[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Jagiellonian University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":643},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,30,0,25,[9,52,71,101,128,147,164,188,211,235,254,284,306,322,350,372,395,424,447,467,493,518,557,587,616],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":33,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100644228","quality-of-recovery-15-after-opioid-free-versus-opioid-based-general-anesthesia-in-major-urological-surgery-100644228",false,"NCT07665463","Quality of Recovery-15 After Opioid-free Versus Opioid-based General Anesthesia in Major Urological Surgery","Uality of Recovery-15 After Opioid-free Versus Opioid-based General Anesthesia in Patients Undergoing Elective Major Urological Surgery: A Randomized Controlled Trial","QoR-OFA-URO","Inclusion Criteria:\n\n* Adults aged 18 to 75 years.\n* Scheduled for elective major urological surgery under general anesthesia, including laparoscopic or robotic nephrectomy, laparoscopic or robotic prostatectomy, or laparoscopic or robotic cystectomy.\n* Ability to operate a patient-controlled analgesia pump postoperatively.\n* Ability to understand and use the Numeric Rating Scale for pain assessment.\n* Ability to understand and complete the Quality of Recovery-15 questionnaire.\n* Written informed consent.\n\nExclusion Criteria:\n\n* Patient refusal to participate.\n* Inability to operate the patient-controlled analgesia pump.\n* Inability to understand the Numeric Rating Scale for pain assessment.\n* Inability to understand or complete the Quality of Recovery-15 questionnaire.\n* Known hypersensitivity to any of the study drugs, including anesthetics, ketamine, dexmedetomidine, lidocaine, ropivacaine, oxycodone, metamizole, paracetamol, or ibuprofen.\n* Second- or third-degree atrioventricular block.\n* Symptomatic bradycardia.\n* Chronic opioid use.\n* Contraindication to the planned regional anesthesia technique, including coagulopathy, therapeutic anticoagulation, or infection at the puncture site.","ALL","18 Years","75 Years",{"count":22,"type":23},200,"ESTIMATED","INTERVENTIONAL",[26],"NA","This randomized controlled trial evaluates postoperative quality of recovery assessed with the Quality of Recovery-15 questionnaire in adult patients undergoing elective major urological surgery under opioid-free versus opioid-based general anesthesia.\n\nOpioid-free anesthesia is a multimodal anesthetic technique that avoids intraoperative opioids by combining non-opioid analgesic and sympatholytic agents such as dexmedetomidine, ketamine, lidocaine, non-steroidal anti-inflammatory drugs, and regional analgesia. Opioid-based general anesthesia in this trial includes intraoperative remifentanil infusion.\n\nParticipants will undergo elective urological surgery, including laparoscopic nephrectomy, robotic nephrectomy, laparoscopic prostatectomy, robotic prostatectomy, laparoscopic cystectomy, or robotic cystectomy.\n\nThe primary objective is to compare patient-reported quality of recovery between the opioid-free anesthesia group and the remifentanil-based anesthesia group using the Quality of Recovery-15 questionnaire. QoR-15 will be assessed before surgery and on postoperative day 7.\n\nSecondary objectives include total postoperative oxycodone dose administered via patient-controlled analgesia during the first 24 hours after surgery, postoperative pain intensity measured using the Numeric Rating Scale at 1, 2, 6, 12, and 24 hours after surgery, incidence of postoperative nausea and vomiting, change in serum creatinine from baseline to postoperative day 1, change in white blood cell count from baseline to postoperative day 1, and the ratio of demanded to delivered PCA boluses.\n\nPre-specified subgroup analyses will compare outcomes according to surgical procedure type: laparoscopic nephrectomy, robotic nephrectomy, laparoscopic prostatectomy, robotic prostatectomy, laparoscopic cystectomy, and robotic cystectomy. Subgroup-by-treatment interaction tests will be performed.\n\nPlanned enrollment is approximately 600 patients, with 300 patients per treatment arm. The primary patient-reported recovery endpoint will be assessed on postoperative day 7, while analgesic, pain, and early postoperative safety outcomes will be assessed during the first 24 hours after surgery.",[29,30,31,32],"Postoperative Recovery","Anesthesia, General","Analgesics, Opioid","Urologic Surgical Procedure",[34,35,36,37,38],"Quality of Recovery-15","QoR-15","Opioid-free anesthesia","Remifentanil","Urological surgery","NOT_YET_RECRUITING","2026-06-18",{"date":42,"type":43},"2026-06-24","ACTUAL",{"date":45,"type":23},"2026-07-01",{"date":47,"type":23},"2027-12-31",{"name":49,"class":50},"Jagiellonian University","OTHER",1,{"id":53,"slug":54,"hasResults":12,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":58,"targetDuration":4,"studyType":24,"phases":60,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":65,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":51},"100545310","opioid-free-anesthesia-as-an-alternative-to-general-anesthesia-in-abdominal-surgery-100545310","NCT06380244","Opioid-free Anesthesia as an Alternative to General Anesthesia in Abdominal Surgery","Inclusion Criteria:\n\n* Adults aged 18-75 years scheduled for elective urological surgery under general anesthesia: laparoscopic or robotic nephrectomy, laparoscopic or robotic prostatectomy, or laparoscopic or robotic cystectomy.\n* Ability to operate a patient-controlled analgesia (PCA) pump postoperatively.\n* Ability to understand and use the Numeric Rating Scale (NRS) for pain assessment.\n* Written informed consent.\n\nExclusion Criteria:\n\n* Patient's refusal to participate.\n* Inability to operate the PCA pump.\n* Inability to understand the NRS pain scale.\n* Known hypersensitivity to any of the study drugs (anesthetics, ketamine, dexmedetomidine, ropivacaine, oxycodone, metamizole, paracetamol, ibuprofen).\n* Second- or third-degree atrioventricular block, or symptomatic bradycardia.\n* Chronic opioid use.\n* Contraindication to the planned regional anesthesia technique (e.g. coagulopathy or therapeutic anticoagulation, infection at the puncture site).",{"count":59,"type":23},600,[26],"Opioid-free anesthesia (OFA) is a multimodal technique that eliminates intraoperative opioids by combining dexmedetomidine, ketamine, lidocaine, NSAIDs, and regional analgesia. Growing evidence suggests OFA reduces postoperative opioid consumption, opioid-related adverse effects, and may have favorable oncological implications in cancer surgery.\n\nThis randomized controlled trial compares OFA with opioid-based anesthesia (remifentanil) in patients undergoing elective urological surgery: laparoscopic nephrectomy, robotic nephrectomy, laparoscopic prostatectomy, robotic prostatectomy, laparoscopic cystectomy, and robotic cystectomy.\n\nThe PRIMARY OBJECTIVE is to compare the total postoperative oxycodone dose (mg) administered via patient-controlled analgesia (PCA) during the first 24 hours after surgery between the OFA and remifentanil groups.\n\nSECONDARY OBJECTIVES include: postoperative pain intensity (NRS) at 1, 2, 6, 12, and 24 hours; incidence of postoperative nausea and vomiting (PONV); change in serum creatinine from baseline to postoperative day 1; change in white blood cell (WBC) count from baseline to postoperative day 1; and the ratio of demanded to delivered PCA boluses.\n\nPRE-SPECIFIED SUBGROUP ANALYSES will compare outcomes by surgical procedure type: laparoscopic nephrectomy, robotic nephrectomy, laparoscopic prostatectomy, robotic prostatectomy, laparoscopic cystectomy, and robotic cystectomy. Subgroup-by-treatment interaction tests will be performed and reported as forest plots.