[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Iran University of Medical Sciences\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":151},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,39,66,93,120],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100614278","the-effect-of-integrating-pain-neuroscience-educationpne-with-conventional-physiotherapy-on-pain-and-functional-disability-in-patients-with-acute-low-back-pain-100614278",false,"NCT07277517","The Effect of Integrating Pain Neuroscience Education(PNE) With Conventional Physiotherapy on Pain and Functional Disability in Patients With Acute Low Back Pain","Inclusion Criteria:\n\n* Adults aged 18 years and older.\n* A primary complaint of acute low back pain (defined as pain between the bottom of the ribs and the gluteal fold), with or without leg pain.\n* Pain duration of less than 6 weeks.\n* Absence of any \"red flags\" for serious spinal pathology (e.g., tumor, infection, fracture, cauda equina syndrome), as confirmed by an orthopedist or neurologist.\n\nExclusion Criteria:\n\n* Low back pain lasting more than 3 months (chronic low back pain).\n* History of spinal surgery within the past 3 years.\n* Inability to read or understand Persian.\n* Diagnosed cognitive impairments.\n* Unwillingness to continue the treatment or study protocol.\n* Diagnosed rheumatic, neurological, cardiac, metabolic, or respiratory diseases.\n* Diagnosis of fibromyalgia, chronic fatigue syndrome, loss of skin sensation, or skin inflammation\u002Fswelling in the low back area.\n* Presence or emergence of any \"red flag\" condition.\n* Missing more than 3 consecutive treatment sessions.\n* Previous participation in Pain Neuroscience Education sessions.","ALL","18 Years",{"count":18,"type":19},48,"ESTIMATED","INTERVENTIONAL",[22],"NA","Acute low back pain is one of the most common health problems in the world. Most people experience it at least once in their lives, and although many cases improve within a few weeks, a significant number of patients continue to struggle with pain, fear of movement, stress, and reduced daily function. These psychological factors-such as catastrophizing (\"my back is damaged\"), fear of movement (\"if I move, it gets worse\"), and avoidance behaviors-can slow recovery and increase the risk of the pain becoming chronic.\n\nPain Neuroscience Education (PNE) is a modern educational approach that teaches patients how pain actually works in the nervous system. Instead of focusing only on muscles and bones, PNE helps people understand how the brain interprets pain, why pain can persist even without serious injury, and how thoughts, emotions, and behaviors can influence the experience of pain. Research shows that PNE can reduce fear, improve movement, and help people participate better in rehabilitation-especially in chronic pain. However, there is very limited high-quality evidence about its effects in acute low back pain.\n\nThe purpose of this study is to determine whether adding Pain Neuroscience Education to routine physiotherapy can improve recovery in people with acute low back pain.\n\nTo do this, the investigators will conduct a single-blind randomized clinical trial with two groups of patients:\n\nControl group: Receives conventional physiotherapy, including soft-tissue mobilization and TENS, along with routine patient education about posture and back care.\n\nIntervention group: Receives the same physiotherapy plus two structured sessions of Pain Neuroscience Education, delivered individually using simple explanations, metaphors, and visual materials.\n\nBoth groups will receive eight treatment sessions over four weeks.\n\nThe investigators will measure several important outcomes before starting treatment and immediately after the 8th session, including:\n\nPain intensity\n\nFunctional disability\n\nPain catastrophizing\n\nFear-avoidance beliefs\n\nFear of movement (kinesiophobia)\n\nThe investigators' hypothesis is that patients who receive PNE in addition to routine physiotherapy will show greater reductions in pain, disability, fear, and catastrophizing compared to those receiving physiotherapy alone.\n\nIf proven effective, this approach could provide a simple, low-cost, and safe addition to physiotherapy that not only reduces pain but also prevents acute low back pain from turning into a chronic condition. This could help improve patients' quality of life and reduce the economic and healthcare burden caused by low back pain.",[25],"Acute Low-back Pain","RECRUITING","2026-03-30",{"date":29,"type":30},"2026-04-03","ACTUAL",{"date":32,"type":30},"2025-10-05",{"date":34,"type":19},"2026-08",{"name":36,"class":37},"Iran University of Medical Sciences","OTHER",1,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":46,"enrollmentInfo":47,"targetDuration":4,"studyType":20,"phases":48,"briefSummary":49,"conditions":50,"keywords":52,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":38},"100503258","effects-of-core-stability-exercises-and-cognitive-tasks-on-chronic-non-specific-back-pain-100503258","NCT05832918","Effects of Core Stability Exercises and Cognitive Tasks on Chronic Non-specific Back Pain","Effects of Core Stability Exercises and Cognitive Tasks Compared to General Exercises and Cognitive Tasks on Chronic Non-specific Back Pain","Inclusion Criteria:\n\n* Orthopedist-confirmed diagnosis of chronic nonspecific low back pain that has lasted at least three months since its onset.