[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Institute of Automation, Chinese Academy of Sciences\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":65},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100549158","phase-1-study-of-vegf-a-targeting-nir-ii-fluorescence-endoscopy-in-the-gastrointestinal-tract-100549158",false,"NCT06430372","Study of VEGF-A Targeting NIR-II Fluorescence Endoscopy in the Gastrointestinal Tract","Study of Vascular Endothelial Growth Factor A Targeting NIR-II Fluorescence in the Endoscopy of Gastrointestinal Tract","Inclusion Criteria:\n\n* Known or suspected gastrointestinal lesions.\n* Scheduled for a clinically-indicated endoscopy.\n* Mentally competent person, 18 years or older.\n* Approved to sign the informed consent.\n* Adequate potential for follow-up.\n\nExclusion Criteria:\n\n* Subjects with known allergy or negative reaction to ICG or derivatives.\n* Undesirable function of heart, lung, kidney, or any other organs.\n* Enrolled in other trials in the past 3 months.\n* Pregnant or trying to conceive.\n* Unable to tolerate an endoscopy.\n* Medical or psychiatric conditions that compromise the patient's ability to give informed consent.\n* The researchers considered inappropriate to be included.","ALL","18 Years","75 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"PHASE1","In this study, the investigators are studying new ways to look for abnormal tissues of the gastrointestinal tract during an endoscopy. We are using a VEGF-A targeting fluorescent probe and a NIR-II fluorescent endoscope to help detect abnormal tissues that are hard to see by the naked eye.\n\nThe main purposes of this study include:\n\n1. To translate the NIR-II approach into the endoscopy, and understand its advantages and limitations on detecting abnormal tissues in gastrointestinal.\n2. To validate whether topical administration of a targeting probe can stick to abnormal tissues and be detected by the NIR-II endoscope.\n3. To validate the safety and effectiveness of the topical administration of VEGF-A targeting probes for clinical application.",[27,28,29],"Gastrointestinal Carcinoma","Dysplasia","Gastrointestinal Polyp","RECRUITING","2025-05-08",{"date":33,"type":34},"2025-05-13","ACTUAL",{"date":36,"type":34},"2023-07-20",{"date":38,"type":21},"2026-05-30",{"name":40,"class":41},"Institute of Automation, Chinese Academy of Sciences","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":5},"100531825","phase-1-itga6-targeting-nir-ii-fluorescence-image-guided-surgery-100531825","NCT06204835","ITGA6 Targeting NIR-II Fluorescence Image Guided Surgery","ITGA6 Targeting NIR-II Fluorescence Image Guided Surgery of HCC Patients","Inclusion Criteria:\n\n1. Patients who have been diagnosed with hepatocellular carcinoma.\n2. Planned to receive hepatectomy.\n3. Liver function Child-Pugh A.\n4. ITGA6 was validated highly expressed preoperatively.\n5. Aged 18 to 80, and the expected lifetime is longer than 6 months.\n6. Approved to sign the informed consent.\n\nExclusion Criteria:\n\n1. Allergic to Cy7.\n2. Enrolled in other trials in the past 3 months.\n3. Another malignant tumor was found.\n4. Undesirable function of heart, lung, kidney, or any other organs.\n5. Unable to tolerate a hepatectomy.\n6. The researchers considered inappropriate to be included.","80 Years",{"count":52,"type":21},90,[24],"In this study, the investigators will detect hepatocellular carcinoma lesions using fluoescence imaging with ITGA6 targeting probes during tumor resection surgery. The aim is to evaluate wether intraoperative fluorescence imaging targeting ITGA6 can help to improve the detction effect of hepatocellular carcinoma, and finally help the accurate surgical resection.\n\nThe main purposes of this study include:\n\n1. To raise the detection rate of hepatocellular carcinoma intraoperatively using the novel NIR-II fluorescence molecular imaging and the ITGA6 targeting probe.\n2. To validate the safety and effectiveness of the proposed ITGA6 targeting probes for clinical application.",[56],"Hepatocellular Carcinoma","2024-05-20",{"date":59,"type":34},"2024-05-22",{"date":61,"type":34},"2024-01-07",{"date":63,"type":21},"2039-12-31",{"name":40,"class":41},""]