[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Istanbul Medipol University Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":673},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,36,0,25,[9,50,83,112,143,170,197,227,260,286,312,336,363,382,405,430,455,477,507,533,554,581,605,629,652],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":4},"100642126","comparison-of-early-mobilization-and-electrical-stimulation-on-functional-recovery-after-lumbar-disc-herniation-surgery-100642126",false,"NCT07575477","Comparison Of Early Mobilization And Electrical Stimulation On Functional Recovery After Lumbar Disc Herniation Surgery","Comparison Of Early Mobilization And Electrical Stimulation-Supported Rehabilitation On Functional Recovery, Pain Level, And Mobility After Lumbar Disc Herniation Surgery: A Prospective Randomized Controlled Trial","EMES-LDH","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* Patients who have undergone primary lumbar disc herniation surgery\n* Being in the early postoperative period (within the first 2 weeks after surgery)\n* Clinically stable condition\n* Ability to understand and follow instructions\n* Willingness to participate in the study and provide informed consent\n\nExclusion Criteria:\n\n* History of previous spinal surgery\n* Presence of severe neurological deficits (e.g., progressive motor loss, cauda equina syndrome)\n* Contraindications to electrical stimulation (e.g., pacemaker, implanted electronic devices)\n* Presence of severe systemic or uncontrolled chronic diseases (e.g., severe cardiovascular, respiratory, or metabolic disorders)\n* Cognitive impairment or inability to cooperate with rehabilitation program Pregnancy","ALL","18 Years","65 Years",{"count":22,"type":23},60,"ESTIMATED","INTERVENTIONAL",[26],"NA","This randomized controlled trial aims to compare the effectiveness of early mobilization alone versus early mobilization combined with electrical stimulation on functional recovery following lumbar disc herniation surgery. Lumbar disc herniation is a common cause of low back pain and functional limitation, significantly affecting quality of life.\n\nAlthough surgical intervention is effective in patients who do not respond to conservative treatment, optimal postoperative recovery largely depends on appropriate rehabilitation strategies. Early mobilization is widely recommended to prevent complications, preserve muscle function, and facilitate return to daily activities. In addition, electrical stimulation modalities such as neuromuscular electrical stimulation (NMES) and transcutaneous electrical nerve stimulation (TENS) have been increasingly integrated into rehabilitation programs to enhance pain control, muscle activation, and neuromuscular re-education.\n\nIn this study, a total of 60 participants who have undergone primary lumbar disc herniation surgery will be randomly assigned into two groups. The first group will receive an early mobilization program alone, while the second group will receive early mobilization combined with electrical stimulation (NMES\u002FTENS). The intervention period will last 6 to 8 weeks, with sessions conducted three times per week.\n\nPrimary outcomes include functional disability measured by the Oswestry Disability Index (ODI) and pain intensity measured by the Visual Analog Scale (VAS). Secondary outcomes include functional mobility assessed by the Timed Up and Go (TUG) test, walking speed assessed by the 10-Meter Walk Test (10MWT), and muscle strength evaluated using manual muscle testing (MMT).\n\nThe findings of this study are expected to contribute to the development of evidence-based postoperative rehabilitation protocols and to clarify the clinical effectiveness of electrical stimulation in patients undergoing lumbar disc herniation surgery",[29,30,31],"Lumbar Disc Herniation","Low Back Pain","Postoperative Rehabilitation",[33,34,35,36,37],"Lumbar Surgery","Early Mobilization","Electrical Stimulation","Physiotherapy","Functional Recovery","NOT_YET_RECRUITING","2026-06-12",{"date":41,"type":42},"2026-06-16","ACTUAL",{"date":44,"type":23},"2026-06-30",{"date":46,"type":23},"2026-07-30",{"name":48,"class":49},"Istanbul Medipol University Hospital","OTHER",{"id":51,"slug":52,"hasResults":12,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":57,"targetDuration":4,"studyType":24,"phases":59,"briefSummary":60,"conditions":61,"keywords":66,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},"100617670","ultrasound-guided-regional-blocks-for-postoperative-analgesia-after-laparoscopic-cholecystectomy-100617670","NCT07321639","Ultrasound-Guided Regional Blocks for Postoperative Analgesia After Laparoscopic Cholecystectomy","Comparison of the Effectiveness of Ultrasound-Guided Recto-Intercostal Fascial Plane Block and Transversus Abdominis Plane Block in Postoperative Analgesia Management of Patients Undergoing Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* ASA physical status I-II\n* Scheduled for elective laparoscopic cholecystectomy\n\nExclusion Criteria:\n\n* Known allergy to local anesthetics or opioid medications\n* Infection at the planned block site\n* History of alcohol or drug dependence\n* Use of anticoagulant therapy\n* Refusal to participate in the study",{"count":58,"type":23},90,[26],"Ultrasound (US)-guided recto-intercostal fascial plane block (RIFPB) is a recently described abdominal wall block performed by injecting local anesthetic between the rectus abdominis muscle and the costal cartilage of the 7th rib. Due to the cranial attachment of the rectus muscle, this technique provides effective analgesia to the sternal, epigastric, and upper-mid abdominal regions, corresponding to the T6-T10\u002F11 dermatomal levels. RIFPB may be used as an adjunct technique for thoracic procedures or as a standalone block for abdominal surgery.\n\nUltrasound-guided transversus abdominis plane block (TAPB) is performed by injecting local anesthetic into the fascial plane between the internal oblique and transversus abdominis muscles. TAPB provides sensory blockade of the anterolateral abdominal wall at the T6-L1 dermatomal levels and is widely used for postoperative analgesia following abdominal surgeries, including laparoscopic cholecystectomy.\n\nThis study aims to compare the effectiveness of US-guided RIFPB and TAPB on postoperative pain control after laparoscopic cholecystectomy.",[62,63,64,65],"Laparoscopic Cholecystectomy","Acute Pain","Pain Management","Plane Blocks",[67,68,69,70,71,72],"Laparoscopic cholecystectomy","Postoperative analgesia","Recto-intercostal fascial plane block","Transversus abdominis plane block","Regional anesthesia","Opioid consumption","RECRUITING","2026-06-10",{"date":76,"type":42},"2026-06-11",{"date":78,"type":42},"2026-01-19",{"date":80,"type":23},"2027-07-15",{"name":48,"class":49},1,{"id":84,"slug":85,"hasResults":12,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":24,"phases":92,"briefSummary":93,"conditions":94,"keywords":98,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":82},"100633228","paraffin-oil-for-preventing-tourniquet-related-skin-lesions-in-upper-extremity-surgery-100633228","NCT07523958","Paraffin Oil for Preventing Tourniquet-Related Skin Lesions in Upper Extremity Surgery","Paraffin Oil for Preventing Tourniquet-Related Skin Lesions in Upper Extremity Surgery (PARA-TOUR RCT)","PARA-TOUR","IInclusion Criteria:\n\n* Age ≥18 years\n* Patients scheduled for elective upper extremity surgery requiring pneumatic tourniquet application\n* ASA physical status I-III\n* Body mass index (BMI) \\\u003C30 kg\u002Fm²\n* Ability to provide informed consent\n* Willingness to participate in the study\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* Known dermatological disease or existing skin lesion at the tourniquet application site\n* Allergy or sensitivity to paraffin oil or related substances\n* Severe systemic disease (ASA IV or higher)\n* Obesity (BMI ≥30 kg\u002Fm²)\n* Emergency surgery\n* Patients transferred to intensive care postoperatively\n* Development of major postoperative complications (e.g., hematoma, seroma, nerve injury, significant bleeding)\n* Inability to communicate or comply with study procedures\n* Withdrawal from the study at any time",{"count":58,"type":23},[26],"This randomized controlled trial aims to evaluate the effectiveness of topical paraffin oil application in preventing tourniquet-related skin lesions in patients undergoing upper extremity surgery. Pneumatic tourniquets are commonly used to provide a bloodless surgical field; however, they may cause skin complications such as erythema, edema, abrasions, blisters, and burns.\n\nIn this study, adult patients undergoing elective upper extremity surgery will be randomly assigned to either an intervention group receiving topical paraffin oil application in addition to routine protective dressing or a control group receiving routine care only. Skin integrity will be assessed immediately after tourniquet removal and at 30 and 60 minutes postoperatively using standardized skin assessment criteria.