[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Jiangsu Taizhou People's Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":221},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,41,69,91,114,134,156,182,199],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":36,"leadSponsor":38,"locationsCount":4},"100645220","llm-assisted-diabetes-and-hypertension-management-by-village-doctors-100645220",false,"NCT07678658","LLM-Assisted Diabetes and Hypertension Management by Village Doctors","Large Language Model-Assisted Decision Support for Improving Village Doctors' Integrated Management of Patients With Type 2 Diabetes and Hypertension: A Randomized Controlled Study","Inclusion Criteria:\n\n1. Certified village doctors or primary care physicians practicing in rural primary healthcare institutions;\n2. At least 1 year of experience in the management of chronic diseases, including type 2 diabetes mellitus and hypertension;\n3. Able to complete the case assessment tasks required by the study;\n4. Willing to participate in the study and provide informed consent.\n\nExclusion Criteria:\n\nNone.",true,"ALL","18 Years","80 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"NA","This is a prospective, assessor-blinded, randomized controlled study designed to evaluate whether large language model (LLM)-assisted decision support can improve village doctors' abilities in the comprehensive management of patients with type 2 diabetes mellitus and hypertension.\n\nFor each standardized clinical case, two village doctors will independently review the same patient information and develop management plans. An independent statistician will randomly assign one doctor to receive LLM-assisted decision support, while the other will complete the assessment without assistance. All management plans and questionnaire responses will be de-identified and evaluated by an independent expert panel blinded to group allocation. The study will compare the quality of clinical decision-making, risk assessment, treatment recommendations, and follow-up planning between the LLM-assisted and control groups.",[28,29],"Type 2 Diabetes Mellitus","Hypertension","NOT_YET_RECRUITING","2026-06-25",{"date":33,"type":34},"2026-07-01","ACTUAL",{"date":33,"type":22},{"date":37,"type":22},"2026-07-14",{"name":39,"class":40},"Jiangsu Taizhou People's Hospital","OTHER",{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":17,"minAge":48,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":23,"phases":51,"briefSummary":52,"conditions":53,"keywords":56,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":68},"100635557","auricular-acupuncture-therapy-administered-by-village-doctors-improves-sleep-quality-in-elderly-patients-with-comorbid-diabetes-mellitus-and-hypertension-100635557","NCT07554235","Auricular Acupuncture Therapy Administered by Village Doctors Improves Sleep Quality in Elderly Patients With Comorbid Diabetes Mellitus and Hypertension","Auricular Acupuncture Therapy Administered by Village Doctors Improves Sleep Quality in Elderly Patients With Comorbid Diabetes and Hypertension","Inclusion Criteria:\n\n1. Age ≥65 years;\n2. Patients with comorbid diabetes mellitus and hypertension:\n3. Sleep disturbance: Pittsburgh Sleep Quality Index (PSQI) total score ≥8;\n4. Willing to participate in this study and sign the informed consent form;\n5. Has resided in this village for at least six months.\n\nExclusion Criteria:\n\n1. Stroke;\n2. Severe mental illness or cognitive impairment;\n3. Severe organ failure (e.g., end-stage renal disease);\n4. Ear infection, eczema, breakage, or deformity;\n5. Currently receiving regular other acupuncture treatments;\n6. Use of any hypnotic medications within the past month\n7. Bleeding disorders or use of anticoagulants (increased bleeding risk);\n8. History of fainting during acupuncture;\n9. Life expectancy less than six months.","65 Years",{"count":50,"type":22},320,[25],"This study aims to apply traditional auricular press-needle acupuncture to treat sleep disturbances in elderly patients (aged ≥65 years) with comorbid diabetes mellitus and hypertension in rural areas of China. Given the complex bidirectional relationship between diabetes mellitus with hypertension and sleep disturbances, this cluster randomized trial is designed to test whether a village doctor-led intervention model supported by telemedicine can improve sleep disturbances in patients with comorbid diabetes mellitus and hypertension, compared to sham auricular press-needle acupuncture. Participants will be recruited by local village doctors according