[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Isabel Moreno Hay\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":83},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,54],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":34,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100600934","ioa-preventing-occlusal-changes-with-mad-use-100600934",false,"NCT07103941","IOA Preventing Occlusal Changes With MAD Use","Effectiveness of Interocclusal Aligner (IOA) on Preventing Occlusal Changes in Patients Treated With a Mandibular Advancement Device (MAD): A Preliminary Study","Inclusion Criteria:\n\n* adult participants (≥18 years)\n* diagnosed with SRBD and prescribed Mandibular Advancement Device (MAD) therapy\n* Participants will include patients with well restored natural dentition with all posterior teeth, excluding third molars, one missing premolar secondary to orthodontic treatment.\n\nExclusion Criteria:\n\n* pervious orthognathic surgery\n* anterior cross bite\n* posterior cross bite\n* existing open bite or implant supported restorations\n* tooth mobility\n* significant dental caries or periodontitis\n* severe bruxism\n* planned upcoming dental work including caps, crowns, implants, or braces\n* inadequate mandibular protrusion\n* severe micrognathia\n* large tori\n* significant claustrophobia\n* significant nasal obstruction\n* large oropharyngeal masses or large tonsils",true,"ALL","18 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study is evaluating two standard-of-care strategies used to prevent bite changes (occlusal changes) in patients treated with a Mandibular Advancement Device (MAD) for sleep-related breathing disorders such as obstructive sleep apnea (OSA). While MAD therapy is effective, it can lead to changes in how the teeth fit together, including the development of a posterior open bite.\n\nParticipants in this study will be randomly assigned to one of two standard-of-care approaches: using an interocclusal aligner each morning after removing the MAD, or performing daily jaw exercises. Both methods aim to reduce the risk of occlusal changes.\n\nThe study will follow participants over a 3-month period and includes dental evaluations, 3D oral scans, and short daily surveys. Findings from this research may help guide best practices for preserving occlusion during MAD therapy.",[27,28,29,30,31,32,33],"Sleep Related Breathing Disorder","Snoring","Obstructive Sleep Apnea (OSA)","Open Bite","Occlusal Changes","Tooth Migration","Posterior Open Bite",[35,36,33,31,37,38,39,40],"Interocclusal Aligner","Mandibular advancement Device","Dental Changes","Protrusion","Sleep Appliance","Obstructive Sleep Apnea","RECRUITING","2026-05-14",{"date":44,"type":45},"2026-05-18","ACTUAL",{"date":47,"type":45},"2025-11-17",{"date":49,"type":21},"2026-12-30",{"name":51,"class":52},"Isabel Moreno Hay","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":22,"phases":64,"briefSummary":65,"conditions":66,"keywords":69,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":53},"100607297","home-based-under-mattress-monitor-for-osa-100607297","NCT07186725","Home-based Under Mattress Monitor for OSA","Home-Based Under-Mattress Monitoring Device to Estimate Mandibular Advancement in Oral Appliance Therapy for Obstructive Sleep Apnea","Inclusion Criteria:\n\n* Diagnosis of Obstructive Sleep Apnea demonstrated with a sleep study polysomnography or home sleep study (PSG or HSAT), manually scored by a sleep physician according to the 2017 American Academy of Sleep medicine scoring guidelines.\n* Willingness to commute to the OFP clinic every 2 weeks during MAD titration period.\n* Consent to partake in the study.\n\nExclusion Criteria:\n\n* Diagnosis of central or mixed sleep apnea.\n* Neurocognitive disease.\n* Concomitant therapy with PAP therapy.\n* Allergic to the appliance material (Polyamide 12).\n* Presence of active dental decay, ill-fitting dental restorations, or crown to root ratio unfavorable.\n* Inadequate English language comprehension.\n* Lack of coordination or dexterity to insert\u002Fremove the MAD intraorally.\n* Inability to tolerate digital dental impressions.\n* Patients with concomitant diagnosed sleep disorders, including narcolepsy, restless leg syndrome, rapid eye movement sleep behavior disorder).","80 Years",{"count":63,"type":21},70,[24],"The aim of the study is to evaluate the effectiveness of the under-mattress monitoring device to aid in the titration process of a mandibular advancement device (MAD) for the management of obstructive sleep apnea (OSA). A secondary aim is to evaluate changes in subjective OSA symptoms and patient's satisfaction with MAD. A third aim is to analyze if there are differences between the sleep parameters recorded by the under-mattress monitor between responders and non-responders to MAD therapy.",[67,68],"Obstructive Sleep Apnea (OSAS)","Obstructive Sleep Apnea (SAOS)",[70,71,72,73,40,74],"Mandibular Advancement","Sleep Apnea","Oral Appliance","Home-based","Home-based device","2026-02-02",{"date":77,"type":45},"2026-02-03",{"date":79,"type":45},"2026-01-07",{"date":81,"type":21},"2027-03",{"name":51,"class":52},""]