\n\nPlanned enrollment: approximately 600 patients (300 per arm). Follow-up: 24 hours postoperatively.",[31,63,30],"Anesthesia, Endotracheal","RECRUITING",{"date":42,"type":43},{"date":67,"type":43},"2024-03-10",{"date":69,"type":23},"2026-12-31",{"name":49,"class":50},{"id":72,"slug":73,"hasResults":12,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":12,"sex":78,"minAge":19,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":82,"phases":4,"briefSummary":83,"conditions":84,"keywords":88,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":51},"100579597","immune-cell-populations-in-the-endometrium-100579597","NCT06826365","Immune Cell Populations in the Endometrium","Analysis of Immune Cell Populations in the Endometrium and Peripheral Blood in Women With Reduced and Normal Fertility","Inclusion Criteria:\n\n* age 18-45 years\n* idiopathic infertility\n* at least 2 miscarriages\n* other benign gynecological conditions subjected to endometrial sampling\n\nExclusion Criteria:\n\n* miscarriage within last 3 months\n* abdominal\u002Futerine surgery within last 3 months\n* viral\u002Fbacterial infection within last 3 months\n* antibiotic therapy within last 3 months","FEMALE","45 Years",{"count":81,"type":23},50,"OBSERVATIONAL","Specialized immunological studies in the diagnostics of idiopathic infertility and recurrent miscarriages have limited applicability, as the role of the immune system in these conditions is not thoroughly understood. In ovulatory cycles, changes occur in the populations of uterine lymphocytes, which may influence the receptivity of the endometrium and the implantation of the embryo. Particularly notable are the changes in natural killer (NK) cells, which reach their peak during the luteal phase and regulate the invasion of the trophoblast. The dominant NK cells exhibit a CD56bright phenotype and differ in cytokine profiles from peripheral blood cells. Cyclical changes also affect macrophages and T lymphocytes; however, it is unclear whether their proportions differ in women with reduced fertility. There is a need to investigate how the composition of lymphocytes in blood influences the populations in the endometrium. The aim of this study is to analyze the correlation between peripheral and endometrial lymphocytes in women with idiopathic infertility and recurrent miscarriages, compared to fertile women.",[85,86,87],"Infertility, Female","Recurrent Miscarriage","Gynecologic Disease",[89,90,91,92],"Idiopathic infertility","Endometrial immunology","Endometrial aspiration biopsy","Recurrent miscarriage","2026-03-17",{"date":95,"type":43},"2026-03-19",{"date":97,"type":43},"2025-07-01",{"date":99,"type":23},"2026-06-30",{"name":49,"class":50},{"id":102,"slug":103,"hasResults":12,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":108,"sex":78,"minAge":19,"maxAge":79,"enrollmentInfo":109,"targetDuration":4,"studyType":82,"phases":4,"briefSummary":111,"conditions":112,"keywords":115,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":127,"locationsCount":51},"100577038","functional-proteins-in-polycystic-ovary-syndrome-100577038","NCT06793098","Functional Proteins in Polycystic Ovary Syndrome","Assessment of the Concentrations of Functional Proteins as Potential Early Markers of Insulin Resistance in Women With Polycystic Ovary Syndrome","Inclusion Criteria:\n\n* women aged 18-45 years\n\nExclusion Criteria:\n\n* removal of at least one ovary\n* treated diabetes of any type\n* diagnosed and treated metabolic diseases\n* diagnosed and treated autoimmune diseases\n* diagnosed and treated autoinflammatory diseases",true,{"count":110,"type":23},100,"The concentration of functional proteins: kisspeptin, ghrelin, zonulin will be measured and compared in women with polycystic ovary syndrome (PCOS) and insulin resistance (IR), in women with PCOS without IR, and in women without PCOS.",[113,114],"Reproductive Age","PCOS (Polycystic Ovary Syndrome)",[116,117,118,119,120,121],"insulin resistance","kisspeptin","ghrelin","zonulin","metabolic syndrome","Polycystic Ovary Syndrome",{"date":123,"type":43},"2026-03-18",{"date":125,"type":43},"2025-01-20",{"date":47,"type":23},{"name":49,"class":50},{"id":129,"slug":130,"hasResults":12,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":4,"eligibilityCriteria":134,"healthyVolunteers":108,"sex":78,"minAge":19,"maxAge":79,"enrollmentInfo":135,"targetDuration":4,"studyType":82,"phases":4,"briefSummary":137,"conditions":138,"keywords":140,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":143,"startDateStruct":144,"completionDateStruct":145,"leadSponsor":146,"locationsCount":51},"100577036","adipokines-in-polycystic-ovary-syndrome-100577036","NCT06793072","Adipokines in Polycystic Ovary Syndrome","Assessment of Adipokine Concentrations and Their Association With the Metabolic Profile of Women With PCOS","Inclusion Criteria:\n\n* Age 18-45\n\nExclusion Criteria:\n\n* previous removal of at least one ovary\n* treated diabetes of any type\n* diagnosed and treated metabolic diseases\n* diagnosed and treated autoimmune diseases\n* diagnosed and treated autoinflammatory diseases(Edited)Restore original",{"count":136,"type":23},300,"The aim of the study is to compare the concentrations of leptin, resistin, and omentin-1 in women across three research groups: those with polycystic ovary syndrome without insulin resistance, those with polycystic ovary syndrome with insulin resistance, and women without polycystic ovary syndrome.",[139,113],"PCOS",[116,141,120,142],"polycystic ovary syndrome","adipokines",{"date":123,"type":43},{"date":125,"type":43},{"date":47,"type":23},{"name":49,"class":50},{"id":148,"slug":149,"hasResults":12,"nctId":150,"briefTitle":151,"officialTitle":152,"acronym":4,"eligibilityCriteria":153,"healthyVolunteers":108,"sex":78,"minAge":19,"maxAge":79,"enrollmentInfo":154,"targetDuration":4,"studyType":82,"phases":4,"briefSummary":155,"conditions":156,"keywords":157,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":160,"startDateStruct":161,"completionDateStruct":162,"leadSponsor":163,"locationsCount":51},"100577037","pro--and-anti-inflammatory-cytokines-in-pcos-100577037","NCT06793085","Pro- and Anti-inflammatory Cytokines in PCOS","Assessment of the Concentrations of Pro- and Anti-inflammatory Cytokines and Their Association With the Metabolic Profile of Women With PCOS","Inclusion Criteria:\n\n* women aged 18-45 years\n\nExclusion Criteria:\n\n* previous removal of at least one ovary\n* treated diabetes of any type\n* diagnosed and treated metabolic diseases\n* diagnosed and treated autoimmune diseases\n* diagnosed and treated autoinflammatory diseases",{"count":110,"type":23},"The study will involve measurements and comparisons of the concentrations of pro-inflammatory cytokines: IL-6, TNF-α, IL-18, as well as anti-inflammatory cytokine IL-4 in women with polycystic ovary syndrome (PCOS) and insulin resistance, women with polycystic ovary syndrome without carbohydrate metabolism disorders, and women without PCOS (control group).",[113,114],[158,159,116,120,121],"menstrual disorders","chronic inflammation",{"date":123,"type":43},{"date":125,"type":43},{"date":69,"type":23},{"name":49,"class":50},{"id":165,"slug":166,"hasResults":12,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":170,"eligibilityCriteria":171,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":172,"targetDuration":4,"studyType":82,"phases":4,"briefSummary":174,"conditions":175,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":180,"lastUpdatePostDateStruct":181,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":51},"100599749","occupational-situation-and-return-to-work-of-urological-patients-100599749","NCT07088536","Occupational Situation and Return to Work of Urological Patients","Occupational Situation of Patients With Urological Diseases and Return to Work in Patients Undergoing Major Uro-Oncological Operations and Procedures for Urinary Tract Stones","OCCURORTW","Inclusion Criteria:\n\n1. Adult patients (≥18 years) admitted to the Department of Urology and Oncological Urology, University Hospital in Kraków, during the 6-month study period.