[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Istinye University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":626},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,72,0,25,[9,44,72,95,130,154,179,203,228,248,275,297,330,357,375,394,423,457,484,502,525,543,567,586,602],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100643875","interoception-in-stroke-100643875",false,"NCT07669246","Interoception in Stroke","Association of Interoception With Somatosensory Function, Proprioception, and Balance in Patients With Hemiplegia","Inclusion Criteria:\n\n* Presence of hemiplegia due to a physician-diagnosed stroke,\n* At least 6 months have passed since the stroke,\n* Voluntary agreement to participate in the study.\n\nExclusion Criteria:\n\n* History of traumatic brain injury, brain tumor, meningitis, or secondary neurological disease,\n* Having experienced a cardiovascular event or any acute medical condition within the last 3 months,\n* Insufficient visual or auditory ability to understand the questionnaires and tests.","ALL","18 Years",{"count":20,"type":21},60,"ESTIMATED","1 Day","OBSERVATIONAL","This study aims to examine the associations of interoceptive awareness and interoceptive accuracy with plantar superficial sensory threshold, knee joint proprioception, pain intensity, and dynamic balance performance in cognitively intact individuals with chronic hemiplegia.\n\nHypotheses are:\n\n* H0: There is no significant relationship between interoception and light touch, proprioception, pain, or dynamic balance performance in cognitively intact individuals with chronic hemiplegia.\n* H1: There is a significant relationship between interoception and light touch, proprioception, pain, or dynamic balance performance in cognitively intact individuals with chronic hemiplegia All participants will undergo a single assessment session and will not be invited for any treatment or follow-up evaluation. Participants will not take any intervention.",[26],"Stroke",[28,29,30],"Plantar sensation","Joint position sense","Fear of falling","RECRUITING","2026-07-01",{"date":34,"type":35},"2026-07-02","ACTUAL",{"date":37,"type":21},"2026-06-20",{"date":39,"type":21},"2026-12-25",{"name":41,"class":42},"Istinye University","OTHER",1,{"id":45,"slug":46,"hasResults":12,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":52,"enrollmentInfo":53,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":43},"100644701","fear-avoidance-beliefs-and-physical-function-in-patients-with-lumbar-disc-herniation-100644701","NCT07674407","Fear-Avoidance Beliefs and Physical Function in Patients With Lumbar Disc Herniation","The Relationship Between Fear-Avoidance Beliefs and Trunk Muscle Endurance, Balance, and Functional Impairment in Patients With Lumbar Disc Herniation","FAB-LDH","Inclusion Criteria:\n\n* Aged between 18 and 65 years\n* Clinically and\u002For radiologically diagnosed with lumbar disc herniation\n* Presence of low back pain for at least 3 months\n* Sufficient cognitive capacity to understand and perform the assessment procedures\n* Ability to walk independently\n* Willingness to participate voluntarily and provide written informed consent\n\nExclusion Criteria:\n\n* History of lumbar spine surgery\n* History of neurological disorders, such as stroke or Parkinson's disease\n* Vestibular disorders or severe balance impairment\n* History of orthopedic injury or surgery affecting the lower extremities\n* Presence of rheumatological disease\n* Pregnancy\n* Severe pain or an acute inflammatory condition that prevents completion of the assessment procedures","65 Years",{"count":54,"type":21},65,"Lumbar disc herniation is one of the most common causes of low back pain and is associated with substantial functional limitations and reduced quality of life, particularly among working-age individuals. Displacement of disc material toward the spinal canal may result in mechanical compression and inflammation of the nerve roots, leading to pain, restricted movement, and reduced functional performance.\n\nThe course of low back pain cannot be explained solely by biomechanical and anatomical factors. Psychosocial factors also play an important role in symptom persistence and functional outcomes. Within this context, the fear-avoidance model provides an important theoretical framework, suggesting that individuals may develop fear of movement and avoid physical activities because they believe these activities may increase pain or cause further injury. Over time, avoidance behaviors may contribute to physical deconditioning, reduced muscle function, and increased functional impairment.\n\nThe Fear-Avoidance Beliefs Questionnaire is commonly used to assess individuals' beliefs regarding the relationship between pain, physical activity, and work-related activities. Higher levels of fear-avoidance beliefs have been associated with greater pain severity, increased disability, and poorer physical performance in individuals with low back pain.\n\nTrunk muscle endurance plays a key role in maintaining spinal stability. Adequate endurance of the paraspinal and abdominal muscles supports mechanical stability of the spine and contributes to the safe performance of functional movements. The Biering-Sørensen Test and plank test are commonly used to assess trunk muscle endurance in clinical and research settings. The Biering-Sørensen Test evaluates the endurance of the trunk extensor muscles, whereas plank-based tests assess the endurance of the anterior and lateral trunk musculature.\n\nFunctional impairment in individuals with low back pain can be evaluated using the Oswestry Disability Index, a self-reported questionnaire that assesses limitations experienced during activities of daily living. Functional mobility and performance may also be evaluated using the Timed Up and Go test, which involves standing up from a chair, walking a short distance, turning, returning to the chair, and sitting down. This test reflects mobility, dynamic balance, and functional performance during daily activities.\n\nPostural control and balance may also be affected in individuals with low back pain. Reduced static balance performance can negatively influence functional activities and mobility. The Single-Leg Stance Test is a practical clinical measure used to assess postural stability and static balance.\n\nAlthough previous studies have examined associations between psychosocial factors and functional status in individuals with low back pain, studies evaluating the relationship between fear-avoidance beliefs, trunk muscle endurance, balance, and functional performance together remain limited. Identifying these relationships may contribute to the development of more comprehensive rehabilitation programs for individuals with lumbar disc herniation.",[57],"Disc Herniation",[59,60,61,62,63],"fear-avoidance beliefs","trunk muscle endurance","balance","functional impairment","low back pain","2026-06-23",{"date":66,"type":35},"2026-06-29",{"date":68,"type":21},"2026-06-30",{"date":70,"type":21},"2026-10-30",{"name":41,"class":42},{"id":73,"slug":74,"hasResults":12,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":4},"100639763","motion-sickness-severity-and-sensorimotor-performance-100639763","NCT07619469","Motion Sickness Severity and Sensorimotor Performance","The Relationship of Balance, Proprioception, Coordination, and Reaction Time Measurements With Motion Sickness Severity in Individuals With Motion Sickness: A Cross-Sectional Study","Inclusion Criteria:\n\n* Individuals aged between 18 and 40 years.\n* Diagnosed with motion sickness according to the Motion Sickness -Susceptibility Questionnaire Short Form (MSSQ-SF).\n* Normal hearing acuity.\n* No history of acute or chronic vestibular disease, other than motion sickness.\n* Normal or corrected-to-normal vision.\n* Adequate physical capability to fully perform the measurement protocols, including balance, proprioception, coordination, and reaction time tests.\n\nExclusion Criteria:\n\n* Presence of any physical or orthopedic problem that could interfere with testing.\n* History of acute or chronic instability, unsteadiness, or vertigo.\n* Severe visual impairment.\n* History of prior ear surgery.\n* Presence of any neurological condition or disorder.\n* History of migraines.\n* Current use of medications that could affect balance or vestibular function (e.g., vestibular suppressants, sedatives).\n* Use of alcohol or psychoactive substances within the last 48 hours prior to testing.","40 Years",{"count":81,"type":21},41,"Background: Motion sickness (MS) is a common syndrome characterized by autonomic and behavioral symptoms, such as nausea and dizziness, resulting from exposure to motion stimuli. Its pathophysiology is closely linked to sensory conflict and postural instability theories. While previous studies suggest that postural control, proprioception, and reaction times are affected in individuals susceptible to MS, there is a lack of comprehensive, comparative research evaluating all these parameters concurrently within the same cohort using standardized methods. Objective: This study aims to systematically measure balance, proprioceptive sensitivity, coordination, and reaction time parameters, and quantitatively analyze their relationship with motion sickness severity. Methodology: In this prospective, cross-sectional study, at least 41 participants aged 18-40 with motion sickness will be recruited. Participants will undergo motion sickness susceptibility and severity grading using the Motion Sickness Susceptibility Questionnaire Short Form (MSSQ-SF) and the Graybiel Scale. Objective assessments will include static and dynamic balance testing (ProKin®), knee joint position sense (Clinometer app), manual dexterity and dynamic balance coordination (Nine-Hole Peg Test, Tandem Walk, Romberg Test), and upper\u002Flower extremity reaction time measurements (BlazePod system).",[84,85,86],"Motion Sickness","Somatosensory Disorders","Dizziness","NOT_YET_RECRUITING",{"date":89,"type":35},"2026-06-26",{"date":91,"type":21},"2026-06-01",{"date":93,"type":21},"2026-08-05",{"name":41,"class":42},{"id":96,"slug":97,"hasResults":12,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":102,"sex":103,"minAge":104,"maxAge":18,"enrollmentInfo":105,"targetDuration":4,"studyType":107,"phases":108,"briefSummary":110,"conditions":111,"keywords":115,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":43},"100641050","effects-of-core-and-inspiratory-muscle-training-on-muscle-oxygenation-and-athletic-performance-n-young-soccer-players-100641050","NCT07657065","Effects of Core and Inspiratory Muscle Training on Muscle Oxygenation and Athletic Performance İn Young Soccer Players","Effects of Core and Inspiratory Muscle Training On Muscle Oxygenation and Athletic Performance İn Young Soccer Players","Inclusion Criteria:\n\n* Being between 15 and 18 years of age.