[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":398},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,42,62,88,125,155,187,219,242,264,296,319,339,368],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":24,"studyType":25,"phases":4,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100528902","capture-of-healthy-gut-bacteria-associated-to-high-fiber-diet-100528902",false,"NCT06166810","Capture of Healthy Gut Bacteria Associated to High Fiber Diet","In Silico and in Vitro Targeting of Healthy Gut Bacteria With Fiber Degrading Metabolic Potential","iTARGET","Inclusion Criteria:\n\n* Healthy adult subjects ;\n* Age between 20 and 50 (limits included) ;\n* BMI between 18.5 and 25 kg\u002Fm2 (excluding limits) ;\n* Consumption of more than 5 portions of fruit and vegetables a day;\n* Intake of at least 25g of dietary fibre per day;\n* A varied diet with little processed food.\n\nExclusion Criteria:\n\n* Antibiotics and\u002For transit modulators taken in the 3 months prior to sampling;\n* Known pathologies;\n* Current treatment;\n* History of digestive surgery having an impact on the microbiota, deemed incompatible with the study (bariatric surgery);\n* Consumption of food supplements based on protein preparations, probiotics or prebiotics;\n* Smoking (even occasionally);\n* Alcohol consumption \\> 2 glasses (i.e. 20 g) per day;\n* Intense sporting activity;\n* Pregnant or breast-feeding women;\n* Persons under legal protection (curatorship, guardianship, etc.);\n* Volunteers taking part in another intervention study;\n* Persons refusing to be registered on the French Ministry of Health's Fichier National des Volontaires Sains (National Register of Healthy Volunteers);\n* Subject not affiliated to the social security system;\n* Subject in a period of exclusion from a previous study or having received a total amount of compensation exceeding 6000 euros over the 12 consecutive months prior to the start of the trial (after verification in the Fichier des Volontaires pour la Recherche Biomédicale).",true,"ALL","20 Years","50 Years",{"count":22,"type":23},10,"ESTIMATED","24 Months","OBSERVATIONAL","The role of the intestinal microbiota on health is now well recognised, and diet is one of the factors influencing the maintenance of a healthy intestinal microbiota. More specifically, the consumption of fruit, vegetables and cereals is associated with good health and, in particular, with an increase in the relative abundance of bacterial groups described as beneficial. To date, a large number of bacterial species in the intestinal microbiota have yet to be isolated and cultivated, which limits the characterisation of their potential health benefits. In order to isolate and cultivate these intestinal bacteria, it is particularly relevant to recruit individuals with a high-fibre diet.",[28],"General Population","RECRUITING","2026-06-25",{"date":32,"type":33},"2026-06-29","ACTUAL",{"date":35,"type":33},"2023-10-24",{"date":37,"type":23},"2026-12-31",{"name":39,"class":40},"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":17,"sex":18,"minAge":49,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":25,"phases":4,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":41},"100497570","le-french-gut-characterization-of-gut-microbiota-profiles-in-france-100497570","NCT05758961","Le French Gut: Characterization of Gut Microbiota Profiles in France","Le French Gut : the French Microbiota","Inclusion Criteria:\n\n* Persons over the age of 18 living in France.\n* Consent form signed electronically.\n\nNon inclusion Criteria:\n\n* Non-adult person (declarative);\n* Person not living in France (declarative);\n* Persons subject to a protective measure, in particular under guardianship or curatorship or unable to express their consent (declarative);\n* Person having had a colectomy (declarative);\n* Person with a digestive stoma (declarative);\n* Person who has not signed the consent;\n* Person who did not answer the entry questionnaire;\n* Person who has not sent a compliant stool sample;\n* Antibiotic intake in the 3 months before inclusion (declarative);\n* Performing a colonoscopy in the 3 months preceding inclusion (declarative).","18 Years",{"count":51,"type":23},100000,"\" The French Gut \" is a national contribution aiming to collect 100,000 faecal samples and associated nutritional and clinical data by 2027. Le French Gut is initiated by MetaGenoPolis-INRAE, supported by INRAE with Prof. R. Benamouzig, (AP-HP) as principal investigator of the project. The main goal of this national trial is a better understanding of the observed heterogeneity between gut microbiome of healthy subjects, its connections with the diet and lifestyle, but also changes in gut microbiota associated with diseases (diabetes, obesity, allergies, cancer, Parkinson, Alzheimer…).",[28],"2026-06-11",{"date":56,"type":33},"2026-06-15",{"date":58,"type":33},"2022-09-15",{"date":60,"type":23},"2042-09-15",{"name":39,"class":40},{"id":63,"slug":64,"hasResults":11,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":17,"sex":18,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":4,"studyType":25,"phases":4,"briefSummary":74,"conditions":75,"keywords":78,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":41},"100640909","evolution-of-food-oral-processing-behaviours-food-bolus-formation-and-texture-preferences-between-6-to-12-years-old-and-adult-age-100640909","NCT07631195","Evolution of Food Oral Processing Behaviours, Food Bolus Formation and Texture Preferences Between 6 to 12 Years Old and Adult Age","Rôle de la Texture Des Aliments et du