\n\nThe findings of this study are expected to contribute to the development of effective, simple, and cost-efficient strategies to prevent tourniquet-related skin complications and improve patient safety and postoperative comfort.",[95,96,97],"Pressure Injury","Skin Lesions","Skin Injury",[99,100,101,102,103],"Paraffin Oil","Tourniquet","Upper Extremity Surgery","Skin Injury Prevention","Randomized Controlled Trial","2026-06-02",{"date":106,"type":42},"2026-06-04",{"date":108,"type":42},"2026-01-12",{"date":110,"type":23},"2026-07",{"name":48,"class":49},{"id":113,"slug":114,"hasResults":12,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":12,"sex":18,"minAge":119,"maxAge":4,"enrollmentInfo":120,"targetDuration":4,"studyType":122,"phases":4,"briefSummary":123,"conditions":124,"keywords":128,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":140,"leadSponsor":142,"locationsCount":82},"100637415","effects-of-comprehensive-community-support-programs-on-cognitive-function-and-quality-of-life-in-older-adults-100637415","NCT07610109","Effects of Comprehensive Community Support Programs on Cognitive Function and Quality of Life in Older Adults","THE EFFECTS OF COMPREHENSIVE COMMUNITY SUPPORT PROGRAMS FOR THE ELDERLY ON COGNITIVE FUNCTIONS AND QUALITY OF LIFE: THE VEFAHANE MODEL","Inclusion Criteria:\n\n* Elderly individuals aged 60 and over who attend or will attend Vefahane Life Center\n* Able to cooperate,\n* Individuals who speak Turkish\n* Individuals who are literate\n\nExclusion Criteria:\n\n* Individuals previously diagnosed with dementia,\n\n  * Individuals with neurological and psychiatric diagnoses that affect cognitive skills,\n  * Individuals receiving occupational therapy interventions aimed at improving cognitive skills within the center,\n  * Individuals with illnesses that prevent participation in the activity program (cancer, cardiovascular instability, etc.),\n  * Individuals with severe visual and hearing loss that hinders communication.","60 Years",{"count":121,"type":23},120,"OBSERVATIONAL","This prospective observational study aims to investigate the effects of a multidomain community-based support program on cognitive function and quality of life in older adults attending the Vefahane Life Center in Istanbul, Türkiye. The study will compare elderly individuals actively participating in community-based social, cognitive, physical, and supportive activities with individuals registered at the center but not actively participating during the study period. Participants will undergo neuropsychological and psychosocial assessments at baseline and after 3 months. The primary outcome is change in global cognitive performance measured by the Mini Mental State Examination (MMSE). Secondary outcomes include memory, executive functions, depression, neuropsychiatric symptoms, and quality of life measures.",[125,126,127],"Cognitive Decline","Aging","Quality of Life",[129,130,131,132,133,134,135],"older adults","aging","cognitive rehabilitation","cognitive function","community-based intervention","social wellbeing","social participation","2026-05-20",{"date":138,"type":42},"2026-05-27",{"date":136,"type":42},{"date":141,"type":23},"2026-12-30",{"name":48,"class":49},{"id":144,"slug":145,"hasResults":12,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":149,"eligibilityCriteria":150,"healthyVolunteers":12,"sex":18,"minAge":151,"maxAge":152,"enrollmentInfo":153,"targetDuration":4,"studyType":24,"phases":154,"briefSummary":155,"conditions":156,"keywords":159,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":4},"100633317","effects-of-proprioceptive-neuromuscular-facilitation-based-lower-extremity-training-on-balance-gait-and-functional-independence-in-individuals-with-stroke-100633317","NCT07525115","Effects of Proprioceptive Neuromuscular Facilitation-Based Lower Extremity Training on Balance, Gait, and Functional Independence in Individuals With Stroke","The Effects of Proprioceptive Neuromuscular Facilitation-Based Lower Extremity Rehabilitation on Balance, Gait Performance, Functional Independence, and Quality of Life in Individuals With Stroke: A Randomized Controlled Study","PNF-STROKE","Inclusion Criteria:\n\n* Diagnosis of stroke confirmed by a neurologist\n* Age between 40 and 80 years\n* Ability to walk with or without an assistive device\n* Medically stable condition\n* Ability to understand and follow verbal instructions\n* Willingness to participate and provide informed consent\n\nExclusion Criteria:\n\n* Severe cognitive impairment preventing participation\n* Other neurological disorders affecting mobility\n* Severe musculoskeletal disorders affecting lower extremity function\n* Severe cardiovascular conditions contraindicating exercise\n* Participation in another rehabilitation study","40 Years","80 Years",{"count":22,"type":23},[26],"This study aims to investigate the effects of a proprioceptive neuromuscular facilitation (PNF)-based lower extremity rehabilitation program on balance, gait performance, functional independence, and quality of life in individuals with stroke.\n\nStroke is a leading cause of long-term disability and is commonly associated with impairments in motor control, balance, and walking ability, which negatively affect independence and daily functioning.\n\nIn this randomized controlled trial, participants with stroke will be randomly assigned to either a PNF-based rehabilitation group or a control group receiving conventional physiotherapy. The intervention will focus on lower extremity PNF techniques to improve motor control, balance, and gait performance.\n\nAssessments will be conducted at baseline and at the end of the intervention period.\n\nThe findings are expected to contribute to the development of evidence-based rehabilitation strategies for individuals with stroke.",[157,158],"Stroke","Proprioceptive Neuromuscular Facilitation",[157,160,158,161,162],"Stroke Rehabilitation","Neurological Rehabilitation","Gait Physiotherapy",{"date":164,"type":42},"2026-05-22",{"date":166,"type":23},"2026-04-30",{"date":168,"type":23},"2026-08-20",{"name":48,"class":49},{"id":171,"slug":172,"hasResults":12,"nctId":173,"briefTitle":174,"officialTitle":175,"acronym":176,"eligibilityCriteria":177,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":178,"targetDuration":4,"studyType":24,"phases":180,"briefSummary":181,"conditions":182,"keywords":187,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":4},"100640039","effects-of-functional-electrical-stimulation-on-spasticity-quadriceps-muscle-strength-and-functional-mobility-in-individuals-with-paraplegia-100640039","NCT07583576","Effects of Functional Electrical Stimulation on Spasticity, Quadriceps Muscle Strength and Functional Mobility in Individuals With Paraplegia","Effects of Functional Electrical Stimulation on Spasticity, Quadriceps Muscle Strength and Functional Mobility in Individuals With Paraplegia: A Randomized Controlled Trial","FES-PAR-RCT","Inclusion Criteria:\n\n* Participants will be included in the study if they meet all of the following criteria:\n* Aged between 18 and 65 years\n* Diagnosed with spinal cord injury resulting in paraplegia (traumatic or non-traumatic etiology)\n* Classified as ASIA Impairment Scale C or D\n* Medically stable condition\n* Presence of lower extremity spasticity (Modified Ashworth Scale ≥ 1)\n* Ability to understand and follow simple instructions\n* Willingness to participate and provide informed consent\n\nExclusion Criteria:\n\n* Participants will be excluded if they present any of the following conditions:\n* Presence of cardiac pacemaker or implanted electrical device\n* Severe cognitive impairment or communication difficulties preventing participation\n* Active infection or systemic inflammatory condition\n* Severe lower extremity contractures or deformities limiting movement\n* Dermatological conditions or open wounds preventing FES application\n* History of severe autonomic dysreflexia triggered by electrical stimulation\n* Uncontrolled medical conditions that may interfere with participation or safety",{"count":179,"type":23},40,[26],"Spinal cord injury (SCI)-related paraplegia is a complex neurological condition characterized by motor impairment, increased spasticity, and significant functional limitations in daily activities. Spasticity is one of the most common secondary complications after upper motor neuron lesions and can negatively affect rehabilitation outcomes, gait ability, and functional independence.\n\nThis randomized controlled study aims to investigate the effects of Functional Electrical Stimulation (FES) applied to the quadriceps muscle in individuals with paraplegia. Participants will be randomly assigned to either a control group receiving conventional neurorehabilitation or an intervention group receiving additional FES treatment.\n\nThe primary outcomes include changes in spasticity level, quadriceps muscle strength, and functional mobility. Spasticity will be assessed using the Modified Ashworth Scale (MAS), muscle strength will be evaluated with Manual Muscle Testing (MMT), and functional mobility will be measured using the Spinal Cord Independence Measure (SCIM), Timed Up and Go Test (TUG), and 6-Minute Walk Test (6MWT).