in mindfulness-based or yoga programs\n  * Incomplete baseline assessments\n  * Failure to attend intervention sessions",{"count":629,"type":22},[25],"Menopause is a natural transition characterized by vasomotor symptoms such as hot flashes and sleep disturbances, which can significantly impair quality of life. Non-pharmacological interventions are increasingly recommended for women who cannot or prefer not to use hormone therapy. Mindfulness-Based Stress Reduction (MBSR) is a structured behavioral intervention that has shown beneficial effects on stress-related symptoms and sleep quality; however, evidence regarding its effects on menopausal symptoms remains limited.\n\nThis randomized controlled trial aims to evaluate the effectiveness of an 8-week MBSR program on hot flash frequency and severity and sleep quality in menopausal women. A total of 90 menopausal women will be randomly assigned to either an intervention group receiving the MBSR program or a control group receiving no intervention. Participants in the intervention group will attend weekly sessions and engage in mindfulness practices, including breathing awareness, body scan, and stress management techniques.\n\nPrimary outcomes include changes in hot flash frequency and severity and sleep quality, assessed using validated self-report measures. The findings of this study are expected to contribute to evidence-based, non-pharmacological management strategies for menopausal symptoms.",[170,653,654],"Hot Flashes","Sleep Wake Disorders",[170,653,656],"Non-pharmacological intervention","2026-02-03",{"date":613,"type":37},{"date":660,"type":22},"2026-05-15",{"date":411,"type":22},{"name":43,"class":44},{"id":664,"slug":665,"hasResults":12,"nctId":666,"briefTitle":667,"officialTitle":667,"acronym":4,"eligibilityCriteria":668,"healthyVolunteers":52,"sex":86,"minAge":669,"maxAge":18,"enrollmentInfo":670,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":672,"conditions":673,"keywords":676,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":681,"lastUpdatePostDateStruct":682,"startDateStruct":683,"completionDateStruct":685,"leadSponsor":686,"locationsCount":78},"100622390","effect-of-adherence-to-a-gluten-free-diet-on-cognitive-and-motor-dual-task-performance-in-adolescents-diagnosed-with-celiac-disease-100622390","NCT07382999","Effect of Adherence to a Gluten-Free Diet on Cognitive and Motor Dual-Task Performance in Adolescents Diagnosed With Celiac Disease","Inclusion Criteria:\n\n* Participants aged between 8 and 18 years with a serologically confirmed diagnosis of celiac disease\n* Who have been followed for at least six months after diagnosisn\n* For whom written informed consent has been obtained from both the participant and their parent\u002Flegal guardian, will be included in the study.\n* The healthy control group will consist of individuals in the same age range with no history of chronic neurological, psychiatric, or gastroenterological diseases.\n\nExclusion Criteria:\n\n* Will include the presence of an acute infection or systemic disease\n* Diagnosed neurological disorders (such as epilepsy or cerebral palsy);\n* A history of severe psychiatric disorders; conditions that may interfere with test administration, including visual, hearing, or ambulatory impairments\n* Initiation of psychotropic medication or changes in the current dosage within the past four weeks; the presence of unstable metabolic or endocrine disorders\n* Failure to obtain the required informed consent for participation.","8 Years",{"count":671,"type":22},82,"The aim of this cross-sectional observational study is to comprehensively examine the effects of adherence to a gluten-free diet on cognitive, motor, and psychosocial functions in adolescents aged 8-18 years diagnosed with celiac disease. In this context, dual-task gait performance, cognitive processing speed and attention, working memory and executive functions, muscle strength, quality of life, and fatigue levels of individuals with celiac disease who are adherent or non-adherent to a gluten-free diet will be compared with those of healthy peers. In addition, sleep patterns, pubertal development, socioeconomic indicators, and serological markers will be taken into account to evaluate the unique effects of diet adherence on neurocognitive and functional outcomes. All assessments will be conducted in accordance with a predefined standardized protocol. The order of measurement instruments will be randomized to minimize potential bias. Inclusion criteria will consist of being between 8 and 18 years of age, having a celiac disease diagnosis confirmed by serology, being followed with this diagnosis for at least six months, and obtaining written informed consent from both the participant and their parent\u002Fguardian. For the healthy control group, participants must be within the same age range and have no history of chronic neurological, psychiatric, or gastroenterological conditions. Data analysis will be performed using SPSS",[674,675],"Celiac Disease in Children","Celiac Disease in Adolescents",[677,678,679,680],"Celiac","Cognitive function","10 MWT","TMT A-B","2026-02-01",{"date":657,"type":37},{"date":684,"type":22},"2026-02-12",{"date":157,"type":22},{"name":43,"class":44},""]