Comportement Masticatoire Dans Les propriétés du Bol Alimentaire et la Perception Sensorielle Chez Les Enfants d'âge Scolaire (6 à 12 Ans) en Comparaison à un Groupe Adulte","MARELLE","Inclusion Criteria:\n\n* Being aged between 6 and 12 years old included or between 25 and 35 years old Being consumers of carrot, comté cheese, rice and biscuit\n\nExclusion Criteria:\n\n* No French social security coverage\n* Ongoing orthodontic and\u002For dental treatment\n* Oral motor difficulties\n* Food allergies\n* Diabetes","6 Years","12 Years",{"count":73,"type":23},120,"This cross sectional study investigates how the oral physiological changes during the period of dental transition (6-12 years old) influence on texture preferences, food oral processing behaviour and food bolus properties, for different foods varying in texture and in comparison to the adult population.",[76,77],"Food Oral Processing","Texture Preference",[79],"Food texture Food oral processing Food bolus Chewing Dentition Texture prfrence Eating behaviour","2026-06-01",{"date":82,"type":33},"2026-06-05",{"date":84,"type":33},"2025-09-24",{"date":86,"type":23},"2026-08-01",{"name":39,"class":40},{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":92,"acronym":93,"eligibilityCriteria":94,"healthyVolunteers":17,"sex":18,"minAge":49,"maxAge":95,"enrollmentInfo":96,"targetDuration":4,"studyType":98,"phases":99,"briefSummary":101,"conditions":102,"keywords":104,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":124},"100636633","tolerance-to-an-artisanal-bread-in-a-population-intolerant-of-the-conventional-bread-and-study-of-associated-markers-100636633","NCT07568223","Tolerance to an Artisanal Bread in a Population Intolerant of the Conventional Bread and Study of Associated Markers","TOLERBREAD","Inclusion Criteria:\n\n* Normal weight (18 \\\u003C BMI \\\u003C 25 kg.m-2)\n* Male or female\n* 18 to 65 years old\n* Adults reporting intolerance to \"conventional\" bread\n* Absence of celiac disease\n* Affiliated to a social security scheme\n* Free, informed and express consent\n\nExclusion Criteria:\n\n* People under protective supervision: legal guardianship, tutorship or curatorship\n* People with eating disorders (anorexia, bulimia, binge eating)\n* Any known food allergy\n* Women who are pregnant or potentially pregnant (based on a positive urine pregnancy test at inclusion)\n* Breastfeeding women\n* Alcohol abuse (\\>2 drinks\u002Fday). At the time of inclusion, the investigator will assess whether the participant exhibits harmful alcohol consumption\n* Untreated hypertension, uncontrolled diabetes, or diseases of the digestive tract (excluding functional intestinal disorders), liver, kidneys, or severe heart disease. The investigator will assess the presence of these conditions on standard clinical criteria and the participants' self-reported medical history at the time of inclusion\n* Participation in a clinical study in the three months preceding the study\n* Absence of express consent","65 Years",{"count":97,"type":23},40,"INTERVENTIONAL",[100],"NA","The objective of this study is to evaluate the effect of consuming an \"artisanal\" bread for 15 days on gastrointestinal symptoms in individuals intolerant to \"conventional\" bread.\n\n\"Conventional bread\" refers to bread made with refined wheat flour (ash = 0.55% of dry matter), containing gluten, and leavened with baker's yeast (Saccharomyces cerevisiae). \"Artisanal bread\" refers to bread made with whole wheat flour (ash = 1.50% of dry matter) from an ancient durum wheat variety (Russello) and leavened with sourdough.",[103],"Intolerance to \"Conventional\" Bread",[105,106,107,108,109,110,111,112,113,114,115],"Bread","Wholemeal flour","Ancient wheat","Sourdough","Gluten","FODMAPs","Digestive tolerance","Postprandial metabolism","Inflammation","Intestinal permeability","Microbiota","2026-05-04",{"date":118,"type":33},"2026-05-05",{"date":120,"type":33},"2026-01-28",{"date":122,"type":23},"2027-06",{"name":39,"class":40},2,{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":131,"eligibilityCriteria":132,"healthyVolunteers":17,"sex":18,"minAge":49,"maxAge":133,"enrollmentInfo":134,"targetDuration":4,"studyType":98,"phases":136,"briefSummary":137,"conditions":138,"keywords":142,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":154,"locationsCount":41},"100633015","effect-of-vegetarien-diet-on-protein-digestibility-in-young-and-elderly-volunteers-100633015","NCT07521189","Effect of Vegetarien Diet on Protein Digestibility in Young and Elderly Volunteers","Effect of a Vegetarian Diet on the Bioavailability of Amino Acids From Plant Protein in Healthy Young and Elderly Volunteers (VEGAA)","VEGAA","Inclusion Criteria:\n\n* Normal weight or overweight (18 \\\u003C BMI \\\u003C 30 kg·m-²)\n* Male or female\n* Aged 18-23 years (young groups) or 65-75 years (older groups)\n* Following an omnivorous diet (regular consumption of meat products, with meat intake \\> 3 times\u002Fweek and \\> 70% of protein intake from animal sources) or vegetarian diet (exclusion of meat and fish\u002Fseafood, with \\> 70% of protein intake from plant sources)\n* In good general health (WHO = 0)\n* Affiliated with a social security system\n* Free and informed consent, provided in writing after receiving the information required by the Public Health Code\n\nExclusion Criteria:\n\n* Adults under legal protection or unable to give informed consent (e.g., under guardianship, trusteeship, or legal protection)\n* Any known food allergy\n* Positive serology for HBsAg, anti-HBc, HCV, or HIV\n* Anemia: hemoglobin level \\\u003C 13 g\u002FdL in men and \\\u003C 12 g\u002FdL in women\n* Pregnant women or those who may be pregnant (based on a positive urine pregnancy test at inclusion)\n* Excessive alcohol consumption (\\> 2 drinks\u002Fday). Harmful alcohol use will be assessed by the investigator at inclusion.