[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Instituto Politécnico de Leiria\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":184},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,46,76,107,136,163],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100601088","manipulating-exercise-intensity-and-affective-responses-for-cardiac-rehabilitation-program-acute-coronary-syndrome-patients-100601088",false,"NCT07105943","Manipulating Exercise Intensity and Affective Responses for Cardiac Rehabilitation Program Acute Coronary Syndrome Patients","Manipulating Exercise Intensity and Affective Responses on a Cardiac Rehabiliattion Program for Patients With Acute Coronary Syndrome: Protocol for a Randomized Controlled Trial","Selection criteria include:\n\n* patients older than 18 years\n* diagnosis of ACS within the past 12 months who have not previously participated in a CR program\n* patients classified as low-risk (Class B) according to the American Heart Association: (a) New York Heart Association (NYHA) class I or II, (b) exercise capacity greater than 6 METs, (c) no evidence of heart failure, (d) no signs of myocardial ischemia or angina at rest or during exercise testing at or below 6 METs, (e) appropriate systolic blood pressure response during exercise, and (f) absence of sustained or non-sustained ventricular tachycardia at rest or during exercise.\n\nStandard exclusion criteria include:\n\n* left ventricular ejection fraction (LVEF) \\\u003C 40% at rest\n* uncontrolled arrythmias (e.g., complex ventricular arrhythmias, atrial fibrillation or flutter with rapid ventricular response, second-degree atrioventricular block Mobitz type II, or third-degree atrioventricular block)\n* presence of an implantable cardiac device\n* symptomatic peripheral arterial disease\n* comorbidities that may interfere with the ability to perform the exercise program safely.","ALL","18 Years",{"count":19,"type":20},52,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to learn if pleasure-oriented exercise intensity manipulation increases physical activity (PA) behavior in patients who have suffered acute coronary syndrome during a cardiac rehabilitation program. The main question it aims to answer is:\n\n• the manipulation of exercise intensity performed to produce more pleasure and arousal will impact the PA behavior? Researchers will compare the PA levels and affective responses to see if the manipulation of exercise intensity guided to pleasure and arousal works to increase PA behavior compared to the control group who will follow a conventional exercise program.\n\nParticipants will do:\n\n* sixteen individualized hospital exercise sessions (two per week) and complementary physical activity program integrated into their daily life\n* be evaluated before and at the end of the exercise sessions and after 3 months",[26],"Affect and Exertion During and Post-exercise",[28,29,30,31,32],"acute coronary syndrome","cardiac rehabilitation","physical activity","affective response","motivation","RECRUITING","2026-04-28",{"date":36,"type":37},"2026-05-04","ACTUAL",{"date":39,"type":37},"2026-03-01",{"date":41,"type":20},"2028-03-31",{"name":43,"class":44},"Instituto Politécnico de Leiria","OTHER",2,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},"100625791","dual-task-vs-multicomponent-exercise-in-institutionalized-seniors-100625791","NCT07427225","Dual-Task vs. Multicomponent Exercise in Institutionalized Seniors","Effects of Dual-Task Versus Multicomponent Exercise Programs on Fear of Falling and Fall Risk in Institutionalized Older Adults: A Randomized Controlled Trial","DT-Fall","Inclusion Criteria:\n\n* Aged 65 years or older.\n* Resident in the institution (nursing home) for at least 6 months.\n* Autonomous ambulation capacity (independent walking ability, with or without walking aids like canes or walkers).\n* Medical clearance\u002Fapproval to participate in physical exercise.\n* Ability to understand verbal instructions and communicate.\n* Absence of severe cognitive impairment that prevents understanding of the tasks.\n\nExclusion Criteria:\n\n* Uncontrolled cardiovascular or metabolic conditions (e.g., severe heart failure, unstable angina, recent myocardial infarction in the last month).\n* Severe musculoskeletal, visual, or auditory impairments that preclude participation in the exercise program.\n* Diagnosis of severe dementia or other neurological conditions that prevent following the protocol instructions.