[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Jin Yang\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":138},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,45,70,92,117],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100641136","effect-of-dry-eye-treatment-on-corneal-astigmatism-measurements-100641136",false,"NCT07657858","Effect of Dry Eye Treatment on Corneal Astigmatism Measurements","Effect of Dry Eye and Ocular Surface Treatment on Agreement and Repeatability of Corneal Astigmatism Measurements Among Three Devices","Inclusion Criteria:\n\n* Patients with age-related cataract undergoing preoperative ocular examination.\n* Ability to complete ocular surface evaluation, including the Ocular Surface\n* Disease Index questionnaire, non-invasive tear film break-up time, tear meniscus height, Schirmer test, and ocular surface staining.\n* Ability to complete repeated corneal astigmatism measurements using IOLMaster 700, Pentacam AXL, and iTrace Prime.\n* Ability to maintain stable fixation during device measurements. Provision of written informed consent.\n\nExclusion Criteria:\n\n* Previous ocular surgery or ocular trauma.\n* Corneal degeneration, corneal dystrophy, or other corneal diseases that could affect corneal measurements.\n* Active corneal or conjunctival infection.\n* Uveitis.\n* Use of any topical eye drops within 24 hours before examination.\n* Use of antiglaucoma medications.\n* Contact lens wear within 1 month before examination.\n* Previous or ongoing treatment for dry eye disease.\n* Poor fixation during device measurements.\n* Poor-quality measurements from any study device","ALL",{"count":18,"type":19},400,"ESTIMATED","INTERVENTIONAL",[22],"NA","This prospective single-center study evaluates the effect of dry eye disease and short-term ocular surface treatment on the agreement and repeatability of corneal astigmatism measurements in patients with age-related cataract. Participants undergoing preoperative cataract evaluation are classified into a control group or a dry eye disease group according to ocular surface symptoms and objective tear film findings.\n\nAll participants undergo ocular surface assessment and repeated corneal measurements using three commonly used devices: IOLMaster 700, Pentacam AXL, and iTrace Prime. Measurements include keratometric corneal astigmatism, total corneal astigmatism, and vector components of astigmatism. Patients with dry eye disease receive 0.3% sodium hyaluronate eye drops four times daily for 2 weeks, after which ocular surface assessment and device measurements are repeated.\n\nThe primary objective is to determine whether dry eye disease reduces interdevice agreement and test-retest repeatability of corneal astigmatism measurements, and whether short-term ocular surface treatment improves measurement stability. Interdevice agreement is assessed using Bland-Altman analysis, and repeatability is evaluated using within-subject standard deviation, test-retest repeatability, and intraclass correlation coefficient.",[25,26],"Dry Eye","Cataract",[28,26,29,30,31],"Dry Eye Disease","Corneal Astigmatism","Ocular Surface",";Biometry","RECRUITING","2026-06-15",{"date":35,"type":36},"2026-06-18","ACTUAL",{"date":38,"type":36},"2026-01-01",{"date":40,"type":19},"2030-12-31",{"name":42,"class":43},"Jin Yang","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":20,"phases":55,"briefSummary":56,"conditions":57,"keywords":58,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":69,"locationsCount":44},"100627850","postoperative-rotational-dynamics-of-three-toric-intraocular-lens-designs-100627850","NCT07453992","Postoperative Rotational Dynamics of Three Toric Intraocular Lens Designs","Postoperative Rotational Dynamics of Different Toric Intraocular Lens Designs","3 TORIC ROTATE","Inclusion Criteria:\n\n* Adults aged 18 years or older with age-related cataract scheduled for phacoemulsification cataract surgery.\n* Presence of regular corneal astigmatism requiring toric intraocular lens implantation.\n* Eligible for implantation of one of the three study toric intraocular lenses based on preoperative evaluation.\n* Ability to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* History of prior ocular surgery in the study eye.\n* History of ocular trauma in the study eye.\n* Irregular corneal astigmatism or corneal pathology affecting reliable biometric measurement.\n* Intraoperative complications, including anterior capsular tear or posterior capsular rupture.