\n2. For the prospective follow-up cohort:\n\n   1. Occupationally active (employed) at baseline.\n   2. Undergoing major uro-oncological surgery (e.g., radical cystectomy, radical prostatectomy, nephrectomy) or a procedure for urinary tract stones (e.g., ureterorenoscopy, percutaneous nephrolithotripsy).\n3. Able and willing to provide written informed consent.\n\nExclusion Criteria:\n\n1. Patients unwilling or unable to provide informed consent.\n2. Patients who are unemployed or retired at baseline (excluded from the prospective follow-up cohort but included in the baseline cross-sectional survey).\n3. Patients not undergoing major uro-oncological surgery or urinary tract stone procedures (for the prospective follow-up cohort).",{"count":173,"type":23},2000,"This study will examine the work status of all adult patients admitted over a 6-month period to the University Hospital in Kraków, Poland, for treatment of urological diseases. All admitted patients will be surveyed about their job situation. Patients who are occupationally active and undergoing major oncological surgeries (such as radical cystectomy, prostatectomy, or nephrectomy) or procedures for urinary tract stones will also complete a quality-of-life questionnaire and be followed up by phone at 3 and 6 months. The goal is to learn how treatment affects patients' ability to return to work and their well-being, to help guide support and rehabilitation strategies.",[176,177,178,179],"Bladder Cancer","Prostate Cancer","Renal Cancer","Urinary Stones","2026-03-02",{"date":182,"type":43},"2026-03-03",{"date":184,"type":43},"2025-07-21",{"date":186,"type":23},"2027-04",{"name":49,"class":50},{"id":189,"slug":190,"hasResults":12,"nctId":191,"briefTitle":192,"officialTitle":193,"acronym":4,"eligibilityCriteria":194,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":195,"targetDuration":4,"studyType":82,"phases":4,"briefSummary":196,"conditions":197,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":206,"completionDateStruct":208,"leadSponsor":210,"locationsCount":51},"100624525","advanced-endoscopic-resections-for-rectal-neoplasms-100624525","NCT07410767","Advanced Endoscopic Resections for Rectal Neoplasms","Adoption of Advanced Endoscopic Resection Methods in the Treatment of Rectal Neoplasms","Inclusion Criteria:\n\n* Patients with rectal neoplasms treated by advanced endoscopic resection\n\nExclusion Criteria:\n\n* hybrid resection performed\n* full-thickness resection performed\n* essential procedural or outcome data were unavailable",{"count":136,"type":23},"This study evaluates how advanced endoscopic resection techniques affect treatment outcomes in adults with rectal cancer.\n\nRectal cancer has traditionally been treated with standard abdominal surgery. Newer endoscopic techniques allow removal of selected early tumors and may reduce treatment-related complications. However, their effectiveness and safety in tumors with deeper invasion are not yet fully established.\n\nThis multicenter retrospective observational study uses existing medical records from adults who underwent endoscopic or surgical resection of rectal tumors between 2015 and 2025. Researchers will analyze anonymized information on procedures performed and treatment outcomes to assess the safety and effectiveness of advanced endoscopic approaches.\n\nThe results of this study may help guide treatment selection and improve care for people with rectal cancer.",[198,199,200,201,202],"Rectal Cancer","Rectal Adenocarcinoma","Rectal Adenoma","Rectal Neuroendocrine Neoplasm","Recurrent Rectal Adenocarcinoma","2026-02-13",{"date":205,"type":43},"2026-02-18",{"date":207,"type":23},"2026-03-01",{"date":209,"type":23},"2026-04-30",{"name":49,"class":50},{"id":212,"slug":213,"hasResults":12,"nctId":214,"briefTitle":215,"officialTitle":215,"acronym":216,"eligibilityCriteria":217,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":218,"enrollmentInfo":219,"targetDuration":4,"studyType":24,"phases":220,"briefSummary":221,"conditions":222,"keywords":224,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":228,"lastUpdatePostDateStruct":229,"startDateStruct":231,"completionDateStruct":233,"leadSponsor":234,"locationsCount":51},"100622020","opioid-free-anesthesia-as-an-alternative-to-general-anesthesia-in-patients-undergoing-laparoscopic-peripheral-pancreatic-resection-100622020","NCT07378189","Opioid-free Anesthesia as an Alternative to General Anesthesia in Patients Undergoing Laparoscopic Peripheral Pancreatic Resection","OFAPP","Inclusion Criteria:\n\n* Patient consent to participate in the study\n* Qualified for laparoscopic peripheral pancreatic resection\n* Age 18-80 years\n* ASA II and III\n\nExclusion Criteria:\n\n* Patient refusal to participate in the study\n* Inability to operate a PCA pump\n* Lack of understanding of the NRS scale\n* Hypersensitivity to anesthetics\n* First- or second-degree heart block.","80 Years",{"count":22,"type":23},[26],"Opioid-free anesthesia is not associated with greater pain than opioid anesthesia and is associated with reduced postoperative pain.",[223],"Pain Management",[225,226,227],"Pain","OFA","Opioid Free Anesthesia","2026-01-28",{"date":230,"type":43},"2026-01-30",{"date":232,"type":23},"2026-02-01",{"date":47,"type":23},{"name":49,"class":50},{"id":236,"slug":237,"hasResults":12,"nctId":238,"briefTitle":239,"officialTitle":239,"acronym":4,"eligibilityCriteria":240,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":218,"enrollmentInfo":241,"targetDuration":4,"studyType":24,"phases":242,"briefSummary":243,"conditions":244,"keywords":245,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":248,"lastUpdatePostDateStruct":249,"startDateStruct":251,"completionDateStruct":252,"leadSponsor":253,"locationsCount":51},"100620995","opioid-free-anesthesia-as-an-alternative-to-general-anesthesia-in-patients-undergoing-duodenopancreatic-surgery-by-laparotomy-100620995","NCT07364864","Opioid-free Anesthesia as an Alternative to General Anesthesia in Patients Undergoing Duodenopancreatic Surgery by Laparotomy.","Inclusion Criteria:\n\n* Age 18-80 years\n* ASA II and III\n* Patient consent to the proposed regional anesthesia\n* Patient consent to participate in the study\n* Surgical procedure in the pancreaticoduodenal area by laparotomy Exclusion criterion\n* Patient refusal to participate in the study\n* Inability to operate the PCA pump\n* Lack of understanding of the NRS scale\n* Hypersensitivity to anesthetics\n* First- or second-degree heart block.",{"count":22,"type":23},[26],"Opioid-free anesthesia is not associated with greater pain than opioid anesthesia and reduces the need for opioids in the postoperative period.",[223],[226,246,247],"Opioid consumption","Opioid free anesthesia","2026-01-18",{"date":250,"type":43},"2026-01-23",{"date":232,"type":23},{"date":47,"type":23},{"name":49,"class":50},{"id":255,"slug":256,"hasResults":12,"nctId":257,"briefTitle":258,"officialTitle":259,"acronym":260,"eligibilityCriteria":261,"healthyVolunteers":12,"sex":18,"minAge":79,"maxAge":4,"enrollmentInfo":262,"targetDuration":4,"studyType":24,"phases":264,"briefSummary":266,"conditions":267,"keywords":271,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":275,"lastUpdatePostDateStruct":276,"startDateStruct":278,"completionDateStruct":280,"leadSponsor":282,"locationsCount":283},"100584125","phase-3-noradrenaline-versus-standard-blood-pressure-management-for-perioperative-hypotension-in-non-cardiac-surgery-100584125","NCT06885268","Noradrenaline Versus Standard Blood Pressure Management for Perioperative Hypotension in Non-cardiac Surgery","The Effect of Noradrenaline Infusion Versus Standard Blood Pressure Management on Perioperative HYPotension in NOn-caRdiac Surgery HYP-NOR Trial","HYP-NOR","Inclusion Criteria:\n\n1. ≥45 years old\n2. Elective or accelerated\\* non-cardiac surgery expected to last ≥1 hour and requiring general, neuraxial, or combined general with neuraxial anesthesia\n3. Expected to stay overnight in the hospital after surgery\n4. Written informed consent to participate in the HYP-NOR Trial provided\n5. American Society of Anesthesiologists (ASA) physical status class II or higher.