\n\nThe intervention period will last 8 weeks, with standardized rehabilitation programs applied to both groups. The FES group will additionally receive quadriceps stimulation with specific neuromuscular electrical stimulation parameters.\n\nThe findings of this study are expected to provide evidence regarding the effectiveness of FES as an adjunct to conventional rehabilitation in improving motor function and functional independence in individuals with paraplegia.",[183,184,185,186],"Spinal Cord Injury","Paraplegia","Spasticity","Neurorehabilitation",[183,188,186,185,184],"Paraplegia Rehabilitation","2026-05-15",{"date":191,"type":42},"2026-05-19",{"date":193,"type":23},"2026-05-10",{"date":195,"type":23},"2026-07-10",{"name":48,"class":49},{"id":198,"slug":199,"hasResults":12,"nctId":200,"briefTitle":201,"officialTitle":202,"acronym":4,"eligibilityCriteria":203,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":204,"enrollmentInfo":205,"targetDuration":4,"studyType":24,"phases":207,"briefSummary":208,"conditions":209,"keywords":212,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":226,"locationsCount":82},"100616350","effects-of-terlipressin-and-somatostatin-on-portal-pressure-in-patients-undergoing-living-donor-liver-transplantation-100616350","NCT07304466","Effects of Terlipressin and Somatostatin on Portal Pressure in Patients Undergoing Living Donor Liver Transplantation","Comparison of the Effects of Terlipressin and Somatostatin on Portal Pressure in Patients Undergoing Living Donor Liver Transplantation","Inclusion Criteria:\n\nPatients scheduled for right lobe living donor liver transplantation with clinically significant portal hypertension (esophageal varices, thrombocytopenia (\\\u003C100,000), ascites, encephalopathy; Child-Turcotte-Pugh class B-C)\n\nExclusion Criteria:\n\n* Allergy to any of the medications to be used\n* Portal vein thrombosis\n* Being treated with terlipressin with a diagnosis of hepatorenal syndrome\n* Portopulmonary hypertension\n* Acute on chronic liver failure\n* Chronic renal failure (glomerular filtration rate ≤ 30%)\n* Myocardial ischemia\n* Uncontrolled hypertension\n* Arrhythmia\n* Multiple solid organ transplantation","70 Years",{"count":206,"type":23},50,[26],"The goal of this clinical trial is to compare the effects of somatostatin and terlipressin on lowering portal pressure in patients with portal hypertension undergoing liver transplantation, and to investigate whether there are differences in clinical outcomes between the two drugs. The study will evaluate the decrease in portal pressure from baseline following drug administration at defined time points. It will also compare the effects of these drugs on hemodynamics, bleeding, and transfusion requirements. After baseline intraoperative direct portal pressure measurement, a bolus dose of the study drug will be administered, followed by continuous intravenous infusion intraoperatively and for 24 hours postoperatively. Direct portal pressure will be measured again 5 minutes after the bolus dose, after the portal vein anastomosis, after the hepatic artery anastomosis, and, if performed after splenic artery ligation. Hemodynamic parameters will be recorded, and the drugs will be compared in terms of their intraoperative hemodynamic effects. As elevated portal pressure is associated with increased bleeding, intraoperative blood loss and transfusion needs will also be assessed between the groups. Patients will be followed for 7 days postoperatively for clinical and laboratory outcomes.",[210,211],"Liver Transplantation","Portal Hypertension",[213,214,215,216,217,218],"liver transplantation","portal pressure","portal hypertension","living donor liver transplantation","somatostatin","terlipressin","2026-04-27",{"date":221,"type":42},"2026-04-29",{"date":223,"type":42},"2025-12-29",{"date":225,"type":23},"2027-03-30",{"name":48,"class":49},{"id":228,"slug":229,"hasResults":12,"nctId":230,"briefTitle":231,"officialTitle":232,"acronym":4,"eligibilityCriteria":233,"healthyVolunteers":234,"sex":18,"minAge":19,"maxAge":235,"enrollmentInfo":236,"targetDuration":4,"studyType":24,"phases":238,"briefSummary":239,"conditions":240,"keywords":245,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":253,"startDateStruct":255,"completionDateStruct":257,"leadSponsor":259,"locationsCount":4},"100634558","comparison-of-peer-role-playing-based-simulation-with-case-based-learning-in-physical-therapy-education-100634558","NCT07541248","Comparison of Peer Role-Playing-Based Simulation With Case-Based Learning in Physical Therapy Education","A Semi-Experimental Comparison of Peer Role-Playing-Based Simulation With Case-Based Learning in Physical Therapy Undergraduate Education","Inclusion Criteria:\n\n* Current enrollment as a senior (4th-year) undergraduate student in the Department of Physiotherapy and Rehabilitation at Istanbul Medipol University.\n* Active participation in the \"Clinical Problem Solving\" course.\n* Voluntary agreement to participate and signing of the informed consent form.\n\nExclusion Criteria:\n\n* Students who have previously taken the \"Clinical Problem Solving\" course or a similar simulation-based elective.\n* Failure to attend more than 20% of the 12-week course sessions.",true,"30 Years",{"count":237,"type":23},200,[26],"This study primarily aims to evaluate the impact of a 12-week peer role-play simulation model on the professional development of undergraduate physiotherapy students. Unlike traditional teacher-led case discussions, this study explores the effect of active participation in clinical scenarios, in which students alternate between the roles of 'clinician' and 'patient', on their academic achievement, self-efficacy and perceived clinical readiness. Specifically, the study aims to determine whether this interactive, low-cost pedagogical approach is a superior alternative to conventional lecture-based methods for preparing students for real-world clinical environments, particularly in high-enrolment academic settings.",[241,242,243,244],"Physiotherapy and Rehabilitation","Clinical Reasoning","Simulation Based Learning","Student Education",[246,242,247,248,249,250,251],"Physiotherapy Education","Simulation-Based Learning","Clinical Competence","Peer Role-Play","Health Profession Students","Self-Efficacy","2026-04-14",{"date":254,"type":42},"2026-04-21",{"date":256,"type":23},"2026-05-01",{"date":258,"type":23},"2026-07-01",{"name":48,"class":49},{"id":261,"slug":262,"hasResults":12,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":266,"eligibilityCriteria":267,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":268,"targetDuration":4,"studyType":24,"phases":270,"briefSummary":271,"conditions":272,"keywords":275,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":279,"lastUpdatePostDateStruct":280,"startDateStruct":281,"completionDateStruct":283,"leadSponsor":285,"locationsCount":4},"100633173","effect-of-extracorporeal-shock-wave-therapy-on-spasticity-and-mobility-in-stroke-patients-100633173","NCT07523243","Effect of Extracorporeal Shock Wave Therapy on Spasticity and Mobility in Stroke Patients","Efficacy of Extracorporeal Shock Wave Therapy on Spasticity, Mobility, Motor Function, and Health-Related Quality of Life in Stroke Survivors: A Prospective Randomized Sham-Controlled Trial","ESWT-STROKE","Inclusion Criteria:\n\n* Adults aged 18-65 years\n* Diagnosed with ischemic or hemorrhagic stroke at least 3 months prior to enrollment Presence of lower extremity spasticity with a Modified Ashworth Scale (MAS) score ≥1+\n* Ability to walk independently with or without assistive devices\n* Ability to understand and follow instructions for exercise interventions and assessments\n* Provided written informed consent\n\nExclusion Criteria:\n\n* Receipt of botulinum toxin injection in the affected lower limb within the last 3 months\n* Severe cognitive impairment preventing participation in assessments\n* Presence of fixed joint contractures limiting range of motion\n* Orthopedic or musculoskeletal disorders affecting lower limb function (e.g., fracture, severe osteoarthritis)\n* Uncontrolled cardiovascular, respiratory, or systemic disease contraindicating exercise\n* Participation in another interventional clinical trial\n* Any condition judged by the investigator to interfere with participation or safety",{"count":269,"type":23},85,[26],"This study aims to evaluate the effectiveness of extracorporeal shock wave therapy (ESWT) in individuals with lower limb spasticity following stroke. Spasticity is a common complication after stroke and can negatively affect walking ability, mobility, and quality of life.\n\nParticipants will be randomly assigned to one of two groups. Both groups will receive a standard physiotherapy and rehabilitation program. In addition, the intervention group will receive ESWT applied to the lower limb muscles, while the control group will receive a sham (placebo) ESWT application.\n\nThe treatment program will be conducted three times per week for four weeks. Clinical assessments will be performed at baseline, after treatment, and during follow-up.