\n* Hypertension, diabetes, gastrointestinal, liver or kidney diseases, or severe heart disease. These conditions will be assessed by the investigator based on standard clinical evaluation and participants' self-reports at inclusion.\n* Hypertension: significant arterial hypertension according to the investigator, or systolic blood pressure ≥ 140 mmHg and\u002For diastolic blood pressure ≥ 90 mmHg at inclusion.\n* Diabetes: type 1 or type 2 diabetes, or fasting blood glucose \\> 1.25 g\u002FL.\n* Gastrointestinal disease: clinically significant gastrointestinal disorders (bleeding, vomiting, constipation\u002Fdiarrhea grade \\> 1) as judged by the investigator, any inflammatory bowel disease, or acute gastroenteritis in the month prior to the intervention.\n* Liver disease: any significant hepatic disorder according to the investigator, or ASAT\u002FALAT \\> 2.5 times the upper normal limit.\n* High-level athletes (\\> 8 hours of training per week)\n* Blood donation within 8 weeks prior to study start\n* Absence of free, informed, written consent after receiving the information required by the Public Health Code\n* Not affiliated with a social security system","75 Years",{"count":135,"type":23},48,[100],"Plant proteins are usually less digestible than animal proteins, but they may benefit gut health through effects on the microbiome. The long-term impact of diets rich in plant products on protein digestion and metabolism is still unknown, especially in older adults with higher protein needs. This study aims to compare the digestion and use of pea proteins in young and older adults, both vegetarians and omnivores. Volunteers are divided into four groups: young omnivores, young vegetarians, older omnivores, and older vegetarians. They take part in two clinical investigation days. On the first day, nitrogen retention and protein metabolism is measured after consumption of a pea-based meal. On the second day, amino acid digestibility of pea is evaluated. These results will provide valuable data on how plant proteins are digested and metabolized depending on age and diet. They will also help determine whether aging reduces the availability of plant proteins. This knowledge is important to support nutritional strategies for populations with specific protein needs, such as older adults.",[139,140,141],"Vegetarian Diet","Elderly","Young Healthy Adults",[143,144,140,145,146,147],"Amino acid bioavailability","Vegetarian diet","Plant protein","Protein utilization","Isotopic method","2026-04-07",{"date":150,"type":33},"2026-04-09",{"date":152,"type":33},"2025-10-22",{"date":37,"type":23},{"name":39,"class":40},{"id":156,"slug":157,"hasResults":11,"nctId":158,"briefTitle":159,"officialTitle":160,"acronym":161,"eligibilityCriteria":162,"healthyVolunteers":17,"sex":18,"minAge":163,"maxAge":133,"enrollmentInfo":164,"targetDuration":4,"studyType":25,"phases":4,"briefSummary":166,"conditions":167,"keywords":172,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":124},"100569556","food-typologies-and-multidimensional-phenotyping-of-elderly-in-auvergne-rhne-alpes-partage-100569556","NCT06695780","Food Typologies and Multidimensional Phenotyping of Elderly in Auvergne-Rhône-Alpes (Part'AGE)","Exploration Des Typologies Alimentaires et caractérisation Par un phénotypage Multidimensionnel d'Une Population de Personnes âgées de la région Auvergne-Rhône Alpes","Part'AGE","Inclusion Criteria:\n\n* Male or female (balanced sex ratio or at least 40% male to 60% female) in complete autonomy at home.\n* 55 to 75 years old, including the limits\n* 20 ≤ BMI ≤35 kg\u002Fm2\n* Available to carry out the entire protocol, including self-sampling (not sensitive to the sight of one's own blood for example) and agreeing to stop taking food supplements during the study.\n* Having a scale available: at home, pharmacy, family, etc.\n* Having internet access and a device with a screen and camera (PC, tablet, smartphone, etc.) at home or able to go to a project partner (CCAS, Point France Service, Community, Association, etc.) that can provide this access\n* Subject agreeing to give written consent (by phone or videoconferencing), and registration in the national file of volunteers who participate in research\n* Person declaring to be subject to a social security scheme.\n\nExclusion Criteria:\n\n* Weight loss ≥ 5% in 1 month or ≥ 10% in 6 months or ≥ 10% compared to usual weight\n* Treated diabetes\n* Sub-acute pathology (flu, gastroenteritis, bacterial infection, etc.) or trauma (fracture, surgical intervention, etc.) in the 30 days prior to inclusion.\n* Hepatocellular insufficiency,\n* Heart failure with decompensation,\n* Renal insufficiency (clearance \\\u003C30 ml\u002Fmin)\n* Chronic anti-inflammatory treatment, long-term corticosteroid therapy \\> 1 month, infiltration\n* Progressive pathology at the time of inclusion (cancer, etc.)\n* Gastrointestinal pathology deemed incompatible with the protocol\n* Unstable thyroid diseases\n* Recent change in eating habits in the last 30 days (weight loss diet, veganism, intermittent fasting, ketogenic diet, etc.)