[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Jason Sperry\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":103},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100512891","phase-2-calcium-and-vasopressin-following-injury-early-resuscitation-cavalier-trial-100512891",false,"NCT05958342","CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial","CAVALIER","Inclusion Criteria:\n\nPrehospital Phase:\n\nInjured patients at risk of hemorrhagic shock being transported from scene or referral hospital to a participating CAVALIER trial site who meet the following criteria:\n\n1A. Systolic blood pressure ≤ 90mmHg and tachycardia (HR ≥ 108) at scene, at outside hospital, or during anticipated transport to a participating CAVALIER trial site\n\nOR\n\n1B. Systolic blood pressure ≤ 70mmHg at scene, at outside hospital, or during anticipated transport to a participating CAVALIER trial site\n\nEarly In-Hospital Phase:\n\nInjured patients at a participating CAVALIER trial site at risk of hemorrhagic shock who meet the following criteria:\n\n1A. Systolic blood pressure ≤ 90mmHg and tachycardia (HR ≥ 108) at scene, at outside hospital, during transport, or in emergency department of a participating CAVALIER trial site\n\nOR\n\n1B. Systolic blood pressure ≤ 70mmHg at scene, at outside hospital, during transport, or in emergency department of a participating CAVALIER trial site\n\nAND\n\n2.Blood\u002Fblood component transfusion initiated in prehospital setting or deemed clinically indicated within 60 minutes of arrival at the enrolling trauma center\n\nAND 3. Clinical team deems Operating Room for major hemorrhage control procedure (e.g., laparotomy, thoracotomy, vascular exploration or extremity amputation) indicated within 60 minutes of arrival at the enrolling trauma center\n\nAND\n\n4\\. Anticipated admission to intensive care unit (ICU)\n\nExclusion Criteria:\n\nPrehospital Phase\n\n1. Wearing NO CAVALIER opt-out bracelet\n2. Age \\> 90 or \\\u003C 18 years of age\n3. Isolated fall from standing injury mechanism\n4. Known prisoner\n5. Known pregnancy\n6. Traumatic arrest with \\> 5 minutes of CPR without return of vital signs\n7. Brain matter exposed or penetrating brain injury\n8. Isolated drowning or hanging victims\n9. Objection to study voiced by subject or family member at the scene or at the trauma center\n10. Inability to obtain IV\u002FIO access\n\nEarly In-Hospital Phase:\n\n1. Wearing NO CAVALIER opt-out bracelet\n2. Age \\> 90 or \\\u003C 18 years of age\n3. Isolated fall from standing injury mechanism\n4. Known prisoner\n5. Known pregnancy\n6. Traumatic arrest with \\> 5 minutes of CPR without return of vital signs\n7. Brain matter exposed or penetrating brain injury\n8. Isolated drowning or hanging victims\n9. Objection to study voiced by subject or family member at the scene or at the trauma center\n10. Inability to obtain IV access","ALL","18 Years","90 Years",{"count":20,"type":21},1050,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","The CAlcium and VAsopressin following Injury Early Resuscitation (CAVALIER) Trial is a proposed 4 year, double-blind, mutli-center, prehospital and early in hospital phase randomized trial designed to determine the efficacy and safety of prehospital calcium and early in hospital vasopressin in patients at risk of hemorrhagic shock.",[27,28],"Trauma","Hemorrhage",[30,31,32,33],"hemorrhagic shock","trauma","calcium gluconate","vasopressin","RECRUITING","2026-06-01",{"date":37,"type":38},"2026-06-03","ACTUAL",{"date":40,"type":38},"2024-06-30",{"date":42,"type":21},"2028-03",{"name":44,"class":45},"Jason Sperry","OTHER",15,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},"100609316","phase-3-plasma-resuscitation-early-for-evaluating-volume-and-endotheliopathy-of-thermal-injury-preevent-trial-100609316","NCT07212998","Plasma