\n\nExclusion Criteria:\n\n1. Newly diagnosed, untreated, or uncontrolled hypertension -in two measurements on the day before surgery Systolic Blood Pressure (SBP) ≥180 mm Hg or Diastolic Blood Pressure (DBP) ≥110 mm Hg\n2. Persistent difference in recorded SBP between right and left upper limb \\>10 mm Hg\n3. Persistent atrial fibrillation\n4. Have a documented history of dementia\n5. Have language, vision, or hearing impairments that may compromise cognitive assessments\n6. Have a condition that precludes routine blood pressure management such as surgeon request for relative hypotension\n7. Receiving irreversible nonselective monoamine oxidase inhibitors (e.g. tranylcypromine, phenelzine) within 2 weeks preceding study enrolment\n8. The use of tricyclic antidepressants\n9. Have Prinzmetal angina\n10. Have contraindications to noradrenaline per clinician judgement\n11. Noradrenaline infusion started before surgery or plan to use continuous noradrenaline infusion throughout the procedure\n12. Treating physician (surgeon\u002Fanaesthetist) decides on the necessity of extended continuous hemodynamic monitoring during or after surgery\n13. Severe kidney disease (MDRD creatinine clearance \\\u003C15 mL\u002Fmin\u002F1.73m2) or renal replacement therapy\n14. End-stage heart failure: defined as NYHA Class IV - severe limitations in daily activity. Patients experience symptoms even while at rest. Mostly bedbound patients.\n15. Known severe liver disease: defined as the presence of liver cirrhosis or any of the symptoms of severe liver dysfunction: portal hypertension (esophageal varices, ascites), hepatocellular insufficiency (e.g., jaundice, hepatic encephalopathy) and coagulopathy (prolonged INR\u002FAPTT associated with known liver dysfunction).\n16. Emergency and urgent surgery defined as performed within 24 hours of sudden illness\u002Funplanned admission to hospital\n17. Have previously participated in the trial: patient already took a part in the HYP-NOR trial in the past\n18. Pregnant or breastfeeding women.",{"count":263,"type":23},750,[265],"PHASE3","The effect of noradrenaline infusion versus standard blood pressure management on perioperative HYPotension in NOn-caRdiac surgery.\n\nThe study aims to determine whether perioperative noradrenaline infusion is superior to standard blood pressure management for the occurrence of perioperative hypotension.",[268,269,270],"Blood Pressure Management","Intraoperative Hypotension","Non-cardiac Surgery",[272,273,274],"hypotension","noradrenaline infusion","perioperative care","2026-01-12",{"date":277,"type":43},"2026-01-14",{"date":279,"type":43},"2025-06-25",{"date":281,"type":23},"2027-06-30",{"name":49,"class":50},5,{"id":285,"slug":286,"hasResults":12,"nctId":287,"briefTitle":288,"officialTitle":289,"acronym":4,"eligibilityCriteria":290,"healthyVolunteers":12,"sex":78,"minAge":19,"maxAge":79,"enrollmentInfo":291,"targetDuration":4,"studyType":82,"phases":4,"briefSummary":292,"conditions":293,"keywords":295,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":299,"startDateStruct":301,"completionDateStruct":303,"leadSponsor":304,"locationsCount":305},"100616521","posttraumatic-stress-disorder-in-ectopic-pregnancy-100616521","NCT07306689","Posttraumatic Stress Disorder in Ectopic Pregnancy","Posttraumatic Stress Disorder Symptoms Complicating Ectopic Pregnancy","Inclusion Criteria:\n\n* ectopic pregnancy\n* gestational age up to 14 weeks.\n\nExclusion Criteria:\n\n* heterotopic pregnancy",{"count":22,"type":23},"The objective of the study is to prospectively assess the prevalence of post-traumatic stress disorder (PTSD) symptoms in a population of women who have experienced a diagnosis of ectopic pregnancy. The investigation into the prevalence of PTSD symptoms will aid in better identifying women who may benefit from early psychological intervention.",[294],"Ectopic Pregnancy",[296,297],"ectopic pregnancy","PTSD","2025-12-14",{"date":300,"type":43},"2025-12-29",{"date":302,"type":43},"2025-12-15",{"date":47,"type":23},{"name":49,"class":50},2,{"id":307,"slug":308,"hasResults":12,"nctId":309,"briefTitle":310,"officialTitle":311,"acronym":4,"eligibilityCriteria":312,"healthyVolunteers":12,"sex":78,"minAge":19,"maxAge":79,"enrollmentInfo":313,"targetDuration":4,"studyType":82,"phases":4,"briefSummary":314,"conditions":315,"keywords":317,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":318,"startDateStruct":319,"completionDateStruct":320,"leadSponsor":321,"locationsCount":51},"100616520","post-traumatic-stress-disorder-in-spontaneous-abortion-100616520","NCT07306676","Post-traumatic Stress Disorder in Spontaneous Abortion","Symptoms of Post-traumatic Stress Disorder Complicating Spontaneous Abortion","Inclusion Criteria:\n\n* spontaneous abortion\n* gestational age up to 14 weeks.\n\nExclusion Criteria:\n\n* none",{"count":22,"type":23},"The objective of this questionnaire-based study is to prospectively assess the prevalence of post-traumatic stress disorder (PTSD) symptoms in a population of women who have experienced a spontaneous miscarriage during the first trimester of pregnancy. The investigation into the prevalence of PTSD symptoms will assist in better identifying women who may benefit from early psychological intervention.",[316],"Spontaneous Abortion",[316,297],{"date":300,"type":43},{"date":302,"type":43},{"date":47,"type":23},{"name":49,"class":50},{"id":323,"slug":324,"hasResults":12,"nctId":325,"briefTitle":326,"officialTitle":327,"acronym":4,"eligibilityCriteria":328,"healthyVolunteers":108,"sex":78,"minAge":19,"maxAge":329,"enrollmentInfo":330,"targetDuration":4,"studyType":82,"phases":4,"briefSummary":332,"conditions":333,"keywords":336,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":342,"lastUpdatePostDateStruct":343,"startDateStruct":345,"completionDateStruct":347,"leadSponsor":349,"locationsCount":51},"100615682","the-assessment-of-fibrin-clot-phenotype-and-thrombin-generation-in-women-after-urogynecological-surgeries-100615682","NCT07295782","The Assessment of Fibrin Clot Phenotype and Thrombin Generation in Women After Urogynecological Surgeries.","Fibrin Clot Properties and Thrombin Generation in Women After Urogynecological Surgery.","Inclusion Criteria:\n\n* Age 18-70\n* treatment failure (pharmacotherapy) due to uterine prolapse or urine incontinence\n\nExclusion Criteria:\n\n* prolonged thromboprophylaxis\n* planned surgery other than due to urine incontinence\u002Futerine prolapse\n* acquired or congenital thrombophilia","70 Years",{"count":331,"type":23},60,"Determination of fibrin clot properties along with thrombin generation in women after urigynecological surgery.",[334,335],"Uterine Prolapse","Urine Incontinence",[337,338,339,340,341],"uterine prolapse","urine incontinence","fibrin clot","fibrinolysis","thrombin","2025-12-08",{"date":344,"type":43},"2025-12-22",{"date":346,"type":23},"2025-12-10",{"date":348,"type":23},"2026-05-30",{"name":49,"class":50},{"id":351,"slug":352,"hasResults":12,"nctId":353,"briefTitle":354,"officialTitle":355,"acronym":4,"eligibilityCriteria":356,"healthyVolunteers":108,"sex":78,"minAge":19,"maxAge":357,"enrollmentInfo":358,"targetDuration":4,"studyType":82,"phases":4,"briefSummary":359,"conditions":360,"keywords":364,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":366,"lastUpdatePostDateStruct":367,"startDateStruct":368,"completionDateStruct":369,"leadSponsor":371,"locationsCount":51},"100614121","pregnancy-and-fibrin-clot-properties-100614121","NCT07275476","Pregnancy and Fibrin Clot Properties","Fibrin Clot Properties and Thrombin Generation in Pregnancy Women With and Without Obstetric Complications.","Inclusion Criteria:\n\nI. age 18-40 years; II. natural conception (without assisted reproductive techniques).