\n* Intense physical activity (activity causing shortness of breath and sweating) \\> 10 hours per week\n* Person in a period of exclusion from the National File of Healthy Volunteers\n* Subject under guardianship, curator-ship, deprived of liberty or under judicial protection","55 Years",{"count":165,"type":23},1000,"To better understand how diet influences health during aging, the French National Research Institute for Agriculture, Food and the Environment (INRAE) is working with the Gérontopôle Auvergne-Rhône-Alpes on a project called Part'AGE. Part'AGE is a participatory research project where researchers want to recruit 1,000 people aged between 55 and 75 years, men and women, living in Auvergne-Rhône-Alpes in urban or rural areas. The goal is to study eating habits and state of health. To do this, researchers will examine many factors that can influence them, such as physical activity, overall health, consumption patterns or territories. Researchers will collect detailed information to classify participants into different groups (food typologies) based on their eating habits and state of health. With this distribution, the goal is to be able to give each group personalized nutritional advice to age in better health.\n\nTo participate in the study, the participants will need to collect a few drops of blood from the end of the finger, a urine sample, and do some tests (mobility, oral health). It will also be necessary to fill out questionnaires on eating habits, physical activity, and other aspects that may influence health. The benefices for to participants will be to contribute to nutrition research and to receive personalized feedback and advices on eating habits.",[168,169,170,171],"Nutritional Assessment","Physical Activity","Health","Oral Health",[173,174,175,176,177,178],"eating behaviors","elderly","health","phenotyping","food typologies","prevention","2026-03-24",{"date":181,"type":33},"2026-03-27",{"date":183,"type":33},"2025-02-03",{"date":185,"type":23},"2028-02",{"name":39,"class":40},{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":193,"eligibilityCriteria":194,"healthyVolunteers":17,"sex":18,"minAge":195,"maxAge":133,"enrollmentInfo":196,"targetDuration":4,"studyType":98,"phases":198,"briefSummary":199,"conditions":200,"keywords":202,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":212,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":218},"100528670","multidimensional-phenotyping-towards-personalized-preventive-nutritional-support-for-elderly-people-100528670","NCT06163794","Multidimensional Phenotyping Towards Personalized Preventive Nutritional Support for Elderly People","New Participatory Research Strategy and Multidimensional Phenotyping Towards Personalized Preventive Nutritional Support for Elderly People","MetabotypAGE","Inclusion Criteria:\n\n* \\- Subject with grip strength (assessed with a dynamometer) ≥16kg for women and ≥26 kg for men.\n* 21 ≤ BMI ≤35\n* Participant living in a rural or peri-urban area or city dweller, according to the population density grid of the Territorial Observatory (categories 3, 2 or 1 respectively).\n* Cognitively able to perform tests and answer questionnaires according to the judgment of the recruiting doctor and on the basis of the Mini-Mental State Examination (MMSE)\n* Available to carry out the entire protocol\n* Biological assessment considered by the investigator as compatible with participation in the study,\n* Subject agreeing to give written consent, and registration in the national file of volunteers who lend themselves to research\n* Person subject to a social security system.\n\nExclusion Criteria:\n\n* \\- Diabetes treated\n* Sub-acute pathology (flu, gastroenteritis, bacterial infection, etc.) or trauma (fracture, surgical intervention, etc.) in the 30 days preceding inclusion.\n* Hepatocellular insufficiency,\n* Heart failure with decompensation,\n* Renal insufficiency (clearance \\\u003C30 ml\u002Fmin)\n* Chronic anti-inflammatory treatment, long-term corticosteroid therapy \\> 1 month, infiltrations\n* Antibiotic treatment within 30 days prior to recruitment\n* Progressive pathology at the time of inclusion (cancer, etc.)\n* Gastrointestinal pathology deemed incompatible with the protocol\n* Eating habits incompatible with the protocol (allergies, test food intolerances\u002Faversions, vegan diets, ketogenic diets, etc.)\n* Unstabilized thyroid diseases\n* Intense physical activity (activity causing shortness of breath and sweating) \\> 10 hours per week\n* Person who is in a period of exclusion on the National File of Healthy Volunteers\n* Subject presenting a psychiatric pathology or cognitive disorders making them incapable of giving informed consent.\n* Subject under guardianship, curatorship, deprived of freedoms or under the protection of justice","60 Years",{"count":197,"type":23},250,[100],"There is high inter-individual variability in the response to feeding, which is determined by multiple interacting factors such as age, sex, genotype, gut microbiota, eating behaviors, physical activity or even socio-demographic factors. Original studies have recently demonstrated the possibility of predicting the postprandial response to the diet of healthy individuals on the basis of in-depth phenotyping, and of offering them foods adapted to their own metabolic capacities according to their belonging to different groups of individuals defined on the basis of the similarity of their metabolic capacities. Due to different life trajectories, inter-individual variability could be amplified upon entry into the aging period, which could explain at least in part why traditional strategies for managing chronic age-related pathologies are insufficient. The investigators aim is to propose a new strategy to better understand inter-individual variability in the response to food in