\n* Being a male soccer player.\n* Actively and regularly participating in trainings at Alagöz Soccer Club.\n* Having participated in regular soccer training for at least the last 6 months.\n* Being able to continue routine trainings throughout the study period.\n* Being fully informed about the research.\n* Having obtained voluntary informed consent, and parental\u002Fguardian consent for participants under 18 years of age.\n* Having the cognitive and physical capacity to understand and fulfill the specific test and exercise instructions.\n\nExclusion Criteria:\n\n* Having a history of lower extremity, trunk-core, or athletic performance-limiting injury within the last 6 months.\n* Having undergone orthopedic lower extremity or spine surgery within the last 1 year.\n* Having active musculoskeletal pain or any orthopedic\u002Fneurological condition that prevents exercise.\n* Having any health condition that prevents the safe execution of balance, sprint, agility, jump, or core endurance tests.\n* Having asthma, chronic respiratory system diseases, exercise-induced bronchospasm, cardiovascular disease, or a physician-imposed restriction on high-intensity exercise that could affect respiratory muscle or exercise testing.\n* Having open wounds, infections, or severe skin sensitivity that prevents the application of sensors placed on the skin.\n* Currently participating in another structured respiratory muscle training or structured core exercise program that could affect the study results.\n* Having a body mass index (BMI) of 30 kg\u002Fm² or above.\n* Being deemed unsuitable for the study by the researcher due to safety concerns.\n* Withdrawal from the study at the request of the participant or their parent\u002Fguardian.\n* Missing two consecutive exercise sessions or having an insufficient overall attendance rate.\n* Developing an exercise-preventing injury or illness during the study period.\n* Occurrence of any safety risk during testing or exercise sessions.\n* Non-compliance with the study protocol.\n* Starting another additional exercise program during the study.\n* Technical inability to obtain reliable measurement data.",true,"MALE","15 Years",{"count":106,"type":21},54,"INTERVENTIONAL",[109],"NA","The purpose of this randomized controlled trial is to investigate the effects of core training and inspiratory muscle training (IMT) on muscle oxygenation and athletic performance in youth male soccer players aged 15-18. A total of 54 healthy soccer players will be included and randomly assigned into three equal groups: the Control Group, the Core Training Group, and the Core Training + IMT Group.\n\nAll interventions will be implemented for 8 weeks in addition to routine soccer training sessions. Assessments will be performed at baseline (Week 0), mid-intervention (Week 4), and post-intervention (Week 8). The primary outcome measures of the study are aerobic capacity assessed by the Yo-Yo Intermittent Recovery Test Level 1 and muscle oxygenation parameters monitored via near-infrared spectroscopy (NIRS) using a MOXY monitor. Secondary outcome measures include sprint performance, agility, dynamic balance, core muscle strength and endurance, inspiratory muscle strength, lower extremity explosive power, and soccer-specific technical performance tests.\n\nOverall, this study aims to reveal the combined effects of core training and inspiratory muscle training on muscle oxygenation, respiratory functions, aerobic capacity, and soccer performance, while explaining the underlying physiological mechanisms in youth athletes.",[112,113,114],"Athletic Performance","Muscle Oxygenation","Respiratory Function",[116,117,118,119,120,121],"Youth Soccer","Core Training","Inspiratory Muscle Training","Near-Infrared Spectroscopy","Aerobic Capacity","Diaphragm","2026-06-17",{"date":124,"type":35},"2026-06-18",{"date":126,"type":21},"2026-08",{"date":128,"type":21},"2027-12",{"name":41,"class":42},{"id":131,"slug":132,"hasResults":12,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":12,"sex":137,"minAge":18,"maxAge":138,"enrollmentInfo":139,"targetDuration":4,"studyType":107,"phases":140,"briefSummary":141,"conditions":142,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":43},"100630093","effectiveness-of-thoracoabdominal-nerve-block-m-tapa-on-postoperative-pain-relief-in-laparoscopic-hysterectomy-100630093","NCT07483190","Effectiveness of Thoracoabdominal Nerve Block (M-TAPA) on Postoperative Pain Relief in Laparoscopic Hysterectomy","Effectiveness of Modified-Thoracoabdominal Nerve Block With Perichondrial Approach (M-TAPA) on Postoperative Pain Relief in Laparoscopic Hysterectomy Surgery: A Prospective, Randomized, Double-Blind, Controlled Study","Inclusion Criteria:\n\n* Aged between 18 and 70 years\n* ASA (American Society of Anesthesiologists) physical status I, II, or III\n* Scheduled for elective laparoscopic hysterectomy\n* Voluntary participation with signed informed consent\n\nExclusion Criteria:\n\n* Hepatic or renal disease.\n* Coagulation disorders.\n* Uncontrolled cardiovascular or respiratory diseases.\n* Psychiatric disorders.\n* History of allergy to local anesthetics.\n* History of alcoholism, drug or substance abuse.\n* Body Mass Index (BMI) greater than 35 kg\u002Fm2\n* Refusal of the regional block procedure","FEMALE","70 Years",{"count":20,"type":21},[109],"This study aims to investigate the effectiveness of a specific regional anesthesia technique, the Modified-Thoracoabdominal Nerve Block through a Perichondrial Approach (M-TAPA), on reducing pain after laparoscopic hysterectomy surgery. Hysterectomy is a common major surgical procedure, and managing postoperative pain is crucial for patient comfort and faster recovery.\n\nParticipants will be randomly assigned to one of two groups:\n\nThe M-TAPA Group: Patients will receive the nerve block using a local anesthetic (bupivacaine) before the surgery begins.\n\nThe Control Group: Patients will receive standard postoperative pain management without the nerve block.\n\nThe primary goal is to determine if the M-TAPA block reduces the total amount of opioid (morphine) used by patients in the first 24 hours after surgery. The researchers will also evaluate pain scores (NRS), the time until the first request for additional pain medication, patient satisfaction, and any side effects like nausea or vomiting",[143,144,145],"Postoperative Pain","Hysterectomy","Plane Blocks","2026-06-12",{"date":148,"type":35},"2026-06-16",{"date":150,"type":35},"2026-06-09",{"date":152,"type":21},"2026-11-15",{"name":41,"class":42},{"id":155,"slug":156,"hasResults":12,"nctId":157,"briefTitle":158,"officialTitle":159,"acronym":4,"eligibilityCriteria":160,"healthyVolunteers":102,"sex":17,"minAge":18,"maxAge":161,"enrollmentInfo":162,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":164,"conditions":165,"keywords":167,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":43},"100632999","functional-capacity-subjective-dyspnea-and-fatigue-in-smokers-100632999","NCT07520981","Functional Capacity, Subjective Dyspnea and Fatigue in Smokers","Relationship Between Functional Capacity and Subjective Dyspnea and Fatigue in Young Adult Smokers","Inclusion Criteria:\n\n* Being between 18 and 30 years of age.\n* Being actively enrolled in university.\n* Being a current smoker,\n* Having been a regular smoker for at least the last 6 months,\n* Having a daily cigarette consumption of ≥1 cigarette\u002Fday.\n* Volunteering to participate in the study and providing written informed consent.\n* Having the cognitive and physical capacity to understand and complete the tests to be administered.\n\nExclusion Criteria:\n\n* Having a diagnosed chronic respiratory disease (asthma, COPD, bronchiectasis, interstitial lung disease, etc.),\n* Having had an upper or lower respiratory tract infection within the last 4 weeks. Having a diagnosed heart disease (coronary artery disease, heart failure, arrhythmia, etc.),\n* Having a history of uncontrolled hypertension.\n* Having orthopedic problems affecting walking, sitting\u002Fstanding, or balance,\n* Having a history of lower extremity surgery or serious injury within the last 6 months.\n* Having a history of neurological disease affecting balance, coordination, or motor control (stroke, multiple sclerosis, epilepsy, etc.).\n* Having a systemic disease that may prevent participation in exercise (uncontrolled diabetes, severe anemia, etc.),\n* Being pregnant or within the first 6 months postpartum.\n* Having conditions that may endanger the participant's safety during functional tests, o Refusal to complete the tests or inability to cooperate during the evaluation.","30 Years",{"count":163,"type":21},107,"Smoking remains a significant public health problem among the young adult population. Epidemiological studies in Turkey show a steadily decreasing age of smoking initiation and a remarkably high rate of smoking among university-aged individuals. Exposure to secondhand smoke is known to have negative effects on the respiratory system, cardiovascular system, and peripheral muscle function.\n\nImpaired lung ventilation, reduced gas exchange, and insufficient oxygen transport due to smoking can lead to decreased exercise tolerance, premature fatigue, and increased perception of exertional dyspnea. These effects can manifest as a decrease in functional capacity even before the development of a clinically significant respiratory disease.