\n* Absence from more than 5 consecutive sessions or attendance of less than 75% of the total sessions.","65 Years",{"count":56,"type":20},54,[23],"The aging global population faces a major public health challenge regarding the growing number of older adults in long-term care facilities. Institutionalized older adults exhibit high rates of sedentary behavior, accelerating physiological decline (such as sarcopenia, diminished muscle strength, and impaired balance) and increasing fall risk. Beyond biomechanical risks, the fear of falling acts as a psychological barrier, creating a negative spiral of frailty where a lack of confidence leads to activity restriction. This further reduces functional capacity and paradoxically increases the actual fall risk. Addressing fall risk requires interventions targeting both the physical mechanisms of balance and the psychological mechanisms of self-efficacy.\n\nCurrent WHO guidelines emphasize multicomponent physical activity (combining balance, strength, and aerobic training) to prevent falls. However, traditional programs may not fully address the cognitive-motor interference of real-world falls, which often occur during complex, divided-attention tasks. Institutionalized older adults often struggle to allocate attentional resources efficiently. This study posits that breaking the spiral of inactivity requires stimulating the complex demands of daily living. The investigators hypothesize that a Dual-Task Exercise Program, integrating cognitive challenges (e.g., executive function tasks, memory recall) into a multicomponent routine, will provide superior benefits compared to a Multicomponent Exercise Program alone. By training cognitive functions to process mental stimuli while maintaining motor control, the goal is to improve physical and cognitive capabilities and enhance participants' confidence.\n\nThis randomized controlled trial aims to compare the effects of these two modalities on physical fall risk and psychological fear of falling. Conducted in a nursing home for over 12 weeks, participants will be randomly assigned to either the Control Group (Multicomponent Training: physical strength and balance) or the Experimental Group (Dual-Task Training: physical protocol with simultaneous cognitive stimulation).",[60],"Fear of Falling",[62,63,64,65,66],"Accidental Falls","Exercise Therapy","Postural Balance","Psychomotor Performance","Homes for the Aged","NOT_YET_RECRUITING","2026-02-21",{"date":70,"type":37},"2026-02-24",{"date":39,"type":20},{"date":73,"type":20},"2026-07-30",{"name":43,"class":44},1,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":84,"phases":4,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":45},"100625958","data-driven-phenotyping-in-heart-failure-with-preserved-ejection-fraction-100625958","NCT07429396","Data-Driven Phenotyping in Heart Failure With Preserved Ejection Fraction","Inclusion Criteria\n\n1. Retropective observational phase (Phase I):\n\n   * Age ≥18 years;\n   * Established diagnosis of heart failure with preserved ejection fraction (LVEF ≥50%);\n   * Patients receiving care (outpatient or inpatient) at the Local Health Unit of the Leiria Region (ULS RL) since September 2018.\n2. Cross-sectional observational phase (Phase II - CPET):\n\n   * Age ≥18 years;\n   * Established diagnosis of HFpEF;\n   * Selection as a volunteer representative of phenotypes identified in the retrospective clustering analysis;\n   * Provision of written informed consent prior to any study-specific procedures.\n\nExclusion Criteria:\n\n1. Retropective observational phase (Phase I):\n\n   * Incomplete or inadequate medical records preventing full data extraction.\n2. Cross-sectional observational phase (Phase II - CPET):\n\n   * Medical contraindication or physical inability to perform cardiopulmonary exercise testing (CPET);\n   * Inability to provide informed consent.",{"count":83,"type":20},200,"OBSERVATIONAL","The goal of this observational study is to learn how people with Heart Failure with Preserved Ejection Fraction (HFpEF) can be grouped into different \"phenotypes\" based on their clinical information. The researchers want to understand whether these groups have different health profiles and different responses during a cardiopulmonary exercise test (CPET).\n\nThe main questions this study aims to answer are:\n\n* Can clinical data be used to identify meaningful HFpEF phenotypes?\n* Do these phenotypes match well-known HFpEF scores, such as the H2FPEF and Heart Failure Association Pre-test Assessment, Echocardiography and Natriuretic Peptide (HFA-PEFF) scores?\n* Do people in different phenotypes show different results on a CPET?