[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Jingen Xia\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":46},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100584586","pulmonary-deposition-of-ultrasound-rock-salt-aerosol-inhalation-therapy-100584586",false,"NCT06891274","Pulmonary Deposition of Ultrasound Rock Salt Aerosol Inhalation Therapy","Study on the Lung Aerosol Deposition of Ultrasonic Rock Salt Inhalation Therapy","Inclusion Criteria:\n\nHealthy volunteers; Patients with chronic airway disease requiring nebulization therapy.\n\nExclusion Criteria:\n\nThose aged \\\u003C 18 years; Refusing to participate in the study; Patients requiring invasive ventilator assisted breathing; Patients with artificial airways. Patients with chronic liver and kidney function injury. Allergic to radioactive elements.",true,"ALL","18 Years",{"count":20,"type":21},26,"ESTIMATED","INTERVENTIONAL",[24],"NA","In the in vitro modeling phase, the investigators plan to use a realistic human upper respiratory tract model and an asymmetric ideal bronchial tree model. By combining 3D printing experiments with CFD simulations, the investigators will investigate the respiratory tract deposition rate and distribution of micro - moist particles in ultrasound rock salt aerosol inhalation therapy. This will be compared with a small - volume nebulizer to verify the effectiveness of ultrasound rock salt aerosol inhalation therapy and lay the foundation for further research on the application of this inhalation technique to other drug formulations.\n\nIn the clinical phase, the investigators plan to have subjects inhale radioactive aerosols and use PET\u002FCT imaging technology to assess the deposition rate of aerosol particles in the lungs. By quantitatively analyzing the images, the investigators will study their distribution characteristics in real human bodies to verify the accuracy of the in vitro models and the potential for clinical application.",[27,28,29],"COPD","Asthma Bronchiale","Chronic Bronchitis",[31,32,33],"Ultrasound Rock Salt Aerosol Inhalation Therapy","Pulmonary deposition rate","small volume nebulizer","NOT_YET_RECRUITING","2025-03-17",{"date":37,"type":38},"2025-03-24","ACTUAL",{"date":40,"type":21},"2025-03-31",{"date":42,"type":21},"2026-03-31",{"name":44,"class":45},"Jingen Xia","OTHER",""]