\n\nFunctional capacity is an important indicator reflecting an individual's ability to perform daily living activities and is frequently assessed in clinical research using submaximal exercise tests. The 6-Minute Walk Test is a widely used, valid, and reliable test for assessing cardiorespiratory endurance and overall functional status. Similarly, the 1-Minute Sit-Stand Test is recommended as a practical and applicable method for evaluating lower extremity muscle endurance and functional performance.\n\nDyspnea is a multidimensional symptom reflecting an individual's subjective perception of respiratory discomfort and is assessed using scales such as the Modified Medical Research Council and the Borg Dyspnea Scale. The Turkish Thoracic Society's dyspnea assessment reports indicate that exertional dyspnea may increase in smokers even if respiratory function tests are within normal limits.\n\nFatigue, on the other hand, is a significant symptom that negatively affects an individual's daily living activities and physical functionality, arising from inflammatory processes, impaired oxygenation, and decreased physical activity levels associated with smoking. The Fatigue Severity Scale is a validated and reliable scale for assessing the impact of fatigue on an individual's physical and social life.\n\nWhile studies in the literature examine the effects of smoking on respiratory function and exercise capacity, studies that address the relationship between functional capacity and subjective dyspnea and fatigue in young adult smokers are limited. In particular, evaluating functional test results such as the 6-Minute Walk Test and the 1-Minute Sit-Stand Test together with dyspnea and fatigue perception will contribute to the early identification of subclinical functional effects.\n\nThe aim of this study is to examine the relationships between functional capacity (6-Minute Walk Test, 1-Minute Sit-Stand Test, and Timed Up and Go Test) and subjective dyspnea (Modified Medical Research Council Scale - mMRC) and fatigue level (Fatigue Severity Scale) in young adult smokers aged 18-30 years. The findings of this study are expected to draw attention to the functional effects of smoking in young adults, contribute to the development of preventive health approaches, and facilitate the planning of physiotherapy-based assessment and intervention programs.",[166],"Smoking",[168,169,170,171],"functional capacity","subjectice dyspnea","fatigue","young adult smoker","2026-06-07",{"date":150,"type":35},{"date":175,"type":35},"2026-04-15",{"date":177,"type":21},"2026-07-30",{"name":41,"class":42},{"id":180,"slug":181,"hasResults":12,"nctId":182,"briefTitle":183,"officialTitle":184,"acronym":4,"eligibilityCriteria":185,"healthyVolunteers":102,"sex":17,"minAge":18,"maxAge":186,"enrollmentInfo":187,"targetDuration":4,"studyType":107,"phases":189,"briefSummary":190,"conditions":191,"keywords":194,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":202,"locationsCount":43},"100639451","muscular-fatigue-vs-mental-fatigue-on-balance-proprioception-and-reaction-time-100639451","NCT07620860","Muscular Fatigue vs. Mental Fatigue on Balance, Proprioception and Reaction Time","Comparison of the Effects of Extremity Fatigue and Mental Fatigue on Balance, Proprioception and Reaction Time","Inclusion Criteria:\n\n* Being between 18 and 35 years of age\n* Self-reporting good general health status\n* Not having any physician-diagnosed medical condition\n* Not using any assistive device or orthotic insoles\n\nExclusion Criteria:\n\n* History of neurological disorders affecting balance (e.g., stroke, Parkinson's disease, multiple sclerosis, vestibular disorders)\n* Current or recent (within the past 6 months) lower extremity or spinal injury\n* Current lower extremity pain\n* Uncontrolled cardiovascular disease\n* Uncorrected visual impairment affecting balance\n* Current pregnancy","35 Years",{"count":188,"type":21},66,[109],"This study aims to understand how different types of fatigue affect balance and reaction time, proprioception, and fine motor in healthy young adults. Fatigue is a common experience in daily life and can arise from physical activity or prolonged mental effort. The study seeks to determine whether fatigue of the upper body, lower body, or mental fatigue from cognitively demanding tasks can negatively affect balance and reaction time, proprioception, and fine motor abilities.\n\nTo examine this, participants will undergo controlled fatigue protocols designed to tire specific parts of the body or the mind. the Upper body fatigue will be induced through repeated maximal push-up sets performed until the participant can no longer maintain proper form. Lower body fatigue will be created through repeated maximal 1-minute squat jump sets, with participants touching a low box to ensure standardized depth and proper movement. Mental fatigue will be induced using a 20-minute computer-based cognitive task that alternates between the 2-back working memory task and the numerical Stroop task. These tasks are designed to require continuous attention, mental effort, and inhibitory control. Each type of fatigue will be induced independently, and participants' performance will be measured before and after each fatigue protocol.\n\nFollowing fatigue induction, participants will complete a series of tests designed to assess balance and reaction time, proprioception, and fine motor abilities. This includes both static and dynamic postural tasks, as well as reaction time and proprioceptive accuracy assessments. By evaluating these measures before and after fatigue, the study will determine how different forms of physical and mental fatigue impact postural stability, sensory processing, and precise motor control.\n\nThe study addresses the question: \"Do upper body fatigue, lower body fatigue, or mental fatigue reduce balance and reaction time, proprioception, and fine motor performance in healthy young adults?\" The hypothesis is that each form of fatigue upper body, lower body, or mental-will meaningfully impair balance and reaction time, proprioception, and fine motor performance compared to non-fatigued conditions.",[192,193],"Mental Fatigue","Muscular Fatigue",[170,195,61,196],"reaction time","cognitive",{"date":198,"type":35},"2026-06-02",{"date":200,"type":35},"2025-11-11",{"date":177,"type":21},{"name":41,"class":42},{"id":204,"slug":205,"hasResults":12,"nctId":206,"briefTitle":207,"officialTitle":208,"acronym":4,"eligibilityCriteria":209,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":210,"enrollmentInfo":211,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":212,"conditions":213,"keywords":215,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":220,"lastUpdatePostDateStruct":221,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":227,"locationsCount":43},"100637027","pain-and-upper-extremity-function-in-smartphone-and-digital-game-addiction-100637027","NCT07573345","Pain and Upper Extremity Function in Smartphone and Digital Game Addiction","The Effects of Smartphone and Digital Game Addiction on Pain and Upper Extremity Function: A Comparative Study","Inclusion Criteria:\n\n* Being between 18-45 years old\n* Volunteering to participate in the study\n\nExclusion Criteria:\n\n* Individuals who have undergone major surgery or trauma related to the musculoskeletal system, primarily the upper extremities and trunk\n* Individuals with neurological diseases\n* Individuals with active rheumatic diseases\n* Individuals with systemic diseases (diabetes, hypothyroidism, infection, malignancy, etc.)\n* Individuals with serious psychological problems (scoring 30 or higher on the BDE)\n* Individuals with contraindications to the assessment methods (acute inflammations, viral and bacterial infections, infectious diseases, fever, deep vein thrombosis, active malignant disease, aneurysms)\n* Obesity (BMI ≥ 30 kg\u002Fm2)","45 Years",{"count":20,"type":21},"With the expansion of technology-based applications, daily phone use has increased significantly. According to a 2020 study, phone use habits among young adults aged 18-34 increased by 38.1%, and the time spent on the phone exceeding one hour increased by 68%. Currently, there is no clear definition of smartphone \"addiction\" or smartphone use, but like other types of addiction, it refers to the effort to control smartphone habits that cause problems or distress in daily life. Recent studies have reported a correlation between excessive screen use and individuals' mental and physical health. Excessive use of phones and video games causes many negative effects, including attention deficit, inability to enjoy life, hyperactivity, depression, anxiety, pain, and functional loss.\n\nVideo games are a type of game played through an audiovisual device and can be story-based. While many video games improve players' critical thinking, strategic planning, and problem-solving skills, they can also cause musculoskeletal problems due to the long hours spent at the desk and the repetitive movements involved.\n\nThe human spine is a kinematic chain with all joints interconnected; this means that changes in other body parts, such as the increased head tilt while texting on a smartphone, can have significant effects on the entire spine. A 2023 study showed an increase in spinal curvature, particularly in the cervical region, as smartphone use time increased. A study in Korea linked smartphone use to increased pain in the neck, wrists, hands, shoulders, and back. Another significant problem for smartphone users and video game players is \"text neck,\" which occurs from prolonged screen time. This causes tension in the cervical spine, leading to neck pain and stiffness.\n\nSmartphone addiction leads to hand-related problems, primarily hand and wrist pain. Furthermore, excessive use of smartphones, game controllers, and joysticks can lead to repetitive strain injuries such as carpal tunnel syndrome. Prolonged phone use, repetitive movements, and uncomfortable hand positions during use cause inflammation of the muscles and tendons in the hands and wrists, leading to swelling, pain, and loss of function in these joints. Video games are played using devices such as computers, consoles, handheld computers, and smartphones. The continuous, repetitive, and uninterrupted movements performed while using these devices can lead to musculoskeletal disorders, particularly in the upper extremities. Prolonged playing of these games results in musculoskeletal problems such as carpal tunnel syndrome and tendinitis. Extensive studies have shown that individuals' pain and symptoms worsen after prolonged gaming sessions. However, to date, there has been no study comparing smartphone addicts and video game players.