\n\nThe main outcomes of the study include muscle tone (spasticity), walking performance, motor function, and quality of life. The results of this study may help improve rehabilitation strategies and provide evidence for the use of ESWT in stroke patients.",[157,273,274],"Post-Stroke Spasticity","Lower Limb Spasticity",[276,277,278,127,185],"Extracorporeal Shock Wave","ESWT Stroke Rehabilitation","Mobility Fugl-Meyer","2026-04-09",{"date":252,"type":42},{"date":282,"type":23},"2026-04",{"date":284,"type":23},"2026-06-20",{"name":48,"class":49},{"id":287,"slug":288,"hasResults":12,"nctId":289,"briefTitle":290,"officialTitle":291,"acronym":292,"eligibilityCriteria":293,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":294,"targetDuration":4,"studyType":24,"phases":295,"briefSummary":296,"conditions":297,"keywords":299,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":304,"lastUpdatePostDateStruct":305,"startDateStruct":307,"completionDateStruct":309,"leadSponsor":311,"locationsCount":82},"100632029","menthol-massage-for-post-bypass-pain--anxiety-100632029","NCT07508371","Menthol Massage for Post-Bypass Pain & Anxiety","The Effect of Back Massage With Mentholated Ointment After Coronary Artery Bypass Graft Surgery on Pain and Anxiety Levels","Menthol Care","Inclusion Criteria:\n\n* Willing to participate in the study,\n* Who has undergone bypass surgery,\n* Aged 18 years or older,\n* No visual impairment (except those who can see better with visual aids), hearing impairment (except those who can hear better with hearing aids), or speech impairment\u002Fcommunication problems that would prevent them from understanding the information provided and accurately describing their pain,\n* Literate,\n* Possesses orientation to person, place, and time,\n* Has a sternum exposure time of at least 2 hours during surgery,\n* Does not use any complementary alternative medicine methods,\n* Meets ASA 1 and ASA 2 criteria,\n* Elective (planned) surgery patients will be included.\n\nExclusion Criteria:\n\n* Individuals with allergies to menthol ointment and paraffin oil used during the procedure,\n* Individuals participating in a different study conducted at the clinic,\n* Individuals experiencing confusion,\n* Individuals with physical and cognitive problems that prevent massage from being applied,\n* Individuals diagnosed with mood disorders (depression, panic attacks, dysthymia, bipolar disorder, or taking any medication for these conditions),\n* Individuals with respiratory problems,\n* Individuals who cannot speak Turkish, and cannot read or write Turkish\n* Transferred to intensive care during the postoperative period,\n* Experiencing severe bleeding, hematoma, seroma, or nerve injury during the postoperative period,\n* Developing an allergy to mentholated ointment\u002Fparaffin oil used during massage,\n* Voluntarily requesting to leave the job,\n* Individuals who do not comply with the work process and conditions will be removed from the study.",{"count":121,"type":23},[26],"This randomized controlled trial aims to evaluate the effectiveness of mentholated ointment massage in reducing pain and anxiety levels in patients who have undergone coronary bypass surgery, volunteered to participate in the study, and met the inclusion criteria.\n\nGroup 1: Back massage with mentholated ointment (Vicks) Group 2: Back massage with paraffin oil Group 3 (Control): Routine clinical treatment The comparison group consists of the group receiving a back massage with paraffin oil and the control group (routine clinical treatment).\n\nThe questions it aims to answer are:\n\nH1: Back massage with mentholated ointment after coronary artery bypass graft surgery reduces back pain levels compared to patients receiving routine treatment.\n\nH2: Back massage with paraffin oil after coronary artery bypass graft surgery reduces back pain levels compared to patients receiving routine treatment.\n\nH3: Back massage with mentholated ointment after coronary artery bypass graft surgery reduces anxiety levels compared to patients receiving routine treatment.\n\nH4: Back massage with paraffin oil after coronary artery bypass graft surgery reduces anxiety levels compared to patients receiving routine treatment.\n\nH5: Back massage with mentholated ointment after coronary artery bypass graft surgery reduces back pain levels compared to back massage with paraffin oil.\n\nH6: Back massage with mentholated ointment after coronary artery bypass graft surgery reduces anxiety levels compared to back massage with paraffin oil.\n\nPain intensity and vital signs will be monitored in all participants before surgery, at 0 minutes (before analgesia administration), and at 30 minutes after surgery. Additionally, vital signs will be observed before the back massage at 0 minutes and after at 15 minutes. Anxiety levels will be measured before surgery and 15 minutes after the back massage application. A total of 5 back massage applications will be performed until the patients are discharged.",[298],"Bypass, Cardiopulmonary",[300,301,302,303],"massage","menthol","anxiety","pain","2026-03-30",{"date":306,"type":42},"2026-04-02",{"date":308,"type":23},"2026-09-25",{"date":310,"type":23},"2027-01-30",{"name":48,"class":49},{"id":313,"slug":314,"hasResults":12,"nctId":315,"briefTitle":316,"officialTitle":316,"acronym":4,"eligibilityCriteria":317,"healthyVolunteers":234,"sex":18,"minAge":19,"maxAge":151,"enrollmentInfo":318,"targetDuration":4,"studyType":24,"phases":320,"briefSummary":321,"conditions":322,"keywords":324,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":328,"lastUpdatePostDateStruct":329,"startDateStruct":331,"completionDateStruct":333,"leadSponsor":335,"locationsCount":82},"100603858","effects-of-tdcs-on-cognitive-flexibility-and-eeg-oscillations-in-orthorexia-nervosa-100603858","NCT07141979","Effects of tDCS on Cognitive Flexibility and EEG Oscillations in Orthorexia Nervosa","Inclusion Criteria:\n\n* Being between the ages of 18-40,\n* Having a score of 17 or less on the Beck Depression Inventory\n* Having a score of 61 or more on the Test for Orthorexia Nervosa (TON-17) for the orthorexia group\n\nExclusion Criteria:\n\n* Having a history of serious neurological and psychiatric illness,\n* Currently taking medication that alters the cortical excitability level,\n* Having visual defects that cannot be corrected with glasses\n* Use of intracranial metal objects, implanted stimulating devices or pacemakers",{"count":319,"type":23},48,[26],"Orthorexia Nervosa (ON); is a condition characterized by individuals being overly focused on healthy eating habits, constantly checking and classifying the foods they will consume. ON has not yet been clinically defined as an eating disorder or in a different category, and has not been included in DSM-5. Cognitive flexibility can be defined as a person's ability to quickly change their thinking and behaviors to adapt to different situations and changing conditions. It has been reported that cognitive flexibility skills are impaired in ON. There is evidence that tDCS, a neuromodulation method, increases cognitive flexibility skills. On the other hand, although there are EEG studies on eating disorders, there is no EEG study directly studying ON, and there is no information on the EEG profiles of individuals with high ON scores. For this reason, EEG studies on eating disorders and obsessive behaviors are generally generalized to orthorexia nervosa and are interpreted. This study aims to compare the EEG oscillations and cognitive flexibility skills of individuals with high ON scores with a control group and to examine the effects of anodal tDCS application on these two variables. For this purpose, a total of 48 individuals, 24 healthy and 24 high ON scores, will be included in the study. Participants will be randomly assigned to tDCS experimental and control groups. Therefore, 48 participants will be divided into 4 different subgroups of 12 people each. Data collection tools will be Informed Consent Form, Demographic Information Form, Beck Depression Inventory, Orthorexia Nervosa Test (TON-17), Cognitive flexibility task. First, participants will be subjected to a cognitive flexibility task by taking simultaneous EEG recordings, then tDCS stimulation will be initiated (active or sham) and after stimulation, a cognitive flexibility task will be performed by taking simultaneous EEG recordings again. EEG analyses will be performed using the Brain-Vision Analyzer program. Repeated Measures Analysis of Variance (within-group and between-groups) will be used in statistical analyses.",[323],"Orthorexia Nervosa",[323,325,326,327],"cognitive flexibility","tDCS","EEG Oscillations","2026-03-27",{"date":330,"type":42},"2026-04-01",{"date":332,"type":42},"2025-11-01",{"date":334,"type":23},"2027-07",{"name":48,"class":49},{"id":337,"slug":338,"hasResults":12,"nctId":339,"briefTitle":340,"officialTitle":341,"acronym":4,"eligibilityCriteria":342,"healthyVolunteers":234,"sex":18,"minAge":151,"maxAge":119,"enrollmentInfo":343,"targetDuration":4,"studyType":24,"phases":345,"briefSummary":346,"conditions":347,"keywords":352,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":356,"lastUpdatePostDateStruct":357,"startDateStruct":359,"completionDateStruct":361,"leadSponsor":362,"locationsCount":82},"100615522","iastm-effects-on-pain-functionality-and-proprioception-in-subacromial-impingement-100615522","NCT07293702","IASTM