\n\nExclusion Criteria:\n\nI. use of hormonal therapy (i.e., oral contraceptives, progestogens) within 3 months before or during pregnancy; II. use of anticoagulants oral\u002Fsubcutaneous within 3 months before or during pregnancy; III. increased risk factors of VTE (i.e., obesity - body mass index \\>30 kg\u002Fm2; smoking) or history of VTE; IV. Concomitant diseases, i.e: severe hypertension, diabetes mellitus, autoimmune diseases (i.e., systemic lupus erythematosus, antiphospholipid syndrome); V. congenital or acquired thrombophilia (i.e., mutation factor V Leiden, prothrombin mutation).","40 Years",{"count":110,"type":23},"1. The structure of fibrin clot and thrombin generation may vary between trimesters of pregnancy.\n2. Unfavorably altered fibrin clot properties along with enhanced thrombin generation may lead to the development of complications during pregnancy such as TE and hypertensive disorders.\n3. The application of machine learning techniques may help to identify previously undetected phenotypes with increased risk of TE and hypertensive disorders during pregnancy.",[361,362,363],"Fibrin Blood Clot","Pregnancy","Pregnancy Complicated by Cardiovascular Disorders as Postpartum Condition, Delivered During Previous Episode",[340,339,365],"thrombin generation","2025-11-28",{"date":346,"type":43},{"date":366,"type":43},{"date":370,"type":23},"2027-12",{"name":49,"class":50},{"id":373,"slug":374,"hasResults":12,"nctId":375,"briefTitle":376,"officialTitle":377,"acronym":4,"eligibilityCriteria":378,"healthyVolunteers":12,"sex":78,"minAge":19,"maxAge":357,"enrollmentInfo":379,"targetDuration":4,"studyType":24,"phases":380,"briefSummary":381,"conditions":382,"keywords":384,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":366,"lastUpdatePostDateStruct":388,"startDateStruct":390,"completionDateStruct":392,"leadSponsor":394,"locationsCount":51},"100375311","ovarian-hyperstimulation-and-fibrin-clot-properties-100375311","NCT04166825","Ovarian Hyperstimulation and Fibrin Clot Properties.","The Impact of Different Ovarian Hyperstimulation Protocols on Coagulation and Fibrinolysis.","Inclusion Criteria:\n\n* infertility defined based on the WHO 2010 criteria\n\nExclusion Criteria:\n\n* ovarian involvement\n* oral contraceptives use within previous 3 months\n* dienogest therapy within 3 months until ART\n* thrombotic events in the medical history\n* severe hypertension\n* diabetes mellitus\n* the presence of known VTE risk factors, including obesity, recent major surgery with prolonged immobilization or trauma,\n* deficiency of antithrombin, protein C or protein S,\n* antiphospholipid syndrome,\n* known malignancy,\n* any chronic inflammatory diseases (e.g. rheumatoid arthritis)\n* advanced chronic renal disease (estimated glomerular filtration rate \\[eGFR\\] \\\u003C30 ml\u002Fmin),\n* international normalized ratio (INR) more than 1.2 at the day of blood draw\n* pregnancy.",{"count":136,"type":23},[26],"The impact evaluation of ovarian hyperstimulation on coagulation and fibrinolysis in infertile women.\n\nComparative analysis between different ovarian stimulation protocols on thrombin formation and efficiency of fibrinolysis in women diagnosed with infertility.",[361,85,383],"Endometriosis",[385,340,386,387],"coagulation","ovarian hyperstimulation","infertility",{"date":389,"type":43},"2025-12-05",{"date":391,"type":43},"2019-11-18",{"date":393,"type":23},"2026-01",{"name":49,"class":50},{"id":396,"slug":397,"hasResults":12,"nctId":398,"briefTitle":399,"officialTitle":400,"acronym":401,"eligibilityCriteria":402,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":403,"enrollmentInfo":404,"targetDuration":4,"studyType":24,"phases":406,"briefSummary":407,"conditions":408,"keywords":412,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":416,"lastUpdatePostDateStruct":417,"startDateStruct":419,"completionDateStruct":421,"leadSponsor":423,"locationsCount":51},"100605091","comparison-of-nissen-sleeve-and-gastric-bypass-for-gerd-in-obese-patients-100605091","NCT07158008","Comparison of Nissen-Sleeve and Gastric Bypass for GERD in Obese Patients","The SLEEVE-GERD Trial: A Comparative Study of Nissen-Sleeve and Roux-en-Y Gastric Bypass in Obese Patients With GERD","SLEEVE-GERD","Inclusion Criteria:\n\nFor N-Sleeve Gastrectomy (N-SG) and Roux-en-Y Gastric Bypass (RYGB) arms:\n\n* Age ≥ 18 years\n* Written informed consent provided\n* Eligible for bariatric surgery according to national guidelines (BMI ≥ 40 kg\u002Fm² or BMI ≥ 35 kg\u002Fm² with obesity-related comorbidities)\n* Presence of symptomatic gastroesophageal reflux disease (GERD), defined by at least one of the following:\n* Regular use of proton pump inhibitors (PPIs)\n* GerdQ score \\> 6\n* Endoscopic evidence of esophagitis (Los Angeles classification grade B or higher)\n\nFor Sleeve Gastrectomy (SG) observational control group:\n\n* Age ≥ 18 years\n* Written informed consent provided\n* Eligible for bariatric surgery according to national guidelines (BMI ≥ 40 kg\u002Fm² or BMI ≥ 35 kg\u002Fm² with obesity-related comorbidities)\n* No symptoms or history of GERD\n\nExclusion Criteria:\n\n* History of prior anti-reflux surgery\n* History of upper gastrointestinal tract surgery\n* Active smoking or history of nicotine use\n* Severe cardiac insufficiency (New York Heart Association Class III or IV)\n* Pregnancy or planned pregnancy during the study period (if applicable based on future additions)\n* Any condition that, in the opinion of the investigator, would interfere with the participant's ability to comply with the study protocol or would pose additional risk","65 Years",{"count":405,"type":23},560,[26],"This randomized clinical trial aims to compare two surgical techniques for the treatment of obesity in patients who also have symptoms of gastroesophageal reflux disease (GERD). The study will compare Nissen-Sleeve Gastrectomy (N-SG)-a sleeve gastrectomy combined with a reflux-preventing procedure-to the Roux-en-Y Gastric Bypass (RYGB), which is the current standard surgical option for obese patients with GERD.\n\nBoth procedures are widely used to treat severe obesity, but they differ in how they affect the digestive system and the potential for reflux control, nutritional outcomes, and future surgical options. N-SG is a newer technique that preserves the natural pathway of the gastrointestinal tract and allows standard endoscopic access to the bile ducts, which may be beneficial for long-term patient care. RYGB, on the other hand, bypasses part of the stomach and small intestine, which may lead to better reflux resolution but carries risks of nutritional deficiencies and altered anatomy.\n\nEligible participants with obesity and GERD symptoms will be randomly assigned to receive either N-SG or RYGB. The primary goal is to evaluate whether N-SG is not inferior to RYGB in reducing GERD symptoms one year after surgery. Secondary outcomes include weight loss, quality of life, surgical complications, and changes in the hormone ghrelin, which is involved in appetite regulation.\n\nIn addition, a larger control group of patients without GERD undergoing standard sleeve gastrectomy will be recruited to allow further comparisons. All participants will be followed for one year after surgery, with blood samples, questionnaires, and clinical data collected to assess both metabolic and reflux-related outcomes.