to the inclusion and exclusion criteria. The protocol is based on Traditional Chinese Medicine theory for core point selection: Heart, Liver, Kidney, Shenmen, and Forehead area, along with optimized medication regimens supported by remote cardiovascular specialists. The investigators will evaluate the overall improvement in sleep disturbances using the Pittsburgh Sleep Quality Index (PSQI) at the end of the 6-week treatment period, and assess sleep disturbances, anxiety, depression, daytime sleepiness, and fatigue at 12 weeks.",[54,55,29],"Insomnia Disorder","Diabetes",[57,58,29,55,59],"Village Doctors","Acupuncture needles","insomnia","RECRUITING",{"date":62,"type":34},"2026-06-29",{"date":64,"type":34},"2026-04-22",{"date":66,"type":22},"2027-02-20",{"name":39,"class":40},1,{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":76,"enrollmentInfo":77,"targetDuration":4,"studyType":23,"phases":79,"briefSummary":80,"conditions":81,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":68},"100642618","transcranial-focused-ultrasound-neuromodulation-for-post-stroke-motor-dysfunction-100642618","NCT07637825","Transcranial Focused Ultrasound Neuromodulation for Post-Stroke Motor Dysfunction","Transcranial Focused Ultrasound Neuromodulation in Post-Stroke Motor Dysfunction","Inclusion Criteria:\n\n* (1) Patients with a confirmed imaging diagnosis of first-ever ischemic stroke; (2) Unilateral limb motor involvement; (3) Modified Ashworth Scale (MAS) grade ≤3 for the upper extremity, Brunnstrom stage II-V, and upper extremity Fugl-Meyer Assessment (FMA-UE) score between 15 and 60 (inclusive); (4) Age 18-75 years, onset within 21 days to 6 months, in the subacute or recovery phase; (5) Stable vital signs, no consciousness impairment, informed consent provided, ability to cooperate with clinical assessments, and approval obtained from the institutional ethics committee.\n\nExclusion Criteria:\n\n* (1) Contraindications to MRI; (2) Infarction involving the thalamus; (3) Risk of intracranial hemorrhage; (4) Presence of intracranial metallic foreign bodies, cardiac pacemakers, or cochlear implants; (5) Unstable medical condition, severe cognitive impairment or psychiatric disorders rendering the patient unable to comprehend the study or cooperate with assessments; (6) Conditions affecting limb motor function, including fractures, joint contractures, or severe limb spasticity; (7) Current use of medications that alter cortical excitability.","75 Years",{"count":78,"type":22},60,[25],"This study aims to evaluate how transcranial focused ultrasound (tFUS) technology can promote neural network remodeling and functional recovery after stroke. By integrating signals from electroencephalography (EEG) and magnetic resonance imaging (MRI), the study will investigate how activating or inhibiting specific brain regions affects motor and cognitive recovery. The goal is to improve patients' motor and cognitive functions, reduce long-term disability, and enhance quality of life. The study also seeks to optimize stimulation parameters to maximize rehabilitation outcomes and explore the mechanisms underlying neuroprotection and functional reconstruction after stroke.\n\nThis is a case-control study involving a total of 60 participants. Participants will be ischemic stroke survivors aged 18-75 years, with first-ever stroke onset between 21 days and 6 months, stable vital signs, no consciousness disorders, and the ability to provide informed consent and cooperate with assessments. Eligible participants must have unilateral limb motor impairment, with an upper extremity modified Ashworth score ≤3, Brunnstrom stage II-V, and an upper extremity Fugl-Meyer Assessment (FMA-UE) score between 15 and 60.\n\nParticipants will be assigned to either a neuromodulation group (receiving multi-modal neuromodulation targeting specific brain regions) or a control group (receiving sham stimulation or conventional treatment). Primary outcome measures include changes in FMA-UE scores, neuroimaging data (CT\u002FMRI), EEG measurements (resting-state and task-state spectral power, functional connectivity), and laboratory markers (complete blood count, CRP, IL-6, S100β, BDNF). Secondary outcome measures include Brunnstrom stage, Ashworth grade, muscle strength, and patient comfort ratings. Safety will be monitored through blood routine tests, blood biochemistry, and coagulation function.