Effects on Pain, Functionality, and Proprioception in Subacromial Impingement","**Effect of Instrument-Assisted Soft Tissue Mobilization on Pain, Functionality, and Proprioception in Individuals With Subacromial Impingement Syndrome**","Inclusion Criteria:\n\n* Individuals diagnosed with SIS by MRI\n* Men and women between 40 and 60 years of age\n* Individuals with symptoms persisting for at least one month\n* Individuals with a minimum of 60° of shoulder flexion and abduction range of motion\n\nExclusion Criteria:\n\n* Individuals with a history of surgery on the affected arm\n* Individuals with an open wound on the arm\n* Individuals with an active infection\n* Individuals with inflammatory joint disease\n* Individuals with malignant or benign tumors were excluded from the study.",{"count":344,"type":23},38,[26],"The aim of this study will be to investigate the effects of Instrument-Assisted Soft Tissue Mobilization (IASTM), applied in addition to a conventional exercise program, on pain, range of motion, proprioception, functionality, and quality of life in individuals with Subacromial Impingement Syndrome (SIS).",[348,349,350,351],"Subacromial Impingement Syndrome","Massage","Instrument-Assisted Soft Tissue Mobilization","Soft Tissue Injuries",[353,354,355],"Subakromial Impingement Syndrome","IASTM","Shoulder","2026-03-24",{"date":358,"type":42},"2026-03-25",{"date":360,"type":42},"2026-01-25",{"date":136,"type":23},{"name":48,"class":49},{"id":364,"slug":365,"hasResults":12,"nctId":366,"briefTitle":367,"officialTitle":368,"acronym":4,"eligibilityCriteria":369,"healthyVolunteers":234,"sex":18,"minAge":235,"maxAge":119,"enrollmentInfo":370,"targetDuration":4,"studyType":24,"phases":372,"briefSummary":373,"conditions":374,"keywords":4,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":356,"lastUpdatePostDateStruct":377,"startDateStruct":378,"completionDateStruct":380,"leadSponsor":381,"locationsCount":82},"100615520","iastm-and-vibration-effects-on-pain-functionality-and-kinesiophobia-in-lumbar-disc-herniation-100615520","NCT07293676","IASTM and Vibration Effects on Pain, Functionality, and Kinesiophobia in Lumbar Disc Herniation","The Effects of Instrument-Assisted Soft Tissue Mobilization and Vibration Therapy on Pain, Functionality, and Kinesiophobia in Individuals With Lumbar Disc Herniation","Inclusion Criteria:\n\n* Individuals between 30 and 60 years of age\n* Individuals diagnosed with lumbar disc herniation at the protrusion level\n* Individuals with no cognitive, intellectual, or mental impairments and who are able to express themselves\n* Individuals with a VAS score greater than 5\n* Individuals experiencing pain for at least 3 months\n\nExclusion Criteria:\n\n* Individuals with a history of lumbar surgery\n* Individuals who are pregnant\n* Individuals who have had a spinal tumor or any other malignancy within the past six months\n* Individuals who have received physiotherapy for low back pain within the last six months\n* Individuals with orthopedic conditions such as fractures\n* Individuals diagnosed with neurological, rheumatological, or psychological disorders\n* Individuals with diagnoses such as infection, spondylosis, spondylolysis, osteoporosis, or ankylosing spondylitis will be excluded from the study.",{"count":371,"type":23},45,[26],"The aim of this study is to investigate the effects of Instrument-Assisted Soft Tissue Mobilization and vibration massage therapy on pain, functionality, and kinesiophobia in individuals with lumbar disc herniation.",[375,29,376],"Vibration","Soft Tissue Mobilization",{"date":328,"type":42},{"date":379,"type":42},"2026-01-05",{"date":189,"type":23},{"name":48,"class":49},{"id":383,"slug":384,"hasResults":12,"nctId":385,"briefTitle":386,"officialTitle":387,"acronym":4,"eligibilityCriteria":388,"healthyVolunteers":234,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":389,"targetDuration":4,"studyType":24,"phases":391,"briefSummary":392,"conditions":393,"keywords":395,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":397,"lastUpdatePostDateStruct":398,"startDateStruct":400,"completionDateStruct":402,"leadSponsor":404,"locationsCount":4},"100628871","low-fodmap-diet-and-intestinal-permeability-in-patients-with-irritable-bowel-syndrome-100628871","NCT07467278","Low-FODMAP Diet and Intestinal Permeability in Patients With Irritable Bowel Syndrome","The Effect of Low-FODMAP Diet on Leaky Gut ,Symptoms and Quality of Life in Patient With Irritable Bowel Syndrome","Inclusion Criteria:Age between 18 and 65 years\n\nDiagnosis of Irritable Bowel Syndrome (IBS) according to Rome IV criteria\n\nPatients presenting to Internal Medicine or Gastroenterology outpatient clinics\n\nAbility to provide written informed consent\n\nWillingness to comply with the assigned dietary intervention and follow-up schedule\n\nPatients who were mostly compliant or fully compliant with the dietary protocol (≥51%)\n\n\\-\n\nExclusion Criteria:\n\n* IBS-specific treatment within the last 1 month\n\nAntibiotic or probiotic use within the previous 2 weeks\n\nHistory of major abdominal surgery\n\nActive malignancy\n\nHeart failure\n\nRenal failure\n\nAutoimmune disease\n\nInflammatory bowel disease\n\nCeliac disease\n\nLactose intolerance\n\nIndividuals currently following another dietary regimen\n\nPregnancy\n\nPoor adherence to diet protocol (\\\u003C51%)\n\nFailure to submit dietary diaries regularly\n\nNeed for antibiotic therapy during the intervention period",{"count":390,"type":23},24,[26],"This study aimed to evaluate the effects of a Low-FODMAP diet on intestinal permeability, symptom severity, and quality of life in patients with Irritable Bowel Syndrome (IBS). Twenty-four patients diagnosed with IBS according to the Rome IV criteria were randomized to either a Low-FODMAP diet or a traditional diet for four weeks. Stool zonulin family peptides (ZFP), IBS Symptom Severity Score (IBS-SSS), and IBS Quality of Life (IBS-QOL) questionnaires were recorded at baseline and after the dietary intervention. In the Low-FODMAP group, FODMAP-containing foods were gradually reintroduced under dietitian supervision, and assessments were repeated at week 16 to evaluate long-term effects.",[394],"Irritable Bowel Syndrome",[396],"IBS,FODMAP DIET,ZONULIN","2026-03-09",{"date":399,"type":42},"2026-03-12",{"date":401,"type":23},"2026-03-15",{"date":403,"type":23},"2026-08-30",{"name":48,"class":49},{"id":406,"slug":407,"hasResults":12,"nctId":408,"briefTitle":409,"officialTitle":410,"acronym":4,"eligibilityCriteria":411,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":412,"targetDuration":414,"studyType":122,"phases":4,"briefSummary":415,"conditions":416,"keywords":418,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":397,"lastUpdatePostDateStruct":423,"startDateStruct":425,"completionDateStruct":427,"leadSponsor":429,"locationsCount":82},"100628993","validity-of-the-turkish-situational-vertigo-questionnaire-100628993","NCT07468864","Validity of the Turkish Situational Vertigo Questionnaire","Turkish Adaptation of the Situational Vertigo Questionnaire: Validity and Reliability Study","Inclusion Criteria:\n\n* Presence of dizziness triggered by visual or environmental stimuli\n* Able to read and write Turkish\n* Voluntary agreement to participate in the study\n* Having the mental capacity to give informed consent (Mini Mental State Scale score ≥ 24)\n\nExclusion Criteria:\n\n* Individuals with severe cognitive impairment or communication difficulties\n* Acute neurological disease (stroke, acute MS relapse, etc.)\n* Having undergone vestibular surgery within the last 3 months",{"count":413,"type":23},3,"1 Year","This study was planned to examine the validity and reliability of the Turkish version of the Situational Vertigo Questionnaire (SVQ), which is used to evaluate dizziness symptoms frequently seen in vestibular pathologies and triggered by visual or environmental stimuli. The research is designed as a methodological scale adaptation and psychometric evaluation study. The study plans to include individuals aged 18 and over who can read and understand Turkish and have complaints of situational dizziness. The Turkish adaptation process of the SVQ will be carried out using the back-and-forth translation method; a pilot application will be conducted after ensuring linguistic and cultural equivalence. For the psychometric evaluation, the sample size is planned to be at least 10 times the number of items, and participants will be asked to complete the SVQ, as well as the Dizziness Handicap Inventory (DHI), Vertigo Symptom Scale (VSS), and Visual Analog Scale (VAS). To evaluate test-retest reliability, a subgroup of participants will be re-administered the SVQ after 7 days. No invasive procedures will be performed on participants during the research; only survey forms will be used. Written informed consent will be obtained from all participants, and data will be coded and analyzed in accordance with confidentiality principles. It is expected that the findings of this study will contribute to the literature by establishing a valid and reliable measurement tool in Turkish for the