[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Internist.Ro\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":65},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100583456","exploring-the-multimorbidity-burden-in-primary-care-in-romania-100583456",false,"NCT06876558","Exploring the Multimorbidity Burden in Primary Care in Romania","MULTIMORB-PC-R","Inclusion Criteria:\n\n* Active AMBULATORY CARE medical practice in Romania.\n* Experience in managing patients with multimorbidity.\n* Willingness to participate in the study.\n\nExclusion Criteria:\n\n* None",true,"ALL",{"count":19,"type":20},500,"ESTIMATED","OBSERVATIONAL","Multimorbidity, the coexistence of two or more chronic conditions, is a growing challenge in primary care, significantly impacting healthcare systems worldwide. Its prevalence is rising, particularly among socioeconomically disadvantaged populations, leading to increased healthcare utilization, polypharmacy, and fragmented care. Current clinical guidelines primarily address single-disease management, failing to provide comprehensive strategies for multimorbid patients.\n\nAlthough multimorbidity has been extensively studied in Western Europe and North America, data on its burden in Romania and other Eastern European countries remain scarce. There is limited knowledge on how primary care physicians (PCPs) in Romania perceive and manage multimorbidity, particularly regarding clinical decision-making, interdisciplinary collaboration, and adherence to treatment guidelines.\n\nThis cross-sectional study aims to explore the impact of multimorbidity on Romanian PCPs, assessing their challenges in managing complex patients, their clinical and therapeutic approaches, and their level of comfort with deprescription and guideline adaptation. We will conduct a nationwide survey among primary care physicians and ambulatory specialists to evaluate the prevalence of multimorbidity in their practice, the difficulties they encounter, and potential strategies to improve care delivery.\n\nKey outcomes include the identification of multimorbidity prevalence in ambulatory settings, challenges related to consultation time and treatment complexity, barriers to interdisciplinary collaboration, and the balance between defensive and proactive medicine. Findings will provide valuable insights to guide policy changes, enhance clinical training, and promote patient-centered approaches in primary care",[24,25,26],"Multimorbidity","General Practice (GP), Primary Care Settings","Specialist Referral",[28,29,30],"multimorbidity","priamary care","specialized care","NOT_YET_RECRUITING","2025-03-10",{"date":34,"type":35},"2025-03-14","ACTUAL",{"date":37,"type":20},"2025-03-20",{"date":39,"type":20},"2025-06-01",{"name":41,"class":42},"Internist.Ro","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":51,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":59,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":43},"100583455","vitamin-c-deficiency-in-hospitalized-adults-systematic-screening-vs-traditional-judgment---a-before-and-after-observational-study-100583455","NCT06876545","\"Vitamin C Deficiency in Hospitalized Adults: Systematic Screening Vs. Traditional Judgment - a Before-and-After Observational Study\"","Identification of Vitamin C Deficiency in Hospitalized Adults Through a Systematic Approach Vs. Traditional Medical Judgment: a Before-and-After Observational Study","Inclusion Criteria:\n\nHospitalized adult patients (≥18 years old) who had Vitamin C testing performed during their hospital stay.\n\nDocumented hemorrhagic manifestations in medical records, including at least one of the following:\n\nHematuria (macroscopic or detected via urine dipstick\u002Fmicroscopy). Ecchymoses (bruising). Petechiae. Epistaxis (nosebleeds). Gastrointestinal bleeding (melena, hematemesis, or positive fecal occult blood test).\n\nCerebral hemorrhage. Medical records available with sufficient clinical and laboratory data to assess eligibility and study variables.\n\nPatients from two distinct periods:\n\nHistorical Control Group: Patients tested for Vitamin C \"as needed\" based on traditional medical judgment.\n\nActive Group: Patients tested systematically according to Scurvy Suspicion upon Hemorrhagic Risk (SFI) criteria after protocol implementation.","18 Years",{"count":53,"type":20},150,"Brief Summary of the Study The goal of this observational study is to assess the incidence of vitamin C deficiency among hospitalized adults presenting with hemorrhagic signs. The study will also evaluate the effectiveness of a standardized screening protocol compared to traditional clinical judgment.\n\nThe main questions it aims to answer are:\n\nWhat is the incidence of vitamin C deficiency in hospitalized patients with hemorrhagic symptoms? Is a standardized screening protocol more effective than traditional clinical judgment in identifying vitamin C deficiency? Is vitamin C deficiency associated with anemia, other micronutrient deficiencies (folate, B12, albumin, iron), or infectious conditions? Does vitamin C deficiency impact hospital length of stay? Researchers will compare a systematic screening approach based on predefined hemorrhagic criteria (e.g., hematuria, ecchymosis, epistaxis, petechiae, gastrointestinal bleeding, or intracranial hemorrhage) to the traditional physician-judgment approach to determine its effectiveness in identifying vitamin C deficiency.\n\nStudy Design\n\nParticipants will:\n\nBe hospitalized adults (≥18 years old) presenting with documented micro- or macroscopic hemorrhagic signs.\n\nUndergo vitamin C level assessment either as part of the standardized screening protocol (prospective arm) or based on physician judgment (retrospective control group).\n\nHave additional clinical and laboratory data collected, including hemoglobin levels, platelet count, iron status, vitamin B9\u002FB12 levels, and other relevant parameters.\n\nThis non-interventional study will not modify the standard of care but will systematically assess the prevalence of vitamin C deficiency in at-risk patients and evaluate the utility of a structured screening protocol.",[56],"Scurvy",[58],"Scurvy, vitamin C defficiency, hospitalized",{"date":34,"type":35},{"date":61,"type":20},"2025-04-01",{"date":63,"type":20},"2025-04-30",{"name":41,"class":42},""]