[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Instituto Nacional de Rehabilitacion\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":141},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,53,82,112],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100644229","effectiveness-of-an-inpatient-rehabilitation-and-prosthetic-training-model-in-patients-with-vascular-and-metabolic-transfemoral-amputation-100644229",false,"NCT07665775","Effectiveness of an Inpatient Rehabilitation and Prosthetic Training Model in Patients With Vascular and Metabolic Transfemoral Amputation","Effectiveness of an Inpatient Multidisciplinary Rehabilitation and Prosthetic Training Model in Patients With Vascular and Metabolic Transfemoral Amputation Treated at a National Rehabilitation Center: An Ambispective Cohort Study","Inclusion Criteria:\n\n* Unilateral transfemoral amputation secondary to vascular disease or diabetes-related complications.\n* Participation in the INRLGII inpatient prosthetic rehabilitation program.\n* Availability of complete clinical records or willingness to participate in follow-up assessments .\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Current prosthesis user before admission to the INRLGII rehabilitation program.\n* Bilateral major lower-limb amputation.\n* Inability to complete follow-up assessments.\n\nWithdrawal Criteria\n\n* Incomplete or inconsistent clinical information.\n* Loss to follow-up during the 6-month observation period.\n* Participant withdrawal of consent.","ALL","18 Years",{"count":19,"type":20},54,"ESTIMATED","6 Months","OBSERVATIONAL","Patients with vascular and metabolic transfemoral amputations experience substantial functional limitations and high rates of prosthetic abandonment. Although multidisciplinary inpatient rehabilitation programs have been associated with improved outcomes, evidence regarding their effectiveness in low- and middle-income countries remains limited.\n\nThis study aims to evaluate the effectiveness of an inpatient rehabilitation and prosthetic training model implemented at the National Institute of Rehabilitation \"Luis Guillermo Ibarra Ibarra\" (INRLGII), Mexico. An ambispective cohort design will be used, including a retrospective review of patients treated between 2013 and 2025 and a prospective cohort enrolled between 2026 and 2029.\n\nThe primary objective is to determine the proportion of patients who achieve functional prosthesis use after hospital discharge. Secondary objectives include identifying clinical, metabolic, functional, and psychosocial factors associated with successful prosthetic use, adherence, and abandonment.",[25,26,27,28],"Diabetes Mellitus","Transfemoral Amputation","Peripheral Arterial Disease","Vascular Thrombosis",[26,30,25,31,32,33,34,35,36,37,38,39],"Vascular Amputation","Prosthetic Rehabilitation","Lower Limb Amputation","Prosthesis Use","Prosthetic Adherence","Prosthetic Abandonment","Functional Outcomes","Inpatient Rehabilitation","Multidisciplinary Care","Houghton Scale","NOT_YET_RECRUITING","2026-06-18",{"date":43,"type":44},"2026-06-24","ACTUAL",{"date":46,"type":20},"2026-06-19",{"date":48,"type":20},"2030-09",{"name":50,"class":51},"Instituto Nacional de Rehabilitacion","OTHER_GOV",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":52},"100465623","efficacy-of-a-brain-computer-interface-controlled-functional-electrical-stimulation-therapy-for-spinal-cord-injury-neurorehabilitation-100465623","NCT05343130","Efficacy of a Brain-Computer Interface Controlled Functional Electrical Stimulation Therapy for Spinal Cord Injury Neurorehabilitation","Efficacy of a Therapy With Brain-Computer Interface Controlled Functional Electrical Stimulation for Neurorehabilitation of Patients With Spinal Cord Injury (Eficacia de Una Terapia Con estimulación eléctrica Funcional Controlada Con Interfaz Cerebro-computadora Para neurorrehabilitación de Pacientes Con lesión Medular)","Inclusion Criteria:\n\n* Spinal Cord Injury at neurological levels C6 or C7\n* American Spinal Injury Association (ASIA) classification A, B, C or D\n* Upper limb spasticity of less or equal to +1 measured with the Modified Ashworth Scale\n* Time since disease onset of more than 6 months and less than 60 months\n* Normal or corrected to normal vision\n\nExclusion Criteria:\n\n* Severe attention deficits\n* Previous diagnosis of traumatic brain injury\n* Previous diagnosis of peripheral nerve injury\n* Previous stroke diagnosis\n* Previous diagnosis of neurodegenerative diseases\n* History of fractures in upper extremities\n* Skin lesions\n* Contractures in upper extremities that hamper mobility\n* Excessive muscle spasms",{"count":61,"type":20},32,"INTERVENTIONAL",[64],"NA","The study's main goal is to determine the efficacy of a therapy with brain-computer interface controlled functional electrical stimulation for neurorehabilitation of spinal cord injury patients' upper limbs. For this purpose, a randomized controlled trial will be performed to compare the clinical and physiological effects of the brain-computer interface therapy with those of a sham intervention comprised by the application of functional electrical stimulation independently of brain-computer interface control.",[67],"Cervical Spinal Cord Injury",[69,70,71,72],"brain-computer interface","functional electrical stimulation","motor rehabilitation","tetraplegia","RECRUITING","2025-06-20",{"date":76,"type":44},"2025-06-25",{"date":78,"type":44},"2022-08-01",{"date":80,"type":20},"2027-12",{"name":50,"class":51},{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":88,"sex":16,"minAge":17,"maxAge":89,"enrollmentInfo":90,"targetDuration":92,"studyType":22,"phases":4,"briefSummary":93,"conditions":94,"keywords":97,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":52},"100582503","evaluation-of-micrornas-and-vitamin-b12-expression-in-subjects-with-neurologic-symptoms-of-depression-anxiety-and-fatigue-in-long-covid-19-100582503","NCT06864156","Evaluation of MicroRNAs and Vitamin B12 Expression in Subjects with Neurologic Symptoms of Depression, Anxiety and Fatigue in Long COVID-19","Inclusion Criteria:\n\n* Subjects with confirmed diagnosis of COVID-19 by SARS-CoV-2 infection by PCR or antigen testing.