[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Jan Kochanowski University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":83},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":5},"100641833","genetic-microbiological-and-behavioral-factors-in-obesity-100641833",false,"NCT07650149","Genetic, Microbiological and Behavioral Factors in Obesity","OPTIMIZE GEN - Outcomes of Persistence and Treatment With tIrzepatide deterMined by Genetic, mIcrobiological & bEhavioral Factors in obEsity","OPTIMIZE-GEN","Inclusion criteria\n\n* Age 18-60 years\n* Consent to participate in the study and providing informed written consent\n* Overweight or obese with a BMI \\>27\n\nExclusion criteria\n\n* Contraindications to tirzepatide use:\n* Type 1 or type 2 diabetes\n* Pregnancy or breastfeeding\n* Cancer\n* Heart failure\n* Expected lack of patient compliance\n* Taking immunosuppressive medications, steroids, NSAIDs, antibiotics (within 2 weeks prior to sample collection),\n* Autoimmune and inflammatory diseases, acute infectious diseases, AIDS, tuberculosis\n* Mental illness\n* Alcohol dependence syndrome\n* Liver cirrhosis\n* Post-myocardial infarction or stroke","ALL","18 Years","60 Years",{"count":21,"type":22},200,"ESTIMATED","OBSERVATIONAL","This study will assess the impact of genetic markers, microbiological (microbiome) and behavioral factors on tolerance, adherence and effectiveness of dual GLP1\u002FGIP RA in the treatment of obesity.\n\n200 consecutive patients who meet all inclusion and none of the exclusion criteria will be enrolled.",[26,27,28],"Obesity & Overweight","Obesity","Genetics",[30,31,32,33,34,35,36],"tirzepatide","obesity","genetics","microbiom","adherence","compliance","gene","RECRUITING","2026-06-15",{"date":40,"type":41},"2026-06-16","ACTUAL",{"date":43,"type":41},"2026-05-23",{"date":45,"type":22},"2028-05",{"name":47,"class":48},"Jan Kochanowski University","OTHER",{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":59,"conditions":60,"keywords":67,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},"100578786","prevention-of-postoperative-hernias-in-emergency-surgery-100578786","NCT06815822","Prevention of Postoperative Hernias in Emergency Surgery","PROPHECY","Inclusion criteria:\n\n* Patient age \\> 18 years.\n* Emergency or urgent surgery.\n* Specific surgical indications (acute appendicitis, acute cholecystitis, incarcerated hernia, gastrointestinal perforation, and obstruction).\n\nExclusion criteria:\n\n* Lack of patient consent.\n* Open abdomen technique applied.","100 Years",{"count":58,"type":22},500,"The aim of this observational study is to understand the risk factors and incidence of postoperative hernias among patients undergoing emergency surgery. The main question it aims to answer is:\n\nWhat is the incidence of postoperative hernias in this group of patients?\n\nA brief telephone interview will be conducted with participants who will be included in this study one year after the surgery. If the presence of a postoperative hernia is suspected, the patient will be invited to a follow-up visit to the surgical clinic, where the diagnosis will be confirmed by imaging tests.",[61,62,63,64,65,66],"Incarcerated Hernia","Appendicitis Acute","Cholecystitis, Acute","Ileus","Perforated Gastro-duodenal Ulcers","Perforated Bowel",[68,69,70,71,72,73],"postoperative hernia","trocar site hernia","parastomal hernia","incisional hernia","outcomes","emergency surgery","2025-06-12",{"date":76,"type":41},"2025-06-15",{"date":78,"type":41},"2025-06-01",{"date":80,"type":22},"2026-12-31",{"name":47,"class":48},1,""]