\n\nThis study is being conducted at the University Hospital in Kraków, Poland, and aims to improve the personalization of bariatric treatment for patients suffering from both obesity and reflux.",[409,410,411],"Gastro Esophageal Reflux","Severe Obesity","Bariatric Surgery",[413,414,415],"Nissen-Sleeve","Gastric Bypass","GERD","2025-08-28",{"date":418,"type":43},"2025-09-05",{"date":420,"type":43},"2025-07-31",{"date":422,"type":23},"2028-09",{"name":49,"class":50},{"id":425,"slug":426,"hasResults":12,"nctId":427,"briefTitle":428,"officialTitle":429,"acronym":430,"eligibilityCriteria":431,"healthyVolunteers":12,"sex":432,"minAge":19,"maxAge":4,"enrollmentInfo":433,"targetDuration":4,"studyType":82,"phases":4,"briefSummary":435,"conditions":436,"keywords":438,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":440,"lastUpdatePostDateStruct":441,"startDateStruct":443,"completionDateStruct":445,"leadSponsor":446,"locationsCount":51},"100589424","voiding-and-erectile-function-after-retroperitoneal-lymph-node-dissection-for-testicular-cancer-100589424","NCT06954233","Voiding and Erectile Function After Retroperitoneal Lymph Node Dissection for Testicular Cancer","Voiding, Erectile and Ejaculatory Function After Retroperitoneal Lymph Node Dissection for Testicular Cancer","VEEF-RPLND-TC","Inclusion Criteria:\n\n* Adult male with testicular cancer undergoing retroperitoneal lymph node dissection (RPLND)\n\nExclusion Criteria:\n\n* History of RPLND\n* Lack of consent","MALE",{"count":434,"type":23},20,"This study aims to evaluate how retroperitoneal lymph node dissection (RPLND), a surgical treatment for testicular cancer, may affect urinary and sexual functions in men. RPLND involves the removal of lymph nodes from the abdominal area and is sometimes necessary in patients who are not eligible for chemotherapy or who have residual disease after chemotherapy. While this surgery is known to carry a risk of affecting ejaculation, its potential impact on other areas such as urination or erection is not well understood.\n\nThe study will prospectively follow adult men undergoing RPLND. It will assess changes in lower urinary tract symptoms, urine flow, ejaculation, erection, and overall quality of life before surgery and during follow-up visits up to 6 months after the operation. Patients will complete standardized questionnaires and undergo simple, non-invasive tests such as urine flow measurement.\n\nBy identifying how RPLND may influence urinary and sexual health, this study seeks to improve understanding of the full range of effects of this treatment. The findings may help clinicians better inform patients before surgery and support improved post-operative care.",[437],"Testicular Cancer",[437,439],"Retroperitoneal Lymph Node Dissection","2025-07-13",{"date":442,"type":43},"2025-07-16",{"date":444,"type":43},"2025-05-14",{"date":370,"type":23},{"name":49,"class":50},{"id":448,"slug":449,"hasResults":12,"nctId":450,"briefTitle":451,"officialTitle":452,"acronym":4,"eligibilityCriteria":453,"healthyVolunteers":12,"sex":78,"minAge":19,"maxAge":79,"enrollmentInfo":454,"targetDuration":4,"studyType":24,"phases":455,"briefSummary":456,"conditions":457,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":459,"lastUpdatePostDateStruct":460,"startDateStruct":462,"completionDateStruct":464,"leadSponsor":466,"locationsCount":51},"100502635","endometriosis-and-peritoneal-dysbiosis-100502635","NCT05824819","Endometriosis and Peritoneal Dysbiosis","\"Is the Reduced Quality of Life of Women With Endometriosis the Result of Peritoneal Dysbiosis?\"","Inclusion Criteria:\n\n* age 18-45 years\n* indications for surgical treatment of endometriosis by laparoscopy and\u002For indications for invasive diagnostics by laparoscopy due to idiopathic infertility.\n\nExclusion Criteria:\n\n* abdominal surgeries performed within 6 months prior hospitalisation\n* active infection of the genital tract\n* inflammatory bowel disease\n* antibiotic therapy and use of probiotics within 3 months before surgery",{"count":110,"type":23},[26],"Endometriosis is a complex clinical syndrome that impairs many aspects of a woman's life, characterized by a chronic estrogen-dependent inflammatory process, mainly affecting the pelvic organs, with ectopic presence of tissue analogous to the uterine mucosa (endometrium). Despite intensive research in the field of etiopathogenesis, its cause has not yet been determined, and treatment remains symptomatic. Endometriosis causes two main complications, i.e. pelvic pain syndrome and infertility. In recent years, thanks to the analysis of the human microbiome, it has become possible to deepen the knowledge of the physiological and pathological interactions between microorganisms inhabiting various body areas and the host. Bacteria may enter the peritoneal cavity in the mechanism of retrograde menstruation and translocate from the intestines, and then promote the development of local and systemic inflammation, leading to the symptoms of endometriosis. The study is to determine whether the presence of a specific intestinal, peritoneal and uterine microbiome correlates with endometriosis stage and whether its presence predisposes to increased pain or infertility. Concordance or divergence of bacterial populations inhabiting the peritoneal and uterine cavities could have clinical implications, i.e. the possibility of empirical antibiotic therapy in patients undergoing only endometrial aspiration biopsy and not opting for surgical treatment.",[383,458],"Infertility Unexplained","2025-04-13",{"date":461,"type":43},"2025-04-15",{"date":463,"type":43},"2023-05-01",{"date":465,"type":23},"2025-12-30",{"name":49,"class":50},{"id":468,"slug":469,"hasResults":12,"nctId":470,"briefTitle":471,"officialTitle":472,"acronym":473,"eligibilityCriteria":474,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":475,"targetDuration":4,"studyType":24,"phases":476,"briefSummary":477,"conditions":478,"keywords":481,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":486,"lastUpdatePostDateStruct":487,"startDateStruct":489,"completionDateStruct":491,"leadSponsor":492,"locationsCount":51},"100577071","comparison-of-the-efficacy-of-celiac-plexus-blockade-esp-and-lidocaine-infusion-under-ofa-100577071","NCT06793527","Comparison of the Efficacy of Celiac Plexus Blockade, ESP and Lidocaine Infusion Under OFA","Comparison of the Efficacy of Celiac Plexus Blockade, Erector Spinae Compartment Blockade (ESP), and Intravenous Lidocaine Infusion Under Opioid-free Anesthesia in Patients Undergoing Bariatric Surgery","LECO","Inclusion Criteria:\n\n* Patients over 18 years who underwent laparoscopic bariatric surgery\n* Must be able to sign agreement for study\n\nExclusion Criteria:\n\n* Patients with a history of allergic reactions to drugs\n* Patients with a history of drug addiction\n* Patients with chronic pain who require analgesics\n* History of hospitalization for psychiatric disorders\n* Preoperative pulse oximetry (SpO2) \\\u003C 95 %\n* bradycardia (HR\\\u003C50bpm)\n* hypotension\n* atrioventricular block\n* intraventricular or sinus block\n* Blood clotting disorders\n* Pregnant\u002Flactating women\n* Cognitive impairment\n* Unable to read consent",{"count":136,"type":23},[26],"Modern anesthesiology, in search of alternatives to opioid-based pain management, is turning to low-opioid and non-opioid protocols. Replacing opioids with non-opioid analgesics, co-analgesics, and regional and local anesthesia techniques allows avoiding the adverse effects of opioids while maintaining satisfactory analgesia. This is of particular importance in bariatric surgery, where reducing the incidence of respiratory depression, sedation, opioid hyperalgesia, and postoperative nausea and vomiting is a priority. Standard