evaluation of situational dizziness symptoms and will support clinical evaluation processes.",[417],"Vestibular Pathology",[419,420,421,422],"situational vertigo questionnaire","validity","reliability","vestibular pathology",{"date":424,"type":42},"2026-03-13",{"date":426,"type":42},"2026-02-16",{"date":428,"type":23},"2027-02-20",{"name":48,"class":49},{"id":431,"slug":432,"hasResults":12,"nctId":433,"briefTitle":434,"officialTitle":435,"acronym":4,"eligibilityCriteria":436,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":437,"targetDuration":4,"studyType":24,"phases":438,"briefSummary":439,"conditions":440,"keywords":442,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":447,"lastUpdatePostDateStruct":448,"startDateStruct":450,"completionDateStruct":452,"leadSponsor":454,"locationsCount":82},"100555850","optokinetic-virtual-reality-stimulation-in-unilateral-vestibular-hypofunction-100555850","NCT06517446","Optokinetic Virtual Reality Stimulation in Unilateral Vestibular Hypofunction","Effect of Optokinetic Virtual Reality Stimulation in Unilateral Vestibular Hypofunction Patients","Inclusion Criteria:\n\n* Diagnosed with unilateral vestibular hypofunction with VNG test,\n* Being between the ages of 18-65,\n* Being in the A+ class on the System Usability Scale (SCS) and having a value between 96-100 percentile\n\nExclusion Criteria:\n\n* Having bilateral vestibular hypofunction\n* Having a visual impairment,\n* Having a neurological disorder\n* Inability to communicate",{"count":319,"type":23},[26],"The study will be conducted on patients diagnosed with UVH who apply to Prof. Dr. Mete İşeri Ear, Nose and Throat Diseases Polyclinic and Güneşli Erdem Hospital Ear, Nose and Throat and Vestibular Rehabilitation Unit. Participants will be divided into 3 groups by simple randomization (closed envelope) method. To the vestibular rehabilitation group; A conventional rehabilitation program based on structured Cawthorne Cooksey exercises will be applied for 45 minutes once a week with the support of a physiotherapist for 8 weeks. To the optokinetic stimulation group; optokinetic stimulation will be given with virtual reality glasses, and to the combined group; Participants in the vestibular exercise group will receive additional optokinetic stimulation. The application will be done once a week for 8 weeks. Inclusion criteria for the study are; diagnosed with unilateral vestibular hypofunction with VNG test, between the ages of 18-65, class A+ in the System Usability Scale (SUS) and the percentage range being between 96-100%; Exclusion criteria for the study are; Bilateral vestibular hypofunction, visual impairment, neurological disorder and inability to communicate.",[441],"Vestibular Hypofunction",[443,444,445,446],"Unilateral Vestibular Hypofunction","Virtual Reality","Optokinetic stimulation","Motion Sickness","2026-03-02",{"date":449,"type":42},"2026-03-04",{"date":451,"type":42},"2025-09-07",{"date":453,"type":23},"2026-05-07",{"name":48,"class":49},{"id":456,"slug":457,"hasResults":12,"nctId":458,"briefTitle":459,"officialTitle":460,"acronym":4,"eligibilityCriteria":461,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":462,"targetDuration":4,"studyType":122,"phases":4,"briefSummary":463,"conditions":464,"keywords":466,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":470,"lastUpdatePostDateStruct":471,"startDateStruct":473,"completionDateStruct":475,"leadSponsor":476,"locationsCount":82},"100626749","preoperative-anxiety-and-its-impact-on-intraoperative-hemodynamics-and-postoperative-pain-edema-and-trismus-in-orthognathic-surgery-100626749","NCT07439679","Preoperative Anxiety and Its Impact on Intraoperative Hemodynamics and Postoperative Pain, Edema, and Trismus in Orthognathic Surgery","The Effect of Preoperative Anxiety Levels on Intraoperative Hemodynamic Parameters and Postoperative Edema, Pain, and Trismus in Patients Undergoing Bimaxillary Orthognathic Surgery: A Prospective Observational Study","Inclusion Criteria:\n\n* ASA physical status I or II\n* Patients scheduled for bimaxillary orthognathic surgery (Le Fort I osteotomy and bilateral sagittal split ramus osteotomy)\n* Ability to understand and complete the STAI questionnaire\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Previous orthognathic surgery\n* History of maxillofacial trauma\n* History of radiotherapy or chemotherapy in the head and neck region\n* Presence of psychiatric disorders or current use of psychiatric medications\n* Chronic systemic disease affecting bone metabolism or wound healing\n* Active smoking or substance abuse\n* Pregnancy or lactation\n* Incomplete questionnaire responses\n* Inability to attend follow-up visits",{"count":371,"type":23},"This study aims to investigate the relationship between preoperative anxiety and intraoperative hemodynamic changes, as well as postoperative pain and facial edema, in patients undergoing orthognathic surgery.\n\nOrthognathic surgery is a corrective jaw surgery performed to treat dentofacial deformities. Although the procedure improves functional and aesthetic outcomes, patients may experience significant anxiety before surgery. Elevated anxiety levels may influence physiological responses during the operation and may affect postoperative recovery.\n\nIn this study, preoperative anxiety levels will be evaluated using validated assessment scales prior to surgery. During the intraoperative period, hemodynamic parameters such as heart rate and blood pressure will be recorded. After surgery, postoperative pain and facial edema will be assessed using standardized clinical evaluation methods.\n\nThe objective of this research is to determine whether higher levels of preoperative anxiety are associated with changes in intraoperative hemodynamic stability and increased postoperative discomfort. The findings may contribute to improved perioperative management strategies and enhanced patient care in orthognathic surgery.",[465],"Dentofacial Deformities",[467,468,469],"orthognathic surgery","preoperative anxiety","facial edema","2026-02-26",{"date":472,"type":42},"2026-02-27",{"date":474,"type":42},"2025-02-01",{"date":282,"type":23},{"name":48,"class":49},{"id":478,"slug":479,"hasResults":12,"nctId":480,"briefTitle":481,"officialTitle":482,"acronym":483,"eligibilityCriteria":484,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":485,"targetDuration":487,"studyType":122,"phases":4,"briefSummary":488,"conditions":489,"keywords":493,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":499,"lastUpdatePostDateStruct":500,"startDateStruct":502,"completionDateStruct":504,"leadSponsor":506,"locationsCount":82},"100624354","clinical-efectiveness-of-a-multiplex-pcr-based-rapid-diagnostic-method-in-bloodstream-infections-100624354","NCT07408544","Clinical Efectiveness of a Multiplex PCR-Based Rapid Diagnostic Method in Bloodstream Infections","Evaluation of the Clinical Efectiveness of a Multiplex PCR-Based Rapid Diagnostic Method in Bloodstream Infections: A Prospective Randomized Controlled Study","CEMP-RDI","Inclusion Criteria:\n\n* Age 18 years or older\n* Clinical suspicion of bloodstream infection\n* Positive blood culture signal\n* Patients managed in hospital wards or intensive care units\n* Ability to provide informed consent (patient or legally authorized representative)\n\nExclusion Criteria:\n\n* Recurrent episode of the same bloodstream infection\n* Inadequate or insufficient blood culture sample for analysis\n* Refusal or inability to provide informed consent\n* Death within the first 24 hours after blood culture collection\n* Loss to follow-up during the study period",{"count":486,"type":23},300,"4 Weeks","Bloodstream infections (BSIs) are associated with high morbidity and mortality, and delays in initiating appropriate antimicrobial therapy significantly worsen clinical outcomes. Conventional culture-based microbiological methods require 24-72 hours to provide definitive pathogen identification and antimicrobial susceptibility results, often leading to prolonged use of broad-spectrum empirical therapy. Rapid multiplex PCR-based diagnostic tests have the potential to shorten diagnostic timelines by identifying pathogens and resistance genes within approximately one hour; however, data on their real-world clinical impact remain limited.\n\nThis prospective, randomized, controlled, single-center study aims to evaluate the clinical effectiveness and diagnostic performance of a multiplex PCR-based rapid diagnostic method applied directly to positive blood culture bottles in adult patients with bloodstream infections. A total of 300 patients (≥18 years) with positive blood culture signals will be randomized 1:1 to either a study group or a control group. In the study group, positive blood cultures will be analyzed using both standard microbiological methods and a multiplex PCR panel, while the control group will undergo standard microbiological diagnostics alone.\n\nThe primary endpoint is time to optimal antimicrobial therapy (OTT), defined as the time from blood culture collection to initiation of the narrowest-spectrum, guideline-recommended antimicrobial agent active against the identified pathogen. Secondary endpoints include time to effective antimicrobial therapy (ETT), time to pathogen identification, antimicrobial escalation or de-escalation rates, length of hospital stay, total duration of antimicrobial therapy, and 28-day all-cause mortality.