[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Institute of Mountain Emergency Medicine\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":147},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,49,70,97,124],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100636312","physiological-effects-of-different-preoxygenation-strategies-100636312",false,"NCT07564050","Physiological Effects of Different Preoxygenation Strategies","Physiological Effects of Different Preoxygenation Strategies in Adults and Children: A Comparative Study of NRM and BVM With and Without PEEP","PREOXY II","Inclusion Criteria:\n\n* Adults with an American Society of Anesthesiologists (ASA) physical status score ≤ 2\n* Children aged 5 to 12 years with an ASA physical status score ≤ 2\n* Ability (or legal guardian ability) to provide written informed consent\n\nExclusion Criteria:\n\n* Children aged \\\u003C 5 years or 13 to 18 years\n* ASA physical status score \\> 2\n* Body mass index (BMI) ≥ 30 kg\u002Fm²\n* Known airway pathology or anatomical abnormality that could affect mask fit, ventilation, or oxygenation\n* Presence of an active airway infection at the time of the study\n* Pregnancy\n* Refusal or inability to provide informed consent",true,"ALL","5 Years","75 Years",{"count":22,"type":23},30,"ESTIMATED","INTERVENTIONAL",[26],"NA","The goal of this clinical trial is to evaluate the performance and physiological effects of different preoxygenation devices in healthy adult and pediatric volunteers (children aged 5-12 years). The study aims to determine how these devices influence oxygen delivery, airway pressure, and cardiopulmonary physiology during preoxygenation.\n\nThe main questions it aims to answer are:\n\n* What fraction of inspired oxygen (FiO₂) is delivered by non-rebreather masks (NRM) compared to bag-valve masks (BVM) with and without positive end-expiratory pressure (PEEP)?\n* How do these devices differ in terms of generated PEEP, inspiratory effort, and their effects on lung ventilation and cardiac function?\n\nResearchers will compare NRM, BVM without PEEP, and BVM with PEEP (each with or without supplemental oxygen via nasal cannula) to evaluate differences in oxygenation and physiological effects.\n\nParticipants will:\n\n* Complete multiple 3-minute preoxygenation sessions using each device in randomized order\n* Breathe spontaneously through each device, with or without additional oxygen via nasal cannula\n* Undergo non-invasive monitoring of oxygen concentration (FiO₂), respiratory parameters, airway pressures, and ultrasound assessment of the lungs, diaphragm, and heart\n* Perform a brief breath-holding maneuver to assess airway pressure generation",[29],"Preoxygenation",[29,31,32,33,34,35],"Bag-valve mask (BVM)","Non-rebreather mask (NRM)","Positive end-expiratory pressure (PEEP)","Fraction of inspired oxygen (FiO₂)","Respiratory physiology","RECRUITING","2026-05-06",{"date":39,"type":40},"2026-05-08","ACTUAL",{"date":42,"type":23},"2026-05-23",{"date":44,"type":23},"2026-06-30",{"name":46,"class":47},"Institute of Mountain Emergency Medicine","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":48},"100638477","esotip-tee-defining-an-easy-landmark-to-guide-correct-esophageal-probe-placement-with-transesophageal-echocardiography-100638477","NCT07574736","ESOTIP-TEE: Defining an Easy Landmark to Guide Correct Esophageal Probe Placement With Transesophageal Echocardiography","ESOTIP-TEE","Inclusion Criteria:\n\n* Adult (≥18 years) patients admitted to the ICU\n* Clinical indication to perform a transesophageal echocardiography\n\nExclusion Criteria:\n\n* \\\u003C18 years",{"count":22,"type":23},"OBSERVATIONAL","This prospective observational study aims to identify simple external anatomical landmarks that allow reliable prediction of correct esophageal probe insertion depth. Accurate placement in the lower third of the esophagus is essential for reliable core temperature monitoring. Transesophageal echocardiography (TEE) will be used as the reference standard to confirm correct probe position. The study will evaluate the agreement between landmark-based insertion depth and TEE-confirmed placement in adult ICU patients undergoing clinically indicated TEE.",[60,61,62],"Monitoring","Esophageal