the elderly based on deep phenotyping.",[201],"Non Dependant 60 to 75 Year-old Men and Women",[203,204,205,206,207,208,209,210,211],"personalized nutrition","deep phenotyping","inter-individual variability","metabotypes","post-prandial response to food","metabolomics","physical activity and food intake behaviors","aging","citizen science",{"date":181,"type":33},{"date":214,"type":33},"2024-02-14",{"date":216,"type":23},"2027-03",{"name":39,"class":40},3,{"id":220,"slug":221,"hasResults":11,"nctId":222,"briefTitle":223,"officialTitle":224,"acronym":225,"eligibilityCriteria":226,"healthyVolunteers":17,"sex":18,"minAge":49,"maxAge":195,"enrollmentInfo":227,"targetDuration":4,"studyType":25,"phases":4,"briefSummary":229,"conditions":230,"keywords":232,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":235,"startDateStruct":237,"completionDateStruct":239,"leadSponsor":241,"locationsCount":41},"100609271","collection-of-stool-from-healthy-donors-for-the-ex-vivo-study-of-shifts-of-microbiome-induced-by-dairy-phages-and-antibiotics-a-model-of-bacteriahost-interaction-dairy-shape-100609271","NCT07212400","Collection of Stool From Healthy Donors for the ex Vivo Study of Shifts of Microbiome Induced by Dairy Phages and Antibiotics: a Model of Bacteria\u002FHost Interaction (DAIRY-SHAPE)","Collection of Stool From Healthy Donors for the ex Vivo Study of Shifts of Microbiome Induced by Dairy Phages and Antibiotics: a Model of Bacteria\u002FHost Interaction","DAIRY-SHAPE","Inclusion Criteria:\n\n* Age ≥ 18 years and ≤ 60 years\n* Varied and balanced omnivorous diet\n\nExclusion Criteria:\n\n* Vegetarian, vegan, or restrictive diet\n* Use of medications (antibiotics, anti-inflammatory drugs, immunosuppressants, and\u002For probiotics, prebiotics, or synbiotics), either as drugs or dietary supplements, within the 3 months prior to sample collection\n* Pregnant and\u002For breastfeeding women\n* Presence of an acute or chronic disease (gastrointestinal, metabolic, immune, or inflammatory), diagnosed or suspected\n* Colonoscopy within the past 3 months\n* Known food allergy or intolerance (e.g., gluten, lactose, FODMAPs) that may alter the usual diet and\u002For microbiota composition\n* Individuals under legal protection (guardianship, trusteeship, etc.)",{"count":228,"type":23},4,"The gut microbiota plays a crucial role in health through its involvement in pathogen defense, immune regulation, and nutrient digestion. Microbiota diversity is essential to maintain these functions, and disturbances caused by antibiotic intake or extreme diets can lead to an imbalance (dysbiosis), which is often described as being implicated in numerous diseases as well as in the proliferation of antibiotic-resistant pathogens.\n\nThe microbiota is defined as the community of microorganisms inhabiting the intestine, including bacteria, viruses, and bacteriophages (phages). These phages, through their ability to destroy the bacteria they infect, play an important role in regulating bacterial populations and could therefore be essential for restoring balance and diversity in the gut.\n\nProbiotics, foods that support the microbiota such as dairy products, are of particular interest because the specific interactions between phages and bacteria within these food microbiomes could stimulate microbiota restoration.\n\nThis study aims to evaluate the effectiveness of phage-based functional foods in restoring intestinal homeostasis and, by extension, improving human health. It will serve as a model to examine how phages present in foods, particularly dairy products, influence gut microbial diversity and to determine whether these phages promote recovery after antibiotic-induced disturbances.",[231],"General Population (no Specific Condition or Disease)",[233],"phages, antibiotics","2026-01-12",{"date":236,"type":33},"2026-01-13",{"date":238,"type":33},"2025-10-16",{"date":240,"type":23},"2028-11-16",{"name":39,"class":40},{"id":243,"slug":244,"hasResults":11,"nctId":245,"briefTitle":246,"officialTitle":247,"acronym":248,"eligibilityCriteria":249,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":250,"enrollmentInfo":251,"targetDuration":4,"studyType":25,"phases":4,"briefSummary":253,"conditions":254,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":257,"startDateStruct":259,"completionDateStruct":261,"leadSponsor":263,"locationsCount":41},"100608240","boosting-microbiota-butyrate-producers-to-improve-gut-health-100608240","NCT07198984","Boosting Microbiota Butyrate Producers to Improve Gut Health","Isolate and Characterise Probiotics Capable of Increasing Butyrate Production in Order to Develop Products That Improve Gut Health and Microbiota Balance","BOOST-Mi","Inclusion Criteria:\n\n* People between the ages of 20 and 80, in good health, with a body mass index between 18.5 kg\u002Fm² and 30 kg\u002Fm², who are not deprived of their liberty or under guardianship.\n* Additional criteria for people aged between 20 and 60: Engaging in sports at least twice a week or following a flexitarian diet, No known chronic conditions, Not undergoing chronic treatment.\n\nExclusion Criteria:\n\n* Under the age of 20 or over the age of 80, Part of the principal investigator's team, Reporting to the investigator (intern, student, or employee under their authority), Having been on antibiotic therapy in the 3 months prior to sampling, Having taken probiotics in the 15 days prior to sampling, Having taken synbiotics in the 15 days prior to sampling, Having a BMI below 18.5 kg\u002Fm² or above 30 kg\u002Fm², Being deprived of liberty or under guardianship.