[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Itshak Amsalem\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":60},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,38],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":26,"lastUpdatePostDateStruct":27,"startDateStruct":30,"completionDateStruct":32,"leadSponsor":34,"locationsCount":37},"100638036","the-impact-of-volume-overload-on-obstructive-sleep-apnea-in-patients-with-congestive-heart-failure-100638036",false,"NCT07601724","The Impact of Volume Overload on Obstructive Sleep Apnea in Patients With Congestive Heart Failure","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Hospitalized with decompensated heart failure and clinical evidence of fluid overload\n* Diagnosis of heart failure (reduced or preserved ejection fraction)\n* Clinically indicated for diuretic therapy\n* Able to undergo sleep apnea assessment using the WatchPAT device\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Known central sleep apnea as the predominant sleep-disordered breathing type\n* Current treatment with continuous positive airway pressure (CPAP)\n* Acute respiratory failure requiring mechanical ventilation\n* Conditions preventing proper use of the WatchPAT device (e.g., severe hand or finger injury)\n* Hemodynamic instability precluding participation\n* Pregnancy","ALL","18 Years",{"count":18,"type":19},50,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn how removing extra fluid from the body (diuresis) affects sleep apnea in adults hospitalized with heart failure.\n\nThe main questions it aims to answer are:\n\nDoes sleep apnea severity improve after fluid removal? Is the improvement in sleep apnea related to the amount of fluid removed? Do changes in neck size reflect changes in sleep apnea severity?\n\nParticipants admitted to the hospital with heart failure and fluid overload will take part in this study.\n\nParticipants will:\n\nUse a wearable sleep monitoring device (WatchPAT) on the first night of hospitalization Use the device again after fluid removal, when the treating cardiologist determines that the patient is no longer fluid overloaded Have their neck circumference measured before and after fluid removal Have their weight and fluid balance recorded during hospitalization Have routine blood tests and clinical assessments as part of standard care\n\nResearchers will compare each participant's results before and after fluid removal to see if sleep apnea improves and whether these changes are linked to fluid removal and changes in neck circumference.",[23,24],"Heart Failure","Obstructive Sleep Apnea (OSA)","RECRUITING","2026-05-19",{"date":28,"type":29},"2026-05-22","ACTUAL",{"date":31,"type":29},"2026-01-01",{"date":33,"type":19},"2027-06",{"name":35,"class":36},"Itshak Amsalem","OTHER",1,{"id":39,"slug":40,"hasResults":11,"nctId":41,"briefTitle":42,"officialTitle":42,"acronym":4,"eligibilityCriteria":43,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":44,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":46,"conditions":47,"keywords":4,"overallStatus":51,"whyStopped":4,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":53,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":4},"100636432","changes-in-intramyocardial-fat-assessed-by-cardiac-ct-before-and-after-bariatric-surgery-and-their-relationship-with-cardiac-diastolic-function-100636432","NCT07565610","Changes in Intramyocardial Fat Assessed by Cardiac CT Before and After Bariatric Surgery and Their Relationship With Cardiac Diastolic Function","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Scheduled to undergo bariatric surgery for standard clinical indications\n* Left ventricular ejection fraction (LVEF) ≥50%\n* Able to undergo cardiac computed tomography (CT)\n\nExclusion Criteria:\n\n* Left ventricular ejection fraction (LVEF) \\\u003C50%\n* Known cardiomyopathies, including sarcoidosis, amyloidosis, or myocarditis\n* Significant valvular heart disease\n* Contraindication to cardiac CT (e.g., severe renal dysfunction, contrast allergy)\n* Presence of intracardiac or cardiac-related foreign material that may interfere with imaging (e.g., prosthetic valves, pacemakers, prior transcatheter devices)",{"count":45,"type":19},150,"The goal of this observational study is to learn if weight loss surgery can lower fat inside the heart muscle and improve how the heart relaxes in adults with obesity.\n\nThe main questions it aims to answer are:\n\nDoes fat inside the heart muscle decrease after weight loss surgery? Does heart relaxation (diastolic function) improve after surgery? Are changes in heart fat linked to changes in weight, body fat, and blood markers?\n\nParticipants who are already planning to have weight loss surgery will take part in this study.\n\nParticipants will:\n\nHave a heart CT scan to measure fat in the heart muscle before surgery and about 6 months after surgery Have an ultrasound of the heart (echocardiogram) to check how the heart fills and relaxes Have body composition testing to measure fat and muscle Have blood tests, including routine tests and additional markers related to heart function and metabolism\n\nResearchers will compare each participant's results before and after surgery to see if heart fat decreases and if heart function and blood markers improve.",[48,49,50],"Obesity","Diastolic Dysfunction","Heart Failure With Preserved Ejection Fraction (HFPEF)","NOT_YET_RECRUITING","2026-04-29",{"date":54,"type":29},"2026-05-04",{"date":56,"type":19},"2026-05",{"date":58,"type":19},"2028-05",{"name":35,"class":36},""]