\n\nClinical, demographic, and microbiological data will be collected prospectively, including comorbidity indices and severity scores. Randomization will be stratified by ICU versus ward admission, presence of neutropenia, and Charlson Comorbidity Index to ensure balanced groups. Diagnostic accuracy of the multiplex PCR panel will be assessed by calculating sensitivity, specificity, predictive values, and agreement with standard culture methods.\n\nThis study seeks to determine whether rapid multiplex PCR diagnostics can meaningfully improve antimicrobial stewardship and clinical outcomes in patients with bloodstream infections compared with conventional diagnostic workflows.",[490,491,492],"Bloodstream Infections","Bacteremia and Sepsis","Fungemia",[494,495,496,497,498],"Bloodstream Infection","Rapid Diagnostic Test","Multiplex PCR","Molecular Diagnostics","Time to Optimal Therapy","2026-02-12",{"date":501,"type":42},"2026-02-13",{"date":503,"type":42},"2026-01-01",{"date":505,"type":23},"2027-01-01",{"name":48,"class":49},{"id":508,"slug":509,"hasResults":12,"nctId":510,"briefTitle":511,"officialTitle":512,"acronym":4,"eligibilityCriteria":513,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":514,"targetDuration":4,"studyType":24,"phases":515,"briefSummary":516,"conditions":517,"keywords":522,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":525,"lastUpdatePostDateStruct":526,"startDateStruct":528,"completionDateStruct":530,"leadSponsor":532,"locationsCount":82},"100555715","modified-thoracoabdominal-nerve-plane-block-in-laparoscopic-sleeve-gastrectomy-100555715","NCT06515691","Modified Thoracoabdominal Nerve Plane Block In Laparoscopic Sleeve Gastrectomy","Evaluation of Effectiveness of Ultrasound-Guided Modified Thoracoabdominal Nerve Plane Block Through Perichondrial Approach (M-TAPA) for Postoperative Analgesia Management in Patients Undergoing Laparoscopic Sleeve Gastrectomy Operation","Inclusion Criteria: American Society of Anesthesiologists (ASA) classification II- III Patients Scheduled for LSG under general anesthesia\n\n\\-\n\nExclusion Criteria: Patients\n\n* with a history of bleeding diathesis,\n* receiving anticoagulant treatment,\n* with allergies or sensitivity to drugs used,\n* with an infection on the puncture site\n* with a history of alcohol or drug addiction,\n* with congestive heart failure\n* with liver or kidney disease\n* who do not accept the procedure or participate in the study",{"count":22,"type":23},[26],"Ultrasound-guided Modified Thoracoabdominal Nerve Plane Block (M-TAPA) is performed into the costochondral aspect at the 9th-10th costal level by injecting local anesthetics deep into the chondrium. It provides blockage of both the anterior and lateral cutaneous branches of the thoracoabdominal nerve. Studies show that M-TAPA block is effective for postoperative analgesia and other abdominal surgeries, but its effect on patients undergoing LSG surgery has not yet been studied. The hypothesis is that the M-TAPA block performed in patients undergoing Laparoscopic Sleeve Gastrectomy (LSG) Operation would reduce opioid consumption in the first 24 hours period after surgery.",[518,519,520,521],"Obesity","Bariatric Surgery","Laparoscopic Sleeve Gastrectomy","Acute Post Operative Pain",[523,520,519,524],"ModifiedThoracoabdominal Nerve Plane Block","Acute Postoperative Pain","2025-12-18",{"date":527,"type":42},"2025-12-24",{"date":529,"type":42},"2025-01-03",{"date":531,"type":23},"2026-02-15",{"name":48,"class":49},{"id":534,"slug":535,"hasResults":12,"nctId":536,"briefTitle":537,"officialTitle":537,"acronym":4,"eligibilityCriteria":538,"healthyVolunteers":234,"sex":18,"minAge":19,"maxAge":539,"enrollmentInfo":540,"targetDuration":4,"studyType":24,"phases":541,"briefSummary":537,"conditions":542,"keywords":544,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":547,"lastUpdatePostDateStruct":548,"startDateStruct":550,"completionDateStruct":552,"leadSponsor":553,"locationsCount":82},"100612989","comparison-of-the-effects-of-virtual-reality-based-interventions-on-foot-function-foot-pressure-and-balance-in-sedentary-individuals-100612989","NCT07260747","Comparison of the Effects of Virtual Reality-Based Interventions on Foot Function, Foot Pressure, and Balance in Sedentary Individuals","Inclusion Criteria:\n\n* Sedentary Individual\n* Individuals between the ages of 18-25\n* Being a university student\n\nExclusion Criteria:\n\n* Athletes\n* Individuals with orthopedic or neurological problems.\n* Surgery history\n* Cognitive impairment","45 Years",{"count":371,"type":23},[26],[543],"Foot Diseases",[545,546],"exercise","foot","2025-12-02",{"date":549,"type":42},"2025-12-03",{"date":551,"type":42},"2025-10-13",{"date":453,"type":23},{"name":48,"class":49},{"id":555,"slug":556,"hasResults":12,"nctId":557,"briefTitle":558,"officialTitle":559,"acronym":4,"eligibilityCriteria":560,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":561,"enrollmentInfo":562,"targetDuration":4,"studyType":24,"phases":564,"briefSummary":565,"conditions":566,"keywords":568,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":573,"lastUpdatePostDateStruct":574,"startDateStruct":576,"completionDateStruct":578,"leadSponsor":580,"locationsCount":82},"100453874","telerehabilitation-in-patients-with-idiopathic-pulmonary-fibrosis-100453874","NCT05190211","Telerehabilitation in Patients With Idiopathic Pulmonary Fibrosis","The Effectiveness of Synchronized Online and Video-based Exercise Programs in Patients With Idiopathic Pulmonary Fibrosis","Inclusion Criteria:\n\n* Being between the ages of 18-75\n* Having a diagnosis of IPF disease diagnosed according to the following clinical diagnostic criteria according to the American Thoracic and European Respiratory Societies (ATS-ERS)\n* Presence of dyspnea on exertion\n* Stable clinical state at the time of admission without infection or exacerbation in the previous 4 weeks\n\nExclusion Criteria:\n\n* Patients with severe comorbid diseases, unstable coronary artery disease, collagen vascular diseases and needing high flow oxygen therapy (˃ 3-4 L \\\\min).\n* A history of effort-related syncope or any comorbidity (such as severe orthopedic or neurological deficits or unstable heart disease) that precludes exercise training.\n* Participation in a pulmonary rehabilitation program within the past 12 months.","75 Years",{"count":563,"type":23},44,[26],"It is to determine the effectiveness of different telerehabilitation exercise programs received to 2 groups randomly formed in idiopathic pulmonary fibrosis (IPF) patients. The cases meeting the inclusion criteria will be randomized and divided into two groups, the groups will be named as Telerehabilitation Exercise Group (TGr) and Video Group (VGr).",[567],"IPF",[567,569,570,545,571,572],"telerehabilitation","videobased rehabilitation","physical therapy","pulmonary rehabilitation","2025-11-20",{"date":575,"type":42},"2025-11-21",{"date":577,"type":42},"2021-11-26",{"date":579,"type":23},"2026-08-01",{"name":48,"class":49},{"id":582,"slug":583,"hasResults":12,"nctId":584,"briefTitle":585,"officialTitle":586,"acronym":4,"eligibilityCriteria":587,"healthyVolunteers":234,"sex":18,"minAge":19,"maxAge":588,"enrollmentInfo":589,"targetDuration":4,"studyType":24,"phases":590,"briefSummary":591,"conditions":592,"keywords":594,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":597,"lastUpdatePostDateStruct":598,"startDateStruct":600,"completionDateStruct":602,"leadSponsor":604,"locationsCount":82},"100530180","tdcs-stimulation-after-covid-19-infection-100530180","NCT06183424","TDCS Stimulation After Covid-19 Infection","Effects of aTDCS Stimulation of the Dorsolateral Prefrontal Cortex on Cognitive Functions and the Parietal Memory Network, Default Mode Network in Patients Presenting Cognitive Symptoms After Covid-19 Infection: A Controlled Randomized Clinical Trial","Inclusion Criteria:\n\n* Have received a positive value from the COVID-19 RT-PCR test in the last 60 days and turned negative\n* Being between the ages of 18-50\n* 21 days have passed since the disease onset date\n\nExclusion Criteria:\n\n* Having any neurological or psychiatric disease","50 Years",{"count":206,"type":23},[26],"In this study, the effects of bilateral stimulation of the dorsolateral prefrontal cortex (DLPFC) with active tDCS (transcranial direct stimulation\u002Ftranscranial direct stimulation) on neurocognitive (memory and executive) functions in patients with Covid-19 infection and subjective cognitive complaints, as well as resting-state fMRI In the case of dfMRI, it is aimed to examine the default mode network (DMN) and parietal memory network (PMN) inter- and intra-network connectivity alterations and the hippocampal region connectivity alterations and contribute to the relevant literature.",[593],"COVID-19",[595,326,596],"Covid-19","Cognitive