[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Italian Academy of Rhinology\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":48},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":5},"100511149","rhinosinusitis-italian-network-the-italian-registry-for-severe-uncontrolled-chronic-rhinosinusitis-100511149",false,"NCT05935683","Rhinosinusitis Italian Network: the Italian Registry for Severe, Uncontrolled Chronic Rhinosinusitis","Rhinosinusitis Italian Network (RINET): the Italian Registry for Severe, Uncontrolled Chronic Rhinosinusitis","RINET","Inclusion Criteria:\n\n* Participants with a confirmed diagnosis of bilateral Chronic Rhinosinusitis that have at least three (in case of patients previously treated with surgical approaches) or four (in case of patients never treated with nasal sinus surgery) of the following criteria:\n\n  * Evidence of type 2 inflammation (at least 250 blood eosinophils per microliter and \u002F or at least 10 eosinophils \u002F HPF from a histological sample of sinus mucosa and \u002F or at least one finding of moderate eosinophilia on nasal cytology and \u002F or total serum IgE \\>100 IU \u002F ml);\n  * at least two Short courses of systemic corticosteroids or lorg-term Systemic Corticosteroids therapy for Chronic Rhinosinusitis;\n  * Significant deterioration in the quality of life (Sinonasal Outcome Test 22 - SNOT-22\\>= 40 and \u002F or Visual Analogue Scale - Global VAS of symptoms\\>= 5);\n  * Loss of Smell (VAS for hyposmia\\> = 7)\n\nExclusion Criteria:\n\n\\-","ALL","18 Years",{"count":20,"type":21},5000,"ESTIMATED","10 Years","OBSERVATIONAL","This observatory aims to collect, as widely as possible, the Italian cases of patients with uncontrolled CRS. Patient will be enrolled by the centers of the Italian Network of Rhinosinusitis (Rhinosinusitis Italian Network: RINET), and they will be treated using a multidisciplinary team approach (allergists, otolaryngologists and pneumologists) in a real-world clinical set-up.\n\nThis real-life chronic rhinosinusitis registry aims at longitudinal data collection from patients attending specialist care centres across Italy.",[26],"Chronic Rhinosinusitis",[28,29,30,31,32,33,34,35],"chronic rhinosinusitis with nasal polyps","chronic rhinosinusitis without nasal polyps","Otorhinolaryngologic Diseases","Respiratory Tract Diseases","Paranasal Sinus Diseases","Sinusitis","Nose Diseases","chronic rhinosinusitis (diagnosis)","RECRUITING","2024-07-18",{"date":39,"type":40},"2024-07-19","ACTUAL",{"date":42,"type":40},"2021-11-01",{"date":44,"type":21},"2031-10-31",{"name":46,"class":47},"Italian Academy of Rhinology","OTHER",""]