[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Istanbul Mehmet Akif Ersoy Educational and Training Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":148},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,45,75,97,120],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100633093","arterial-wave-energy-flux-and-multidimensional-recovery-in-patients-with-chronic-thromboembolic-pulmonary-hypertension-undergoing-balloon-pulmonary-angioplasty-100633093",false,"NCT07522203","Arterial Wave Energy Flux and Multidimensional Recovery in Patients With Chronic Thromboembolic Pulmonary Hypertension Undergoing Balloon Pulmonary Angioplasty","WE FIX BPA","Inclusion Criteria:\n\n* Age 18-85 years.\n\nConfirmed diagnosis of CTEPH by a multidisciplinary CTEPH team and deemed eligible for BPA.\n\nHemodynamics compatible with pre-capillary PH according to current guidelines, as assessed by RHC (Right Heart Catheterization).\n\nTechnically inoperable CTEPH or persistent\u002Frecurrent PH following PEA (Pulmonary Endarterectomy).\n\nWritten informed consent.\n\nExclusion Criteria:\n\n* Predominant diagnosis of PH other than CTEPH or concomitant severe parenchymal lung disease.\n\nActive infection, uncontrolled systemic disease, active malignancy, or life expectancy \\\u003C 12 months.\n\nPregnant or lactating patients.\n\nAdvanced renal failure (e.g., eGFR \\\u003C 30 \\\\text{ mL\u002Fmin\u002F1.73 m\\^2}) or contraindications to contrast media (per institutional routine).\n\nInadequate image quality precluding reliable echocardiographic analysis.\n\nPressure tracings with significant artifacts hindering analysis or uncontrolled arrhythmia (e.g., atrial fibrillation with rapid ventricular response).\n\nDecompensated or hemodynamically unstable patients.\n\nAny other condition deemed clinically unsuitable by the investigator.","ALL","18 Years","85 Years",{"count":20,"type":21},70,"ESTIMATED","12 Months","OBSERVATIONAL","The goal of this observational study is to learn if advanced heart pressure wave analysis (called WIA and REPA) can help track and predict clinical improvement in adults (aged 18-85) with Chronic Thromboembolic Pulmonary Hypertension (CTEPH) who are undergoing Balloon Pulmonary Angioplasty (BPA).\n\nThe main questions it aims to answer are:\n\nDo changes in these advanced heart pressure wave patterns relate to improvements in a patient's walking distance, heart function, and overall quality of life after BPA treatment?\n\nAre these new measurements more effective than standard heart pressure tests at showing how much a patient has truly improved?\n\nParticipants will:\n\nUndergo standard Balloon Pulmonary Angioplasty (BPA) sessions as part of their regular medical care for CTEPH.\n\nHave their heart pressure waves recorded through a catheter during the routine BPA procedure (this does not require any extra surgical steps).\n\nComplete walking tests (6-minute walk test), blood tests, and heart ultrasounds (echocardiography) before starting the treatment and after it is completed.\n\nFill out short surveys regarding their daily physical activity and quality of life.",[26,27],"CTEPH","Pulmonary Hypertension (PH)",[29,30,31],"Arterial Wave Energy","Hemodynamics","Balloon Pulmonary Angioplasty","RECRUITING","2026-04-03",{"date":35,"type":36},"2026-04-13","ACTUAL",{"date":38,"type":36},"2026-03-10",{"date":40,"type":21},"2028-05-01",{"name":42,"class":43},"Istanbul Mehmet Akif Ersoy Educational and Training Hospital","OTHER_GOV",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":57,"studyType":23,"phases":4,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":44},"100632120","pressure-based-evaluation-of-disease-improvement-in-the-course-of-tavi-100632120","NCT07509554","PRessure-based Evaluation of Disease Improvement in the Course of TAVI","Investigation of the Relationship Between Changes in Modern Wave-Based Hemodynamic Metrics and Procedural Success or Clinical Improvement in Patients With Severe Aortic Stenosis Following Transcatheter Aortic Valve Replacement (TAVR)","PREDIC-TAVI","Inclusion Criteria:\n\n* Age 60-90 years.\n\nConfirmed diagnosis of severe Aortic Stenosis (AS) and a confirmed guideline-based indication for Transcatheter Aortic Valve Implantation (TAVI) by a multidisciplinary Heart Team, in accordance with the latest ESC\u002FEACTS guidelines.\n\n(In the presence of Vmax ≥ 4.0 m\u002Fs, Mean Gradient ≥ 40 mmHg, or AVA ≤ 1.0 cm²; applicable primarily to all symptomatic patients, adopting a proactive approach regarding age limits and risk profiles. Guidelines recommend TAVI as the first-line therapy \\[Class I\\] for all patients aged 70 and older with anatomical suitability and a tricuspid valve structure, regardless of surgical risk. For patients under 70, TAVI is recommended when surgical risk is high or surgery is deemed unsuitable. In asymptomatic individuals, a decline in left ventricular ejection fraction \\[LVEF\\] below 55% \\[not attributable to other causes\\] constitutes a Class I indication for intervention. Early intervention \\[Class IIa\\] is considered for patients with preserved EF but high-risk markers such as very severe stenosis \\[Vmax \\> 5.0 m\u002Fs\\], rapid progression \\[increase \\> 0.3 m\u002Fs\u002Fyear\\], significant NT-proBNP elevation \\[\\> 3 times the upper limit of normal\\], or severe pulmonary hypertension. In cases of low-flow, low-gradient \\[LFLG\\] AS, the indication for TAVI arises if true-severe stenosis is confirmed via dobutamine stress echocardiography or CT calcium scoring \\[Male ≥ 2000, Female ≥ 1200\\]. All treatment decisions are finalized by a multidisciplinary Heart Team assessing anatomy, frailty, and patient preferences.)