[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Istanbul Nisantasi University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":177},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,49,82,115,145],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":4},"100638590","metacognitive-bibliotherapy-for-anxiety-depression-and-metacognitions-in-university-students-100638590",false,"NCT07627139","Metacognitive Bibliotherapy for Anxiety, Depression, and Metacognitions in University Students","The Effects of a Metacognitive Bibliotherapy Intervention on Anxiety, Depression, and Metacognitions Among University Students: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Active enrollment in the Faculties of Medicine, Nursing, Pharmacy, Dentistry, or Psychology at Istanbul Nisantasi University\n* Aged between 18 and 25 years\n* Provision of voluntary digital informed consent\n\nExclusion Criteria:\n\n* Currently receiving active psychiatric treatment (psychotherapy or pharmacotherapy)\n* Change in psychopharmacological medication within the past 6 months\n* Prior reading of either of the study books\n* Presence of acute psychotic symptoms or suicidal risk",true,"ALL","18 Years","25 Years",{"count":21,"type":22},110,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to learn if a self-help reading program, called metacognitive bibliotherapy, can reduce anxiety and depression in university students studying medicine and health sciences. It will also examine whether the program changes unhelpful thinking patterns about worry and rumination.\n\nThe main questions it aims to answer are:\n\nDoes metacognitive bibliotherapy lower anxiety and depression symptoms in university students? Does it reduce unhelpful thinking patterns, such as excessive worry and rumination?\n\nResearchers will compare two different self-help books with a waiting list group to see if reading these books helps reduce anxiety and depression.\n\nParticipants will:\n\n* Be randomly assigned to one of three groups: read The Art of Letting Go - How to Stop Rumination, read Anchored: How to Befriend Your Nervous System Using Polyvagal Theory, or join a waiting list\n* Read the assigned book at their own pace over 8 weeks\n* Complete online questionnaires at the start of the study, after 4 weeks, and after 8 weeks\n* Participants in the waiting list group will receive both books for free after the 8-week study period ends",[28,29,30,31],"Anxiety","Depression","Stress (Psychology)","Rumination",[33,34,35,36],"Metacognition","Psychological Distress","self-help","rumination","NOT_YET_RECRUITING","2026-05-30",{"date":40,"type":41},"2026-06-04","ACTUAL",{"date":43,"type":22},"2026-06-15",{"date":45,"type":22},"2026-10-31",{"name":47,"class":48},"Istanbul Nisantasi University","OTHER",{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":62,"conditions":63,"keywords":68,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},"100635215","foot-reflexology-in-neonates-with-hypoxic-ischemic-encephalopathy-100635215","NCT07549789","Foot Reflexology in Neonates With Hypoxic-Ischemic Encephalopathy","Effect of Foot Reflexology on Comfort and Physiological Parameters in Neonates With Hypoxic-Ischemic Encephalopathy Undergoing Therapeutic Hypothermia: A Randomized Controlled Trial","foot massage","Inclusion Criteria:\n\n* Diagnosed with hypoxic-ischemic encephalopathy\n* Undergoing therapeutic hypothermia\n* Hemodynamically stable neonates\n\nExclusion Criteria:\n\n* Major congenital anomalies\n* Hemodynamic instability\n* Skin integrity problems preventing foot reflexology","30 Minutes","3 Hours",{"count":60,"type":22},84,[25],"This randomized controlled trial aims to evaluate the effect of foot reflexology on comfort levels and physiological parameters in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia. Neonates in the intervention group will receive standardized foot reflexology sessions in addition to routine care, while the control group will receive routine care alone. Comfort will be assessed using the COMFORTneo scale, and physiological parameters will be monitored throughout the intervention period.",[64,65,66,67],"Effect of Reflexology","Hypoxic-Ischemic Encephalopathy, Neonatal","Foot Reflexology","Therapeutic Hypothermia",[69,70,71,72],"Foot reflexology","therapeutic hypothermia","Hypoxic-Ischemic Encephalopathy","ComfortNeo","2026-04-17",{"date":75,"type":41},"2026-04-24",{"date":77,"type":22},"2026-07",{"date":79,"type":22},"2027-03",{"name":47,"class":48},1,{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":23,"phases":93,"briefSummary":94,"conditions":95,"keywords":99,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":81},"100625856","contextually-enriched-individualized-exercise-versus-contextually-fixed-exercise-for-rotator-cuff-related-shoulder-pain-100625856","NCT07428070","Contextually Enriched Individualized Exercise Versus Contextually Fixed Exercise for Rotator Cuff-Related Shoulder Pain","Comparison of the Effectiveness