\n\nStatistical analysis will compare key indicator changes between the neuromodulation and control groups before and after intervention. Independent t-tests (for two groups) or ANOVA (for multiple groups) will be used to assess between-group differences, with non-parametric tests applied for data not following a normal distribution.",[82],"Ischemic Stroke","2026-06-05",{"date":85,"type":34},"2026-06-10",{"date":87,"type":22},"2026-06",{"date":89,"type":22},"2028-03-31",{"name":39,"class":40},{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":95,"acronym":4,"eligibilityCriteria":96,"healthyVolunteers":11,"sex":17,"minAge":48,"maxAge":19,"enrollmentInfo":97,"targetDuration":4,"studyType":99,"phases":4,"briefSummary":100,"conditions":101,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":68},"100640360","construction-of-a-cohort-of-elderly-patients-with-atrial-fibrillation-in-rural-china-100640360","NCT07611084","Construction of a Cohort of Elderly Patients With Atrial Fibrillation in Rural China","Inclusion Criteria:\n\n1. Permanent residents with local household registration in rural China.\n2. Aged 65-80 years.\n3. Electrocardiogram confirmation of AF or possession of a diagnostic certificate for AF issued by a specialist.\n4. Willing to participate in HF screening.\n5. Ability to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n1. Expected life expectancy of less than 3 months.\n2. Severe renal insufficiency (Ccr \\\u003C 30ml\u002Fmin) or ongoing dialysis treatment.\n3. Cardiac insufficiency secondary to correctable causes, including hyperthyroid heart disease, anemic heart disease, or uncorrected congenital heart disease.\n4. Indications for pacemaker implantation without having undergone implantation.\n5. Chronic obstructive pulmonary disease complicated by type II respiratory failure.\n6. Special populations, including patients with mental illnesses.",{"count":98,"type":22},2500,"OBSERVATIONAL","Atrial fibrillation (AF) is a common arrhythmia in aging populations and is strongly associated with an increased risk of heart failure (HF) and adverse cardiovascular outcomes. However, early detection of HF among patients with AF remain inadequate in rural settings. This study aims to screen for HF among older adults with AF in rural China and to conduct long-term follow-up in order to observe the disease progression in patients with AF.\n\nThis study will recruit at least 2,500 elderly individuals aged between 65 and 80 years, with confirmed diagnoses of AF, residing in rural areas. Participants will undergo HF screening using NT-proBNP testing and echocardiographic assessment. Additionally, data will be collected on electrocardiographic signals, seismocardiography, voice, and demographic characteristics. Following data collection, participants will be followed up every three months to monitor the incidence and progression of HF as well as the occurrence of adverse cardiovascular events.",[102,103,104,105],"Atrial Fibrillation (AF)","Heart Failure","Screening","Progression","2026-05-22",{"date":108,"type":34},"2026-05-28",{"date":110,"type":34},"2026-03-14",{"date":112,"type":22},"2029-12-31",{"name":39,"class":40},{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":118,"acronym":119,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":121,"targetDuration":4,"studyType":23,"phases":123,"briefSummary":124,"conditions":125,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":68},"100513086","cohort-study-of-chronic-heart-failure-100513086","NCT05960890","Cohort Study of Chronic Heart Failure","CHF","Inclusion Criteria:\n\n1. Age ≥18 years;\n2. Fulfill at least one of the following criteria：①History of chronic heart failure;②New-onset heart failure with LVEF \\\u003C50%；③New-onset heart failure with LVEF≧50%，E\u002Fe'≧15 and BNP\\>400 pg\u002FmL\u002FNT-proBNP(\\\u003C50 years, \\>450 pg\u002FmL; 50\\~75 years, \\>900 pg\u002FmL; \\>75 years, \\>1800 pg\u002FmL)\n3. Etiology: dilated cardiomyopathy, hypertensive heart disease, ischaemic cardiomyopathy, Non-severe valvular heart disease；\n4. Primary post-discharge therapy: oral medication;\n5. Sign the informed consent form.\n\nExclusion Criteria:\n\n1. Patients with renal failure (Ccr\\\u003C30ml\u002Fmin) or patients on dialysis therapy;\n2. Various correctable secondary causes of cardiac insufficiency including hyperthyroid heart disease, anaemic heart disease, uncorrected congenital heart disease; severe valvular heart disease (including severe stenosis or closure of organic aortic and mitral valves);\n3. Patients with indications for pacemaker implantation but have not received a pacemaker implant;\n4. Patients with chronic obstructive pulmonary disease accompanied by type II respiratory failure.\n5. Patients who cannot understand and sign an informed consent form.