non-opioid anesthesia (OFA) includes ketamine, lidocaine, and dexmedetomidine infusions, while regional techniques additionally reduce the need for analgesics. Despite the widespread use of these methods, there is no clear data on the superiority of any of them in bariatric procedures.",[479,480],"Regional Anaesthesia","Anesthesia and Analgesia",[482,483,226,484,485],"ESP","celiac plexus block","erector spinal plane block","opioid free anesthesia","2025-04-02",{"date":488,"type":43},"2025-04-04",{"date":490,"type":43},"2025-02-06",{"date":69,"type":23},{"name":49,"class":50},{"id":494,"slug":495,"hasResults":12,"nctId":496,"briefTitle":497,"officialTitle":497,"acronym":4,"eligibilityCriteria":498,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":403,"enrollmentInfo":499,"targetDuration":4,"studyType":24,"phases":501,"briefSummary":502,"conditions":503,"keywords":506,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":511,"lastUpdatePostDateStruct":512,"startDateStruct":514,"completionDateStruct":515,"leadSponsor":517,"locationsCount":305},"100584752","the-effect-of-deep-tissue-massage-on-respiratory-parameters-in-people-with-asthma-100584752","NCT06893445","The Effect of Deep Tissue Massage on Respiratory Parameters in People With Asthma","Inclusion Criteria:\n\n* diagnosed with bronchial asthma\n* stable health condition, allowing participation in the study\n* informed consent to participate in the study\n\nExclusion Criteria:\n\n* acute or chronic comorbidities that may affect the results (e.g. COPD, heart failure, cancer)\n* any chest surgery performed within the last 6 months\n* contraindications to massage (e.g. skin infections, wounds)\n* pregnancy\n* participation in other clinical trials in the last 3 months",{"count":500,"type":23},40,[26],"Bronchial asthma, as a chronic inflammatory disease of the respiratory tract, significantly reduces the quality of life of patients. Standard treatment includes pharmacotherapy, but a holistic approach, including manual therapies, can support pharmacological therapy, reducing the need for drugs.\n\nThe aim of the research is to verify whether deep tissue massage (DTM) techniques applied to the chest significantly affect respiratory parameters in people with asthma. The study is the next stage of the study conducted on healthy people. After obtaining positive results in the study involving people not suffering from respiratory diseases, the next step is to examine people with, in this case, bronchial asthma. It is important to determine whether the use of this form of manual therapy can bring benefits in the context of improving respiratory functions, reducing respiratory muscle tension and relieving subjective symptoms associated with asthma, such as shortness of breath or limitations in everyday functioning.\n\nThe hypothesis assumes that DTM techniques can have a bigger effect on the respiratory system than classic massage (CM).\n\nThe study is a randomized controlled trial, where participants will be randomly assigned to one of two groups: the study group (subjected to DTM) or the control group (subjected to CM). Before and after the massage intervention, participants will undergo spirometry to assess the changes in respiratory parameters. The obtained data will then be analyzed for effects on respiratory parameters and differences between both groups.",[504,505],"Massage","Asthma Patients",[507,508,509,510],"deep tissue massage","spirometry","asthma","respiratory parameters","2025-03-18",{"date":513,"type":43},"2025-03-25",{"date":97,"type":23},{"date":516,"type":23},"2026-08-28",{"name":49,"class":50},{"id":519,"slug":520,"hasResults":12,"nctId":521,"briefTitle":522,"officialTitle":523,"acronym":4,"eligibilityCriteria":524,"healthyVolunteers":108,"sex":18,"minAge":19,"maxAge":525,"enrollmentInfo":526,"targetDuration":527,"studyType":82,"phases":4,"briefSummary":528,"conditions":529,"keywords":536,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":549,"lastUpdatePostDateStruct":550,"startDateStruct":552,"completionDateStruct":554,"leadSponsor":556,"locationsCount":305},"100555716","mental-health-of-the-polycrisis-generation-100555716","NCT06515704","Mental Health of the Polycrisis Generation","The Mental Health of Young Adults in Times of Polycrisis","Inclusion Criteria:\n\n* Age between 18 and 29 years\n* Standard educational opportunities\n* Polish fluent\n* Polish nationality\n\nExclusion Criteria:\n\n* Intellectual disability\n* Inability to self-complete the research questionnaires","29 Years",{"count":59,"type":23},"12 Months","The goal of this observational, longitudinal study is to identify risk and protective factors that buffer the effects of individual daily stress and adaptation to global crises on the quality of life and mental health conditions of young people entering adulthood (aged 18-29, fluent in Polish, and living in Poland). Moderators such as factors related to development, personality variables compatible with the domains according to ICD-11, psychological resilience, closeness in relationships with a partner\u002Ffriends\u002Fparents, and the level of postformal thinking will also be considered.\n\nThe main hypotheses it aims to consider are:\n\nH1: Poorer adaptation to individual and global crises is associated with higher levels of perceived stress, leading to worse indicators of mental health and quality of life.\n\nH2: A higher level of implementation of developmental tasks, including more fulfilled criteria of adulthood and a mature identity, mitigates the relationship between stress\u002F crisis adaptation and health and quality of life indicators.\n\nH3: Resilience and better relationships (closeness with a partner\u002F friends\u002F parents) buffer the negative effect of stress on health and quality of life.\n\nH4: A higher level of postformal thinking mitigates the relationship between stress\u002F crisis adaptation and health and quality of life indicators.\n\nH5: A higher intensity of psychopathological personality traits is a risk factor that amplifies the negative effect of stress on health and quality of life.\n\nResearchers will analyze measurements taken from the same group (a representative sample of Polish young adults) at two time points - now and in 12 months. The aim is to observe the extent to which the effects of current daily stressors and adaptation to the crisis, as well as the effects of potential moderators, are relatively stable.",[530,531,532,533,534,535],"Stress","Stress-related Problem","Cumulative Trauma","Mental Health Issue","Mental Stress","Quality of Life",[537,538,539,540,541,542,543,544,545,546,547,548],"cumulative stress","quality of life","mental health","young adults","stress syndrome","resilience","closeness relationships","postformal thinking","personality","development","risk factors","protective factors","2025-02-18",{"date":551,"type":43},"2025-02-19",{"date":553,"type":43},"2024-09-01",{"date":555,"type":23},"2025-10-31",{"name":49,"class":50},{"id":558,"slug":559,"hasResults":12,"nctId":560,"briefTitle":561,"officialTitle":562,"acronym":563,"eligibilityCriteria":564,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":565,"targetDuration":4,"studyType":82,"phases":4,"briefSummary":566,"conditions":567,"keywords":573,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":580,"lastUpdatePostDateStruct":581,"startDateStruct":582,"completionDateStruct":584,"leadSponsor":586,"locationsCount":51},"100534691","clinical-application-of-the-j-pet-scanner-prototype-100534691","NCT06242119","Clinical Application of the J-PET Scanner Prototype","Clinical Use of a J-PET Scanner Prototype Made of Plastic Scintilators","JPET2Clinic","Inclusion Criteria:\n\n* The patient is referred for a PET\u002FCT scan, in accordance with recognized indications for examining the entire body.