\n\nThe aim of this research is to compare individuals with smartphone addiction, those who play video games for extended periods, and those without these habits in terms of pain, posture, and upper extremity function.",[214],"Addiction",[216,217,218,219],"upper extremity performance","Pain","Smartphone","Game","2026-05-24",{"date":222,"type":35},"2026-05-27",{"date":224,"type":35},"2026-05-01",{"date":226,"type":21},"2026-07-15",{"name":41,"class":42},{"id":229,"slug":230,"hasResults":12,"nctId":231,"briefTitle":232,"officialTitle":233,"acronym":4,"eligibilityCriteria":234,"healthyVolunteers":102,"sex":103,"minAge":18,"maxAge":186,"enrollmentInfo":235,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":237,"conditions":238,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":241,"lastUpdatePostDateStruct":242,"startDateStruct":243,"completionDateStruct":245,"leadSponsor":247,"locationsCount":4},"100637638","respiratory-function-and-athletic-performance-in-professional-soccer-players-100637638","NCT07617116","Respiratory Function and Athletic Performance in Professional Soccer Players","Association Between Respiratory Function and Athletic Performance Parameters in Professional Soccer Players: A Cross-Sectional Study","Inclusion Criteria:\n\n* Participants will be actively competing, licensed professional soccer players. -Participants will be engaged in regular, team-based training and competitive match schedules.\n* Participants will voluntarily provide written informed consent before any study-related physical performance assessments are conducted.\n\nExclusion Criteria:\n\n* Participants will be excluded if they present with an acute upper or lower respiratory tract infection that could potentially affect pulmonary function or maximal respiratory muscle performance.\n* Participants will be excluded if they have a documented history of major cardiothoracic surgery.\n* Participants will be excluded if they have any diagnosed respiratory and\u002For cardiovascular disorder associated with dyspnea or impaired pulmonary mechanics.\n* Participants will be excluded if they present with any condition that elevates clinical risk during maximal inspiratory and expiratory pressure assessments.\n* Participants will be excluded if they have sustained an acute musculoskeletal injury within the preceding 6 weeks that could compromise maximal physical exertion during sport-specific performance testing.",{"count":236,"type":21},31,"This prospective observational study aims to investigate the relationship between respiratory function and multidimensional athletic performance parameters in professional soccer players. The primary hypothesis of the study is that soccer players with enhanced respiratory function and superior respiratory muscle strength will exhibit optimized motor performance outcomes and shorter (faster) reactive reaction times. Investigators will evaluate respiratory muscle strength, spirometric pulmonary functions, dynamic balance, core and abdominal endurance, and reactive visuomotor reaction times during a single testing session within the competitive season.",[114,239,112,240],"Respiratory Muscle Strength","Reaction Time","2026-05-23",{"date":91,"type":35},{"date":244,"type":21},"2026-05-25",{"date":246,"type":21},"2026-07-10",{"name":41,"class":42},{"id":249,"slug":250,"hasResults":12,"nctId":251,"briefTitle":252,"officialTitle":253,"acronym":4,"eligibilityCriteria":254,"healthyVolunteers":102,"sex":17,"minAge":18,"maxAge":161,"enrollmentInfo":255,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":257,"conditions":258,"keywords":260,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":267,"lastUpdatePostDateStruct":268,"startDateStruct":270,"completionDateStruct":272,"leadSponsor":274,"locationsCount":43},"100640854","cervical-position-sense-core-stability-and-postural-balance-in-university-students-with-upper-crossed-syndrome-100640854","NCT07577492","Cervical Position Sense, Core Stability, and Postural Balance in University Students With Upper Crossed Syndrome","Relationship Between Cervical Position Sense, Core Stabilization, and Postural Balance in University Students Aged 18 to 30 Years With Upper Crossed Syndrome","Inclusion Criteria:\n\n* University students aged 18-30 years.\n* Diagnosis of Upper Crossed Syndrome (UCS) confirmed by postural assessment.\n* Forward Head Posture with Craniovertebral Angle (CVA) less than 49 degrees.\n* Rounded Shoulder Posture greater than 2.5 cm.\n* Presence of chronic neck pain.\n* Impaired cervical position sense.\n\nExclusion Criteria:\n\n* History of cervical spine surgery.\n* Neurological disorders (e.g., stroke, multiple sclerosis, Parkinson's disease).\n* Acute musculoskeletal injury to the neck, back, or upper extremities within the past 3 months.\n* Previous traumatic injuries to the neck or back.\n* Any diagnosed vestibular or balance disorder.\n* Visual impairment that affects balance.\n* Pregnancy.\n* Participation in another interventional clinical trial within the past 30 days.",{"count":256,"type":21},48,"This study aims to investigate the relationship between cervical position sense, core stabilization, and postural balance in university students aged 18-30 years with Upper Crossed Syndrome (UCS). Upper Crossed Syndrome is a common musculoskeletal disorder characterized by muscle imbalance, including weakness of the deep cervical flexors, middle and lower trapezius, rhomboids, and serratus anterior, along with tightness of the upper trapezius, levator scapulae, sternocleidomastoid, and pectoralis major and minor. This condition frequently affects university students due to prolonged sitting, extensive computer use, and poor posture. While previous research has focused on discrete components of UCS such as posture correction or pain management, the combined effects of cervical proprioception, core stability, and postural balance remain poorly understood. A total of 48 participants will be enrolled and divided into two equal groups: 24 students diagnosed with Upper Crossed Syndrome and 24 healthy students as a control group. Assessments include cervical joint position error testing, core stabilization endurance tests (Unilateral Hip Bridge Endurance Test and Sahrmann Five-Level Core Stability Test), static balance evaluation using the Balance Error Scoring System (BESS), and dynamic balance assessment using the Y-Balance Test. Pain intensity will be measured using the Visual Analog Scale (VAS). This study will help identify neuromuscular and sensory mechanisms underlying these parameters and support evidence-based rehabilitation techniques to improve postural alignment, reduce musculoskeletal dysfunction, and enhance overall functional performance in this population.",[259],"Upper Crossed Syndrome",[261,262,263,264,265,266],"neck pain","cervical position sense","upper crossed syndrome","core stabilization","postural control","proprioception","2026-05-15",{"date":269,"type":35},"2026-05-19",{"date":271,"type":35},"2026-04-20",{"date":273,"type":21},"2026-05-30",{"name":41,"class":42},{"id":276,"slug":277,"hasResults":12,"nctId":278,"briefTitle":279,"officialTitle":280,"acronym":4,"eligibilityCriteria":281,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":282,"enrollmentInfo":283,"targetDuration":4,"studyType":107,"phases":285,"briefSummary":286,"conditions":287,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":290,"lastUpdatePostDateStruct":291,"startDateStruct":292,"completionDateStruct":294,"leadSponsor":296,"locationsCount":4},"100637903","sciatic-neural-mobilization-in-lumbar-related-leg-pain-100637903","NCT07588919","Sciatic Neural Mobilization in Lumbar-Related Leg Pain","Immediate Effects of Sciatic Neural Mobilization on Balance and Proprioception in Patients With Low Back Pain and Radiating Leg Pain: A Prospective Randomized Clinical Trial","Inclusion Criteria:\n\n* Having low back pain accompanied by radiating leg pain (radicular or pseudoradicular pain) for at least 3 weeks\n* Demonstration of peripheral nerve sensitivity through clinical evaluation and neurodynamic tests\n* Pain intensity of at least 3 on the Visual Analog Scale (VAS)\n* Ability to understand verbal and written Turkish instructions\n* Providing signed informed consent\n\nExclusion Criteria:\n\n* Presence of surgical indication due to acute disc herniation or advanced lumbar disc pathology\n* History of spinal surgery or spinal trauma\n* Low back pain associated with other pathologies (e.g., rheumatic diseases, multiple sclerosis, malignancy)\n* Instability conditions such as spondylolysis and spondylolisthesis\n* Pregnancy\n* Obesity (BMI ≥ 30 kg\u002Fm²)\n* Orthopedic problems or chronic diseases that may limit exercise participation\n* Physiotherapy or steroid injection treatment within the last 3 months","50 Years",{"count":284,"type":21},52,[109],"Low back pain is one of the most prevalent musculoskeletal disorders worldwide and significantly reduces individuals' quality of life, functional capacity, and productivity. Lumbar-related leg pain (LRLP) is observed in a substantial proportion of patients with low back pain and is associated with neurodynamic dysfunctions arising from peripheral nerve sensitization. Although the effects of neural mobilization on pain and functional outcomes have been investigated in the literature, studies examining its short-term effects on balance and proprioception remain limited. Therefore, this study aims to determine the immediate effects of sciatic nerve neural mobilization on balance and proprioception in individuals with LRLP exhibiting peripheral nerve sensitivity.