\n6. Patients with mental illness, pregnant women, and other special populations.",{"count":122,"type":22},1000,[25],"The goal of this observational study is to learn about the influencing factors of chronic heart failure prognosis in heart failure patients. The main question it aims to answer is that what are the influencing factors of clinical outcomes in chronic heart failure. Participants will be collected multiple omics data such as phenotype group, environmental exposure group, intestinal microbiome, genome, metabolome, and noninvasive biomarkers.",[103],"2026-05-18",{"date":128,"type":34},"2026-05-20",{"date":130,"type":34},"2023-06-08",{"date":132,"type":22},"2028-12",{"name":39,"class":40},{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":141,"targetDuration":4,"studyType":99,"phases":4,"briefSummary":143,"conditions":144,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":68},"100633865","survey-of-knowledge-practice-and-recommendation-behaviors-regarding-healthy-lifestyles-among-healthcare-workers-100633865","NCT07532239","Survey of Knowledge, Practice, and Recommendation Behaviors Regarding Healthy Lifestyles Among Healthcare Workers","Investigation of Healthy Lifestyle Knowledge, Practice, and Recommendation Behaviors Among Healthcare Workers Across Different Levels of Healthcare Institutions","Inclusion Criteria:\n\n* Healthcare workers employed at participating healthcare institutions\n\nExclusion Criteria:\n\n* Individuals unwilling or unable to provide informed consent",{"count":142,"type":22},150,"This cross-sectional observational study aims to assess healthy lifestyle knowledge, personal health practices, and lifestyle recommendation behaviors among healthcare workers across different levels of healthcare institutions. The study will also collect clinical examination and biochemical indicators to evaluate the health status of participants and explore their associations with lifestyle-related knowledge and behaviors.\n\nHealthcare workers play a critical role in promoting healthy lifestyles among patients; however, their own health behaviors and recommendations may vary depending on training background and institutional settings. This study seeks to better understand these differences and identify potential gaps between knowledge and practice.\n\nThe findings of this study may help inform targeted training strategies and support the development of effective health promotion programs for healthcare professionals, ultimately improving the quality of lifestyle guidance provided to patients.",[145,146,147],"Healthy Lifestyle","Health Knowledge","Health Behavior","2026-04-08",{"date":150,"type":34},"2026-04-15",{"date":152,"type":22},"2026-04-10",{"date":154,"type":22},"2026-04-20",{"name":39,"class":40},{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":4,"eligibilityCriteria":162,"healthyVolunteers":11,"sex":17,"minAge":48,"maxAge":19,"enrollmentInfo":163,"targetDuration":4,"studyType":23,"phases":165,"briefSummary":166,"conditions":167,"keywords":169,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":175,"startDateStruct":177,"completionDateStruct":179,"leadSponsor":181,"locationsCount":4},"100630809","telemedicine-based-integrated-care-for-heart-failure-prevention-in-older-patients-with-atrial-fibrillation-miracle-af-iii-100630809","NCT07492498","Telemedicine-Based Integrated Care for Heart Failure Prevention in Older Patients With Atrial Fibrillation (MIRACLE-AF III)","Prevention of Incident Heart Failure With a Telemedicine-based Integrated Care Model Among Older Atrial Fibrillation Patients in Rural China: the MIRACLE-AF-Prevention Cluster Randomized Trial","Inclusion Criteria:\n\n1. Permanent residents with household registration in primary care jurisdictions of Jiangsu Province, aged 65 to 80 years;\n2. Availability of an electrocardiogram confirming atrial fibrillation, or an official diagnosis certificate of atrial fibrillation issued by a specialist;\n3. Receiving healthcare management from the primary medical institution nearest to the place of residence;\n4. Capable of understanding and signing the informed consent form.