[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Institute for Oncology and Radiology of Serbia\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":43},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100640032","the-5050-nitrous-oxide-vs-2-lidocaine-challenge-100640032",false,"NCT07618676","The 50:50 Nitrous Oxide vs 2% Lidocaine Challenge","The 50:50 Nitrous Oxide Challenge: A Prospective Randomised Trial - Needle, Meet Your Match","Inclusion Criteria:\n\n* Subjects who have not previously received Nitrous Oxide.\n* Subjects of both sexes, aged between 18 and 65 inclusive.\n* Subjects who have signed informed consent with full disclosure; no study-related procedure may begin until the subject signs the consent form.\n\nExclusion Criteria:\n\n* Infection at the planned puncture site.\n* Pregnancy.\n* Intracranial hypertension.\n* Vitamin B12 deficiency.\n* Hemodynamic instability.\n* BMI over 35.\n* Glasgow Coma Scale (GCS) score less than 15.\n* Presence of chronic pain.\n* Neurological disorders.\n* Hematologic disorders.\n* More than two attempts at venous puncture (Subject Withdrawal Criterion).\n* Subject experienced an adverse event requiring early discontinuation (Subject Withdrawal Criterion).\n* Withdrawal of consent by the subject (Subject Withdrawal Criterion)",true,"ALL","18 Years","65 Years",{"count":21,"type":22},62,"ESTIMATED","INTERVENTIONAL",[25],"NA","The main goal of the project is to assess pain levels and patient comfort during the administration of a 50:50 Nitrous Oxide\u002FOxygen gas mixture, in comparison to the same parameters under the standard method used at our institution, which includes injecting a local anaesthetic at the site of planned puncture for central venous catheterisation.",[28,29,30],"Acute Pain","Anxiety","Central Venous Catheter","RECRUITING","2026-05-25",{"date":34,"type":35},"2026-06-01","ACTUAL",{"date":37,"type":35},"2025-06-06",{"date":39,"type":22},"2026-07-01",{"name":41,"class":42},"Institute for Oncology and Radiology of Serbia","OTHER",""]