Temperature","Hypothermia","2026-05-05",{"date":39,"type":40},{"date":66,"type":40},"2025-12-12",{"date":68,"type":23},"2026-07-30",{"name":46,"class":47},{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":18,"minAge":78,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":81,"conditions":82,"keywords":86,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":48},"100627579","field-study-on-intravenous-iloprost-for-treatment-of-severe-frostbite-at-high-altitude-100627579","NCT07450469","Field Study on Intravenous Iloprost for Treatment of Severe Frostbite at High Altitude","High-Altitude Iloprost Feasibility Study for Treatment of Frostbite","HAI-Frost","Inclusion Criteria:\n\n* Frostbite grade 3\u002F4 eligible for Iloprost\n* \\\u003C72h of thawing\n* min. age of 18 years\n* provision of written informed consent\n\nExclusion Criteria:\n\n* age \\\u003C18 years\n* general contraindication\n* pregnancy\n* inability\u002Fdenial to provide informed consent","18 Years",{"count":80,"type":23},10,"The goal of this observational study is to learn whether intravenous iloprost treatment for severe frostbite (grades 3-4) is feasible and safe when delivered in pre-hospital, remote high-altitude settings.\n\nThe main questions it aims to answer are:\n\n* Is it feasible to initiate and deliver guideline-based intravenous iloprost for grade 3-4 frostbite at high altitude and what logistical barriers arise?\n* Does field-based initiation of iloprost increase tissue preservation and reduce amputations (compared to historical cases from similar settings)?\n\nParticipants receiving Iloprost as part of a frostbite treatment will be followed up after discharge as well as 6, 12 and 18 months to assess tissue preservation and long-term sequelae from the initial frostbite injury.",[83,84,85],"Frostbite","Altitude","Field Physician Care",[87],"iloprost","NOT_YET_RECRUITING","2026-03-05",{"date":91,"type":40},"2026-03-09",{"date":93,"type":23},"2026-05",{"date":95,"type":23},"2028-05",{"name":46,"class":47},{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":101,"acronym":102,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":18,"minAge":78,"maxAge":4,"enrollmentInfo":104,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":106,"conditions":107,"keywords":110,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":4},"100575086","aid-omie---artificial-intelligence-in-detection-of-occlusive-myocardial-infarction-in-emergency-medicine-100575086","NCT06767709","AID-OMIE - Artificial Intelligence in Detection of Occlusive Myocardial Infarction in Emergency Medicine","AID-OMIE","Inclusion Criteria:\n\n* OHCA from with ROSC in the Province of Bolzano, Italy\n* Coronary angiography (CAG) within 7 days post-OHCA\n* Age \\> 18 years\n* Available prehospital post-ROSC ECG\n* Available CAG report\n\nExclusion Criteria:\n\n* In-Hospital Cardiac Arrest (IHCA)\n* Age \\\u003C 18 years\n* Traumatic cardiac arrest\n* Cardiac arrest from a clear non-cardiac cause\n* Corrupted ECG images\n* Poor ECG digitalization quality",{"count":105,"type":23},200,"Study Objective and Hypothesis The study hypothesizes that artificial intelligence (AI)-assisted interpretation of the 12-lead electrocardiogram (ECG) can improve the care of patients resuscitated after out-of-hospital cardiac arrest (OHCA) by enabling faster and more accurate detection of occlusion myocardial infarction (OMI). This enhanced diagnostic approach could reduce the time required for revascularization, improve patient outcomes, and decrease unnecessary activations of cardiac catheterization laboratories. The primary objective of the study is to assess the effectiveness of an AI-powered ECG model in identifying acute OMI in OHCA patients whose post-return of spontaneous circulation (ROSC) ECG does not show ST-elevation.\n\nMethods\n\nThis is a retrospective observational study involving OHCA patients in Bolzano, Italy, who meet the following inclusion criteria:\n\nAged 18 years or older. Achieved ROSC after cardiac arrest. Underwent coronary angiography (CAG) within seven days post-OHCA. Prehospital post-ROSC ECG and CAG reports available.