[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Instituto Valenciano de Infertilidad, IVI Alicante\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":77},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100631737","effect-of-prp-in-donor-semen-during-cryoprervation-100631737",false,"NCT07504575","Effect of PRP in Donor Semen During Cryoprervation","Effect of Platelet-rich Plasma (PRP) on the Quality of Donor Semen During Cryopreservation","PRP","Inclusion Criteria:\n\nAge from 18 to 35 years\n\nConcentration higher than 50 million progressively motile sperm.\n\nMorphology: more than 4% normal sperm shapes.\n\nExclusion Criteria:\n\nPresence of personal or hereditary pathology.\n\nPresence of psychological or behavioral disorder.\n\nSemen parameters below those indicated in the inclusion criteria.",true,"MALE","18 Years","35 Years",{"count":22,"type":23},20,"ESTIMATED","OBSERVATIONAL","Sperm cryopreservation allows the preservation of sperm biological function for long periods of time for later use in assisted reproductive techniques (ART). However, the freezing and thawing process causes structural and functional damage to sperm, leading to decreased motility and vitality, a loss of plasma membrane integrity and even DNA damage.\n\nIn recent years, various strategies have been studied to protect sperm from cryodamage, including the optimization of freezing processes, the design of freezing devices, and improved freezing media.\n\nOne possible measure to mitigate the cryodamage suffered by sperm is the addition of PRP, or platelet-rich plasma, to the freezing medium. In previous studies, PRP components have been shown to have positive effects on semen quality, improving motility, viability, and plasma membrane integrity after cryopreservation. In light of these positive results, this study will evaluate the possibility of incorporating PRP into sperm cryopreservation media and its potential future benefits for patients and clinical outcomes. To this end, each semen sample after a previous spermiogram will be aliquoted, and 0%, 1%, 2%, and 5% PRP will be added to the cryopreservation medium according to the sperm group to which the belong. A spermiogram will be performed after cryopreservation to assess various semen quality parameters, including sperm count, motility, morphology, vitality, and chromatin dispersion. The data must be processed through statistical analysis to obtain results that allow determining, primarily, whether there is a beneficial effect on sperm quality after sperm motility and sperm during cryopreservation with the addition of PRP.",[27],"Sperm Cryodamage",[29,15,30],"Sperm","Cryopreservation","RECRUITING","2026-04-14",{"date":34,"type":35},"2026-04-17","ACTUAL",{"date":37,"type":35},"2026-02-10",{"date":39,"type":23},"2028-01-30",{"name":41,"class":42},"Instituto Valenciano de Infertilidad, IVI Alicante","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":51,"minAge":19,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":43},"100621887","proteomic-and-biological-characterisation-of-plasma-for-the-study-of-changes-following-ovarian-reactivation-treatment-100621887","NCT07376460","Proteomic and Biological Characterisation of Plasma for the Study of Changes Following Ovarian Reactivation Treatment","Biological and Proteomic Characterisation of Platelet-rich Plasma (PRP) Before and After Mobilisation of Haematopoietic Stem Cells in Peripheral Blood From Women With Low Ovarian Response (Low Responders) and in Vitro Evaluation in Human Ovarian Cell Models","Inclusion Criteria:\n\n* Patients aged between 18 and 43.\n* Patients diagnosed with poor ovarian response (POR) or low ovarian reserve according to Bolonia criteria (ESHRE).\n* Patients who are indicated for a StemCell Regenera procedure with the use of granulocyte colony-stimulating factors (Filgrastim).\n* Patients who agree to participate and sign the informed consent form.\n\nExclusion Criteria:\n\n* Patients over the age of 43.\n* Patients with only one ovary.\n* Patients with an autoimmune or haematological disorder.\n* Patients currently undergoing treatment with anticoagulant drugs.\n* Patients who are allergic to Filgrastim, the granulocyte colony-stimulating factor.","FEMALE","43 Years",{"count":54,"type":23},10,"The samples used in PRGF treatments owe their effectiveness to the handling, concentration, and preservation of their components, which explains why samples obtained with different platelet-rich plasma preparation systems may vary. At IVIRMA Group, we employ the closed system PRGF-Endoret to process these samples for StemCell Regenera samples obtained after mobilizing stem cells with granulocyte colony-stimulating factor stimulators. According to current regulations, PRP samples are considered medicinal products by AEMPS, requiring knowledge of the composition of processed samples to be administered to the patient. The study and quantification of samples used in StemCell Regenera treatments aim to understand how stem cell mobilization performed through this technique influences the characteristics of PRGF-Endoret. In this context, the present project aims to systematically analyse the proteomic profile of PRP\u002FPRGF before and after haematopoietic stem cell mobilisation in poor-responder patients, and to evaluate its biological impact in vitro using human ovarian cell models. This approach will enable the identification of key factors involved in ovarian activation and regeneration, thereby providing a mechanistic basis for optimising regenerative therapies applied in clinical reproductive medicine. Furthermore, it will contribute scientifically relevant insights to the field of research and to patients themselves.",[57,58],"Poor Ovarian Response","Ovarian Reactivation",[60,61,62,63,64,65,15,66,67],"Poor ovarian response","ovarian reactivation","StemCell Regenera","ovarian rejuvenation therapy","ovarian failure","Stem cell mobilization","PRGF","Bone Marrow Derived Stem Cells (BMDSC)","NOT_YET_RECRUITING","2026-02-02",{"date":71,"type":35},"2026-02-04",{"date":73,"type":23},"2026-02",{"date":75,"type":23},"2026-06",{"name":41,"class":42},""]