\n\nExclusion Criteria:\n\n1. A definite history of heart failure, or a confirmed diagnosis of cardiac dysfunction via echocardiography and\u002For NT-proBNP screening. Diagnostic criteria: Presence of typical heart failure symptoms\u002Fsigns, accompanied by either reduced left ventricular ejection fraction (HFrEF, LVEF \\\u003C 40%), mildly reduced left ventricular ejection fraction (HFmrEF, LVEF 40-49%), or preserved left ventricular ejection fraction with elevated NT-proBNP and structural heart disease changes (HFpEF, LVEF ≥ 50%);\n2. Expected survival of less than 3 months;\n3. Patients with severe renal insufficiency (Ccr \\\u003C 30 mL\u002Fmin) or those undergoing dialysis treatment;\n4. Cardiac dysfunction caused by various reversible secondary causes, including hyperthyroid heart disease, anemic heart disease, and uncorrected congenital heart disease;\n5. Presence of indications for pacemaker implantation without subsequent device placement;\n6. Patients with chronic obstructive pulmonary disease (COPD) complicated by type III respiratory failure;\n7. Special populations such as patients with mental illness.",{"count":164,"type":22},1268,[25],"The purpose of this study is to prevent heart failure in older adults (aged 65-80 years) living in rural China who have atrial fibrillation but do not currently have heart failure. Because atrial fibrillation significantly increases the risk of developing heart failure , this cluster-randomized trial tests whether a telemedicine-supported, village doctor-led integrated care model can improve long-term cardiovascular health compared to standard care. Participants are assigned by their local village clinic to receive either conventional routine medical care or a digital-smart management program. The integrated program includes using wearable devices to monitor daily health, participating in structured lifestyle improvement programs focusing on exercise, diet, smoking cessation, and sleep, and receiving optimized medication plans supported by remote cardiovascular specialists. Researchers will measure overall improvements in cardiovascular health using the Life's Essential 8 score at 12 months, track major cardiovascular events like heart failure hospitalizations or stroke at 36 months, and evaluate the development of asymptomatic heart dysfunction at 48 months.",[168,103],"Atrial Fibrillation",[170,171,172,173],"Telemedicine Integrated Care","Integrated Care","Primary Prevention","Cardiovascular Diseases","2026-03-19",{"date":176,"type":34},"2026-03-25",{"date":178,"type":22},"2026-04-01",{"date":180,"type":22},"2030-04-01",{"name":39,"class":40},{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":4,"eligibilityCriteria":188,"healthyVolunteers":11,"sex":17,"minAge":48,"maxAge":19,"enrollmentInfo":189,"targetDuration":4,"studyType":23,"phases":191,"briefSummary":192,"conditions":193,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":194,"startDateStruct":195,"completionDateStruct":196,"leadSponsor":198,"locationsCount":4},"100630811","telemedicine-based-integrated-management-of-atrial-fibrillation-and-heart-failure-in-older-patients-in-village-clinics-100630811","NCT07492524","Telemedicine-based Integrated Management of Atrial Fibrillation and Heart Failure in Older Patients in Village Clinics","Telemedicine-based Integrated Management of Atrial Fibrillation and Heart Failure in Older Patients in Village Clinics: the MIRACLE-AF II Cluster Randomized Trial","Inclusion Criteria:\n\n1. Permanent residents with local household registration at the primary level in Jiangsu Province, aged 65-80 years.\n2. Electrocardiogram (ECG) confirmation of AF or possession of a diagnostic certificate for AF issued by a specialist.\n3. A documented history of HF or a diagnosis of HF based on echocardiography and\u002For NT-proBNP screening, defined by the presence of typical HF symptoms and\u002For signs, together with one of the following: reduced left ventricular ejection fraction (HFrEF; LVEF \\\u003C 40%), mildly reduced left ventricular ejection fraction (HFmrEF; LVEF 40-49%), or preserved left ventricular ejection fraction with elevated NT-proBNP and structural heart disease changes (HFpEF; LVEF ≥ 50%, meeting at least one of the following criteria: LAV 40 ml\u002Fm², E\u002Fe' ≥ 15, or TRV \\> 2.8 m\u002Fs).\n4. Management by a village clinic near the participant's place of residence.\n5. Ability to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n1. Expected life expectancy of less than 3 months.\n2. Severe renal insufficiency (Ccr \\\u003C 30ml\u002Fmin) or ongoing dialysis treatment.\n3. Cardiac insufficiency secondary to correctable causes, including hyperthyroid heart disease, anemic heart disease, or uncorrected congenital heart disease.\n4. Indications for pacemaker implantation without having undergone implantation.\n5. Chronic obstructive pulmonary disease (COPD) complicated by type II respiratory failure.