\n\nExclusion criteria include in-hospital cardiac arrest (IHCA), traumatic cardiac arrest, cardiac arrest from a non-cardiac cause, and poor-quality or corrupted ECG images. Post-ROSC ECGs will be analyzed using the PMcardio App, an AI tool for ECG interpretation. The data will be fully anonymized before storage. Coronary angiography charts will be reviewed for the presence of atherosclerotic lesions, the degree of arterial narrowing, and Thrombolysis in Myocardial Infarction (TIMI) flow, which assesses blood flow in coronary arteries.\n\nStudy Outcomes The primary outcome is the sensitivity and specificity of the AI-assisted ECG in detecting OMI in patients whose post-ROSC ECG does not show ST-elevation. Secondary outcomes include the frequency of OMI in OHCA patients without ST-elevation and the ability of the AI model to rule out OMI accurately in these cases.",[108,109],"Cardiac Arrest, Out-Of-Hospital","Cardiac Arrest Due to Underlying Cardiac Condition",[111,112,113,114,115],"Cardiac arrest","OHCA","Occlusion myocardial infarction","OMI","Artificial intelligence","2025-08-05",{"date":118,"type":40},"2025-08-08",{"date":120,"type":23},"2025-09-01",{"date":122,"type":23},"2026-05-31",{"name":46,"class":47},{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":17,"sex":18,"minAge":131,"maxAge":4,"enrollmentInfo":132,"targetDuration":4,"studyType":24,"phases":134,"briefSummary":135,"conditions":136,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":48},"100544577","comparison-of-three-pre-oxygenation-strategies-100544577","NCT06370689","Comparison of Three Pre-oxygenation Strategies","Comparison of Three Pre-oxygenation Strategies for Prehospital Anaesthesia Induction in Children, Normal Weight Adults and Obese Adults","Inclusion Criteria:\n\n* Normal-weight adults (BMI 18.5-24.9 kg\u002Fm2) with an \"American Society of Anesthesiologists Physical Status Classification System (ASA) \" score of I or II\n* Adults with a BMI 25-39.9 kg\u002Fm2 with and ASA score \\\u003C3\n* Healthy (ASA I) children aged 6-12 years\n\nExclusion Criteria:\n\n* ASA 3\n* Age \\\u003C 6 and age 12-18\n* pregnant women\n* missing informed consent\n* signs and symptoms of an acute respiratory illness on the study day","6 Years",{"count":133,"type":23},45,[26],"Study objective: Comparing the efficacy of three different preoxygenation strategies, i.e. non-rebreather face mask (NRM), bag-valve-mask (BVM) with and BVM without additional positive end-expiratory pressure (PEEP) in three subgroups of spontaneously breathing volunteers.\n\nStudy endpoints\n\nPrimary Endpoint:\n\nDifference in expiratory oxygen concentration (FeO2) at the end of the 3 min preoxygenation sessions.\n\nSecondary endpoints:\n\n* Difference in Oxygen Reserve Index (ORi) at the end of the 3 min preoxygenation sessions.\n* Changes in regional ventilation from baseline to 1.5 min and 3 min into the preoxygenation sessions, assessed using electrical impedance tomography (EIT)\n* Time to reaching an Oxygen Reserve Index (ORi) ≥ 0.5\n* Time to reaching an Oxygen Reserve Index (ORi) =1\n* Time to Oxygen Reserve Index (ORi) back to baseline after the 3 min preoxygenation sessions.\n\nNumber of participants 15 participants per subgroup, i.e. 45 participants in total.\n\nInclusion criteria\n\n* Normal-weight adults (body mass index, BMI 18.5-24.9 kg\u002Fm2) with an \"American Society of Anesthesiologists Physical Status Classification System (ASA) \" score of I or II\n* Adults with a BMI 25-39.9 kg\u002Fm2 with and ASA score \\\u003C3\n* Healthy (ASA I) children aged 6-12 years Exclusion criteria ASA 3, Age \\\u003C 6 and age 12-18, pregnant women, missing informed consent, signs and symptoms of an acute respiratory illness on the study day.\n\nAfter informed consent and a medical check-up, baseline measurements will be done for 10 minutes (peripheral oxygen saturation SpO2, ORI, regional ventilation). Then the participants will undergo 3 different preoxygenation sessions with the 3 interfaces (i.e. non-rebreather facemask with reservoir and a bag-valve-mask with and without PEEP) in a randomized order and a 20 min washout between the sessions. Each preoxygenation session is conducted in a supine position and will be proceeded until the measured FeO2 (end expiratory O2 fraction) reaches 90% or up to a maximum time of 3 min. Afterwards 10 min of SpO2, ORI and regional ventilation measurements will follow.",[137,138],"Emergencies","Anesthesia","2025-03-25",{"date":141,"type":40},"2025-03-28",{"date":143,"type":40},"2024-05-23",{"date":145,"type":23},"2025-07-30",{"name":46,"class":47},""]