\n* Additional criteria for people aged between 20 and 60: Not exercising twice a week or following a flexitarian diet, Having a chronic illness, Undergoing chronic treatment","80 Years",{"count":252,"type":23},25,"The human gut microbiota is a dynamic ecosystem essential to health, influenced by diet, age, and lifestyle. It plays a key role in digestion, immunity, and nervous system regulation. Among its important compounds, short-chain fatty acids, particularly butyrate, are crucial for intestinal and metabolic balance, as they support homeostasis, strengthen the epithelial barrier, and have anti-inflammatory effects.\n\nAn imbalance in the microbiota, especially a decrease in butyrate-producing bacteria, is linked to intestinal, metabolic, and neurological disorders. A fiber-rich diet promotes the growth of these beneficial bacteria.\n\nThis study aims to isolate and characterize probiotics that can enhance butyrate production, thereby improving intestinal health and microbiota balance. Sampling conditions will comply with regulations governing research involving human subjects.",[255],"Adults 20 to 80 Years","2025-12-15",{"date":258,"type":33},"2025-12-16",{"date":260,"type":33},"2025-11-24",{"date":262,"type":23},"2028-11",{"name":39,"class":40},{"id":265,"slug":266,"hasResults":11,"nctId":267,"briefTitle":268,"officialTitle":269,"acronym":270,"eligibilityCriteria":271,"healthyVolunteers":17,"sex":18,"minAge":49,"maxAge":95,"enrollmentInfo":272,"targetDuration":4,"studyType":98,"phases":274,"briefSummary":275,"conditions":276,"keywords":280,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":288,"lastUpdatePostDateStruct":289,"startDateStruct":291,"completionDateStruct":293,"leadSponsor":295,"locationsCount":41},"100611382","goat-vs-cow-milk-digestive-tolerance-100611382","NCT07239856","Goat vs. Cow Milk Digestive Tolerance","Digestive Tolerance and Nutrient Absorption Kinetics of Goat Milk Versus Cow Milk in Individuals With Reported Cow's Milk Intolerance : a Controlled Single-blinded Crossover Trial","DIGIGOAT","Inclusion Criteria:\n\n* Individuals who report being intolerant to cow milk but not to goat milk (one group) or tolerant to both cow milk and goat milk (another group)\n* Good general health (WHO grade = 0)\n* Affiliated with a social security scheme\n* Free, informed, and express consent, in accordance with the public health code: 'No research mentioned in 2° of Article L. 1121-1 can be conducted on a person without their free, informed, and express consent.\n\nExclusion Criteria:\n\n* Individuals under guardianship or curatorship\n* Individuals under legal protection\n* Any known food allergies\n* Anemia: hemoglobin levels below 13 g\u002FdL for men and 12 g\u002FdL for women\n* Pregnant women or those likely to be (based on a positive urine pregnancy test at the time of inclusion)\n* Excessive alcohol consumption (\\>2 drinks\u002Fday). Harmful alcohol consumption is assessed by the investigator at the time of inclusion.\n* Hypertension, diabetes, digestive tract diseases (except for irritable bowel syndrome, IBS), liver or kidney diseases, severe heart disease. The presence of these conditions will be assessed by the investigator based on usual clinical criteria and the volunteers' declarations during inclusion. Hypertension: Significant arterial hypertension as determined by the investigator or systolic blood pressure greater than or equal to 140 mmHg and\u002For diastolic blood pressure greater than or equal to 90 mmHg on the day of inclusion. Diabetes: Type 1 or Type 2 diabetes or any fasting blood glucose level \\> 1.25 g\u002Fl. Digestive tract disease: Gastrointestinal disorders deemed by the investigator as clinically significant (bleeding, vomiting, constipation\u002Fdiarrhea grade \\>1), any inflammatory bowel disease, acute gastroenteritis in the month preceding the intervention. Liver disease: Any significant liver disorder as determined by the investigator or any AST\u002FALT \\> 2.5 times the upper normal limit.\n* Elite athletes (\\> 8 hours per week)\n* Blood donation in the 3 months preceding the start of the study\n* Participation in a clinical study in the 3 months preceding the study\n* Lack of free, informed, and express consent",{"count":273,"type":23},20,[100],"The objective of this study is to assess to what extent goat's milk is better tolerated than cow's milk among individuals who report being intolerant to cow's milk, and, if so, to understand the underlying factors. To achieve this, digestive discomfort sensations and postprandial kinetics of nutrients after ingestion of cow's or goat's milk will be compared in two populations: individuals intolerant to cow's milk but not to goat's milk, and individuals who show no symptoms of intolerance to either cow's or goat's milk. For this purpose, approaches based on stable isotope labeling of milk will be employed.",[277,278,279],"Milk Intolerance","Milk Hypersensitivity","Cow Milk Protein Sensitivity",[281,282,283,284,285,286,287],"Digestive confort","Goat milk","Cow milk","Stable isotopes","Milk hypersensitivity","Milk intolerance","Digestion","2025-11-18",{"date":290,"type":33},"2025-11-20",{"date":292,"type":33},"2025-09-25",{"date":294,"type":23},"2027-02",{"name":39,"class":40},{"id":297,"slug":298,"hasResults":11,"nctId":299,"briefTitle":300,"officialTitle":301,"acronym":302,"eligibilityCriteria":303,"healthyVolunteers":17,"sex":18,"minAge":49,"maxAge":4,"enrollmentInfo":304,"targetDuration":4,"studyType":25,"phases":4,"briefSummary":305,"conditions":306,"keywords":309,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":288,"lastUpdatePostDateStruct":312,"startDateStruct":314,"completionDateStruct":316,"leadSponsor":318,"locationsCount":41},"100605400","improving-nutrition-for-babies-born-by-caesarean-section-100605400","NCT07162025","Improving