\n6. Special populations, including patients with mental illnesses.",{"count":190,"type":22},1227,[25],"The goal of this cluster-randomized clinical trial is to evaluate a telemedicine-based, village doctor-led integrated management program for older adults (aged 65-80 years) who have both atrial fibrillation (AF) and heart failure (HF) in rural clinics in China. It aims to answer whether the digitally-supported program improves heart failure prognosis, assessed by the MAGGIC score, at 12 months , and reduces the risk of composite endpoint events, such as cardiovascular death, stroke, or heart failure hospitalization, over 36 months compared to conventional routine care. In this study, village clinics will be randomly assigned to either the intervention group or the control group. Participants in the control group will receive conventional routine care and basic public health services , while participants in the intervention group will receive a comprehensive management program led by village doctors. This intervention includes optimized medication treatment guided by a digital health platform with remote expert support , as well as a structured multidimensional lifestyle intervention featuring peer-support group exercises, smart wearable device monitoring, and personalized health education.",[168,103],{"date":176,"type":34},{"date":176,"type":22},{"date":197,"type":22},"2029-04-01",{"name":39,"class":40},{"id":200,"slug":201,"hasResults":11,"nctId":202,"briefTitle":203,"officialTitle":203,"acronym":4,"eligibilityCriteria":204,"healthyVolunteers":16,"sex":17,"minAge":205,"maxAge":4,"enrollmentInfo":206,"targetDuration":207,"studyType":99,"phases":4,"briefSummary":208,"conditions":209,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":213,"lastUpdatePostDateStruct":214,"startDateStruct":216,"completionDateStruct":218,"leadSponsor":220,"locationsCount":4},"100558029","construction-of-a-cohort-for-pan-vascular-disease-among-employees-of-taizhou-peoples-hospital-100558029","NCT06545799","Construction of a Cohort for Pan-Vascular Disease Among Employees of Taizhou People's Hospital","Inclusion Criteria:\n\n1. Employed or retired individuals aged 45 years or older;\n2. Willing to sign an informed consent form and voluntarily participate in health examinations and related data collection.\n\nExclusion Criteria:\n\n1. History of myocardial infarction, ischemic or hemorrhagic stroke, or revascularization of coronary, carotid, or peripheral arteries;\n2. Employees with severe psychological disorders who are unable to cooperate with the study;\n3. Pregnant or breastfeeding women.","45 Years",{"count":122,"type":22},"10 Years","1. Participant Recruitment During the annual health check-ups for hospital staff, potential participants are recruited. Those who express interest are provided with a detailed explanation of the study's objectives, content, and procedures, and are required to sign an informed consent form.\n2. Screening Phase Medical history is collected, including any previous occurrences of myocardial infarction, ischemic or hemorrhagic stroke, or history of coronary, carotid, or peripheral arterial revascularization.\n3. Baseline Data Collection\n\n1\\. Health Questionnaire Survey: Collect demographic information, medical history, and data on nutrition, physical activity, and smoking habits through a questionnaire.\n\n2\\. Clinical Assessments: Conduct the following assessments for all enrolled participants:\n\n* High-sensitivity cardiac troponin I and NT-proBNP testing\n* Non-invasive arterial stiffness testing\n* Measurement of visceral and subcutaneous fat content\n* Fundus photography\n* Body composition analysis\n\n  4 Regular Follow-Up\n\nAnnual follow-up for a total of 10 years. The follow-up includes:\n\n1. . Collection of updated demographic information and medical history, as well as repeated questionnaires on nutrition, physical activity, and smoking habits.\n2. . Reassessment of the following items:\n\n   * High-sensitivity cardiac troponin I and NT-proBNP testing\n   * Non-invasive arterial stiffness testing\n   * Measurement of visceral and subcutaneous fat content\n   * Fundus photography\n   * Body composition analysis\n\n     5 Outcome Evaluation\n\n1）. Primary Outcomes: Cardiovascular mortality, non-fatal myocardial infarction, or non-fatal stroke events.\n\n2）. Secondary Outcomes: All vascular events, changes in cardiovascular biomarkers, and degree of arterial stiffness.",[210,211,212],"Cardiovascular Death","Myocardial Infarction","Stroke","2024-08-05",{"date":215,"type":34},"2024-08-09",{"date":217,"type":22},"2024-09-01",{"date":219,"type":22},"2034-09-01",{"name":39,"class":40},""]