[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Jeremy Meyer\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":76},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100580576","phase-3-prophylactic-pipac-in-patients-with-high-risk-colorectal-cancer-100580576",false,"NCT06839092","Prophylactic PIPAC in Patients With High-risk Colorectal Cancer","Prophylactic PIPAC for Reducing the Risk of Peritoneal Carcinomatosis in Patients With Colorectal Cancer: the PROPAC Randomized Clinical Trial","PROPAC","Inclusion criteria:\n\n* Patients operated (in emergency or elective settings) for colorectal cancer (of the colon, colorectal junction or high rectum).\n* Definitive pathological stage pT4 pN0-2 cM0 pMMR and\u002For pT3-4 pN0-2 cM0 pMMR with positive cytology and\u002For pT3-4 pN0-2 M1c pMMR with limited peritoneal carcinomatosis which is limited to one abdominal quadrant and was resected during index surgery and no other distant lesion (small indeterminate pulmonary nodules to be followed are accepted)\n* Performance status 0-1.\n* Age \\> 18 years.\n* Written informed consent.\n\nExclusion criteria:\n\n* Infraperitoneal rectal cancer (middle or low rectum).\n* Age \\\u003C18 year old.\n* Age \\> 80 year old.\n* Hereditary colorectal cancer.\n* dMMR\u002FMSI colorectal cancer.\n* Inflammatory bowel disease.\n* Distant metastasis (outside limited peritoneal carcinomatosis which is limited to one abdominal quadrant and was resected during index surgery and no other distant lesion; small indeterminate pulmonary nodules to be followed are accepted)\n* Neo-adjuvant treatment.\n* Pregnancy or lactation.\n* Immunosuppression.\n* Unable to provide informed consent.\n* Previous cytoreductive surgery (CRS) (outside limited resection of peritoneal carcinomatosis during index surgery).\n* Contraindication to laparoscopy (e.g. severe adhesions, peritonitis).\n* Contraindication to and\u002For no adjuvant chemotherapy.\n* History of allergic reaction to oxaliplatin or other platinum-containing compounds.\n* Renal impairment, defined as GFR \\\u003C 50 ml\u002Fmin, (Cockcroft-Gault equation).\n* Myocardial insufficiency, defined as NYHA class \\> 2.\n* Impaired liver function defined as bilirubin ≥ 1.5 x UNL (upper normal limit).\n* Inadequate hematological function defined as ANC ≤ 1.5 x 109\u002Fl and platelets ≤ 100 x 109\u002Fl.","ALL","18 Years",{"count":20,"type":21},160,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","In a multicentric randomized controlled trial, we will compare standard surgery (consisting in removal of the primary cancer) followed by 6 months of adjuvant chemotherapy associated with 3 cycles of oxaliplatin-based PIPAC (4-6 weeks apart), to standard surgery followed by 6 months of adjuvant systemic chemotherapy (routine treatment), in patients with colorectal cancer at high risk for metachronous peritoneal carcinomatosis (pT4 pN0-2 cM0 pMMR colorectal cancer of the colon, colorectal junction or high rectum and\u002For with positive cytology) in terms of 1-year and 3-year peritoneal metastasis-free survival (as measured by imaging and\u002For surgical exploration), 1-year and 3-year disease-free survival, as well as 1-year and 3-year overall survival. In terms of outcomes measurement, patients in both groups will benefit from diagnostic laparoscopy at 6 months from the index surgery, and standard surveillance consisting in clinical examination, CEA determination and thoraco-abdominal CT at 6, 12, 24, 36, 48 and 60 months after index surgery.",[27,28,29,30],"Colorectal Cancer Control and Prevention","Colorectal Cancer","Colorectal Cancer Stage II","Colorectal Cancer Stage III",[32,33,34,35],"Colorectal cancer","Peritoneal carcinomatosis","PIPAC","Pressurized intraperitoneal aerosol chemotherapy","NOT_YET_RECRUITING","2025-07-27",{"date":39,"type":40},"2025-07-30","ACTUAL",{"date":42,"type":21},"2026-01",{"date":44,"type":21},"2034-01",{"name":46,"class":47},"Jeremy Meyer","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100521286","robotic-right-hemicolectomy-versus-laparoscopic-right-hemicolectomy-100521286","NCT06067620","Robotic Right Hemicolectomy Versus Laparoscopic Right Hemicolectomy","Robotic Right Hemicolectomy With Intracorporeal Anastomosis Versus Laparoscopic Right Hemicolectomy With Extracorporeal Anastomosis (PRORHEM): a Randomized Controlled Trial","PRORHEM","Inclusion Criteria:\n\n* Adult patients requiring elective minimally invasive RHC for cT1-T3 Nx M0 cancer of the right colon (including cancer of the appendix, caecum, ascending colon and hepatic flexure).\n\nExclusion Criteria:\n\n* Not scheduled for minimally invasive RHC (refuses surgery and\u002For planned open approach)\n* Emergency surgery\n* Hereditary colorectal cancer\n* Inflammatory bowel disease\n* Synchronous resection of (an)other organ(s)\n* Synchronous surgical procedure (including more extended resection of the lower gastrointestinal tract)\n* cT4\n* cM+\n* History of laparotomy\n* Pregnancy\n* No anastomosis planned\n* Unable to provide informed consent\n* No informed consent",{"count":57,"type":21},70,[59],"NA","Robotic right hemicolectomy with intra-corporeal anastomosis may have better short-term recovery outcomes and decreased incidence of incisional hernia when compared to the laparoscopic actual standard of care, for similar safety outcomes.",[62,63,64,28,65,66,67],"Colorectal Neoplasms","Colorectal Neoplasms Malignant","Colorectal Neoplasms, Benign","Colorectal Polyp","Colorectal Adenoma","Colorectal Adenocarcinoma","2024-05-09",{"date":70,"type":40},"2024-05-10",{"date":72,"type":21},"2024-08-01",{"date":74,"type":21},"2026-12-31",{"name":46,"class":47},""]