\n* Age over 18 years\n* Informed, voluntary consent to participate in the study\n\nExclusion Criteria:\n\n* Pregnant women, breastfeeding women\n* People with a previously diagnosed allergy to radiopharmaceuticals\n* Age under 18 years\n* Lack of cooperation with the patient\n* Lack of informed consent to participate in the study",{"count":7,"type":23},"Positron emission tomography (PET), an advanced diagnostic imaging technique, exploits the annihilation of positrons (e+) to delineate pathological alterations within diseased tissues. Integral to PET scanners are detector systems that transform gamma photons into fluorescent photons, thereby gleaning insights into the energy, time, and spatial distribution of gamma photons emanating from positron-emitting radiopharmaceuticals. Conventional PET scanners, bear a significant financial burden primarily due to their reliance on LSO (lutetium oxyorthosilicate) or LYSO (lutetium yttrium oxyorthosilicate) scintillation crystals. The exorbitant cost and limited availability of these crystal scintillators impede the widespread adoption of PET scanners. In a departure from conventional PET technology, the prototype J-PET scanner employed in this trial employs plastic scintillators, characterized by unique physical properties. This prototype is further equipped with bespoke software enabling three-photon imaging based on the annihilation of ortho-positronium (o-Ps) generated within diseased tissue. This study delves into the clinical applicability of PET scanners employing plastic scintillators, particularly investigating the feasibility of PET imaging using plastic scintillators where gamma quanta interact by mechanisms other than the photoelectric effect. Furthermore, this study endeavors to contemporaneously acquire and analyze data related to the lifetime of ortho-positronium (o-P) atoms emanating from routine radiopharmaceuticals. Additionally, it seeks to validate the utilization of a novel diagnostic indicator, termed the \\"positron biomarker,\\" through a prospective study, comparing its efficacy to conventional diagnostic PET scanning methodologies.",[177,568,569,570,571,572],"Prostatic Hyperplasia","Prostatic Neoplasms","Prostate Cancer Metastatic","Neuroendocrine Tumors","Neuroendocrine Carcinoma",[574,575,576,577,578,579],"positronium","PET","[18F]FDG","[18F]choline","[68Ga]Ga-DOTA-TATE","[68Ga]Ga-PSMA","2025-02-17",{"date":551,"type":43},{"date":583,"type":43},"2024-03-07",{"date":585,"type":23},"2025-10-30",{"name":49,"class":50},{"id":588,"slug":589,"hasResults":12,"nctId":590,"briefTitle":591,"officialTitle":592,"acronym":4,"eligibilityCriteria":593,"healthyVolunteers":12,"sex":18,"minAge":594,"maxAge":403,"enrollmentInfo":595,"targetDuration":4,"studyType":24,"phases":597,"briefSummary":598,"conditions":599,"keywords":603,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":608,"lastUpdatePostDateStruct":609,"startDateStruct":611,"completionDateStruct":613,"leadSponsor":615,"locationsCount":305},"100576553","artificial-intelligence-in-colonoscopy-100576553","NCT06786793","Artificial Intelligence in Colonoscopy","Artificial Intelligence in Endoscopic Diagnosis of Colorectal Polyps: A Prospective Randomized Study.","Inclusion Criteria:\n\n* Consent to participate in the study,\n* Age between 50 and 65 years,\n* Scheduled outpatient colonoscopy.\n\nExclusion Criteria:\n\n* Previous colonoscopy,\n* History of colorectal surgery,\n* Ongoing biological therapy for any indication,\n* Primary sclerosing cholangitis,\n* Familial polyposis syndrome,\n* Chronic diarrhea,\n* Ulcerative colitis,\n* Crohn's disease.","50 Years",{"count":596,"type":23},630,[26],"Colorectal cancer is the second most common malignancy in the countries of the European Union. Colonoscopy is the primary method for detecting and preventing the development of colorectal cancer is endoscopic examination. This study aims to evaluate the impact of artificial intelligence on the detection rate of polyps and early stages of colorectal cancer.",[600,601,602],"Quality Indicators, Health Care","Artificial Intelligence (AI)","Colonoscopy Diagnostic Techniques and Procedures",[604,605,601,606,607],"Quality Indicatiors","Colonoscopy","Computer-aided Detection (CADe)","Adenoma detection rate (ADR)","2025-01-15",{"date":610,"type":43},"2025-01-22",{"date":612,"type":43},"2024-11-01",{"date":614,"type":23},"2025-12-31",{"name":49,"class":50},{"id":617,"slug":618,"hasResults":12,"nctId":619,"briefTitle":620,"officialTitle":621,"acronym":4,"eligibilityCriteria":622,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":403,"enrollmentInfo":623,"targetDuration":4,"studyType":82,"phases":4,"briefSummary":625,"conditions":626,"keywords":628,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":635,"lastUpdatePostDateStruct":636,"startDateStruct":638,"completionDateStruct":640,"leadSponsor":642,"locationsCount":305},"100570447","psychological-factors-and-pain-in-orthopedic-surgery-patients-100570447","NCT06707363","Psychological Factors and Pain in Orthopedic Surgery Patients","Psychological Predictors of Pain Experience in Patients After Emergency and Elective Orthopedic Surgery: a Longitudinal Study","Inclusion Criteria:\n\n* age: participants aged 18 years or older;\n* surgical procedures: individuals scheduled to undergo either emergency or elective orthopedic surgeries, including but not limited to joint replacements (e.g., hip or knee arthroplasty) and fracture repairs;\n* time after operation: undergoing orthopedic surgery up to 72 hours before the psychological examination;\n* informed consent: ability to provide informed consent and willingness to participate in the study;\n* language proficiency: proficiency in the language of the questionnaires used in the study (Polish).\n\nExclusion Criteria:\n\n* psychiatric disorders: diagnosed psychiatric disorders (e.g., severe depression, anxiety disorders) that are not managed or stable.",{"count":624,"type":23},170,"The goal of this observational study is to verify the association of previously underexplored psychological variables on postoperative pain experience and its progression over time in patients undergoing emergency and elective orthopedic surgeries, including both sexes (age range: 18-65). The main questions it aims to answer are:\n\n1. Do psychological factors such as dysfunctional personality traits and emotional regulation explain the experience of pain after surgery and after six months?\n2. Does the experience of the body mediate the relationship between dysfunctional personality traits and the experience of pain after surgery and after six months?\n3. Does the experience of pain differ between patients who underwent emergency and elective orthopedic surgery (after surgery and after six months)?\n\nResearchers will compare the pain experience of patients undergoing emergency orthopedic surgery to those undergoing elective orthopedic surgery to see if there are significant differences in pain outcomes and recovery trajectories.\n\nParticipants will:\n\n* complete psychological questionnairs to evaluate dysfunctional personality traits, emotional regulation, and body image;\n* report their subjective pain level and provide information on their coping strategies for managing pain and information about pain interference in everyday functioning;\n* engage in follow-up evaluation (6 months after the surgery) to assess the impact of pain on their daily activities and rehabilitation progress and complete some of the questionnaires again.",[627],"Orthopedic Surgical Procedures",[629,630,631,632,633,634],"body image","emotional regulation","dysfunctional personality traits","pain experience","orthopedic surgery","subjective pain intensity","2024-11-23",{"date":637,"type":43},"2024-11-27",{"date":639,"type":43},"2023-04-03",{"date":641,"type":23},"2025-06",{"name":49,"class":50},""]