Resuscitation Early for Evaluating Volume and Endotheliopathy of Thermal Injury (PREEVEnT) Trial","PREEVEnT","Inclusion Criteria:\n\n* Estimated ≥ 20% Total Body Surface Area burn\u002Fthermal injury with 2nd or 3rd degree depth\n* Anticipated admission to burn ICU\n\nExclusion Criteria:\n\n* Estimated rBaux score \\\u003C55\n* Not expected to survive \\>24 hours\n* Wearing NO PREEVENT opt-out bracelet\n* Age \\> 75 or \\\u003C 18 years of age\n* Concomitant traumatic injury with hemorrhagic shock\n* Isolated chemical burn\u002Finjury\n* Isolated deep electrical burn\u002Finjury\n* Known prisoner\n* Known pregnancy\n* Cardiac arrest with \\> 5 continuous minutes of CPR\n* Concern for anoxic injury\u002F fixed pupils bilaterally\n* Objection to study voiced by subject or family member at the scene or at the emergency department\u002Fburn center","75 Years",{"count":56,"type":21},750,[58],"PHASE3","The Plasma Resuscitation Early for Evaluating Volume and Endotheliopathy of Thermal Injury (PREEVEnT) trial will be a 6-year (4-year enrollment), open label, phase-3, multi-center, early in-hospital phase randomized trial utilizing burn centers from within the LITES network and will enroll approximately 750 injured adult patients who have suffered large 2nd or 3rd degree thermal burns on at least 20% of their body surface requiring burn resusciation. The objective is to determine if initiating plasma resuscitation as soon as possible upon arrival to an emergency department or burn unit is the most effective resuscitation for those who have experienced large thermal burns and significantly reduces the morbidity and mortality attributable to post-injury complications as compared to standard in-hospital resuscitation practice.",[61,62],"Burn Injury","Thermal Burn",[64,65],"burn","plasma resuscitation","NOT_YET_RECRUITING","2026-05-01",{"date":69,"type":38},"2026-05-04",{"date":71,"type":21},"2026-06",{"date":73,"type":21},"2030-05",{"name":44,"class":45},1,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},"100472875","phase-3-prehospital-analgesia-intervention-trial-pain-100472875","NCT05437575","Prehospital Analgesia INtervention Trial (PAIN)","PAIN","Inclusion Criteria:\n\n* Transport after injury to a participating PAIN Trauma center\n* 2\\. Patient with compensated shock as defined by Shock Index (SI) ≥0.9 or Heart Rate (HR) ≥115.\n* Intravenous pain medication indicated (CPOT≥2, NRS≥5) prior to arrival at the trauma center\n\nExclusion Criteria:\n\n* No IV access\n* Age \\\u003C18 years\n* Females \\\u003C50 years of age\n* SBP\\>180 mmHg at time of enrollment\n* Advanced airway management prior to first dose administration\n* Known allergy to fentanyl citrate or ketamine hydrochloride\n* Known prisoner\n* Objection to study voiced by subject or family member at scene\n* Pain treatment contraindicated by local protocol\n* Wearing a \"NO PAIN STUDY\" bracelet",{"count":84,"type":21},994,[58],"The Prehospital Analgesia INtervention trial (PAIN) is a proposed 4 year (3-year enrollment) multicenter, prehospital, randomized, double-blind, clinical trial that will enroll approximately 994 patients at select LITES Network sites. The objective is to perform a prospective, interventional, randomized trial among prehospital trauma patients with compensated shock (SI≥0.9 or HR ≥115) and an indication for pain management, comparing patient centered outcomes following prehospital administration of ketamine hydrochloride versus fentanyl citrate.",[88],"Traumatic Injury",[27,90,91,92,93],"ketamine hydrochloride","fentanyl citrate","shock","pain","2026-03-05",{"date":96,"type":38},"2026-03-09",{"date":98,"type":38},"2023-11-27",{"date":100,"type":21},"2029-07",{"name":44,"class":45},11,""]