\n\nThe study will be designed as a prospective, randomized, controlled clinical trial. Participants will be recruited from individuals presenting to the Istinye University Health Practice and Research Center Hospital who meet the inclusion criteria. Following random allocation, 52 participants will be assigned either to the intervention group (neural mobilization) or the sham group (sham mobilization). In addition to a single-session standard conventional physiotherapy program, each group will receive its respective intervention protocol. Assessments will be conducted at two time points: before treatment and immediately after treatment.\n\nStatic and dynamic balance as well as proprioception will be evaluated using the ProKin balance system; muscle mechanical properties will be assessed using the MyotonPRO device; pain threshold will be measured with an algometer; and flexibility will be evaluated using the sit-and-reach test.",[288,289],"Low Back Pain","Leg Pain and\u002For Back Pain","2026-05-09",{"date":267,"type":35},{"date":293,"type":21},"2026-06-15",{"date":295,"type":21},"2026-10-15",{"name":41,"class":42},{"id":298,"slug":299,"hasResults":12,"nctId":300,"briefTitle":301,"officialTitle":301,"acronym":302,"eligibilityCriteria":303,"healthyVolunteers":102,"sex":137,"minAge":304,"maxAge":210,"enrollmentInfo":305,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":307,"conditions":308,"keywords":314,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":322,"lastUpdatePostDateStruct":323,"startDateStruct":325,"completionDateStruct":327,"leadSponsor":329,"locationsCount":43},"100637609","core-stability-postural-balance-and-flexibility-in-healthy-women-a-comparative-study-between-pilates-practitioners-and-sedentary-individuals-100637609","NCT07578714","Core Stability, Postural Balance, and Flexibility in Healthy Women: A Comparative Study Between Pilates Practitioners and Sedentary Individuals","CSBF-P","Inclusion Criteria:\n\n1. Healthy female volunteers aged 20-45.\n2. For the Pilates group: having practiced mat Pilates, reformer Pilates, or any equipment-based Pilates discipline for at least 6 months; attending regular 60-minute sessions at least twice a week with a certified instructor.\n3. For the control group: having a sedentary lifestyle (weekly moderate physical activity time less than 150 minutes).\n4. Objectively demonstrating sedentary status using the International Physical Activity Questionnaire (IPAQ); only participants in the \"low physical activity\" category will be included in the control group.\n5. Having full cognitive ability to understand, follow, and execute all physical assessment instructions.\n6. Willingness to voluntarily sign the informed consent form prior to the study.\n\nExclusion Criteria:\n\n1. History of any surgery involving the spine, pelvis, or lower extremities within the last 12 months prior to the study.\n2. Currently pregnant or less than 6 months postpartum.\n3. Diagnosed vestibular disorders or chronic clinical balance disorders.\n4. History of neurological disease (MS, Parkinson's, etc.) or systemic metabolic disorder (diabetes, etc.).\n5. Having a pain intensity greater than 2\u002F10 on the visual analog scale (VAS) in the lower back or lower extremities.\n6. Professional sports history or participation in other exercise programs exceeding 3 hours per week (excluding Pilates for the Pilates group).\n7. Acute musculoskeletal injuries or acute illnesses that may affect energy levels on the day of evaluation.\n8. Concurrent participation in other intensive core strengthening programs such as \"advanced yoga\" that may affect results.","20 Years",{"count":306,"type":21},55,"This study aims to compare core muscle stability, postural balance, and flexibility between healthy women who regularly practice Pilates and those with a sedentary lifestyle. The researcher will evaluate if long-term Pilates practice (5 months or more) leads to significant improvements in physical performance compared to a lack of regular exercise. Assessment tools include the Pressure Biofeedback Unit (PBU) for core activation, the McGill battery for endurance, the Y-Balance test for dynamic stability, and the Sit-and-Reach test for flexibility.",[309,310,311,312,313],"Core Stability","Postural Balance","Pilates, Core Stability","Pilates","Healthy Life Style",[312,315,316,317,318,319,320,321],"Flexibility","Trunk Muscle Endurance","Women's Health","Sedentary Behavior","Pressure Biofeedback Unit (PBU)","Y-Balance Test","McGill Battery","2026-05-05",{"date":324,"type":35},"2026-05-11",{"date":326,"type":21},"2026-05-13",{"date":328,"type":21},"2027-03-13",{"name":41,"class":42},{"id":331,"slug":332,"hasResults":12,"nctId":333,"briefTitle":334,"officialTitle":335,"acronym":336,"eligibilityCriteria":337,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":52,"enrollmentInfo":338,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":339,"conditions":340,"keywords":345,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":350,"lastUpdatePostDateStruct":351,"startDateStruct":352,"completionDateStruct":354,"leadSponsor":356,"locationsCount":43},"100633601","exercise-pain-beliefs-and-activity-patterns-in-musculoskeletal-pain-100633601","NCT07528807","Exercise, Pain Beliefs, and Activity Patterns in Musculoskeletal Pain","Investigation of the Relationship Between Exercise Benefits and Barriers, Pain Beliefs, and Activity Patterns in Individuals Experiencing Musculoskeletal Pain","EPAP","Inclusion Criteria:\n\nAdults aged 18-65 years Experiencing musculoskeletal pain (must have experienced musculoskeletal pain within the past 6 months) Voluntarily agree to participate and provide signed informed consent Able to read and understand Turkish (to complete questionnaires accurately)\n\nExclusion Criteria Younger than 18 years or older than 65 years Acute trauma, recent surgery, or infection causing temporary musculoskeletal pain Severe cardiovascular, neurological, or psychiatric disorders unrelated to musculoskeletal pain Pregnant women (due to potential physiological changes affecting musculoskeletal pain) Cognitive or mental impairments preventing accurate completion of study questionnaires\n\nExclusion Criteria:\n\n\\-",{"count":306,"type":21},"This observational study aims to investigate the relationship between exercise benefits and barriers, pain beliefs, and activity patterns in individuals experiencing musculoskeletal pain. Participants will complete questionnaires about their pain, exercise habits, and daily activity patterns. The study does not involve any interventions or treatments. The purpose is to better understand how beliefs and perceived barriers influence physical activity in people with musculoskeletal pain, which may help inform future strategies to improve exercise participation and overall well-being.",[341,342,343,344],"Musculoskeletal Pain - Acute and Subacute Conditions","Exercise (EX)","Beliefs","Activity Level",[346,347,348,349],"Musculoskeletal Pain","Barriers to Physical Activity","Pain Beliefs","Activity Patterns","2026-04-27",{"date":224,"type":35},{"date":353,"type":35},"2026-04-26",{"date":355,"type":21},"2026-12-01",{"name":41,"class":42},{"id":358,"slug":359,"hasResults":12,"nctId":360,"briefTitle":361,"officialTitle":362,"acronym":4,"eligibilityCriteria":363,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":52,"enrollmentInfo":364,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":366,"conditions":367,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":368,"startDateStruct":370,"completionDateStruct":372,"leadSponsor":374,"locationsCount":43},"100635010","postoperative-analgesia-and-recovery-quality-in-total-thyroidectomy-100635010","NCT07547124","Postoperative Analgesia and Recovery Quality in Total Thyroidectomy","Association Between Postoperative Analgesic Approaches and Quality of Recovery and Swallowing Pain in Patients Undergoing Elective Total Thyroidectomy: A Prospective Observational Study","Inclusion Criteria:\n\n* Patients aged 18-75 years\n* ASA physical status classification I-III\n* Patients scheduled for elective bilateral total thyroidectomy\n* Patients undergoing surgery under general anesthesia\n* Individuals able to read and understand Turkish and cognitively capable of completing the QoR-15 questionnaire\n* Patients providing written informed consent to participate in the study\n\nExclusion Criteria:\n\n* Chronic opioid use (≥3 months of regular opioid use)\n* Presence of chronic pain syndrome\n* Psychiatric illness or cognitive impairment\n* History of neurological disease (stroke, dementia, Parkinson's disease, etc.)\n* Known allergy to local anesthetic agents\n* Previous surgical interventions in the cervical region (including revision thyroid surgery)\n* Planned extended surgery with concomitant neck dissection\n* Substernal\u002Fretrosternal goiter cases (with potential need for sternotomy or additional procedures)\n* Emergency surgical procedures\n* Patients with ASA physical status IV or higher\n* Pregnancy\n* Patients expected to require postoperative intensive care\n* Patients experiencing intraoperative complications that deviate from the standard monitoring protocol",{"count":365,"type":21},100,"This prospective observational study evaluates the association between postoperative analgesic approaches and recovery outcomes in patients undergoing elective total thyroidectomy. Patients will be followed under routine clinical care without intervention or randomization.