\n\nParticipants will:\n\n* Have their past clinical records reviewed if they were diagnosed with HFpEF at the Local Health Unit of the Leiria Region (ULS RL);\n* A smaller group will attend one visit to complete a CPET, which measures how the heart, lungs and muscles respond during exercise.\n\nThis study includes adults aged 18 years or older who have HFpEF. The study does not involve any new treatments or experimental drugs.",[87,88,89],"Heart Failure","Heart Failure, Diastolic","Heart Failure With Preserved Ejection Fraction (HFPEF)",[87,91,92,93,94,95,96,97,98,99],"HFpEF","Preserved Ejection Fraction","Phenotyping","Machine Learning","Data-driven clustering","Cardiopulmonary Exercise Testing","H2FPEF score","HFA-PEFF score","Exercise tolerance","2026-02-20",{"date":70,"type":37},{"date":103,"type":20},"2026-12-01",{"date":105,"type":20},"2028-05-31",{"name":43,"class":44},{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":114,"sex":16,"minAge":54,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":21,"phases":118,"briefSummary":119,"conditions":120,"keywords":122,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":4},"100597610","exploring-how-exercise-frequency-impacts-muscle-resistance-and-balance-in-institutionalized-seniors-100597610","NCT07060729","Exploring How Exercise Frequency Impacts Muscle Resistance and Balance in Institutionalized Seniors","Exploring How Exercise Frequency Impacts Muscle Resistance and Balance in Institutionalized Seniors: Protocol for a Randomized Controlled Trial","Inclusion criteria:\n\n* 65 years to 90 years.\n* Apparently healthy and without medical contraindications to exercise.\n* Normal weight (BMI ≤ 24.99 kg\u002Fm2) or overweight (BMI \\> 25 ≤ 29.99 kg\u002Fm2)\n* Being institutionalized for more than 6 months.\n* Not having done any exercise regime for the last 6 months or any kind of structured sport activity.\n\nExclusion criteria\n\nBefore Enrollment:\n\n* High risk of cardiovascular disease (ACSM, 2021)\n* High blood pressure (≥ 140\u002F90mmHg) in the pre-exercise evaluation (ESC, 2024)\n* High risk of fall (more than 1 fall over the last 6 months).\n\nDuring the intervention:\n\n* Acquired injury.\n* Acquired medical condition.\n* Related or not related fall during intervention.\n* Inability to perform 5 consecutive exercise sessions.\n* Exercise adherence below 75% of total sessions (n = 24 or n = 36)",true,"90 Years",{"count":117,"type":20},46,[23],"The older population is the least likely to engage in regular physical activity and to meet international recommendations for performing 150 minutes of moderate-intensity physical activity per week. Additionally, older adults living in care institutions tend to have even lower levels of physical activity compared to those living in the community. This physical inactivity among institutionalized older adults carries harmful consequences, such as the loss of muscle mass and strength, both of which are associated with decreased balance and an increased risk of falling, an adverse event with personal, physical, economic, social, and potentially fatal implications. Although this situation is well described in the literature, little is known about whether increasing physical activity levels from near-optimal (almost 150 minutes of physical activity per week) to optimal (more than 150 minutes per week) can influence muscle strength and balance in institutionalized older adults, and thereby reduce the burden related to falls.\n\nThis type of research is essential, as weekly frequency may be a variable to consider in the prescription of physical exercise for this population. The American College of Sports Medicine (ACSM) recommends using the FITT principle (Frequency, Intensity, Type, and Time) to guide exercise prescription. By adjusting these factors, individuals can tailor workouts to their specific goals and fitness levels. While attention has been given to the type of training, its intensity, and its duration, it is important to recognize that total weekly volume may be a determining factor for improvements in components of physical fitness.