[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Ivan Zeljkovic\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":98},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,70],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100637068","cerebral-microembolization-during-transcatheter-aortic-valve-implantation-comparing-balloon-expandable-and-self-expanding-valves-100637068",false,"NCT07614100","Cerebral Microembolization During Transcatheter Aortic Valve Implantation: Comparing Balloon-expandable and Self-expanding Valves","Cerebral Microembolization During Transcatheter Aortic Valve Implantation: A Randomized Study Comparing Balloon-expandable and Self-expanding Valves","MICROTAVI","Inclusion Criteria:\n\n* Age 18 years or older\n* Severe symptomatic aortic valve stenosis\n* Clinical indication for transcatheter aortic valve implantation\n* Feasibility of transcranial Doppler ultrasound monitoring\n* Signed written informed consent\n\nExclusion Criteria:\n\n* Recent stroke or transient ischemic attack\n* Significant cerebrovascular disease preventing reliable transcranial Doppler -assessment\n* Previous aortic valve implantation\n* Active endocarditis\n* Pregnancy or breastfeeding","ALL","18 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study will compare the amount of cerebral microembolization during transcatheter aortic valve implantation (TAVI) between two commonly used types of transcatheter aortic valves: balloon-expandable valves and self-expanding valves.\n\nCerebral microembolization refers to small particles or material that may travel to the brain during the procedure. These signals can be detected using transcranial Doppler ultrasound, a non-invasive method for monitoring blood flow in the brain. Although clinically apparent stroke after TAVI is relatively uncommon, small silent brain lesions may occur, and their mechanisms are not fully understood.\n\nAdult patients with severe symptomatic aortic valve stenosis who are scheduled for TAVI will be included. Participants will be randomly assigned to receive either a balloon-expandable or a self-expanding valve, both of which are established and routinely used treatment options. Transcranial Doppler monitoring will be performed before, during, and after the procedure to record the number of microembolic signals. The study will also record neurological events and procedural characteristics, such as procedure duration and the need for balloon dilatation.\n\nThe aim of the study is to determine whether the type of valve is associated with a different burden of cerebral microembolization during TAVI. The results may help improve understanding of procedural factors related to cerebral embolization and may support future strategies for reducing neurological risk in patients undergoing TAVI.",[27],"Aortic Stenosis",[29,30,31],"Transcatheter Aortic Valve Replacement","Aortic Valve Stenosis","Microembolism","NOT_YET_RECRUITING","2026-05-21",{"date":35,"type":36},"2026-05-29","ACTUAL",{"date":38,"type":21},"2026-06-01",{"date":40,"type":21},"2027-02-01",{"name":42,"class":43},"Ivan Zeljkovic","OTHER",2,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":67,"leadSponsor":69,"locationsCount":44},"100637729","cerebral-microembolization-during-pulmonary-vein-isolation-comparison-of-different-pulsed-field-ablation-systems-100637729","NCT07610018","Cerebral Microembolization During Pulmonary Vein Isolation: Comparison of Different Pulsed Field Ablation Systems","Cerebral Microembolization During Pulmonary Vein Isolation: a Randomized Comparison of Different Pulsed Field Ablation Systems","MICROPFA","Inclusion Criteria:\n\n* Age 18 years or older\n* Paroxysmal or persistent atrial fibrillation\n* Indication for catheter ablation with pulmonary vein isolation\n* Feasibility of transcranial Doppler assessment\n* Signed informed consent\n\nExclusion Criteria:\n\n* Recent stroke or transient ischemic attack\n* Significant cerebrovascular disease preventing reliable transcranial Doppler assessment\n* Severe valvular or structural heart disease\n* Pregnancy or breastfeeding\n* Inability to receive anticoagulation",{"count":54,"type":21},100,[24],"This prospective, randomized, parallel-group interventional study will compare cerebral microembolization during pulmonary vein isolation between different pulsed field ablation systems in patients with paroxysmal or persistent atrial fibrillation. Adult patients with an indication for catheter ablation will be randomized to one of the included ablation systems: PulseSelect, Varipulse, Farapulse, Sphere-9, or Sphere-360. Microembolic signals will be assessed using transcranial Doppler before and after the procedure. The primary outcome will be the difference in the change in microembolic signal burden, expressed as ΔMES, between the different ablation systems.",[58],"Ablation of Arrhythmia's",[60,61,62,63],"Atrial fibrillation","Pulmonary vein isolation","Cerebral microembolization","Pulsed field ablation",{"date":65,"type":36},"2026-05-27",{"date":38,"type":21},{"date":68,"type":21},"2027-01-20",{"name":42,"class":43},{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":22,"phases":79,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},"100633110","comparison-and-analysis-of-functionality-safety-cost-effectiveness-and-environmental-impact-of-reprocessed-and-new-ablation-catheters-in-electrophysiological-procedures-100633110","NCT07522424","Comparison and Analysis of Functionality, Safety, Cost-effectiveness, and Environmental Impact of Reprocessed and New Ablation Catheters in Electrophysiological Procedures.","RE-USE EP","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Indication for ablation according to current clinical guidelines\n* Written informed consent\n\nExclusion Criteria:\n\n* Severe valvular heart disease\n* Significant structural heart disease that precludes (or makes ablation not feasible)\n* Pregnancy or breastfeeding\n* Life expectancy \\\u003C 12 months",{"count":78,"type":21},200,[24],"This study evaluates whether re-sterilized (reprocessed) ablation catheters are as effective and safe as new ablation catheters when used for electrophysiological procedures. Adult patients scheduled for catheter ablation will be randomly assigned to undergo the procedure using either a new catheter or a re-sterilized catheter, with identical procedural techniques applied in both groups. The study will compare procedural efficiency, safety, costs, and environmental impact between the two approaches. The results may support more sustainable and cost-effective use of medical devices in cardiac electrophysiology.",[82],"Arhythmia",[84,85,86,87,88],"Catheter Ablation","Catheter Reprocessing","Cost-Benefit Analysis","Medical Waste","Environmental Impact","2026-04-07",{"date":91,"type":36},"2026-04-13",{"date":93,"type":21},"2026-04-30",{"date":95,"type":21},"2027-05-20",{"name":42,"class":43},1,""]