\n\nWritten informed consent.\n\nExclusion Criteria:\n\n* Active infection, uncontrolled systemic disease, active malignancy, or life expectancy \\\u003C 1 month.\n\nPregnant or lactating patients.\n\nPressure tracings with significant artifacts hindering analysis or uncontrolled arrhythmia (e.g., atrial fibrillation with rapid ventricular response).\n\nAny other condition deemed clinically unsuitable by the investigator.","60 Years","90 Years",{"count":56,"type":21},100,"1 Year","The goal of this prospective observational study is to learn if advanced heart pressure wave analysis (using methods called WIA and REPA) can help predict the success of the procedure and long-term recovery in adults (aged 60-90) with severe Aortic Stenosis who are undergoing Transcatheter Aortic Valve Replacement (TAVR\u002FTAVI).\n\nThe main questions it aims to answer are:\n\nDo changes in heart pressure wave patterns immediately after the new valve is implanted relate to improvements in a patient's quality of life and heart health over the following year?\n\nCan these advanced wave measurements better predict major heart complications (MACE) at 30 days, 180 days and 1 year compared to standard clinical tests?\n\nParticipants will:\n\nUndergo a standard TAVR (TAVI) procedure as part of their regular medical care to replace a narrowed heart valve.\n\nHave their aortic pressure waves recorded through a catheter during the routine procedure (this happens during the surgery and does not require any additional incisions or invasive steps).\n\nComplete quality-of-life surveys (EQ-5D-5L) and clinical assessments before the procedure.\n\nBe followed up via telephone calls or electronic health records at 30 days, 180 days and 12 months after the procedure to check on their recovery and overall health status.",[60],"Aortic Stenosis",[62,63,64,65,66],"TAVI","TAVR","AORTIC STENOSIS","wave intensity analysis","reservoir excess pressure analysis","NOT_YET_RECRUITING","2026-03-29",{"date":33,"type":36},{"date":71,"type":21},"2026-03-30",{"date":73,"type":21},"2029-08",{"name":42,"class":43},{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":82,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":4},"100608530","procedural-complications-and-long-term-mortality-in-complex-coronary-interventions-100608530","NCT07202754","Procedural Complications and Long-Term Mortality in Complex Coronary Interventions","The Impact of Procedural Complications on Long-Term Mortality in Complex Coronary Interventions: The Multicenter COMPLEX-ANATOLIA Study","Inclusion Criteria:\n\n* Patients with complex coronary disease\n* Aged 18-85 years\n\nExclusion Criteria:\n\n* Patients diagnosed with cardiogenic shock\n* Coronary lesions with non-complex features\n* Percutaneous coronary intervention with a bare metal stent\n* Patient life expectancy \\\u003C1 year\n* Known relevant allergies\n* Absence of all medical records\n* Patients with early discontinuation of dual antiplatelet therapy",{"count":83,"type":21},20000,"The relative risks for different non-fatal intraprocedural complications during complex percutaneous coronary intervention (PCI) on subsequent mortality have not been described. This study aimed to assess the association between non-fatal intraprocedural complications and late mortality after complex coronary PCI.",[86],"Complex Coronary Artery Disease",[88],"Complications, death, major adverse cardiac events, target vessel revascularization","2025-10-01",{"date":91,"type":36},"2025-10-02",{"date":93,"type":21},"2025-11-01",{"date":95,"type":21},"2026-03-01",{"name":42,"class":43},{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":104,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":106,"conditions":107,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":119},"100587683","double-kissing-crush-vs-controlled-balloon-crush-techniques-for-complex-coronary-bfurcation-lesions-100587683","NCT06931574","Double Kissing-crush vs Controlled Balloon-crush Techniques For Complex Coronary Bfurcation Lesions","Comparison of Cardiovascular Outcomes of Double Kissing-crush vs Controlled Balloon-crush Techniques For Complex Coronary Bifurcation Lesions","Inclusion Criteria:\n\n* Aged \\>18\n* PCI with either DK-crush or Controlled balloon-crush\n* Complex coronary bifurcation lesion (Medina 0.1.1, Medina 1.1.1)\n\nExclusion Criteria:\n\n* Non-complex bifurcation anatomy\n* Bail-out 2-stent (reverse modified mini-crush)\n* ST-elevation myocardial infarction\n* Cardiogenic shock status\n* In-stent restenosis\n* A previous of coronary artery bypass grafting\n* Implantation of bare-metal stent\n* End-stage