function","2025-04-30",{"date":599,"type":42},"2025-05-02",{"date":601,"type":42},"2023-10-01",{"date":603,"type":23},"2025-12-01",{"name":48,"class":49},{"id":606,"slug":607,"hasResults":12,"nctId":608,"briefTitle":609,"officialTitle":610,"acronym":611,"eligibilityCriteria":612,"healthyVolunteers":12,"sex":18,"minAge":613,"maxAge":4,"enrollmentInfo":614,"targetDuration":4,"studyType":24,"phases":615,"briefSummary":616,"conditions":617,"keywords":619,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":597,"lastUpdatePostDateStruct":623,"startDateStruct":624,"completionDateStruct":626,"leadSponsor":628,"locationsCount":82},"100514330","prediction-of-effectiveness-of-rtms-application-in-alzheimers-patients-100514330","NCT05977088","Prediction of Effectiveness of rTMS Application in Alzheimer's Patients","Prediction of Cognitive, Neurotrophic, Anti-Inflammatory, and Antioxidant Effectiveness of rTMS Application in Alzheimer's Patients","PRIM-A","Inclusion Criteria:\n\n* Have been diagnosed with clinical Alzheimer's Disease in accordance with the NINCDS-ADRDA diagnostic criteria\n* \\>55 years old\n* Clinical Dementia Rating Scale (CDR) score in the 1-2 range\n* Not having any other disease that affects their cognitive functions\n* Volunteer to participate in the study\n\nExclusion Criteria:\n\n* Participant or relative does not give consent\n* The patient's inability to participate in the entire study procedure (eg living in another city)\n* The patient's history of head trauma with alcohol\u002Fsubstance abuse\n* Presence of severe stroke and other neurological sequelae disease in the participant\n* Presence of a metal implant on the head or having a pacemaker and contraindications for other TMS applications During the study or 1 month before, having\u002Fbeen receiving\u002Freceiving an investigational drug targeting Alzheimer's disease or neuromodulation treatment such as tDCS and TMS, other than standard treatment for AD symptom control such as acetylcholine esterase and memantine, with the potential to affect the study","55 Years",{"count":179,"type":23},[26],"Since pharmacological methods are insufficient in the treatment processes of Alzheimer's disease, non-pharmacological methods such as Transcranial Magnetic Stimulation (TMS) have started to be tried as a treatment option as in other neurological and psychiatric diseases. Repeated (rTMS) offers a potential treatment pathway for neurological and psychiatric illnesses. rTMS benefit rate may vary depending on many factors such as the region where it is applied, the progression and the disease degree. The possible effects of TMS on Alzheimer's pathophysiology and modification of disease process (neuroprotective, anti-inflammatory and antioxidant) will also be revealed through blood samples taken from patients before and after treatment. These approaches also constitute the original value of our study.",[618],"Alzheimer Disease",[620,621,622],"Alzheimer's Disease","TMS-EEG","Anti-inflammatory-neuroprotective-antioxidant effect",{"date":599,"type":42},{"date":625,"type":42},"2022-02-16",{"date":627,"type":23},"2025-12-30",{"name":48,"class":49},{"id":630,"slug":631,"hasResults":12,"nctId":632,"briefTitle":633,"officialTitle":634,"acronym":4,"eligibilityCriteria":635,"healthyVolunteers":12,"sex":18,"minAge":539,"maxAge":152,"enrollmentInfo":636,"targetDuration":4,"studyType":24,"phases":637,"briefSummary":638,"conditions":639,"keywords":641,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":597,"lastUpdatePostDateStruct":646,"startDateStruct":647,"completionDateStruct":649,"leadSponsor":651,"locationsCount":82},"100509903","the-effects-of-specific-tdcs-on-cognition-in-mci-100509903","NCT05919485","The Effects of Specific tDCS on Cognition in MCI","The Effects of Specific Transcranial Direct Current Stimulation tDCS on Cognition in Mild Cognitive Impairment: A Novel Study Protocol","Inclusion Criteria:\n\n1. Providing an informed consent;\n2. Literate and between 45-80 years of age;\n3. 60 females and 60 males;\n4. Diagnosed with PD based on criteria suggested by UK Parkinson's Disease Society, Brain Bank and PD-MCI in accordance with the diagnostic criteria suggestions by Litvan;\n5. Diagnosed with aMCI based on diagnosis criteria (CDR\\>0.5) suggested by Petersen;\n6. On a stable pharmacological treatment minimum for one month with no washout period.\n\nExclusion Criteria:\n\n* Illiterate or education level less than primary school\n* Having an existing and\u002For prior neurological disease; psychiatric disease or head trauma; and\u002For irreversible hearing or sight problems or other medical illness (e.g. diabetes mellitus, hypertension);\n* Exhibiting signs of dementia for PD group ;\n* Having medical issues that prevent undergoing fMRI or for tDCS application.",{"count":121,"type":23},[26],"INTRODUCTION:\n\nMild cognitive impairment (MCI) is a critical transitional stage in dementia related disorders. Dorsolateral prefrontal cortex (DLPFC), and the lateral parietal (LPC) cortex are subjected to neuropathological changes in MCI. Parietal memory network (PMN) integrity alterations and default mode network (DMN) alterations also occur in MCI. Transcranial direct current stimulation (tDCS) is a promising neuroprotective tool that modulates functional connectivity and might be useful to interfere with cognitive decline in relation to amnestic MCI (aMCI) and Parkinson's disease-MCI (PD-MCI) when applied to DLPFC and LPC.\n\nMETHODS:\n\nThis is a multicenter, randomized, and controlled study evaluating the effectiveness of anodal tDCS (atDCS ) applied bilaterally to the DLPFC\u002FF3-F4 and LPC\u002F P3-P4 for 5 sessions with a total of 10 sessions in 14 days. The stimulation will be delivered with a 2 mA current frequency and will last 20 minutes a day for 5 days a week. The study consists of anodal, and sham control groups with a total of 120 participants with DLPFC and LPC anodal groups including 40 participants each and sham including 40 participants which are all between 45-80 years of age.\n\nAt baseline and as an outcome measure, neurocognitive evaluation will be conducted using various tests standardized to use in the Turkish population. Functional magnetic resonance (fMRI) will be used to detect possible PMN and DMN alterations and hippocampal connectivity, and electroencephalogram (EEG) will be used to assess possible electrophysiological alterations that may happen as a result of atDCS. Baseline evaluation will be done before atDCS sessions and it will be repeated at the end of 14 days and 90 days.\n\nDISCUSSION:\n\nThis study aims to explore the effectiveness of atDCS in PD-MCI, aMCI and to contribute to the literature in the field.",[618,640],"Parkinson Disease",[642,643,644,645],"Mild cognitive impairment","Alzheimer's disease","Parkinson's disease","Transcranial direct current stimulation",{"date":599,"type":42},{"date":648,"type":42},"2023-08-01",{"date":650,"type":23},"2025-12-15",{"name":48,"class":49},{"id":653,"slug":654,"hasResults":12,"nctId":655,"briefTitle":656,"officialTitle":657,"acronym":4,"eligibilityCriteria":658,"healthyVolunteers":234,"sex":18,"minAge":19,"maxAge":561,"enrollmentInfo":659,"targetDuration":4,"studyType":24,"phases":661,"briefSummary":662,"conditions":663,"keywords":4,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":665,"lastUpdatePostDateStruct":666,"startDateStruct":668,"completionDateStruct":670,"leadSponsor":672,"locationsCount":82},"100532781","respiratory-muscle-fatigue-and-lower-extremity-muscle-oxygenation-100532781","NCT06217276","Respiratory Muscle Fatigue and Lower Extremity Muscle Oxygenation","Examining the Relationship Between Respiratory Muscle Fatigue and Lower Extremity Muscle Oxygenation in Chronic Obstructive Pulmonary Disease Patients.","Inclusion Criteria:\n\n* Having a diagnosis of Stage 2-3 COPD according to the following clinical diagnostic criteria according to the American Thoracic and European Respiratory Societies (ATS-ERS).\n* Having been using the same medications for the last 4 weeks\n\nExclusion Criteria:\n\n* Patients with severe comorbid diseases, unstable coronary artery disease, collagen vascular diseases and requiring high-flow oxygen therapy (˃ 3-4 L\\\\min).\n* Presence of any vascular problem that may affect lower extremity muscle oxygenation\n* Presence of another respiratory system disease other than COPD\n* Patients who have had an acute COPD exacerbation in the last 4 weeks\n* Patients experiencing COPD exacerbations during the study protocol\n* Presence of fatty tissue or scar tissue at the measurement points, which may impair the measurement quality.\n* Have already participated in another clinical trial within the last 30 days that may affect the results of the study.\n\nInclusion Criteria for Healthy Cases\n\n* Being over 18 years of age\n* Not having any diagnosed chronic disease\n* Not being a smoker",{"count":660,"type":23},30,[26],"In our study, changes in vastus lateralis muscle oxygenation will be evaluated with the Moxy device, a functional infrared oxygen measurement device, during the inspiratory muscle fatigue protocol in COPD cases and the healthy control group.",[664],"COPD","2025-04-29",{"date":667,"type":42},"2025-05-01",{"date":669,"type":42},"2024-01-20",{"date":671,"type":23},"2026-01-15",{"name":48,"class":49},""]