[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Institut de Recherche pour le Developpement\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":107},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,51,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100606878","optimization-of-cervical-cancer-screening-strategies-among-women-living-with-hiv-effectiveness-and-implementation-of-decentralized-approach-using-a-mobile-team-with-hpv-testing-in-the-western-region-of-cameroon-100606878",false,"NCT07181278","Optimization of Cervical Cancer Screening Strategies Among Women Living With HIV: Effectiveness and Implementation of Decentralized Approach Using a Mobile Team With HPV Testing in the Western Region of Cameroon","Optimization of HPV-based Cervical Cancer Screening Strategies Among Women Living With HIV: Effectiveness and Implementation of Decentralized Approach Using a Mobile Team With HPV Testing in the Western Region of Cameroon","OptiTri_MT","Inclusion Criteria:\n\n* Women\n* HIV infection\n* Age between 25 and 49 years old\n* Receiving or starting ARV treatment\n* Agreeing to participate in the study and having signed the consent\n\nExclusion Criteria:\n\n* Current pregnancy\n* Hysterectomy\n* Treatment of cervical lesions within 12 months\n* Expected follow-up difficulties: planned absence that could interfere with the participation in the study (e.g., travel abroad, relocation, imminent transfer, etc.);\n* Any pathology or concomitant treatment which, in the opinion of the investigators, contraindicates participation or prevents satisfactory participation in the study\n\nDeferred inclusion if\n\n* menstrual bleeding\n* Postpartum (\\\u003C12 weeks after delivery)\n* Clinical signs of cervical or pelvic infection","FEMALE","25 Years","49 Years",{"count":21,"type":22},1180,"ESTIMATED","INTERVENTIONAL",[25],"NA","Context. Cervical cancer (CC) is a leading cause of death among women living with HIV (WLHIV) in resource-limited settings. Yet, effective methods for screening and preventing CC are available. The recommanded approach for CC screening is based on multiple steps, including initial test to detect human papillomavirus (HPV) infection, visual inspection to identify women with HPV at risk for precancerous lesion and treatment when required.\n\nDropout may occur at these different steps, compromising the success of the CC elimination strategy. Performing all the screening and treatment sequences in a single visit has been recommanded based on the results of a large South African trial. Yet, in many contexts, including those with limited resources, the screening and treatment activities are performed in multiple visites for logistical reasons, resulting in many dropouts.\n\nDifferent strategies for delivering screening with HPV testing for WLHIV are possible. A first approach (\"centralized approach\") consists of having well equipped reference centres with experienced health workers and referring women to these centers. An alternative consists of having a mobile unit who can bring equipment and health workers and perform the CC screening in the usual places of patient care (\"decentralised\" or mobile team approach). Each of these two approaches has advantages and limitations in terms of coverage, completeness, cost and quality of screening. It is necessary to evaluate them in real life to inform national decision-makers on the best strategy to use in their countries.\n\nThe OptiTri-MU study aims to evaluate and compare the effectiveness of these two strategies for delivering CC screening (\"centralized\" screening versus \"decentralized\" screening). It will also assess the implementation of each strategy and include three sub-studies designed to evaluate :\n\n* the performance of urinary HPV testing.\n* the performance of different methods to identify women requiring a treatment.\n* the risk of post-treatment cervical disease. Design This is a trial in which the intervention (mobile team) will be implemented gradually. All sites starts with the centralized screening strategy. At each period, a new site is ransomly selected and start the the decentralized screening strategy. There will be 6 periods of 10 weeks. The effectiveness of the intervention will be assessed by comparing the outcomes at each site before and after implementation and by comparing the sites with each other. The primary outcome for effectiveness is the screening completeness 120 days after enrollment.\n\nThe study will also assess the implementation of each screening strategy in terms of :\n\n* Success through the measure of fidelity, reach and completeness\n* Identification of adaptation, barriers and facilitating\u002Fleverage factors\n* Perception, feasibility and acceptability of the screening strategies (by patients and health care workers)\n\nOther study objectives include :\n\n* To assess the performance of different methods to identify women requiring a treatment\n* To assess the performance of HPV testing on a urine sample compared with vaginal self-collected or cervical (clinician-collected) samples\n* To assess the efficacy of treatment in terms of post-treatment cervical lesions Study population. Participants will be WLHIV aged 25 to 49 and eligible for CC screening. Health care workers will also be invited to participate to the implementation research. The data collected will be quantitative and qualitative.",[28,29],"Cervical Cancer Screening","HIV",[31,32,29,33,34,35,36,37],"cervical cancer","screening","implementation","resource-limited setting","HPV test","decentralization","thermal ablation","RECRUITING","2025-11-24",{"date":41,"type":42},"2025-12-02","ACTUAL",{"date":44,"type":42},"2025-04-28",{"date":46,"type":22},"2028-08-01",{"name":48,"class":49},"Institut de Recherche pour le Developpement","OTHER_GOV",6,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":62,"conditions":63,"keywords":64,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":74},"100606562","impact-of-a-single-versus-multiple-visits-on-the-cervical-cancer-screening-completeness-feasibility-and-acceptability-among-women-living-with-hiv-in-cameroon-100606562","NCT07177170","Impact of a Single Versus Multiple Visits on the Cervical Cancer Screening Completeness, Feasibility and Acceptability Among Women Living With HIV in Cameroon","Optimizing Cervical Cancer