\n* Pain score of 3 or more on a visual analog scale.\n* Pain during quiet standing.\n* Cognitive level above 24 based on mini-mental state examination (MMSE).\n\nExclusion Criteria:\n\n* Radicular pain and any neurological signs.\n* Uncorrected vision impairment.\n* Hearing problems.\n* Vestibular dysfunctions.\n* Cognitive deficit.\n* Previous spinal surgery.\n* Severe deformity or injury to the lower extremities.","55 Years",{"count":18,"type":19},[22],"This randomized control trial study aims to compare the effect of core stability exercises and cognitive tasks with general exercises and cognitive tasks on pain, disability, and postural control strategies of chronic non-specific low back pain patients. The main questions are:\n\n1. Are core stability exercises and cognitive tasks more effective than general exercises and cognitive tasks in reducing the pain of chronic non-specific low back pain patients?\n2. Are core stability exercises and cognitive tasks more effective than general exercises and cognitive tasks in reducing the disability of chronic non-specific low back pain patients?\n3. Are core stability exercises and cognitive tasks more effective than general exercises and cognitive tasks in improving postural stability parameters of chronic non-specific low back pain patients?\n4. Are core stability exercises and cognitive tasks more effective than general exercises and cognitive tasks in improving stabilogram diffusion analysis parameters of chronic non-specific low back pain patients? This study is designed to apply two exercise protocols on two groups of 17 people with non-specific back pain. Group A will receive core stability exercises along with cognitive tasks, and group B will receive general exercises along with cognitive tasks.",[51],"Chronic Non-specific Low Back Pain",[53,54,55,56,57],"Low back pain","Disability","Postural control","Core Stability Exercise","cognitive task","2025-05-03",{"date":60,"type":30},"2025-05-07",{"date":62,"type":30},"2023-05-02",{"date":64,"type":19},"2025-12-15",{"name":36,"class":37},{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":73,"enrollmentInfo":74,"targetDuration":4,"studyType":20,"phases":76,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":38},"100446972","effectiveness-of-dry-needling-in-patients-with-chronic-nonspecific-low-back-pain-100446972","NCT05100381","Effectiveness of Dry Needling in Patients With Chronic Nonspecific Low Back Pain","Effectiveness of Dry Needling on Pain, Functional Disability, Postural Control and Pain Pressure Threshold in Patients With Chronic Nonspecific Low Back Pain: A Double-Blind Randomised Controlled Trial","Inclusion Criteria:\n\n* Patients age between 18 to 45 years.\n* Moderate pain at rest (between 30 and 60 in NPRS).\n* Patients with trigger points in the lumbar multifidus muscle.\n* Patients have the ability to speak and read Persian.\n\nExclusion Criteria:\n\n* Currently taking anticoagulant medications\n* Specific low back pain (Neurogenic low back pain, Spinal stenosis, cauda equina syndrome, spondylolisthesis, and Presence of any signs or symptoms of non-musculoskeletal pathology e.g. cancer, infection and fracture in low back and lower extremities based on paraclinical findings)\n* Prior surgery to the lumbosacral spine\n* Inability to obtain prone lying\n* Severe malalignments in the cervical, thoracic, lumbar or pelvic region and the lower limbs\n* History of uncorrected vision impairment, vestibular, hearing or cognitive impairments\n* Leg length discrepancy which disturbs balance\n* Systemic diseases, such as diabetes, fibromyalgia, rheumatoid arthritis, degenerative diseases and other rheumatoid diseases\n* Needle phobia\n* Sacroiliac pain as identified with six clinical tests: compression, distraction, sacral thrust, thigh thrust, Gaenslen's and FABER's","45 Years",{"count":75,"type":19},40,[22],"Low back pain is a major health problem that affects psychosocial, economical, functional and physical aspects of the patients' life. The aim of this study will be to investigate the effectiveness of dry needling on pain, functional disability, postural control and pain pressure threshold in patients with chronic nonspecific low back pain using a randomized controlled trial design.\n\nPatients with chronic nonspecific low back pain will be randomly divided into two groups: Experimental group (dry needling and routine physical therapy) and control group (sham dry needling and routine physical therapy). Primary outcomes will be pain intensity and functional disability. Postural control and pain pressure threshold will be considered as secondary outcomes.",[79],"Low Back Pain",[81,79,82,83,84],"dry needling","functional disability","postural control","pain pressure threshold","2025-05-01",{"date":87,"type":30},"2025-05-02",{"date":89,"type":30},"2022-07-25",{"date":91,"type":19},"2026-12-30",{"name":36,"class":37},{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":99,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":101,"enrollmentInfo":102,"targetDuration":4,"studyType":20,"phases":104,"briefSummary":106,"conditions":107,"keywords":109,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":38},"100557865","phase-1-limbal-stem-cell-derived-exosome-lsc-exo-eye-drop-for-treatment-of-dry-eye-100557865","NCT06543667","Limbal Stem Cell Derived Exosome (LSC-Exo) Eye Drop for Treatment of Dry Eye","A Clinical Study for Safety and Efficacy Evaluation of Limbal Stem Cell Derived Exosome (LSC-Exo) Eye Drop for Treatment of Dry Eye Syndrome","EXOIUMS","Inclusion Criteria:\n\n* Patients with complaints of burning or itching or feeling of a foreign body in the eye\n* Moderate and severe dry eye severity\n* Age between 18-70 years\n\nExclusion Criteria:\n\n* Previous history of eye surgery\n* Any disease that suppresses the immune system\n* Pregnancy and breastfeeding\n* Eyelid abnormalities\n* Use of eye drops in the past year except artificial tears and lubricating ointments\n* Use of systemic drugs that affect the tear film in last three months\n* Use of contact lenses in the last three months","70 Years",{"count":103,"type":19},30,[105],"PHASE1","The purpose of this study is to determine the safety and efficacy of Limbal Stem Cells derived Exosomes (LSC-Exo) in alleviation of dry eye symptoms",[108],"Dry Eye Syndromes",[110,111,112],"Dry Eye Disease","Sjogren's Syndrome","Chronic Dry Eye","2025-04-30",{"date":85,"type":30},{"date":116,"type":30},"2024-08-01",{"date":118,"type":19},"2026-07-01",{"name":36,"class":37},{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":4,"eligibilityCriteria":126,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":46,"enrollmentInfo":127,"targetDuration":4,"studyType":20,"phases":129,"briefSummary":130,"conditions":131,"keywords":133,"overallStatus":142,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":4},"100468713","deep-neck-flexor-exercises-versus-myofascial-release-of-suboccipital-muscles-in-chronic-tension-type-headache-100468713","NCT05383365","Deep Neck Flexor Exercises Versus Myofascial Release of Suboccipital Muscles in Chronic Tension-type Headache","The Effectiveness of Deep Neck Flexor Exercises in Comparison With Myofascial Release of Suboccipital Muscle on Pain and Forward Head Posture in People With Chronic Tension-type Headache and Forward Head Posture","Inclusion Criteria:\n\n1. Age between 18 and 55 years;\n2. based on ICHD-3, Headache that occurs 15 days per month and lasts on average for \\>3 months (180 days per year), lasting hours to days, or unremitting, and has at least two of the following four characteristics recognized as CTTH: bilateral location, pressing or tightening (non-pulsating) quality, mild or moderate intensity, not aggravated by routine physical activity such as walking or climbing stairs and both of the following: no more than one of photophobia, phonophobia or mild nausea, neither moderate or severe nausea nor vomiting;\n3. Dosage and type of prophylactic medication have not changed in the months before the beginning of the trial;\n4. The participant does not intend to change the dosage and type of prophylactic medication during the study;\n5. CVA less than 49 degrees,\n6. Participants have the ability to understand and read Persian to complete the questionnaire.\n\nExclusion Criteria:\n\n1. Participants with infrequent ETTH, or other primary or secondary types of headache;\n2. Pain aggravated by movement of the head;\n3. Severe pain or significant decrease in ROM of the cervical spine;\n4. Previous trauma to the cervical spine;\n5. History of injection, surgery, severe disc protrusion, or neck or shoulder fracture that affects treatment;\n6. Metabolic or Neurological disorders such as Bow hunter's syndrome or epilepsy;\n7. Taking more than 200 pieces of morphine or other strong analgesics per month;\n8. Physiotherapy treatment for headache within 6 months before starting treatment;\n9. Joint stiffness, atherosclerosis, or advanced osteoarthritis;\n10. Manual contraindication includes: (a)The participant has substance or alcohol abuse; (b)For whatever reason, the participant does not want to be touched by the therapist; (c)Symptoms are severe and irritating; (d)Underlying diseases (such as rheumatoid arthritis) or metabolic disorders (such as osteoporosis or soft tissue laxity of the treatment area);\n11. Pregnancy;\n12. Spielberger State-Trait Anxiety Inventory (STAI) scores more than 85;\n13. Absence of two consecutive sessions and more than treatment sessions.",{"count":128,"type":19},44,[22],"According to the study of the burden of diseases in 2018, tension-type headache(TTH) is the most common type of primary headache and ranks third in terms of prevalence among 328 diseases and injuries in 195 countries from 1990 to 2016. Suffering from this disorder (especially chronic type) reduces the quality of life of patients.\n\nThe main objective of this study is to compare the effects of myofascial release of suboccipital muscles as a bottom-up intervention and Deep Neck Flexor(DNF) exercises with Pressure Biofeedback Unit(PBU) as a top-down intervention on headache parameters, the intensity of Forward Head Posture(FHP), disability, quality of life, and suboccipital Pressure Pain Threshold(PPT) in patients with chronic tension-type headache with forward head posture.",[132],"Chronic Tension-Type Headache",[134,135,136,137,138,139,140,141,54],"Chronic tension-type headache","Chronic primary headache","Forward head posture","Deep neck flexor exercise","Pressure biofeedback","Myofascial release","Pressure pain threshold","Quality of life","NOT_YET_RECRUITING","2024-09-30",{"date":145,"type":30},"2024-10-01",{"date":147,"type":19},"2024-11-01",{"date":149,"type":19},"2026-12-01",{"name":36,"class":37},""]