of Contextually Enriched Exercise Programs in Rotator Cuff-related Shoulder Pain","CONTEXT-RCRSP","Inclusion Criteria:\n\n* Age between 18 and 75 years\n* Clinical diagnosis of rotator cuff-related shoulder pain\n* Shoulder pain duration longer than 3 months\n* Painful arc during shoulder flexion or abduction\n* Positive Neer or Hawkins-Kennedy test\n* Pain during resisted external rotation or abduction, or positive Jobe test\n* Ability to understand and speak Turkish\n* Willingness to participate and provide informed consent\n\nExclusion Criteria:\n\n* Clinical signs of a large rotator cuff tear characterized by marked weakness without pain\n* Other shoulder conditions (e.g., frozen shoulder defined as at least 30 percent passive glenohumeral restriction in two or more directions, advanced osteoarthritis, fracture, dislocation, or severe acromioclavicular joint pathology)\n* Previous shoulder surgery\n* Neurological disorders or significant systemic diseases such as rheumatoid arthritis\n* Current or past history of malignancy\n* Physical or cognitive impairments preventing participation in assessments or intervention sessions\n* Reproduction of shoulder symptoms with active cervical spine movements indicating symptomatic cervical pathology\n* Corticosteroid injection within the previous 6 weeks\n* Participation in other concurrent shoulder treatments during the study","75 Years",{"count":92,"type":22},72,[25],"The goal of this clinical trial is to learn whether adding personalized contextual factors to an exercise program can improve pain and function in people with rotator cuff-related shoulder pain. This condition is a common cause of shoulder pain and can limit daily activities.\n\nThe main questions this study aims to answer are:\n\n1. Does a contextually enriched and individualized exercise program lead to greater improvement in upper-limb disability (measured by the QuickDASH questionnaire) compared with a contextually fixed program?\n2. Does it lead to greater reductions in pain intensity (measured by the Numeric Pain Rating Scale) and greater improvements in autonomic nervous system regulation (measured by heart rate variability)?\n3. Does it result in more favorable changes in psychosocial outcomes, exercise adherence, and therapeutic alliance?\n\nResearchers will compare two exercise programs to determine whether adding personalized contextual features enhances treatment effectiveness.\n\nOne group will receive a standardized, evidence-based exercise program delivered in a fixed and neutral manner.\n\nThe other group will receive the same exercise program with added personalized contextual elements, such as:\n\n* Preferred music and lighting\n* Choice between equivalent exercises (without changing exercise type or dosage)\n* Motivational feedback and supportive communication\n* Personalized progress tracking\n\nBoth groups will:\n\n* Attend supervised exercise sessions twice per week for 12 weeks\n* Follow a structured home exercise program\n* Complete questionnaires assessing pain, function, and psychological factors\n* Undergo heart rate variability assessment to evaluate autonomic regulation\n* Be followed for 12 months after treatment\n\nThe researchers expect that integrating personalized contextual elements into exercise therapy may enhance recovery, increase motivation, and improve long-term outcomes.",[96,97,98],"Rotator Cuff Related Shoulder Pain","Shoulder Pain","Rotator Cuff Injuries",[98,97,100,101,102,103,104,105,106],"Contextual Healing","Placebo Effect","Exercise Therapy","Therapeutic Alliance","Treatment Adherence","Pain Catastrophizing","Kinesiophobia","2026-04-06",{"date":109,"type":41},"2026-04-09",{"date":111,"type":22},"2026-05-06",{"date":113,"type":22},"2028-05-06",{"name":47,"class":48},{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":4,"eligibilityCriteria":121,"healthyVolunteers":11,"sex":122,"minAge":18,"maxAge":123,"enrollmentInfo":124,"targetDuration":4,"studyType":23,"phases":126,"briefSummary":127,"conditions":128,"keywords":130,"overallStatus":136,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":81},"100595789","cbt-effects-on-neural-physiological-and-attentional-responses-in-anorexia-nervosa-100595789","NCT07037017","CBT Effects on Neural, Physiological, and Attentional Responses in Anorexia Nervosa","Neurophysiological Effects of Cognitive-Behavioral Therapy in Anorexia Nervosa: A Pre-Post EEG, GSR, and Eye-Tracking Study","Inclusion Criteria:\n\n* Female participants aged 18 to 35\n* Meeting DSM-5 diagnostic criteria for restrictive-type anorexia nervosa\n* Body Mass Index (BMI) between 15.0 and 18.5\n* Medically stable to participate in psychological and neurophysiological assessments\n* Willingness to participate in weekly therapy sessions (for the CBT group) and to complete pre- and post-assessments\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Current or past diagnosis of bulimia nervosa, binge-eating disorder, or other eating disorders\n* Presence