hepatic or renal disease\n* \\\u003C1-year life expectancy",{"count":105,"type":21},300,"The Crush technique for coronary bifurcation lesions has evolved significantly since its introduction to the literature by Colombo et al. in 2003, with several iterations, including double kissing balloon inflation. The main disadvantage of the historical Crush technique is the low success rate of the final kissing balloon inflation. An improvement came with the introduction of double kissing crush stenting aiming for the shorter protrusion and kissing balloon dilation performed before and after main branch stent implantation. The double kissing crush provides a significant reduction in major adverse cardiovascular events compared to Provisional stenting, Crush, and Culotte techniques. Recently, a novel modified mini-crush technique (controlled balloon-crush) has been introduced to the literature and is one of the most up-to-date crush techniques. The main advantage of this technique over the contemporary mini-crush technique is that the side branch can be easily rewired, and the 1:1 size non-compliant balloon can easily pass through the crushed stent structure in the ostial part of the side branch. The basic rationale of this is that the crushing of the side branch stent is done in a more controlled manner (by slowly deflation of the side branch stent balloon), and this causes less disruption of the stent cells. To date, no data compares the mid-term outcomes of double kissing crush and controlled balloon-crush stenting techniques in patients with complex coronary bifurcation lesions. Hence, this study aimed to determine the clinical results of double kissing crush and controlled balloon-crush techniques under mid-term follow-up.",[108,109,110],"Coronary Arterial Disease (CAD)","Percutaneous Coronary Intervention (PCI)","Bifurcation Coronary Disease","2025-04-15",{"date":113,"type":36},"2025-04-17",{"date":115,"type":36},"2025-04-01",{"date":117,"type":21},"2026-12-30",{"name":42,"class":43},2,{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":124,"acronym":4,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":126,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":128,"conditions":129,"keywords":135,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":44},"100583795","mini-crush-or-controlled-balloon-crush-for-true-coronary-bifurcation-lesions-100583795","NCT06880978","Mini-Crush Or Controlled Balloon-Crush For True Coronary Bifurcation Lesions","Inclusion Criteria:\n\n* Aged \\>18\n* PCI with mini-crush or controlled balloon-crush\n* Complex coronary bifurcation lesion (Medina 0.1.1 and Medina 1.1.1)\n\nExclusion Criteria:\n\n* Non-complex bifurcation anatomy\n* Bail-out 2-stent (reverse mini-crush or reverse controlled balloon-crush)\n* ST-elevation myocardial infarction\n* Cardiogenic shock status\n* In-stent restenosis\n* A history of coronary artery bypass grafting\n* Implantation of bare-metal stent\n* End-stage hepatic or renal disease\n* \\\u003C1-year life expectancy",{"count":127,"type":21},400,"The mini-crush technique is one of the leading 2-stent techniques frequently applied by interventional cardiologists to treat complex bifurcation lesions. In the last 20 years, many technical innovations and iterations of mini-crush technique have been developed, and it maintains its popularity among invasive cardiologists. Moreover, mini-crush and double kissing-crush techniques have been compared in terms of clinical results in both left main and non-left main coronary bifurcation patient populations and no significant difference was found. However, the most important challenges of the mini-crush technique are the rewiring and advancement of a 1:1 non-compliant side-branch balloon after the main branch stent has been implanted. These challenges usually necessitate the use of a low profile balloon or additional support maneuvers (such as anchor balloon). Recently, a novel modified mini-crush-crush technique (controlled balloon-crush) has been introduced to the literature and is one of the most up-to-date crush techniques. The main advantage of this technique over the contemporary mini-crush technique is that the side branch can be easily rewired and the 1:1 size non-compliant balloon can easily pass through the crushed stent structure in the ostial part of the side branch. The basic rationale of this is that the crushing of the side branch stent is done in a more controlled manner (by slowly deflation of the side branch stent balloon) and this causes less disruption of the stent cells. This prospective observational study aims to assess the procedural and 1-year clinical outcomes of the contemporary mini-crush and controlled balloon-crush (modified mini-crush) double stenting techniques in patients with true coronary bifurcation lesions.",[130,131,132,133,134],"Coronary Bifurcation Lesions","Death","Myocardial Infarction (MI)","Stent Thrombosis","Stroke",[136,137,138,139],"Coronary bifurcation","death","revascularization","stenting","2025-03-17",{"date":142,"type":36},"2025-03-18",{"date":144,"type":36},"2025-03-03",{"date":146,"type":21},"2026-08-01",{"name":42,"class":43},""]