\n\nConsidering that this population tends to be physically inactive, incorporating physical activity two or three times per week may lead to different outcomes. While exercising twice per week may seem suboptimal, as it does not meet international guidelines, engaging in physical activity three times per week may be the minimum necessary to observe positive effects on muscle strength and balance.",[121],"Frequency of Treatment Protocol",[123,124,125,126,127],"Institutionalization","Frequency","Exercise","Fall risk","Muscle strength","2025-07-01",{"date":130,"type":37},"2025-07-11",{"date":132,"type":20},"2026-01-02",{"date":134,"type":20},"2026-06-02",{"name":43,"class":44},{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":142,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":16,"minAge":144,"maxAge":4,"enrollmentInfo":145,"targetDuration":4,"studyType":21,"phases":147,"briefSummary":148,"conditions":149,"keywords":152,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":75},"100572407","effectiveness-of-a-physical-activity-coaching-intervention-using-e-health-for-copd-patients-in-pulmonary-rehabilitation-100572407","NCT06732869","Effectiveness of a Physical ACtivity Coaching Intervention Using E-Health for COPD Patients in Pulmonary Rehabilitation","PACE - Physical Activity in COPD Using E-Health: Effectiveness of a Personalised eHealth Platform Integrated Into Pulmonary Rehabilitation to Increase Physical Activity in Patients With COPD - a Randomized Controlled Trial","PACE","Inclusion criteria:\n\n* age \\> 40 years old\n* diagnosis of COPD according to GOLD criteria, clinically stable (i.e., with no exacerbations in the previous month)\n* being enrolled in a pulmonary rehabilitation program\n* having a smartphone with access to the internet\n* being able to understand and provide informed consent.\n\nExclusion criteria:\n\n* simultaneous participation in another behavioural modification program\n* having any clinical condition that precludes participation in a PA intervention (e.g., severe musculoskeletal or neurological disorders and unstable cardiovascular disease)\n* another primary respiratory disease\n* history of recent neoplasia (including last treatment) in the previous year.","40 Years",{"count":146,"type":20},57,[23],"The goal of this randomized controlled trial is to evaluate the efficacy of a physical activity coaching intervention - delivered through an eHealth platform both during and after pulmonary rehabilitation - to enhance physical activity levels and health-related outcomes in patients with Chronic Obstructive Pulmonary Disease (COPD). All participants will attend the pulmonary rehabilitation program for 2 months; the experimental group will receive a physical activity coaching intervention at the end of the 1st month of the rehabilitation program, which will continue for 6 months following the completion of the program. Assessments will be conducted at the beginning, midway, and at the end of the coaching program, as well as 3 months and 6 months after its conclusion.",[150,151],"COPD","Physical Activity",[30,150,153,154],"eHealth","pulmonary rehabilitation","2024-12-09",{"date":157,"type":37},"2024-12-13",{"date":159,"type":37},"2024-12-02",{"date":161,"type":20},"2025-06",{"name":43,"class":44},{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":169,"eligibilityCriteria":170,"healthyVolunteers":114,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":171,"targetDuration":4,"studyType":84,"phases":4,"briefSummary":173,"conditions":174,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":4},"100482177","longitudinal-study-of-health-literacy-in-the-municipality-of-leiria-100482177","NCT05558631","Longitudinal Study of Health Literacy in the Municipality of Leiria","Lisa Cohort Study: Longitudinal Study of Health Literacy in the Municipality of Leiria","Lisa","Inclusion Criteria:\n\n* The study population will be composed by adults (≥ 18 years old) who are non-institutionalized and living in private households in Leiria.\n\nExclusion Criteria:\n\n* Residing in hospitals, asylums, military barracks or prisons. Individuals who are unable to speak Portuguese or who reveal an inability to respond to the questionnaire, either directly or through a person who lives with them.",{"count":172,"type":20},4003,"Health literacy (HL) is a topic of increasing importance todays' ever-changing world. Over the past few decades, HL has gained importance, as it is a factor related to health behaviors and outcomes. In Portugal, the last survey was in 2016 and 61% of the population had a problematic or inadequate level of HL in general. Lisa is a cohort study that will measure HL in the adult population residing in the municipality of Leiria over the next 4 years, with measurements every 2 years. Over the years we will promote activities and interventions adjusted to the needs of Leiria's population. At the end we want to understand the changes during the years and improve the health care provided.",[175],"Health Literacy","2022-09-26",{"date":178,"type":37},"2022-09-28",{"date":180,"type":20},"2022-11-01",{"date":182,"type":20},"2033-01-31",{"name":43,"class":44},""]