\n\nThe primary outcome is the Quality of Recovery-15 (QoR-15) score at 24 hours. Secondary outcomes include swallowing pain, resting pain, opioid consumption, postoperative nausea and vomiting, and additional analgesic requirement.",[143],{"date":369,"type":35},"2026-04-23",{"date":371,"type":21},"2026-04-10",{"date":373,"type":21},"2026-09-10",{"name":41,"class":42},{"id":376,"slug":377,"hasResults":12,"nctId":378,"briefTitle":379,"officialTitle":380,"acronym":4,"eligibilityCriteria":381,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":382,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":384,"conditions":385,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":386,"lastUpdatePostDateStruct":387,"startDateStruct":389,"completionDateStruct":391,"leadSponsor":393,"locationsCount":43},"100634910","rectus-abdominis-muscle-parameters-and-postoperative-opioid-consumption-in-geriatric-patients-100634910","NCT07545824","Rectus Abdominis Muscle Parameters and Postoperative Opioid Consumption in Geriatric Patients","Association Between Ultrasound-Derived Rectus Abdominis Muscle Thickness and Thickening Fraction and Postoperative Opioid Consumption in Geriatric Patients Undergoing Abdominal Surgery: A Prospective Observational Study","Inclusion Criteria:\n\n* Age ≥65 years\n* Scheduled for elective midline abdominal surgery\n* ASA physical status I-III\n* Planned to receive bilateral ultrasound-guided rectus sheath block as part of routine clinical practice\n* Provided written informed consent\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to local anesthetics\n* Infection or skin lesion at the injection site\n* Systemic infection or sepsis\n* Coagulopathy (INR \\>1.5 or platelet count \\\u003C100,000\u002Fmm³)\n* Use of therapeutic anticoagulation not safely managed perioperatively\n* History of previous midline laparotomy\n* History of abdominal mesh implantation or abdominal wall reconstruction\n* Significant abdominal wall pathology (e.g., large hernia) affecting anatomy\n* Neuromuscular disease (e.g., myasthenia gravis, ALS, muscular dystrophy)\n* Inability to perform required maneuver for dynamic ultrasound measurement\n* Moderate to severe cognitive impairment or poor cooperation\n* Body mass index (BMI) \\>40 kg\u002Fm²\n* Cachexia or severe malnutrition\n* Chronic opioid use (≥3 months)\n* Chronic pain syndromes requiring regular analgesic use\n* Alcohol or substance abuse\n* Emergency surgery\n* Use of additional regional anesthesia techniques (e.g., epidural, TAP block)\n* Inadequate ultrasound visualization of the target anatomical plane",{"count":383,"type":21},62,"This prospective observational study aims to evaluate the relationship between ultrasound-derived rectus abdominis muscle thickness and thickening fraction and postoperative opioid consumption in geriatric patients undergoing abdominal surgery. Preoperative ultrasonographic measurements will be performed during routine clinical care, and postoperative pain scores and analgesic requirements will be recorded within the first 24 hours. The findings may help improve individualized analgesic strategies by identifying patient-specific predictors of postoperative opioid needs.",[143],"2026-04-16",{"date":388,"type":35},"2026-04-22",{"date":390,"type":21},"2026-04-25",{"date":392,"type":21},"2026-11-01",{"name":41,"class":42},{"id":395,"slug":396,"hasResults":12,"nctId":397,"briefTitle":398,"officialTitle":399,"acronym":4,"eligibilityCriteria":400,"healthyVolunteers":12,"sex":17,"minAge":282,"maxAge":4,"enrollmentInfo":401,"targetDuration":4,"studyType":107,"phases":403,"briefSummary":404,"conditions":405,"keywords":410,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":386,"lastUpdatePostDateStruct":416,"startDateStruct":418,"completionDateStruct":420,"leadSponsor":422,"locationsCount":43},"100594795","inspiratory-muscle-training-after-vertebroplasty-in-osteoporotic-fracture-patients-100594795","NCT07024095","Inspiratory Muscle Training After Vertebroplasty in Osteoporotic Fracture Patients","\"Effects of Inspiratory Muscle Training on Pulmonary Function, Functional Capacity, and Quality of Life After Percutaneous Vertebroplasty in Individuals With Osteoporotic Vertebral Compression Fracture\"","Inclusion Criteria:\n\n* Being 50 years of age or older at the time of the study,\n* Having a diagnosis of osteoporosis confirmed by a specialist physician,\n* Having undergone percutaneous vertebroplasty surgery due to an osteoporotic vertebral compression fracture in the thoracic region within the past 3 months,\n* Being cooperative with the questionnaires and assessment methods to be used in the study,\n* Being able to read and voluntarily agree to participate in the study by signing the informed consent form.\n\nExclusion Criteria:\n\n* Having a history of diagnosed unstable cardiac disease,\n* Having a diagnosed pulmonary or neurological disorder,\n* Having experienced an acute infection within the past 15 days,\n* Being unable to participate in exercise interventions due to mental or cognitive impairment.",{"count":402,"type":21},24,[109],"This study investigates the long-term effects of inspiratory muscle training (IMT) on pulmonary function, functional capacity, and quality of life in individuals with osteoporotic vertebral compression fractures who have undergone percutaneous vertebroplasty.\n\nParticipants aged 50 and older, diagnosed with osteoporosis and having undergone thoracic vertebroplasty within the past 3 months, will be randomly assigned to either an intervention group (IMT + standard rehabilitation) or a control group (standard rehabilitation only).\n\nThe primary outcome measure is spirometry-based pulmonary function. Secondary outcome measures include inspiratory muscle strength, functional walking capacity (6-minute walk test), diaphragmatic structure and elasticity, and quality of life (SGRQ, NHP).\n\nThis randomized controlled trial will be conducted at the Cardiopulmonary Rehabilitation Unit of Nuh Naci Yazgan University and aims to provide scientific evidence for integrating IMT into routine post-vertebroplasty rehabilitation protocols.",[406,407,408,409],"Osteoporotic Vertebral Compression Fractures","Restrictive Pulmonary Disorders","Inspiratory Muscle Weakness","Postoperative Pulmonary Function",[411,412,413,414,415],"Vertebroplasty","Functional Capacity","Respiratory Muscle Training","Rehabilitation","Physical Fitness",{"date":417,"type":35},"2026-04-21",{"date":419,"type":35},"2025-07-01",{"date":421,"type":21},"2026-04-30",{"name":41,"class":42},{"id":424,"slug":425,"hasResults":12,"nctId":426,"briefTitle":427,"officialTitle":428,"acronym":429,"eligibilityCriteria":430,"healthyVolunteers":102,"sex":17,"minAge":18,"maxAge":79,"enrollmentInfo":431,"targetDuration":4,"studyType":107,"phases":433,"briefSummary":434,"conditions":435,"keywords":440,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":449,"lastUpdatePostDateStruct":450,"startDateStruct":452,"completionDateStruct":454,"leadSponsor":456,"locationsCount":43},"100632553","placebo-effect-of-immediate-kinesio-taping-on-upper-extremity-performance-in-healthy-adults-100632553","NCT07515183","Placebo Effect of Immediate Kinesio Taping on Upper Extremity Performance in Healthy Adults","Immediate Effects of Kinesio Taping on Upper Extremity Motor Performance and Perceived Function in Healthy Adults: A Sham-controlled Randomized Study","KT-PLACEBO","Inclusion Criteria:\n\n* Being healthy adult between 18-40 years\n* No current pain or injury in the dominant upper extremity\n* No history of chronic musculoskeletal conditions affecting the upper extremity\n* Ability to read, understand, and provide informed consent\n* Regular use of a standard keyboard and mouse, with a minimum self-reported typing frequency of ≥5 hours per week, ensuring familiarity with digital typing tasks and adequate baseline fine motor coordination.\n\nExclusion Criteria:\n\n* Respiratory, neurological, or cardiovascular disorders\n* History of surgery or fracture in the dominant upper extremity within the last six months\n* Known allergy or skin sensitivity to adhesives or Kinesio Tape materials\n* Current use of medications affecting physical performance or sensation\n* Participation in ongoing physical therapy or rehabilitation\n* Diagnosed cognitive impairment or visual deficits that could affect typing or reaction-time performance\n* Engagement in high-level upper extremity sports (\\>10 hours\u002Fweek) that could bias grip or typing performance",{"count":432,"type":21},36,[109],"This study investigates whether Kinesio Taping has immediate effects on upper extremity performance in healthy adults and whether these effects may be influenced by placebo mechanisms. Participants are randomly assigned to one of three groups: therapeutic Kinesio Taping, sham Kinesio Taping, or no intervention.\n\nAll participants complete tests of hand function, including grip strength, typing performance, reaction time, and manual dexterity, before and after a short standardized waiting period. Participants also rate their perceived performance, comfort, and overall change.\n\nThe purpose of this study is to determine whether improvements in performance are due to the mechanical effects of the tape or related to sensory and expectation-based (placebo) factors.",[436,437,438,439],"Upper Extremity Function","Motor Performance","Healthy Volunteers","Perceived Function",[441,442,443,444,240,445,446,447,448],"Kinesio Taping","Placebo Effect","Upper Extremity Performance","Grip Strength","Manual Dexterity","Healthy Adults","Sham-Controlled Trial","Strength","2026-04-06",{"date":451,"type":35},"2026-04-09",{"date":453,"type":21},"2026-04-01",{"date":455,"type":21},"2026-09-30",{"name":41,"class":42},{"id":458,"slug":459,"hasResults":12,"nctId":460,"briefTitle":461,"officialTitle":462,"acronym":4,"eligibilityCriteria":463,"healthyVolunteers":12,"sex":17,"minAge":79,"maxAge":464,"enrollmentInfo":465,"targetDuration":4,"studyType":107,"phases":467,"briefSummary":468,"conditions":469,"keywords":472,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":478,"lastUpdatePostDateStruct":479,"startDateStruct":480,"completionDateStruct":481,"leadSponsor":483,"locationsCount":4},"100631966","immediate-effects-of-pettlep-based-aomi-on-upper-limb-kinematics-in-stroke-survivors-100631966","NCT07507552","Immediate Effects of PETTLEP-Based AOMI on Upper Limb Kinematics in Stroke Survivors","Immediate Effects of PETTLEP-Based AOMI on Upper Limb Kinematics in Stroke Survivors: A Randomized Controlled Trial.","Inclusion Criteria:\n\n* Female and male adults aged 40 to 80 years with a diagnosis of unilateral ischemic or hemorrhagic stroke.\n* Residual voluntary movement activity of the affected upper limb.\n* Mild to moderate spasticity (Modified Ashworth Scale ≤ 3).\n* Adequate cognitive function to understand and follow verbal instructions (Mini-Mental State Examination ≥ 21).\n* Medically stable patients, with no active or uncontrolled systemic illness.