[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Islamabad Medical and Dental College\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":145},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,41,65,98,118],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100644105","comparative-outcomes-of-inj-botox-alone-vs-inj-botox-combined-with-fissurectomy-and-anoplasty-in-the-management-of-chronic-anal-fissure-100644105",false,"NCT07665528","Comparative Outcomes of Inj Botox Alone vs Inj Botox Combined With Fissurectomy and Anoplasty in the Management of Chronic Anal Fissure","Comparative Outcomes of Injection Botox Alone Versus Injection Botox Combined With Fissurectomy and Anoplasty in the Management of Chronic Anal Fissure","Inclusion Criteria:\n\nAdults aged 18 to 65 years, regardless of sex Diagnosis of chronic anal fissure persisting for more than 6 weeks Failure of at least 6 weeks of standardized conservative treatment Fit for anesthesia and surgical intervention Willing and able to provide written informed consent\n\nExclusion Criteria:\n\nAcute anal fissure Inflammatory bowel disease Anal malignancy Previous anal surgery Pregnancy Pre-existing fecal incontinence Immunocompromised patients","ALL","18 Years","65 Years",{"count":20,"type":21},108,"ESTIMATED","INTERVENTIONAL",[24],"NA","Chronic anal fissure is a common benign anorectal condition characterized by severe pain during defecation, rectal bleeding, and reduced quality of life. Injection Botox is a widely used sphincter-preserving treatment that produces temporary relaxation of the internal anal sphincter and promotes fissure healing. However, healing rates with injection Botox alone are variable and recurrence remains a concern.\n\nThis prospective comparative trial aims to compare the effectiveness and safety of injection Botox alone versus injection Botox combined with fissurectomy and anoplasty in adults with chronic anal fissure. The study will evaluate healing rate, pain relief, time to healing, recurrence, postoperative complications, continence outcomes, and patient satisfaction.\n\nA total of 108 eligible patients with chronic anal fissure will be enrolled and allocated to one of the two treatment groups. Participants will be followed after treatment to assess clinical outcomes. The results of this study are expected to provide evidence regarding the optimal sphincter-preserving treatment approach for chronic anal fissure and help improve patient care and quality of life.",[27],"Anal Fissure Chronic","RECRUITING","2026-06-24",{"date":31,"type":32},"2026-06-26","ACTUAL",{"date":34,"type":32},"2026-06-03",{"date":36,"type":21},"2026-12-03",{"name":38,"class":39},"Islamabad Medical and Dental College","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":22,"phases":50,"briefSummary":51,"conditions":52,"keywords":54,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":40},"100640843","evaluation-of-post-operative-pain-after-using-intracranial-cryotherapy-during-single-visit-rct-100640843","NCT07598188","Evaluation of Post Operative Pain After Using Intracranial Cryotherapy During Single Visit RCT","Evaluation of Post Operative Pain After Using Intracranial Cryotherapy During Single Visit Root Canal Treatment in Teeth With Symptomatic Apical Periodontitis","Inclusion Criteria:\n\nIndividual (male\u002Ffemale) with age \\>18 years with symptomatic apical periodontitis in permanent teeth\n\nExclusion Criteria:\n\n1. Teeth with calcified canals or aberrant root anatomy,\n2. Female Pregnant patients\n3. Patients using medications such as analgesics or anti-biotics drugs and\n4. Those who refuse to participate in the study",{"count":49,"type":21},60,[24],"A total of 60 patients presenting with single-rooted teeth exhibiting symptomatic apical periodontitis were subjected to a randomized allocation into two groups of 30 each. Irrigation was done using 3% sodium hypochlorite for 5 seconds in all 60 teeth. Group 1 underwent final irrigation utilizing normal saline at room temperature. Group 2 received final irrigation using normal saline refrigerated between 2-5°C. Pain levels were assessed and recorded before the procedure and at 24 and 48-hour time intervals.",[53],"Periapical Diseases",[55],"Cold therapy, Saline solution, periapical diseases, sodium hypochlorite","NOT_YET_RECRUITING","2026-05-19",{"date":59,"type":32},"2026-05-20",{"date":61,"type":21},"2026-07-10",{"date":63,"type":21},"2027-03-31",{"name":38,"class":39},{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":16,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":4,"studyType":22,"phases":78,"briefSummary":79,"conditions":80,"keywords":84,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":40},"100633850","comparison-of-three-orthodontic-separators-for-pain-plaque-and-tooth-separation-100633850","NCT07532044","Comparison of Three Orthodontic Separators for Pain, Plaque, and Tooth Separation","Separation Effect, Plaque Score, Pain Perception, And Impact On Quality Of Life When Comparing Three Types Of Orthodontic Separators: A Randomized Controlled Trial","SEP-ORTHO","Inclusion Criteria:\n\n* Patients requiring fixed orthodontic appliance therapy with maxillary first molar banding\n* Age between 12 and 25 years\n* Good oral hygiene (Plaque Index score 0-1)\n* Good general oral health\n* No previous orthodontic treatment\n* No history of dental extractions\n* Presence of tight interproximal contacts at the site of separator placement (no spacing)\n\nExclusion Criteria:\n\n* Presence of interproximal restorations\n* Presence of interproximal caries\n* Missing maxillary second premolar, first molar, or second molar\n* Unerupted maxillary second molars\n* Systemic diseases affecting oral health (e.g., diabetes mellitus)\n* Regular use of medications affecting pain perception (e.g., analgesics, corticosteroids)\n* Loss of separators before follow-up appointment\n* Failure to return within 72 hours for evaluation",true,"12 Years","25 Years",{"count":77,"type":21},144,[24],"Orthodontic separators are small devices placed between teeth before fitting braces to create space for bands. This procedure may cause pain, discomfort, and changes in oral hygiene, which can affect plaque buildup and daily activities.