Nutrition for Babies Born by Caesarean Section","Development of a Specific Infant Formula for Babies Born by Caesarean Section","SPECIFI-C","Inclusion Criteria:\n\n* Breastfeeding mothers:\n\nAged 18 years and older Breastfeeding for less than 6 months Not having taken probiotics in the 6 months prior to sampling Not having taken antibiotics in the 6 months prior to sampling No chronic medical conditions Not undergoing chronic treatment No history of gestational diabetes Body mass index (BMI) below 25 at the start of pregnancy Having given their consent to participate in the study and to the collection of their baby's stool samples Not deprived of liberty or placed under guardianship\n\n\\- Babies: Aged less than 6 months Born vaginally Born at term or at least 37 weeks of pregnancy Exclusively breastfed Not having received intrapartum antibiotic treatment Having no known medical conditions Not receiving any medical supplements other than conventional vitamins Whose mothers meet the inclusion criteria detailed above\n\nExclusion Criteria:\n\nBreastfeeding mothers:\n\n* Under the age of 18\n* Breastfeeding for 6 months or more\n* Having been on antibiotic therapy in the 6 months prior to sampling\n* Having taken probiotics in the 6 months prior to sampling\n* Having a chronic illness\n* Undergoing chronic treatment\n* Who have developed gestational diabetes\n* Who have a BMI greater than 25 at the start of pregnancy\n* Who have given their consent to participate in the study (breast milk collection) but not to the collection of their baby's stool samples\n* Who are deprived of their liberty or under guardianship.\n\nBabies:\n\n* Aged over 6 months\n* Born by caesarean section\n* Born before 37 weeks of pregnancy\n* Not exclusively breastfed\n* Having undergone intrapartum antibiotic treatment\n* Taking medical supplements other than conventional vitamins\n* Presenting with any type of pathology\n* Whose mothers meet the non-inclusion criteria detailed above\n* Receiving medical supplementation other than conventional vitamins",{"count":97,"type":23},"The ambition of the project is to help with the primal colonisation of babies born by caesarean section and to improve the lipid composition of an infant formula, in order to reduce the short- and long-term health problems associated with caesarean births. This population, which represents around 20% of babies born in France, has not yet received any specific care to date.\n\nThe study aims to develop an optimized infant formula. It includes: (1) isolation of probiotics from breast milk from nursing mothers and stool samples from their babies born vaginally, (2) formulation of an improved milk enriched with physiological lipids and selected probiotics, and (3) preclinical evaluation of its beneficial effects in a cesarean birth model.",[307,308],"Breastfeeding Mothers of Legal Age","Their Babies Under 6 Months Old Born Vaginally",[310,311],"caesarean section","breastfeeding",{"date":313,"type":33},"2025-11-19",{"date":315,"type":33},"2025-09-30",{"date":317,"type":23},"2028-09-30",{"name":39,"class":40},{"id":320,"slug":321,"hasResults":11,"nctId":322,"briefTitle":323,"officialTitle":324,"acronym":4,"eligibilityCriteria":325,"healthyVolunteers":17,"sex":18,"minAge":20,"maxAge":133,"enrollmentInfo":326,"targetDuration":4,"studyType":25,"phases":4,"briefSummary":328,"conditions":329,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":331,"lastUpdatePostDateStruct":332,"startDateStruct":334,"completionDateStruct":336,"leadSponsor":338,"locationsCount":41},"100529473","the-french-gut-colo-100529473","NCT06174233","The French Gut-colo","\"Contribution of Metagenomic Analysis of Faecal Microbiota Combined With Artificial Intelligence for the Prediction of Colorectal Cancer Risk; Study in Patients Scheduled for Colonoscopy\".","Inclusion Criteria:\n\n* Between the ages of 50 and 75\n* Requiring colonoscopy\n* Able to provide a faecal sample and to perform a FIT test prior to colonoscopy\n* Without known inflammatory bowel disease (chronic inflammatory bowel disease (IBD), chronic ulcerative colitis (CUC) and Crohn's disease (CD))\n* No medical condition that, in the opinion of the investigator, should preclude inclusion in the study\n* Not having participated in any other clinical research study in which an investigational drug has been administered within 60 days prior to and including the date of informed consent or is likely to be administered during the period of colonoscopy\n* Participation agreement signed electronically\n\nExclusion Criteria:\n\n* Persons not living in France (declaratory);\n* Persons subject to a protective measure, in particular guardianship or trusteeship, or unable to express their consent (declarative);\n* Persons who have had a colectomy (declaratory);\n* Person with a digestive stoma (declaration);\n* Person who did not sign the consent form;\n* Person who did not answer the entry questionnaire;\n* Person who did not send a compliant stool sample;\n* Antibiotics taken in the 3 months prior to inclusion (self-report);\n* Person aged under 50 or over 75.",{"count":327,"type":23},2500,"Colorectal cancer (CRC) is the second most common type of cancer worldwide. The European Union recommends national CRC screening for people aged between 50 and 74. Generally, an immunological test called FIT (Fecal Immunochemical Test), based on the quantitative detection of