\n* With presence of neurological symptoms of depression, anxiety and fatigue associated with COVID-19 after three months from the first day of acute infection symptoms.\n\nExclusion Criteria:\n\n* Subjects who have presented symptoms of acute infection in the last twelve weeks.\n* Subjects who present diagnostic premorbid neurological alterations.\n* Subjects who do not have at least 2 doses of COVID-19 vaccine, with last application date equal or older than 3 months.",true,"65 Years",{"count":91,"type":20},20,"1 Day","At the moment, the number of people with long COVID is unkown because there is still no effective diagnosis. This is why is very important to analyze the most common symptoms, which are: depression, anxiety and fatigue. This project seeks to analyze some blood components of people with long COVID, such as microRNAs and vitamin B12, in order to identify the body processes that changed after COVID-19 and thereby design better therapies and diagnostic methods focused on each of them.\n\nThe hypothesis is that the expression of miR-21, -146a and -155 will be overexpressed as well as there will be a deficiency of vitamin B12 in serum in subjects suffering from long COVID with neurological symptoms of depression, anxiety and fatigue.",[95,96],"Long COVID","Long COVID Syndrome",[98,99,100,101,102,103],"anxiety","depression","fatigue","microRNAs","vitamin b12","long covid","2025-03-05",{"date":106,"type":44},"2025-03-07",{"date":108,"type":44},"2025-02-18",{"date":110,"type":20},"2025-07",{"name":50,"class":51},{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":118,"eligibilityCriteria":119,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":120,"targetDuration":4,"studyType":62,"phases":122,"briefSummary":123,"conditions":124,"keywords":128,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":52},"100547575","bci-fes-for-upper-limb-rehabilitation-in-chronic-stroke-100547575","NCT06409754","BCI-FES for Upper Limb Rehabilitation in Chronic Stroke","Application of Functional Electrical Stimulation Therapy Coupled to a P300-based Brain-Computer Interface for Paretic Upper Limb Rehabilitation in Chronic Stroke: A Randomized Controlled Trial","BCI-FES","Inclusion Criteria:\n\n* Patients with ischemic or hemorrhagic stroke (evidenced by CT or MRI)\n* ≥6 months from stroke onset, chronic phase\n* Unilateral lesion\n* Age ≥18 years\n* Moderate-severe hemiparesis (FMA-UE: ≤45)\n* Full passive ranges of motion in the elbow, forearm, wrist, and hand\n* Minimal cognitive level necessary to follow instructions and complete tasks\n* Desire to participate in the study\n\nExclusion Criteria:\n\n* Neurological disorders (Parkinsons disease, epilepsy, dementia)\n* Neurological or musculoskeletal condition directly affecting the upper limb (dystonia, severe spasticity -muscle tone for elbow, wrist and fingers \\> 3 according to modified Ashworth scale-)\n* Contraindications for MRI (implantable devices -pacemakers-, claustrophobia, others)\n* Cognitive deficit (MoCA \\\u003C20 points)\n* Severe aphasia\n* Severe psychiatric disorders\n* More than one stroke",{"count":121,"type":20},26,[64],"The objective of this research is to evaluate the efficacy of an experimental therapy for motor recovery of the arm after a stroke, which includes the application of a functional electrical stimulation therapy coupled to P-300 based Brain-Computer Interface system (BCI-FES). For this purpose, the investigators will compare two groups, the first one will receive only conventional physical therapy, while the second one will receive physical conventional therapy together with BCI-FES therapy.\n\nThe control and experimental group will receive 20 sessions of conventional physical therapy at a rate of five sessions per week for 4 weeks, and the experimental group will receive 20 sessions of rehabilitation with the BCI-FES system at a rate of five sessions per week for 4 weeks. Broadly speaking, the BCI is in charge of determining the movement selected by the individual and assist the hand movement while performing functional tasks. The movements included in the sessions will be hand opening, grasping, pinching, pronation and supination, which are combined to facilitate the execution of functional movements that are performed together with the manipulation of daily used utensils. The visual, sensory and motor feedback provided by the BCI-FES system that enables the individual to replicate the afferent-efferent motor circuit, contributes to the activation and recruitment of neural pathways, which is associated with motor recovery.\n\nIt should be noted that this BCI-FES system has already been tested previously in a study with healthy individuals, and in a non-randomized pilot study that used this therapy for upper limb motor function recovery in chronic post-stroke patients. It showed positive results, and the therapy was safe and tolerated by all the patients. Besides no adverse event related to the intervention occurred.\n\nTo evaluate the results, a series of tests will be applied to assess the motor recovery and level of independence, including the FMA-UE: Fugl-Meyer Assessment Scale of Upper Extremity, ARAT: Action Research Arm Test, MAS: Modified Ashworth Scale, FIM: Functional Independence Measure and MAL: Motor Activity Log. Moreover, to assess neuroplasticity, two neuroimaging techniques including magnetic resonance imaging and electroencephalography will be used.",[125,126,127],"Stroke","Upper Extremity Paresis","Neuronal Plasticity",[125,126,129,130,131,127,132],"Neurorehabilitation","Brain-Computer Interfaces","Functional Electrical Stimulation","Magnetic Resonance Imaging","2025-02-25",{"date":135,"type":44},"2025-02-27",{"date":137,"type":44},"2024-08-06",{"date":139,"type":20},"2026-06",{"name":50,"class":51},""]