[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Instituto Portugues de Oncologia, Francisco Gentil, Porto\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":48},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":5},"100409598","surveillance-of-premalignant-stomach---individualized-endoscopic-follow-up-100409598",false,"NCT04613570","SUrveillance of PREMalignant Stomach - Individualized Endoscopic Follow-up","SUPREME","Inclusion Criteria:\n\n* Patients scheduled for upper GI endoscopy with indication for gastric biopsies, including those with known gastric pathology (e.g. auto-immune gastritis) or premalignant conditions (e.g patients under surveillance because of atrophic gastritis);\n* Age above 45 years old\n\nExclusion Criteria:\n\n* History of previous gastrectomy;\n* History of endoscopic resection of neoplastic lesion\n* History of previous gastric dysplasia (even with no detectable lesion)\n* Hereditary syndromes that increase gastric cancer risk (familial adenomatous polyposis; Lynch syndrome)\n* Serious comorbidities (ASA 3 or more)\n* Medication with anticoagulants","ALL","45 Years",{"count":19,"type":20},912,"ESTIMATED","INTERVENTIONAL",[23],"NA","Introduction: Gastric atrophy and intestinal metaplasia are the principal precursors for gastric cancer and, therefore, are considered gastric premalignant conditions. Although current guidelines recommend surveillance of individuals with these conditions, the best method for its identification and staging (histological vs endoscopy) and the best time schedule for follow-up are still controversial. Aims: To describe for the first-time patients with premalignant conditions both clinically (familial history), histologically (OLGA\u002FOLGIM; complete\u002Fincomplete metaplasia) and endoscopically (EGGIM) using validated scales and to describe evolution of these parameters through time. To estimate prospectively the gastric cancer risk according to EGGIM stages. To define the best endoscopic surveillance follow-up for the several stages considering clinical, histological and endoscopic factors.\n\nMethods: Multicenter study involving different gastroenterology departments from several countries. Consecutive patients older than 45 years scheduled for upper endoscopy in each of these centers will be evaluated by High-Resolution- endoscopy with virtual chromoendoscopy and EGGIM will be calculated. Guided biopsies (if areas suspicious of IM) and\u002For random biopsies (if no areas suspicious of IM) in antrum and corpus will be made and OLGA\u002FOLGIM stages calculated. Patients will be evaluated in clinical consultation and database will be fulfilled. All patients will be eradicated for Helicobacter pylori infection if positive. At that occasion, all the patients with EGGIM\\>5 and\u002For OLGA III\u002FIV and\u002For OLGIM III\u002FIV will be randomized for yearly (12 to 16 months) or every three years (32-40 months) endoscopic follow-up during a period of 6 years (SUPREME I). Endoscopic observational follow-up will be scheduled for patients with EGGIM 1-4 and OLGIM I\u002FII at 3 and 6 years (SUPREME II). For individuals with no evidence of IM (EGGIM 0 and OLGIM 0, OLGA 0-II) a follow-up endoscopy 6 years after will be proposed (SUPREME III).",[26,27,28,29],"Atrophic Gastritis","Intestinal Metaplasia","Gastric Dysplasia","Gastric Cancer",[31,32,33,34,35],"atrophic gastritis","gastric cancer","intestinal metaplasia","gastric dysplasia","surveillance","RECRUITING","2022-03-29",{"date":39,"type":40},"2022-03-31","ACTUAL",{"date":42,"type":40},"2021-01-02",{"date":44,"type":20},"2026-12-31",{"name":46,"class":47},"Instituto Portugues de Oncologia, Francisco Gentil, Porto","OTHER",""]