[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Instituto Politécnico de Bragança\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":46},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100623951","the-effect-of-water-physical-exercise-program-in-thermal-water-and-hydropinotherapy-on-cardiovascular-health-100623951",false,"NCT07403305","The Effect of Water Physical Exercise Program in Thermal Water and Hydropinotherapy on Cardiovascular Health","WPEPH","Inclusion Criteria:\n\n* Men or women\n* Age: \\>45 years\n* Written informed consent prior to participation\n* Physical condition suitable for participating in physical exercise activities\n* Controlled health conditions\n\nExclusion Criteria:\n\n* History of chronic or severe diseases that may affect study outcomes or limit study participation, such as:\n* Decompensated cardiovascular disease, renal insufficiency, or severe liver disease\n* Conditions preventing the ability in physical activity (e.g., severe respiratory issues, reduced mobility, severe arthritis)\n* Severe psychiatric or cognitive disorders that could affect comprehension or adherence to the study\n* Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) or corticosteroids\n* Pregnancy or lactation\n* Less than 80% attendance at the 16-week aquatic exercise program",true,"ALL","45 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this randomized four-arm clinical trial is to determine the effect of 16-week water physical exercise program in thermal water and hydroponotherapy on lipide profile in middle-aged and elderly people, with controlled health conditions.\n\nParticipants will be randomizate into four arms:\n\n* Arm I: Control\n* Arm II: Water Physical Exercise Program (WPEP) in thermal water\n* Arm III: Hydropinotherapy with thermal water combined with bay leaf (L. nobilis)\n* Arm IV: WPEP in thermal water and hydropinotherapy with thermal water combined with bay leaf (L. nobilis)\n\nPrimary outcome:\n\n1. Lipid profile (cholesterol total, low-density lipoprotein cholesterol (c-LDL), high-density lipoprotein cholesterol (c-HDL), triglycerides)\n\n   Secondary parameters:\n2. Inflammatory biomarkers: interleukin-6 (IL-6), C-reactive protein (CRP)\n3. Glucose metabolisc: fasting plasma glucose, insulin, Hemoglobin A1c (HbA1c)\n4. Aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase, bilirubin, creatinine.\n5. Anthropometric and clinical variables: weight, waist to hip ratio, body composition and bone mineral density\n6. Systolic and diastolic blood pressure\n7. Physical function\n8. Lifestyle parameters: sleep quality, quality of life and eating habits",[27],"Cardiovascular (CV) Risk",[29,30,31,32,33],"Thermal Water","Water Exercise","Hydropinotherapy","Lipid Profile","Cardiovascular Health","NOT_YET_RECRUITING","2026-02-04",{"date":37,"type":38},"2026-02-11","ACTUAL",{"date":40,"type":21},"2026-01-19",{"date":42,"type":21},"2026-10-31",{"name":44,"class":45},"Instituto Politécnico de Bragança","OTHER",""]