[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Jasper A. Smits\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":69},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100475189","co2-reactivity-as-a-biomarker-of-non-response-to-exposure-based-therapy-100475189",false,"NCT05467683","CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy","Carbon Dioxide (CO2) Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy","Inclusion Criteria:\n\n* A primary DSM-5 diagnosis of panic disorder (with or without an agoraphobia diagnosis), social anxiety disorder, generalized anxiety disorder, obsessive-compulsive disorder, or post-traumatic stress disorder as assessed by the Structured Clinical Interview for the DSM-5 (SCID-5)\n* A score of 8 or greater on the Overall Anxiety Severity and Impairment Scale (OASIS)\n* Ages 18 to 70\n* Willingness and ability to provide informed consent and comply with the requirements of the study protocol.\n* Proficiency in English (because assessment instruments have only been validated in English)\n\nExclusion Criteria:\n\n* A lifetime history of bipolar or psychotic disorders, substance use disorders (other than nicotine) or eating disorder in the past 6 months; serious cognitive impairment.\n* Active suicidal ideation with at least some intent to act with or without specific plan (a rating of 4 for suicidal ideation on the Columbia-Suicide Severity Rating Scale) or suicidal behaviors (actual attempt, interrupted attempt, aborted or self-interrupted attempt, or preparatory acts or behavior) within the past 6 months.\n* Medical conditions contraindicating CO2 inhalation or hyperventilation challenge (e.g., cardiac arrhythmia, cardiac failure, asthma, lung fibrosis, high blood pressure, epilepsy, or stroke).\n* Pregnancy or lactation\n* Ongoing psychotherapy directed toward the primary disorder.\n* Pharmacological treatment started within 8 weeks prior to the screen (patients \"stable\" on their medication regimen will be included and their medication status will be included as a variable in the model)","ALL","18 Years","70 Years",{"count":20,"type":21},600,"ESTIMATED","INTERVENTIONAL",[24],"NA","Anxiety-, obsessive-compulsive and trauma- and stressor-related disorders reflect a significant public health problem. This study is designed to evaluate the predictive power of a novel biomarker based on a CO2 challenge, thus addressing the central question \"can this easy-to-administer assay aid clinicians in deciding whether or not to initiate exposure-based therapy?\"",[27,28,29,30,31],"Obsessive-Compulsive Disorder","Post Traumatic Stress Disorder","Generalized Anxiety Disorder","Social Anxiety Disorder","Panic Disorder","RECRUITING","2026-06-08",{"date":35,"type":36},"2026-06-10","ACTUAL",{"date":38,"type":36},"2022-11-02",{"date":40,"type":21},"2027-02-28",{"name":42,"class":43},"Jasper A. Smits","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":68},"100520207","phase-3-community-based-smoking-cessation-treatment-for-adults-with-high-stress-sensitivity-100520207","NCT06053567","Community-based Smoking Cessation Treatment for Adults With High Stress Sensitivity.","Efficacy and Implementation of Exercise-based Smoking Cessation Treatment for Adults With High Anxiety Sensitivity.","STEP3","Inclusion Criteria:\n\n* Adult (age ≥ 18);\n* High Anxiety Sensitivity (≥5 on the Short Scale Anxiety Sensitivity Index \\[SSASI\\]);\n* Daily smoker, ≥5 cigarettes (including e-cigarettes, little cigars\u002Fcigarillos) for ≥1 year;\n* Motivated to quit smoking as evidenced by a score of ≥5 on a 0-10 Likert scale;\n* Body mass index \\\u003C 40;\n* Medical clearance to participate.\n* Located near a participating YMCA site (within 50 miles)\n\nExclusion Criteria:\n\n* Regular exercise defined as engaging in vigorous-intensity exercise for at least 75 minutes per week for the last 3 months\n* Receiving current intervention for smoking cessation.\n* Outstanding debt to the YMCA\n* Listed as a sex offender on the National Sex Offender Registry",true,{"count":54,"type":21},360,[56],"PHASE3","Anxiety sensitivity, reflecting the fear of bodily sensations, is a risk factor for the maintenance and relapse of smoking. This study is designed to address the question - is a smoking cessation intervention personalized to high anxiety sensitive smokers and adapted for implementation by the YMCA effective among racially\u002Fethnically diverse samples?",[59],"Nicotine Dependence","2026-05-12",{"date":62,"type":36},"2026-05-15",{"date":64,"type":36},"2023-12-27",{"date":66,"type":21},"2029-06-30",{"name":42,"class":43},1,""]