\n* Inadequate pupillary dilation during surgery or postoperative examinations.\n* Evidence of zonular weakness, zonular dialysis, or lens subluxation.\n* Active ocular infection or inflammation.\n* Any other ocular or systemic condition judged by the investigator to potentially affect intraocular lens stability or study outcomes.","18 Years",{"count":18,"type":19},[22],"This prospective comparative cohort study evaluates and compares postoperative rotational stability and time-course dynamics of three commercially available toric intraocular lenses (TECNIS Toric II \\[ZCU\\], AcrySof IQ Toric, and AT TORBI 709M) after phacoemulsification cataract surgery. Rotation is quantified by registering postoperative retroillumination photographs to the end-of-surgery baseline using iris\u002Fscleral landmarks, with follow-up at postoperative day 1, day 3, week 1, week 2, month 1, and month 3. Associations between rotational outcomes and ocular biometric parameters are analyzed using linear mixed-effects models to inform individualized IOL selection and perioperative management.",[26],[59,60,61,62],"toric intraocular lens","rotational stability","cataract","astigmatism","2026-03-05",{"date":65,"type":36},"2026-03-06",{"date":67,"type":36},"2025-01-01",{"date":40,"type":19},{"name":42,"class":43},{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":79,"phases":4,"briefSummary":80,"conditions":81,"keywords":82,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":44},"100607079","performance-of-large-language-models-for-structured-recognition-and-refractive-prediction-100607079","NCT07183891","Performance of Large Language Models for Structured Recognition and Refractive Prediction","Head-to-Head Evaluation of ChatGPT 4o, GPT-5, and DeepSeek for Structured Extraction, Toric IOL Recommendation, and Refractive Prediction","Inclusion Criteria:\n\n-postoperative corrected distance visual acuity (CDVA) of 0.10 logMAR or better -an absolute IOL rotational stability of less than 10∘ at the 1-month follow-up examination\n\nExclusion Criteria:\n\n* incomplete biometric data on the examination report;\n* a history of previous ocular surgery or ocular trauma\n* the occurrence of intraoperative complications, such as an anterior capsular tear or posterior capsular rupture\n* the development of significant postoperative complications, including but not limited to severe intraocular infection or inadequate pupillary dilation.",{"count":78,"type":19},100,"OBSERVATIONAL","We conducted a single-center, retrospective observational study to evaluate large language models (ChatGPT 4o, GPT-5, DeepSeek) for automated interpretation of de-identified IOLMaster 700 reports provided as raster images. Models produced structured biometric extraction, toric IOL recommendation, and refractive predictions (sphere, cylinder, axis). Primary outcomes included parameter-level agreement and refractive error metrics; secondary outcomes included decision-support performance for toric IOL selection and agreement on ordered T-codes. No clinical intervention was performed.",[26],[61,83,62],"toric IOL","2025-09-14",{"date":86,"type":36},"2025-09-19",{"date":88,"type":36},"2025-08-01",{"date":90,"type":19},"2035-12-31",{"name":42,"class":43},{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":4,"eligibilityCriteria":98,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":53,"enrollmentInfo":99,"targetDuration":4,"studyType":79,"phases":4,"briefSummary":100,"conditions":101,"keywords":104,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":116,"locationsCount":44},"100598326","five-year-visual-function-and-refractive-outcomes-after-congenital-cataract-surgery-100598326","NCT07070037","Five-Year Visual Function and Refractive Outcomes After Congenital Cataract Surgery","Five-Year Visual Function and Refractive Outcomes After Congenital Cataract Surgery: A Multicenter Observational Cohort Study","Inclusion Criteria:\n\n* Diagnosis of congenital cataract\n* Underwent cataract extraction before 1 year of age\n* Available for regular follow-up for at least 5 years postoperatively\n* Written informed consent from legal guardian\n\nExclusion Criteria:\n\n* Acquired cataract or traumatic origin\n* Associated ocular malformations (e.g., microphthalmia, coloboma)\n* Systemic syndromes affecting vision (e.g., Down syndrome)\n* History of secondary surgery affecting visual outcome",{"count":18,"type":19},"This prospective multicenter observational study aims to evaluate the 5-year visual function