of comorbid severe psychiatric disorders (e.g., psychosis, bipolar disorder, substance use disorder)\n* History of neurological illness or traumatic brain injury\n* Use of psychotropic medication within the last 6 weeks\n* Prior participation in structured Cognitive-Behavioral Therapy for an eating disorder\n* Pregnancy\n* Visual or neurological impairments that would prevent accurate EEG, GSR, or eye-tracking recordings","FEMALE","35 Years",{"count":125,"type":22},60,[25],"This randomized controlled trial investigates the neurophysiological, physiological, and attentional effects of Cognitive-Behavioral Therapy (CBT) in individuals with restrictive-type anorexia nervosa (AN). The study compares two groups: one receiving a 12-week CBT intervention, and one placed on a waitlist (no active treatment during the study period). All participants undergo pre- and post-intervention assessments using electroencephalography (EEG), galvanic skin response (GSR), and eye-tracking while exposed to visual stimuli related to food, body image, and self-appearance. The primary outcomes include neural changes in attention and emotional processing (P300, LPP, frontal alpha asymmetry), physiological arousal (skin conductance), and visual attention biases (fixation duration and gaze distribution). The aim is to determine whether CBT leads to measurable improvements in neurobiological and attentional mechanisms related to body image disturbance and food-related anxiety in AN, contributing to biomarker-informed psychotherapy approaches.",[129],"Eating Disorders (Excluding Anorexia Nervosa)",[131,132,133,134,135],"Cognitive Behavioral Therapy (CBT)","EEG","Eye-Tracking","Galvanic Skin Response (GSR)","Body Image","RECRUITING","2025-06-17",{"date":139,"type":41},"2025-06-25",{"date":141,"type":41},"2025-05-15",{"date":143,"type":22},"2025-10-15",{"name":47,"class":48},{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":151,"eligibilityCriteria":152,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":153,"enrollmentInfo":154,"targetDuration":4,"studyType":23,"phases":156,"briefSummary":157,"conditions":158,"keywords":161,"overallStatus":136,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":172,"completionDateStruct":174,"leadSponsor":176,"locationsCount":81},"100580957","islamic-oriented-vs-standard-ericksonian-hypnotherapy-for-anxiety-and-depression-100580957","NCT06844058","Islamic-Oriented vs. Standard Ericksonian Hypnotherapy for Anxiety and Depression","Efficacy of Islamic-Oriented Ericksonian Hypnotherapy vs. Standard Ericksonian Hypnotherapy in Reducing Anxiety and Depression: A Randomized Controlled Trial","IEH-RTC","Inclusion Criteria:\n\n* Muslim individuals aged 18-65 years.\n* Mild to moderate anxiety and\u002For depression symptoms (assessed via Beck\n* Depression Inventory-II (BDI-II) and Beck Anxiety Inventory (BAI)).\n* No formal psychiatric diagnosis but experiencing psychological distress.\n* High religious belief levels, assessed via OK-Religious Attitude Scale.\n* Not currently receiving psychotherapy or psychotropic medication.\n* Ability to give informed consent and complete the study requirements.\n\nExclusion Criteria:\n\n* Severe psychiatric disorders (schizophrenia, bipolar disorder, severe MDD).\n* Current use of psychotropic medication or undergoing psychotherapy.\n* History of substance abuse or dependence.\n* Diagnosed dissociative disorders (contraindications for hypnosis).\n* Cognitive impairment affecting comprehension of intervention.\n* Severe medical conditions that may interfere with participation.","65 Years",{"count":155,"type":22},90,[25],"This randomized controlled trial (RCT) aims to compare the effectiveness of Islamic-Oriented Ericksonian Hypnotherapy (IEH) and Standard Ericksonian Hypnotherapy (SEH) in reducing symptoms of anxiety and depression. The study will enroll 90 participants with mild to moderate anxiety and depression, who will be randomly assigned to one of three groups: (1) IEH intervention, (2) SEH intervention, or (3) control group (no intervention). Participants in the intervention groups will receive 12 weekly hypnotherapy sessions, each lasting 60 minutes. The primary outcomes include changes in Beck Depression Inventory-II (BDI-II) and Beck Anxiety Inventory (BAI) scores from baseline to post-intervention and at a 4-week follow-up.\n\nThe study will also assess whether religious belief levels moderate the effects of the intervention using the OK-Religious Attitude Scale. Data collection will be performed at Istanbul Nişantaşı University, and ethical approval has been obtained.",[159,160],"Anxiety Disorders","Depressive Disorder",[162,163,164,165,166,167,168],"Hypnotherapy","Ericksonian Hypnosis","Islamic Psychology","Anxiety Reduction","Depression Treatment","Culturally Adapted Psychotherapy","Religious-Based Therapy","2025-03-21",{"date":171,"type":41},"2025-03-26",{"date":173,"type":41},"2025-01-15",{"date":175,"type":22},"2025-08-15",{"name":47,"class":48},""]