human haemoglobin, is performed on a stool sample. If the haemoglobin level is above the recommended threshold, a colonoscopy is recommended to detect colorectal lesions. Recent studies have identified potential microbiota signatures associated with colon cancer. In this study, we will analyze the microbiota of a population aged 50 to 75 years undergoing colonoscopy as part of routine care in order to confirm the presence of microbiota signatures associated with the presence of adenomas, advanced adenomas and CRC.",[330],"Patients Aged 50-75 and Requiring Colonoscopy","2025-09-10",{"date":333,"type":33},"2025-09-16",{"date":335,"type":33},"2024-06-26",{"date":337,"type":23},"2028-06-25",{"name":39,"class":40},{"id":340,"slug":341,"hasResults":11,"nctId":342,"briefTitle":343,"officialTitle":344,"acronym":345,"eligibilityCriteria":346,"healthyVolunteers":17,"sex":18,"minAge":49,"maxAge":195,"enrollmentInfo":347,"targetDuration":4,"studyType":98,"phases":349,"briefSummary":350,"conditions":351,"keywords":353,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":360,"lastUpdatePostDateStruct":361,"startDateStruct":363,"completionDateStruct":365,"leadSponsor":367,"locationsCount":41},"100549661","protein-quality-of-fava-bean-and-honey-chlorella-in-humans-100549661","NCT06436937","Protein Quality of Fava Bean and Honey Chlorella in Humans","Protein Quality of Fava Bean Meat Analogue and Honey Chlorella Ingested as Mixed Meals in Healthy Volunteers","Giant Leaps","Inclusion Criteria:\n\n* 18\\\u003CBMI\\\u003C30\n* Good health (WHO=0)\n* For woman: use of birth control\n\nExclusion Criteria:\n\n* food allergy\n* allergy against latex\n* pregnant women\n* Positive serology for AgHBS, AcHbc, HCV, HIV\n* Anemia\n* Excessive alcohool consumption\n* Hypertension, diabetes, digestive, hepatic or renal diseases, cardiac disease\n* Exercice\\>7h\u002Fweek\n* Blood donation within 3 months before the study\n* Participation to another clinical study within 3 months before the study",{"count":348,"type":23},16,[100],"The goal of the project is to determine the protein quality of alternative protein sources, honey chlorella and Faba bean, ingested as mixed meals in healthy subjects equipped with naso-ileal tube. For this purpose, Chlorella and Faba bean are intrinsically labelled with 15N. Faba bean is processed to produce a meat analogue. Chlorella is introduced in a drink. The protein quality is determined by following the digestive and metabolic fate of 15N during a 8h postprandial investigation.",[352],"Protein Quality of Chlorella and Fababean Meat Analogue",[354,355,356,357,358,359],"Digestibility","healthy humans","nasoileal tubes","stable isotopes","nitrogen retention","postprandial","2025-05-15",{"date":362,"type":33},"2025-05-20",{"date":364,"type":33},"2024-06-13",{"date":366,"type":23},"2026-09-02",{"name":39,"class":40},{"id":369,"slug":370,"hasResults":11,"nctId":371,"briefTitle":372,"officialTitle":373,"acronym":374,"eligibilityCriteria":375,"healthyVolunteers":17,"sex":18,"minAge":49,"maxAge":4,"enrollmentInfo":376,"targetDuration":4,"studyType":98,"phases":378,"briefSummary":379,"conditions":380,"keywords":382,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":391,"lastUpdatePostDateStruct":392,"startDateStruct":394,"completionDateStruct":396,"leadSponsor":397,"locationsCount":41},"100461217","feeding-guidelines-infant-randomized-controlled-trial-100461217","NCT05285761","feediNg gUidelines infanT RandomIzEd coNtrolled Trial","ECR Visant à évaluer l'Effet d'Une Intervention Sur la Diffusion d'Informations (Conduite de la Diversification Alimentaire) Sur le Comportement de Nourrissage Des Parents, le Comportement Alimentaire et le Statut pondéral de l'Enfant","NUTRIENT","Inclusion Criteria:\n\n* first-time parents\n* child age is between 1 and 54 days\n* parents living in Dijon and its surroundings (\\~ 70 km around Dijon)\n* parents who master enough the french language to understand and answer self-reported questionnaires\n\nExclusion Criteria:\n\n* no affiliation to a social security scheme\n* parents of a child born before 31 weeks of amenorrhea\n* parents of a child presenting since birth with pathologies likely to have a strong impact on his diet or his feeding habits (allergy to cow's milk proteins, feeding through a nasogastric tube or gastrostomy, congenital defect of the digestive tract, oral feeding disorders)\n* parents of a child with a multiple pregnancy (≥ 3 children).\n* in the event of a twin birth, the follow-up for this study only focuses on one of the children (according to a random draw)\n* additional exclusion criteria for participation in filmed meals from the age of 11 months: children with food allergies or intolerances or suffering from celiac disease.",{"count":377,"type":23},330,[100],"The purpose of this randomized controlled trial is to conduct an intervention aimed at providing first-time parents with information on the conduct of complementary feeding through a paper brochure and a smartphone application, to test the effect of this intervention (compared to usual care, i.e. receiving the paper brochure only), on infant corpulence at 36 and 48 months of age, and parental feeding practices and infant eating behavior up to 36 months of age.",[381],"Healthy Volunteers",[383,384,385,386,387,388,389,390],"Complementary feeding","Delivery of information","Recommendations","BMI z-score","Parental feeding practices","Infant eating behavior","Smartphone application","RCT","2024-03-12",{"date":393,"type":33},"2024-03-13",{"date":395,"type":33},"2022-03-24",{"date":216,"type":23},{"name":39,"class":40},""]