[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Jan Biziel University Hospital No 2 in Bydgoszcz\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":46},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100607556","deep-anterior-cerebellar-stimulation-in-treatment-of-poststroke-spasticity-and-motor-function-impairment-100607556",false,"NCT07190092","Deep Anterior Cerebellar Stimulation in Treatment of Poststroke Spasticity and Motor Function Impairment.","Inclusion Criteria:\n\n* One time stroke that occurred 9-36 months ago\n* Ischemic or hemorrhagic stroke\n* Spastic paresis of at least one limb\n* At least 3 months of poststroke rehabilitation in the past\n* No improvement of spasticity\u002Fmotor function for at least 3 months\n\nExclusion Criteria:\n\n* Seizures after the stroke\n* Depression\n* Severe sensory deficits\n* Anosognosia\n* Moderate to severe hemispatial neglect\n* Others contraindications for the DBS procedure, e.g. coagulopathy, decompensated chronic disease, etc.\n* Contraindication for MRI\n* No poststroke rehabilitation","ALL","18 Years",{"count":18,"type":19},12,"ESTIMATED","INTERVENTIONAL",[22],"NA","The aim of this clinical trial is to determine whether deep brain stimulation (DBS) interventions improve rehabilitation and functional recovery in patients with post-stroke spasticity who meet the other inclusion criteria listed below.\n\nPrimary question(s) to be answered:\n\nIs DBS stimulation effective in treating post-stroke spasticity? What stimulation frequency is most effective in treating post-stroke spasticity?\n\nStudy participants will:\n\n* Undergo surgery to implant a DBS electrode targeting the DRTt (dentate-rubro-thalamic tract ) in close proximity of the dentate nucleus of the cerebellum ipsilateral to the spastic side of the body.\n* Each patient will then receive an initial stimulation frequency of 130 Hz (arm 1) and will be assigned to a 4- to 6-week rehabilitation program. After this period, the participant will return for a follow-up visit for a clinical evaluation.\n* The frequency will then be changed to 70Hz (arm 2). Patients who have undergone this change will also undergo a rehabilitation period of 4 to 6 weeks. After this period, they will return to the Clinic for a follow-up evaluation.\n* The frequency will then be changed to 30Hz (arm 3). Patients who have undergone this change will also undergo a rehabilitation period of 4 to 6 weeks.\n\nResearchers will compare the results obtained from patients in each arm to determine the clinical effects of stimulation and whether they are dependent on the stimulation frequency.",[25,26],"Post Stroke Spasticity","Dystonia",[28,29,30,31,32,33],"dentate nucleus","DRTt","dentate-rubro-thalamic tract","deep brain stimulation","post-stroke spasticity","rehabilitation","RECRUITING","2025-09-23",{"date":37,"type":38},"2025-09-24","ACTUAL",{"date":40,"type":38},"2024-09-01",{"date":42,"type":19},"2028-12-30",{"name":44,"class":45},"Jan Biziel University Hospital No 2 in Bydgoszcz","OTHER",""]