\n\nThis study aims to compare three commonly used types of orthodontic separators-elastomeric, Kesling, and customized tie wire separators-in terms of the amount of tooth separation achieved, pain experienced by patients, and plaque accumulation.\n\nIn addition, the study will assess how these separators affect patients' quality of life, including eating, speaking, and daily comfort.\n\nParticipants will be assigned to one of the three separator types and will be evaluated after 48 to 72 hours. The findings of this study may help identify the most effective and comfortable separator, improving patient care and treatment experience in orthodontics.",[81,82,83],"Orthodontic Pain (D013850)","Malocclusion","Orthodontic Treatment",[85,86,87,88,89],"Orthodontic separators","Pain perception","Plaque index","Quality of life","Tooth separation","2026-05-05",{"date":92,"type":32},"2026-05-08",{"date":94,"type":21},"2026-04-10",{"date":96,"type":21},"2028-04-10",{"name":38,"class":39},{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":106,"targetDuration":4,"studyType":22,"phases":108,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":40},"100636640","comparison-of-botulinum-toxin-injection-and-lateral-internal-sphincterotomy-in-chronic-anal-fissure-management-100636640","NCT07568314","Comparison of Botulinum Toxin Injection and Lateral Internal Sphincterotomy in Chronic Anal Fissure Management","A Prospective Comparative Study of Clinical Outcomes Between Botulinum Toxin Injection and Lateral Internal Sphincterotomy in the Management of Chronic Anal Fissure","BOT-LIS-CAF","Inclusion Criteria:Age 18-65 years Diagnosed chronic anal fissure (\\>6 weeks duration) Failure of conservative management Both male and female patients Willingness to provide informed consent -\n\nExclusion Criteria:Acute anal fissure Previous anal surgery Inflammatory bowel disease Pregnancy Neurological disorders affecting continence Known hypersensitivity to botulinum toxin\n\n\\-",{"count":107,"type":21},90,[24],"This study aims to compare two commonly used treatments for chronic anal fissure: botulinum toxin injection and lateral internal sphincterotomy. Chronic anal fissure is a painful condition that causes severe discomfort during bowel movements and can significantly affect a patient's quality of life.\n\nBotulinum toxin injection is a minimally invasive procedure that temporarily relaxes the anal sphincter muscle to promote healing. In contrast, lateral internal sphincterotomy is a minor surgical procedure that permanently reduces sphincter pressure and is considered the standard treatment with high healing rates.\n\nA total of 90 adult patients with chronic anal fissure will be enrolled and divided into two groups. One group will receive botulinum toxin injection, while the other group will undergo lateral internal sphincterotomy. Patients will be followed up regularly to assess healing, pain relief, recurrence of the fissure, and any complications such as incontinence.\n\nThe purpose of this study is to determine which treatment provides better outcomes in terms of effectiveness and safety, helping doctors choose the most appropriate treatment for patients.",[27],"2026-04-28",{"date":90,"type":32},{"date":114,"type":32},"2026-03-02",{"date":116,"type":21},"2026-08-31",{"name":38,"class":39},{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":124,"eligibilityCriteria":125,"healthyVolunteers":73,"sex":16,"minAge":74,"maxAge":126,"enrollmentInfo":127,"targetDuration":4,"studyType":22,"phases":128,"briefSummary":129,"conditions":130,"keywords":132,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":40},"100628169","comparison-of-root-resorption-in-modified-corticotomy-assisted-and-conventional-canine-retraction-100628169","NCT07458139","Comparison of Root Resorption in Modified Corticotomy-Assisted and Conventional Canine Retraction","Comparison of External Apical Root Resorption in Modified Corticotomy-Assisted and Conventionally Retracted Maxillary Canines Using Frictionless T-Loop Mechanics: A Randomized Controlled Clinical Trial","MCA-CR","Inclusion Criteria:\n\n* Patients aged 12-30 years requiring canine retraction into maxillary first premolar extraction spaces\n* Patients with normal vertical skeletal pattern (mandibular plane angle 32° ± 5°)\n* Patients with healthy periodontium\n\nExclusion Criteria:\n\n* Syndromic patients\n* Patients with systemic conditions requiring long-term medication affecting orthodontic tooth movement (e.g., NSAIDs, bisphosphonates, anticonvulsants)\n* Mixed dentition cases\n* Patients with pre-existing root resorption\n* Patients who fail to attend scheduled appointments","30 Years",{"count":49,"type":21},[24],"This randomized controlled clinical trial will compare external apical root resorption in patients undergoing maxillary canine retraction using modified corticotomy-assisted frictionless T-loop mechanics versus conventional frictionless T-loop mechanics. Sixty orthodontic patients requiring extraction of maxillary first premolars will be randomly assigned to two groups. Changes in canine root length will be measured on panoramic radiographs taken before and after retraction to determine the extent of external apical root resorption. The study will evaluate whether modified corticotomy-assisted retraction results in different root resorption outcomes compared to conventional retraction.",[131],"External Apical Root Resorption in Maxillary Canines During Orthodontic Retraction",[133,134,135,136],"Maxillary Canine Retraction","External Apical Root Resorption","Frictionless Mechanics","Modified Corticotomy","2026-03-03",{"date":139,"type":32},"2026-03-09",{"date":141,"type":21},"2026-03",{"date":143,"type":21},"2026-07",{"name":38,"class":39},""]