\n* Ability to sit unsupported for at least 30 minutes and be able to perform brief cognitive-motor exercises.\n\nExclusion Criteria:\n\n* Other central nervous system disorders (e.g., Parkinson's disease, multiple sclerosis, traumatic brain injury).\n* Musculoskeletal or orthopedic conditions causing restriction of movement in the upper-limb (such as fixed contractures, severe joint deformities, shoulder subluxation).\n* Severe sensory deprivation, visual neglect, or inattention that interferes with completion of the task or the ability to engage in motor imagery.\n* Uncontrolled seizures, severe cardiovascular instability, or any other contraindication to imagery.","80 Years",{"count":466,"type":21},28,[109],"The purpose of this study is to investigate the immediate effects of a mental practice technique, called Physical, Environment, Task, Timing, Learning, Emotion, Perspective (PETTLEP)-based Action Observation and Motor Imagery (AOMI), on arm movement in stroke survivors. Stroke often causes difficulty in moving the arm smoothly, leading patients to compensate by using their back or shoulder. In this study, participants will either receive a single session of the AOMI training (watching and mentally practicing a reach-to-grasp movement) or a control relaxation task. The researchers will use a smartphone-based motion capture system (OpenCap) to measure if the mental practice immediately improves the smoothness of the arm movement and reduces compensatory body movements.",[26,470,471],"Hemiplegia","Hemiplegia and\u002For Hemiparesis Following Stroke",[473,474,26,475,476,477],"Motor imagery","Action observation","OpenCap","Kinematics","Upper limb rehabilitation","2026-04-05",{"date":451,"type":35},{"date":453,"type":21},{"date":482,"type":21},"2027-03-20",{"name":41,"class":42},{"id":485,"slug":486,"hasResults":12,"nctId":487,"briefTitle":488,"officialTitle":489,"acronym":4,"eligibilityCriteria":490,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":491,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":493,"conditions":494,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":453,"lastUpdatePostDateStruct":496,"startDateStruct":498,"completionDateStruct":499,"leadSponsor":501,"locationsCount":43},"100632777","serum-bicarbonate-and-enteral-feeding-intolerance-in-adult-icu-a-prospective-clinical-trial-100632777","NCT07518095","Serum Bicarbonate and Enteral Feeding Intolerance in Adult ICU: A Prospective Clinical Trial","Serum Bicarbonate and Enteral Feeding Intolerance in Adult ICU Patients: A Prospective Clinical Trial","Inclusion Criteria:\n\n* Adult patients aged 18 and older.\n* Patients started on enteral nutrition (EN) within the first 48 hours of their intensive care unit admission.\n* Patients predicted to remain in the intensive care unit for at least 72 hours.\n* Patients (or their legal representatives) who have provided consent to participate in the study.\n\nExclusion Criteria:\n\n* Patients under the age of 18.Individuals who are currently pregnant or breastfeeding.\n* Patients with gastrointestinal (GI) perforation, active GI bleeding, or mechanical bowel obstruction.\n* Patients who have undergone major abdominal surgery (e.g., esophagectomy, gastrectomy) within the last month.\n* Patients receiving total parenteral nutrition (TPN) or those who are only fed orally.\n* Patients requiring specialized enteral formulas (e.g., diabetic, renal, immunomodulatory, elemental, or semi-elemental) due to clinical necessity.\n* Patients with a known diagnosis of diabetes or those with HbA1c \\>6.5 requiring a diabetic enteral formula.\n* Patients with terminal-stage malignancy or those requiring specific enteral nutrition protocols.\n* Patients with advanced (Child-Pugh C) liver failure.\n* Patients with chronic kidney failure requiring dialysis.\n* Patients with diabetic ketoacidosis, severe metabolic asidozis, or those requiring initial bicarbonate replacement.\n* Patients who are brain dead or in the palliative care stage.",{"count":492,"type":21},70,"This prospective, observational study evaluates whether serum bicarbonate HCO3 levels can predict enteral nutrition intolerance (EFI) in adult ICU patients.Objective: To determine if lower HCO3 levels correlate with the development of EFI.Design: A 12-month study involving 70 participants at Sultangazi Haseki Training and Research Hospital.Methodology: Patients starting enteral nutrition within 48 hours of admission will be monitored for 72 hours. Daily HCo3 pH, and lactate levels will be recorded from routine morning blood draws.Hypothesis: Lower bicarbonate levels are an independent predictor of EFI development in critically ill patients.",[495],"Enteral Nutrition Intolerance (EFI)",{"date":497,"type":35},"2026-04-08",{"date":175,"type":21},{"date":500,"type":21},"2027-01-15",{"name":41,"class":42},{"id":503,"slug":504,"hasResults":12,"nctId":505,"briefTitle":506,"officialTitle":507,"acronym":4,"eligibilityCriteria":508,"healthyVolunteers":102,"sex":17,"minAge":18,"maxAge":161,"enrollmentInfo":509,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":511,"conditions":512,"keywords":515,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":517,"lastUpdatePostDateStruct":518,"startDateStruct":520,"completionDateStruct":522,"leadSponsor":524,"locationsCount":43},"100627798","physical-fitness-assessment-in-professional-and-amateur-e-sports-players-100627798","NCT07453316","Physical Fitness Assessment in Professional and Amateur E-Sports Players","Comparing the Physical Fitness Levels of Professional and Amateur E-Sports Players","Inclusion Criteria:\n\n* Adults aged 18 to 30 years\n* Able to read and understand Turkish\n* Professional e-sports players:\n* ≥25 hours per week of structured gaming\n* Affiliated with a competitive team or organization\n* Participates in official tournaments at least once per month\n* Receives income or sponsorship related to gaming\n\nAmateur e-sports players:\n\n* ≤15 hours per week of recreational gaming\n* Not affiliated with a professional team or league\n* Does not receive income or sponsorship from gaming\n* Voluntary agreement to participate and provide informed consent\n\nExclusion Criteria:\n\n* History of respiratory, cardiovascular, or neurological disorders\n* History of surgery within the last 6 months\n* Current use of medication that may affect physical performance\n* Currently undergoing physical therapy or rehabilitation\n* Any musculoskeletal injury that may impair performance during physical fitness testing.",{"count":510,"type":21},40,"The aim of this observational cross-sectional study is to compare the physical fitness characteristics of professional and amateur e-sports players and to determine whether differences exist between the two groups in terms of physical fitness parameters.",[415,513,318,514],"Musculoskeletal Health","E-Athletes",[516],"E-Sports, Physical Fitness, Professional Gamers, Amateur Gamers, Sedentary Lifestyle, Musculoskeletal Health, Reaction Time, Balance, Aerobic Capacity","2026-03-02",{"date":519,"type":35},"2026-03-05",{"date":521,"type":21},"2026-03-09",{"date":523,"type":21},"2027-03-09",{"name":41,"class":42},{"id":526,"slug":527,"hasResults":12,"nctId":528,"briefTitle":529,"officialTitle":530,"acronym":4,"eligibilityCriteria":531,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":138,"enrollmentInfo":532,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":534,"conditions":535,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":537,"lastUpdatePostDateStruct":538,"startDateStruct":539,"completionDateStruct":540,"leadSponsor":542,"locationsCount":43},"100627604","tranexamic-acid-dose-and-remifentanil-titration-in-septorhinoplasty-100627604","NCT07450794","Tranexamic Acid Dose and Remifentanil Titration in Septorhinoplasty","Association Between Weight-Based Equivalent of Fixed 1 g Tranexamic Acid and Intraoperative Remifentanil Titration Frequency and Anesthesiologist Workload in Septorhinoplasty: A Prospective Observational Cohort Study","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Elective septorhinoplasty under general anesthesia\n* Intraoperative administration of fixed 1 g intravenous tranexamic acid as part of routine practice\n* Controlled hypotension strategy applied intraoperatively\n* Surgery duration between 60-240 minutes\n* Complete intraoperative hemodynamic and drug titration records available\n\nExclusion Criteria:\n\n* Emergency surgery\n* Additional major surgical procedure performed in the same session\n* Known coagulation disorder\n* Contraindication to tranexamic acid\n* History of thromboembolic disease\n* Chronic opioid use or opioid tolerance\n* Chronic pain syndrome\n* Regular use of sedatives, benzodiazepines, or CNS depressants\n* Severe cardiac, renal, or hepatic failure\n* Uncontrolled hypertension or significant arrhythmia\n* Preoperative hemoglobin \\\u003C10 g\u002FdL\n* Major intraoperative complication\n* Incomplete or missing intraoperative data",{"count":533,"type":21},90,"This prospective observational cohort study aims to investigate whether the weight-based equivalent (mg\u002Fkg) of a fixed 1 g dose of tranexamic acid administered during septorhinoplasty is associated with intraoperative remifentanil titration frequency and perceived anesthesiologist workload. Although tranexamic acid is routinely given as a fixed dose, its mg\u002Fkg equivalent varies according to patient weight and may influence hemodynamic management during controlled hypotension. The primary outcome is the total number of remifentanil infusion rate adjustments during surgery. Secondary outcomes include total remifentanil consumption and postoperative anesthesiologist workload assessed using the NASA Task Load Index (NASA-TLX).",[536],"Anesthesiologist Workload","2026-03-01",{"date":519,"type":35},{"date":519,"type":21},{"date":541,"type":21},"2026-08-15",{"name":41,"class":42},{"id":544,"slug":545,"hasResults":12,"nctId":546,"briefTitle":547,"officialTitle":548,"acronym":4,"eligibilityCriteria":549,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":550,"enrollmentInfo":551,"targetDuration":4,"studyType":107,"phases":553,"briefSummary":554,"conditions":555,"keywords":557,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":560,"lastUpdatePostDateStruct":561,"startDateStruct":562,"completionDateStruct":564,"leadSponsor":566,"locationsCount":43},"100594353","mirror-vs-virtual-reality-therapy-for-upper-extremity-function-in-hemiplegic-patients-100594353","NCT07018336","Mirror vs Virtual Reality Therapy for Upper Extremity Function in Hemiplegic Patients","Comparison of the Acute Effects of Mirror Therapy and Virtual Reality Therapy on Upper Extremity Function and Performance in Hemiplegic Patients","Inclusion Criteria:\n\n* Hemiplegic patients in need of upper extremity rehabilitation.