[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Istanbul Demiroglu Bilim University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":74},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100617354","effects-of-expiratory-muscle-training-added-to-pulmonary-rehabilitation-in-patients-with-bronchiectasis-100617354",false,"NCT07317531","Effects of Expiratory Muscle Training Added to Pulmonary Rehabilitation in Patients With Bronchiectasis","Effects of Expiratory Muscle Training Added to Pulmonary Rehabilitation on Pulmonary Function, Respiratory Muscle Strength, and Functional Capacity in Patients With Bronchiectasis","Inclusion Criteria:\n\n* Age between 18 and 70 years\n\n  * Clinical diagnosis of non-cystic fibrosis bronchiectasis\n  * Stable disease status\n  * Follow-up at the Pulmonary Rehabilitation Unit of University of Health Sciences Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital\n  * Ability to understand and comply with the study procedures\n  * Provided written informed consent\n\nExclusion Criteria:\n\n* Acute exacerbation within the last 3 months\n* Diagnosis of cystic fibrosis-related bronchiectasis\n* Presence of severe cardiac, neurological, or orthopedic diseases that may interfere with exercise training\n* Cognitive impairment, lack of cooperation, or communication difficulties\n* Any medical condition contraindicating participation in pulmonary rehabilitation or expiratory muscle training","ALL","18 Years","70 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized, single-blind, parallel-group controlled trial aims to investigate the effects of expiratory muscle training added to standard pulmonary rehabilitation on respiratory muscle strength, pulmonary function, cough effectiveness, exercise capacity, dyspnea perception, and quality of life in patients with non-cystic fibrosis bronchiectasis. Eligible patients aged 18-70 years with stable disease will be randomly assigned to either a pulmonary rehabilitation-only group or a pulmonary rehabilitation combined with expiratory muscle training group. Outcomes will be assessed at baseline and after completion of the intervention period.",[27,28,29,30,31,32],"Bronchiectasis Adult","Expiratory Muscle Training","Pulmonary Rehabilitation","Lung Function Tests","Functional Capacity","Respiratory Muscle Strength","NOT_YET_RECRUITING","2026-01-02",{"date":36,"type":37},"2026-01-05","ACTUAL",{"date":39,"type":21},"2026-02-01",{"date":41,"type":21},"2027-03-01",{"name":43,"class":44},"Istanbul Demiroglu Bilim University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":64,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":45},"100607781","the-effect-of-bipap-on-diaphragmatic-function-100607781","NCT07193017","The Effect of BIPAP on Diaphragmatic Function","The Effects of Biphasic Positive Airway Pressure (BIPAP) Use on Diaphragm Functions in Patients With Chronic Obstructive Pulmonary Disease (COPD)","Inclusion Criteria:\n\n* Being between 40-80 years of age,\n* Having a diagnosis of stable COPD for at least 1 year,\n* Being in a stable phase (no acute exacerbation within the last 4 weeks),\n* Meeting the GOLD 2025 A-B-E classification according to symptoms and exacerbation history,\n* Having been initiated on BiPAP therapy with a clinical indication,\n* Being willing to participate in the study and providing informed consent.\n\nExclusion Criteria:\n\n* Pregnancy,\n* Diaphragmatic paralysis,\n* Neuromuscular and neurological diseases,\n* Decompensated heart failure,\n* Chest deformity,\n* Acute exacerbation within the last month,\n* Pneumothorax,\n* Body mass index greater than 35 kg\u002Fm²,\n* Long-term corticosteroid use,\n* Chemotherapy,\n* Active malignancy,\n* Inability to cooperate,\n* Thoracoabdominal surgery within the last 3 months.","40 Years","80 Years",{"count":56,"type":21},30,"OBSERVATIONAL","This research is designed to evaluate how long-term treatment with Bilevel Positive Airway Pressure (BiPAP) influences diaphragm function in patients with Chronic Obstructive Pulmonary Disease (COPD) who suffer from chronic hypercapnic respiratory failure. The diaphragm is the primary muscle of breathing, and its dysfunction is linked to unfavorable clinical outcomes such as higher mortality rates and frequent hospitalizations. In this prospective cohort study, COPD patients starting BiPAP therapy based on clinical indication will be monitored through repeated ultrasound assessments of diaphragm structure and function together with pulmonary function testing, respiratory muscle strength evaluation, dyspnea. The main outcome of interest is the change in diaphragm thickness in inspiration, thickness in expiration, diaphragm thickening fraction (DTF), diaphragm maximum contraction velocity and maximum relaxation velocity across a 6 weeks as a early time and 12 months for long time follow-up period. Secondary measures include hospital admissions, and one-year survival. The study is expected to generate valuable evidence about the link between non-invasive ventilation and diaphragm function, which may contribute to optimizing treatment strategies for COPD patients with advanced respiratory failure.",[60,61,62,63],"BIPAP Biphasic Intermittent Positive Airway Pressure","Diaphragm Issues","Ultrasound Diagnostics","COPD (Chronic Obstructive Pulmonary Disease)",[65],"bıpap, diaphragm function, diaphragm ultrasound, copy","2025-09-24",{"date":68,"type":37},"2025-09-25",{"date":70,"type":21},"2025-10-15",{"date":72,"type":21},"2027-06-15",{"name":43,"class":44},""]