[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Iowa State University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":69},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100639851","confident-moves-intervention-efficacy-trial-obesity-care-settings-100639851",false,"NCT07623772","Confident Moves Intervention Efficacy Trial: Obesity Care Settings","Inclusion Criteria:\n\n* Age 18-64 years\n* Body Mass Index (BMI) ≥ 25 kg\u002Fm²\n* Access to a technological device (e.g., computer, smartphone) capable of supporting the online intervention\n* Not currently enrolled in another physical activity (PA) intervention (except standard obesity care programs at participating centers)\n* Willingness to wear a wrist worn accelerometer for two separate 7 day monitoring periods\n* Willingness to respond to study related communications (e.g., email, text, phone call)\n\nExclusion Criteria:\n\n\\- Failure to meet one or more of the inclusion criteria","ALL","18 Years","64 Years",{"count":19,"type":20},348,"ESTIMATED","INTERVENTIONAL",[23],"NA","The objective of this study is to evaluate the efficacy of the Confident Moves (CM) intervention on device-measured physical activity (PA) and the whole person health index in adults with obesity, compared to standard obesity care alone. Confident Moves (CM) is a web-based physical activity (PA)-promoting research intervention developed by the study team to support adults with obesity. CM is not a medical or clinical treatment; rather, it is designed to promote daily PA through structured, self-paced online learning activities. The intervention has been previously pilot-tested in a feasibility study, which demonstrated its acceptability, safety, and feasibility and informed refinements to study procedures. CM aims to strengthen participants' confidence, knowledge, and behavioral skills related to PA across multiple everyday contexts. The intervention is delivered through a secure, ISU-managed website, with access limited to enrolled participants and authorized research personnel. Only study staff have access to participant data, and data are used solely for research purposes.",[26,27],"Obesity","Overweight",[29,30,31,32],"eHealth","Internet applications","information and communication technologies","exercise","NOT_YET_RECRUITING","2026-06-02",{"date":36,"type":37},"2026-06-04","ACTUAL",{"date":39,"type":20},"2026-07",{"date":41,"type":20},"2027-08",{"name":43,"class":44},"Iowa State University","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":55,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":68},"100455625","adjuvant-effect-of-physical-exercise-on-immune-response-to-covid-19-vaccination-and-interactions-with-stress-100455625","NCT05213000","Adjuvant Effect of Physical Exercise on Immune Response to COVID-19 Vaccination and Interactions With Stress","The Effect of Health Behavioral Variables Including Single Session Exercise Post-immunization and Psychosocial Factors on Immune Response to the Initial COVID-19 mRNA Vaccine, and Underlying Mechanisms","Inclusion Criteria:\n\n* Able to donate a small amount of blood,\n* Planning to receive an initial mRNA Severe Acute Respiratory Distress Syndrome Coronavirus 2 vaccine,\n* Between 18-64 years of age,\n* Regularly participate in some form of exercise two or more times per week, including at least one session equal to or greater than 50 minutes exercise sessions or walk three or more times per week with at least one session equal to or greater than 50 minutes.\n* Can safely perform 90 minutes of light to moderate intensity exercise (walk, walk\u002Fjog, or jog) based on American College of Sports Medicine exercise participation guidelines\n\nExclusion Criteria:\n\n* Currently pregnant\n* Weigh less than 110 pounds.\n* Presence of any conditions that could significantly impact the ability to exercise safely, or unable to receive the mRNA COVID-19 vaccine\n* Taking medication that significantly impact immune response or the presence of an immune disorder.",true,{"count":54,"type":20},80,[23],"The purpose of this study is to evaluate the extent to which a single session of light to moderate intensity exercise performed within 30 minutes after receiving either the initial dose of COVID-19 mRNA vaccine may modify the immune response to vaccination, and identify potential underlying mechanisms using gene expression and metabolite analysis. A secondary goal is to establish whether psychosocial factors are associated with immune response to vaccination. Participants will be randomized to either a 90-minute light to moderate intensity exercise session or daily routine as usual (no exercise) after receiving their initial COVID-19 mRNA vaccine. If assigned to exercise, the exercise will begin within 30 minutes after receiving the vaccine and will consist of a brisk walk and\u002For jog supervised by study personnel. Blood will be collected from participants prior the initial dose, two weeks after the initial dose, one week after the second dose if the individual receive the two-dose vaccine regiment or one month after the initial dose if the individual receives a one-dose vaccine regimen, and three, six, and 12 months following the initial dose. . Side effects will be measured for three days post-vaccination. Antibody and cell-mediated immune response to the vaccine will be measured in blood samples. Gene expression profiles will be analyzed by single cell RNA sequencing. Serum metabolites will be assessed to align with immune measures. Participants will be asked to complete surveys to measure physical activity history, psychosocial stress, resilience, and depression. The hypotheses of this study are: 1) a single session of exercise which take place shortly after receiving either the initial dose or the booster dose of COVID-19 will increase antibody and T cell response to the vaccine and will be associated with differentially expressed genes and an altered metabolite profile, and 2) higher levels of reported stress, and lower levels of resilience will be associated with a reduced antibody and T cell response to the vaccine.",[58],"Immunization","RECRUITING","2023-08-22",{"date":62,"type":37},"2023-08-24",{"date":64,"type":37},"2021-03-01",{"date":66,"type":20},"2026-09-30",{"name":43,"class":44},1,""]