\n* Having had a stroke 6 to 12 months prior to the study.\n* Being at least Stage 3 for the upper extremity according to the Brunnstrom motor recovery stages.\n* Age range: between 18 and 75 years.\n* Individuals who volunteer to participate in the study.\n* Individuals who are cognitively suitable for mirror therapy and virtual reality applications (a score of at least 24 on the Mini Mental State Examination)\n\nExclusion Criteria:\n\n* Patients with severe spasticity (score ≥ 3 on the Modified Ashworth Scale)\n* Individuals with secondary neurological conditions (e.g., Parkinson's disease, multiple sclerosis).\n* Individuals diagnosed with vestibular dysfunction (as virtual reality equipment may cause issues like nausea or dizziness).\n* Individuals with communication issues, such as hearing or vision loss.","75 Years",{"count":552,"type":21},42,[109],"Upper extremity impairment in hemiplegic patients significantly impacts daily activities and reduces quality of life. Although traditional rehabilitation methods can help, some patients experience limited progress. Recently, modern techniques such as mirror therapy and virtual reality (VR) have emerged, demonstrating promising results in motor skill improvement.\n\nThis study aims to directly compare the acute effects of mirror therapy and VR therapy on upper limb motor function in hemiplegic patients. Forty-two participants aged 18-75 with hemiplegia due to stroke (6-12 months post-stroke) will be randomly assigned to either mirror therapy or VR therapy. The evaluation includes motor function (Fugl-Meyer Assessment), spasticity (Modified Ashworth Scale), activities of daily living (Barthel Index), fine motor skills (Box and Block Test), proprioception, and reaction time.\n\nThe goal is to identify the effectiveness of the mirror therapy and VR therapy on motor function, spasticity control, proprioception, daily activity performance, and reaction times, contributing valuable insights to clinical rehabilitation practices.",[470,26,556],"Upper Extremity Dysfunction",[26,558,559,240],"Spasticity","Proprioception","2026-02-26",{"date":517,"type":35},{"date":563,"type":35},"2025-05-30",{"date":565,"type":21},"2026-07",{"name":41,"class":42},{"id":568,"slug":569,"hasResults":12,"nctId":570,"briefTitle":571,"officialTitle":572,"acronym":4,"eligibilityCriteria":573,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":574,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":575,"conditions":576,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":578,"lastUpdatePostDateStruct":579,"startDateStruct":581,"completionDateStruct":583,"leadSponsor":585,"locationsCount":43},"100627178","recovery-hypoxemia-after-sedated-upper-gastrointestinal-endoscopy-100627178","NCT07445256","Recovery Hypoxemia After Sedated Upper Gastrointestinal Endoscopy","Incidence, Duration, and Clinical Impact of Recovery-Period Hypoxemia Following Sedated Upper Gastrointestinal Endoscopy: A Prospective Observational Study","Inclusion Criteria:\n\n* Adults aged ≥18 years\n* Scheduled for upper gastrointestinal endoscopy (EGD) under anesthesiologist-administered sedation\n* Able to undergo post-procedure monitoring in the recovery unit\n* Provided written informed consent for participation and data use\n\nExclusion Criteria:\n\n* Colonoscopy or combined procedures (EGD + colonoscopy)\n* Emergency procedures or procedures performed under intensive care conditions\n* Requirement for endotracheal intubation, noninvasive ventilation, or advanced airway support during the procedure\n* Known severe upper airway anatomical abnormalities, facial deformity, or tracheostomy\n* Inability or refusal to provide informed consent\n* Incomplete or unavailable recovery-period oxygen saturation monitoring data",{"count":365,"type":21},"Sedation during upper gastrointestinal endoscopy may lead to respiratory events not only during the procedure but also in the early recovery period. Although most hypoxemic episodes are considered transient, their frequency, duration, and clinical consequences during recovery remain insufficiently defined.\n\nThis prospective observational study aims to evaluate the incidence, duration, and clinical impact of recovery-period hypoxemia following sedated upper gastrointestinal endoscopy. Hypoxemia is defined as SpO₂ \\\u003C90% lasting ≥10 seconds. Associated respiratory events and potential risk factors will be analyzed without altering routine clinical practice.",[577],"Hypoxemia","2026-02-25",{"date":580,"type":35},"2026-03-03",{"date":582,"type":21},"2026-02-28",{"date":584,"type":21},"2026-03-20",{"name":41,"class":42},{"id":587,"slug":588,"hasResults":12,"nctId":589,"briefTitle":590,"officialTitle":591,"acronym":4,"eligibilityCriteria":592,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":593,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":595,"conditions":596,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":578,"lastUpdatePostDateStruct":598,"startDateStruct":599,"completionDateStruct":600,"leadSponsor":601,"locationsCount":43},"100627176","serum-bicarbonate-changes-during-laparoscopic-bariatric-surgery-100627176","NCT07445230","Serum Bicarbonate Changes During Laparoscopic Bariatric Surgery","Metabolic Effects of Pneumoperitoneum During Laparoscopic Bariatric Surgery: Association Between Perioperative Serum Bicarbonate Change and Early Discharge Readiness","Inclusion Criteria:\n\n* Adults aged ≥18 years\n* ASA physical status I-III\n* Scheduled for elective laparoscopic bariatric surgery (laparoscopic sleeve gastrectomy or Roux-en-Y gastric bypass)\n* Provided written informed consent\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* ASA physical status IV or higher\n* Chronic obstructive pulmonary disease (COPD), asthma, or other severe chronic respiratory disease\n* Known chronic metabolic acidosis or renal failure\n* Major intraoperative complications (e.g., severe bleeding, conversion to open surgery)\n* Postoperative reoperation, intensive care requirement, or complications preventing standard recovery evaluation",{"count":594,"type":21},85,"Pneumoperitoneum during laparoscopic bariatric surgery induces carbon dioxide absorption and may lead to perioperative alterations in acid-base balance. Serum bicarbonate (HCO₃-) plays a central role in metabolic compensation; however, the clinical relevance of perioperative bicarbonate changes remains insufficiently defined.\n\nThis prospective observational study aims to evaluate the association between pneumoperitoneum duration and perioperative serum bicarbonate change (ΔHCO₃-), and to investigate whether ΔHCO₃- is associated with early discharge readiness at 48 hours (DR-48) following laparoscopic bariatric surgery. Patients undergoing laparoscopic sleeve gastrectomy or Roux-en-Y gastric bypass will be enrolled consecutively. No alteration of routine clinical care will occur.",[597],"Acid Base Disorder",{"date":580,"type":35},{"date":537,"type":21},{"date":267,"type":21},{"name":41,"class":42},{"id":603,"slug":604,"hasResults":12,"nctId":605,"briefTitle":606,"officialTitle":607,"acronym":4,"eligibilityCriteria":608,"healthyVolunteers":102,"sex":17,"minAge":18,"maxAge":186,"enrollmentInfo":609,"targetDuration":4,"studyType":107,"phases":610,"briefSummary":611,"conditions":612,"keywords":614,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":619,"lastUpdatePostDateStruct":620,"startDateStruct":622,"completionDateStruct":624,"leadSponsor":625,"locationsCount":4},"100622762","rhythm-based-stabilization-training-in-video-gamers-100622762","NCT07387835","Rhythm-Based Stabilization Training in Video Gamers","The Effect of Rhythm-Based Stabilization Training on Scapular Control, Upper Extremity Performance, and Range of Motion in Video Gamers.","Inclusion Criteria:\n\n* Voluntary participants between 18 and 35 years of age\n* Playing video games for at least 3 hours per week for at least 3 months.\n* Healthy individuals with no chronic or acute shoulder\u002Fupper extremity problems.\n* Not participated in any other upper extremity treatment program in the last 6 months.\n* Willingness to participate and sign the informed consent form\n\nExclusion Criteria:\n\n* History of trauma, surgery, or fracture in the shoulder, neck, or hand in the last 6 months.\n* Diagnosis of any neurological disease (e.g., MS, Stroke).\n* Structural causes of upper extremity pain, such as disc herniation or radiculopathy.\n* Vestibular or balance disorders affecting upper extremity movement\n* Inability to perform required exercises due to severe pain or physical limitations",{"count":552,"type":21},[109],"This study aims to evaluate the effectiveness of a 4-week rhythm-based stabilization exercise protocol for professional video gamers diagnosed with scapular dyskinesis. Participants will undergo a structured exercise program consisting of 6 specific scapular stabilization exercises. These exercises will be performed on both stable surfaces (such as a treatment table or wall) and unstable surfaces (such as Swiss balls) to challenge neuromuscular control. The primary goal is to determine how this combined approach affects scapular control, upper extremity functional performance, and joint range of motion. Data will be collected through clinical assessments before and after the 4-week intervention to measure improvements in scapular stability and overall upper limb function.",[613],"Scapular Dyskinesis",[615,616,617,618,443],"Video Gamers","Rhythmic Stabilization","Scapular Control","Neuromuscular Training","2026-02-23",{"date":621,"type":35},"2026-02-24",{"date":623,"type":21},"2026-02-15",{"date":244,"type":21},{"name":41,"class":42},""]