Screening Strategies With HPV Testing Among Women Living With HIV in Cameroon: Feasibility, Acceptability, and Impact of a Single-visit Test and Treat Approach in a Hospital Center With an HPV Testing Platform","OptiTri_GC","Inclusion Criteria:\n\n* HIV infection\n* receiving antiretroviral therapy\n* living in the department of the study hospital\n\nExclusion Criteria:\n\n* ongoing pregnancy\n* hysterectomy\n* treatment of cervical lesion in the past 12 months\n* Expected follow-up difficulties: planned absence that could interfere with the participation in the study (e.g., travel abroad, relocation, imminent transfer, etc.);\n* Any pathology or concomitant treatment which, in the opinion of the investigators, contraindicates participation or prevents satisfactory participation in the study Inclusion deferred if\n* menstrual bleeding\n* post-partum (\\\u003C12 weeks after delivery)\n* clinicla signs of cervical or pelvic infection",{"count":60,"type":22},1422,[25],"Context. Cervical cancer (CC) is a leading cause of death among women living with HIV (WLHIV) in resource-limited settings. Yet, effective methods for screening and preventing CC are available. The recommanded approach for CC screening is based on multiple steps, including initial test to detect human papillomavirus (HPV) infection, visual inspection to identify women with HPV at risk for precancerous lesion and treatment when required.\n\nDropout may occur at these different steps, compromising the success of the CC elimination strategy. Performing the all screening and treatment sequence in a single visit has been recommanded based on the results of a large South African trial. Yet, in many contexts, including those with limited resources, the screening and treatment activities are performed in multiple visites for logistical reasons, resulting in many dropouts. Strategies based on the differentiated prestation approaches, which propose a simplified management centered on the patients preferences, could guide the adaptation of the single-visit approach to account for contextual constraints while maintaining high effectiveness.\n\nThe OptiTri-GC study aims to design and assess the impact of a differentiated CC screen and treat strategy in a district hospital; It will assess both its implementation and its effectiveness based on the completeness at each stage of the screening cascade. In addition, it will also include three sub-studies designed to evaluate :\n\n* The performance of urinary HPV testing.\n* The performance of different methods to identify women requiring a treatment.\n* The risk of post-treatment cervical disease.\n\nThis study has two periods. During the first period, a single visit approach will be used while differentiated approach will be prepared using participatory research. During the second period, the differentiated approach will be implemented. The screening overall completeness will be compared between the two periods to assess the differentiated approach effectiveness.\n\nThe study will also assess the implementation of each screening strategy in terms of :\n\n* Success through the measure of fidelity, reach and completeness\n* Identification of adaptation, barriers and facilitating\u002Fleverage factors\n* Perception, feasibility and acceptability of the screening strategies (by patients and health care workers) It will assess the participants' stress levels during the screening process and to identify potential psychosocial support strategies and document the experience of WLHIV and health workers during the screening process and the post-treatment follow-up.\n\nOther study objectives include :\n\n* To assess the performance of different methods to identify women requiring a treatment\n* To assess the performance of HPV testing on a urine sample compared with vaginal self-collected or cervical (clinician-collected) samples\n* To assess the efficacy of treatment in terms of post-treatment cervical lesions\n\nMethodology. Participants will be WLHIV aged 25 to 49 and eligible for CC screening. Health care workers will also be invited to participate to the implementation research. The data collected will be quantitative and qualitative.",[28,29],[31,32,29,65,33,34,37,35],"differentiated prestation","2025-09-12",{"date":68,"type":42},"2025-09-16",{"date":70,"type":42},"2024-12-12",{"date":72,"type":22},"2027-05",{"name":48,"class":49},1,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":83,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":23,"phases":86,"briefSummary":87,"conditions":88,"keywords":92,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},"100512384","the-triple-elimination-model-of-mother-to-child-transmission-program-tri-mom-100512384","NCT05951751","The TRIple Elimination Model Of Mother-to-child Transmission Program (TRI-MOM)","Integrated Antenatal Screening for HIV, Syphilis, and Hepatitis B Virus (HBV) in Pregnant Women in Burkina Faso and The Gambia","TRI-MOM","Inclusion Criteria:\n\n* Women attending a postnatal visit in one of the selected maternities (no maternal age limit)\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* Unable to provide consent",true,{"count":85,"type":22},2800,[25],"The TRI-MOM program aims to implement and evaluate a simplified (based on inexpensive rapid diagnostic tests), integrated (in governmental health facilities) and coordinated (between health care workers) strategy for the triple elimination of HIV, syphilis and HBV mother-to-child transmission (MTCT) in nine maternal and child health services, 5 in Burkina Faso and 5 in The Gambia.\n\nThe TRI-MOM program has two components:\n\n1. an \"intervention\" component consisting of a pilot study to reinforce the antenatal screening and prevention of MTCT (PMTCT) capacities for the 3 targeted infections through the implementation of a simplified, integrated and coordinated strategy of triple elimination of MTCT.\n2. an \"evaluation\" component which will assess the impact of the TRI-MOM strategy on PMTCT services, reduction of HBV MTCT and women empowerment.",[89,90,91],"Hiv","Syphilis","HBV",[93,94,29,95,90,96,97],"maternal health","child health","Hepatitis B","prevention and control","pregnancy","2024-06-17",{"date":100,"type":42},"2024-06-20",{"date":102,"type":42},"2024-03-18",{"date":104,"type":22},"2025-05",{"name":48,"class":49},2,""]