and refractive outcomes in children undergoing surgery for congenital cataract. Key outcomes include best-corrected visual acuity, stereopsis, refractive error, and axial length growth. The study will help identify long-term trends and prognostic indicators after early cataract intervention in pediatric patients.",[102,103],"Congenital Cataract","Pediatric Cataract",[102,105,106,107,108,109],"Pediatric Cataract Surgery","Visual Function","Stereopsis","Amblyopia","Long-term Outcomes","2025-08-15",{"date":112,"type":36},"2025-08-20",{"date":114,"type":36},"2014-01-01",{"date":90,"type":19},{"name":42,"class":43},{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":121,"acronym":4,"eligibilityCriteria":122,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":123,"enrollmentInfo":124,"targetDuration":4,"studyType":20,"phases":126,"briefSummary":127,"conditions":128,"keywords":130,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":136,"leadSponsor":137,"locationsCount":44},"100597003","the-role-of-capsular-tension-rings-in-intraocular-lens-stability-in-high-myopia-cataract-patients-a-prospective-self-controlled-study-100597003","NCT07052825","The Role of Capsular Tension Rings in Intraocular Lens Stability in High Myopia Cataract Patients: A Prospective Self-Controlled Study","Inclusion Criteria:\n\n1. Age ≥ 18 years.\n2. Diagnosed with bilateral age-related cataracts and scheduled for phacoemulsification with IOL implantation in both eyes.\n3. High myopia in both eyes, defined as axial length (AL) ≥ 26.0 mm.\n4. No significant difference in axial length between the two eyes (e.g., interocular AL difference \\\u003C 1.0 mm).\n5. Willingness and ability to undergo bilateral surgery within a short interval (e.g., within 1-2 weeks).\n6. Able to provide informed consent and comply with the study protocol and follow-up visits.\n\nExclusion Criteria:\n\n1. History of ocular trauma, surgery, or intraocular inflammation in either eye.\n2. Presence of other ocular diseases that may affect visual outcomes, such as glaucoma, diabetic retinopathy, macular degeneration, or corneal opacity.\n3. Evidence of zonular weakness, pseudoexfoliation, or significant phacodonesis preoperatively.\n4. Severe dry eye or poor fixation that may interfere with postoperative imaging.\n5. Systemic diseases affecting visual function (e.g., uncontrolled diabetes, neurologic disorders).\n6. Participation in other clinical trials that may affect the study outcomes.","90 Years",{"count":125,"type":19},120,[22],"Study Purpose:\n\nThis prospective, self-controlled clinical study aims to evaluate the impact of capsular tension rings (CTR) on intraocular lens (IOL) stability in high myopia patients undergoing bilateral cataract surgery. Each patient will receive CTR implantation in one eye, with the fellow eye serving as control. Postoperative outcomes, including visual acuity, refraction, IOL positioning, and visual quality, will be compared between eyes to assess the effectiveness of CTR.\n\nStudy Methods:\n\nEligible participants (axial length ≥ 26.0 mm) will undergo femtosecond-assisted phacoemulsification with identical IOLs implanted in both eyes. One eye will be randomly assigned to receive a CTR. All surgeries will be performed by the same surgeon. Follow-up will be conducted at 1 day, 1 week, 1 month, 3 months, and 6 months postoperatively. Assessments will include UCVA, BCVA, refractive error, anterior segment OCT, IOL decentration and tilt, and visual quality (iTrace).\n\nSample Size and Population:\n\nA total of 60 patients (120 eyes) will be enrolled. Inclusion criteria include age ≥ 18 years and bilateral cataracts with high myopia. Exclusion criteria include other ocular diseases, history of severe ocular trauma, or poor visual potential. Patients will be stratified by axial length into three groups: ≤28 mm, 28-30 mm, and \\>30 mm.\n\nStudy Procedure:\n\nAfter informed consent and baseline examinations (including ocular biometry and imaging), patients will undergo surgery and be followed at specified intervals. All data will be managed securely. Comparative analysis between CTR and non-CTR eyes will be performed to evaluate the effect of CTR on IOL stability and visual outcomes in highly myopic cataract patients.",[129,26],"High Myopia",[131],"Capsular Tension Ring（CTR）, High Myopia, Intraocular lens, Tilt, Decentration, Visual Quality","2025-06-29",{"date":134,"type":36},"2025-07-07",{"date":67,"type":36},{"date":40,"type":19},{"name":42,"class":43},""]